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| 1 | Study of the mechanisms of acupuncture and moxibustion treatmentfor ulcerative colitis ratsinview of the gene expression of cytokines显示文摘AIM To observe the effect of acupuncture and moxibustion on the expression of IL 1β and IL 6 mRNA in ulcerative colitis rats. METHODS The SD rat ulcerative colitis model was created by immunological method associated with local stimulation. Colonic mucosa was prepared from human fresh surgical colonic specimens, homogenized by adding appropriate amount of normal saline and centrifuged at 3000*!r/*!min . The supernatant was collected for measurement of protein conentration and then mixed with Freund adjuvant. This antigen fluid was first injected into the plantae of the model group rats, and then into their plantae, dorsa, inguina and abdominal cavities (no Freund adjuvant for the last injection) again on the 10th, 17th, 24th and 31st day. When a certain titer of serum anti colonic antibody was reached, 2% formalin and antigen fluid (no Freund adjuvant) were administered separately by enema. The ulcerative colitis rat model was thus set up. The animals were randomly divided into four groups: model control group (MC, n =8), electro acupuncture group (EA, n =8), herbs partition moxibustion group (HPM 8), normal control group (NC, n =8). HPM: Moxa cones made of refined mugwort floss were placed on the medicinal pad (medicinal pad dispensing: Radix Aconiti praeparata, cortex Cinnamomi, etc ) for Qihai (RN 6) and Tianshu (ST 25, bilateral) and ignited. Two moxa cones were used for each acupoint once a day and 14 times in all. EA: Tianshu (bilateral) and Qihai were stimulated by the intermittent pulse with 2Hz frequency, 4mA intensity for 20 minutes once a day and 14 times in all. After treatment, rats of all four groups were killed simultaneously. The spleen was separated and the distal colon was dissected. Total tissue RNA was isolated by the guanidinium thiocyanate phenol chloroform extraction method. RT PCR technique was used to study the expression of IL 1β and IL 6 mRNA. RESULTS IL 1β and IL 6 mRNAs were not detected in the spleen and colonic mucosa of the NC rats, whereas they were significantly expressed in that of the MC rats. IL 1β and IL 6 mRNAs were markedly lower in the EA and HPM rats than that in MC rats. There was no significant difference between the levels of IL 1β and IL 6 mRNAs in the EA and HPM rats. The expressions of IL 1β and IL 6 mRNAs were nearly the same in the spleen and colon of all groups. CONCLUSION Acupuncture and moxibustion greatly inhibited the expression of IL 1β and IL 6 mRNA in the experimental ulcerative colitis rats. | Wu HG Zhou LB Pan YY Huang C Chen HP Shi Z Hua XG | 1999 | World Journal of Gastroenterology1999，5，6： | 45 |
| 2 | Appendiceal mucocoeles and pseudomyxoma peritonei显示文摘Mucocoele of the appendix occurs when obstruction of the appendiceal lumen results in mucus accumulation and consequent abnormal dilatation. The most impor- tant aetiology, from a surgical perspective, is either mucinous cystadenoma or cystadenocarcinoma. In the latter, a spontaneous or iatrogenic rupture of the mucocoele can lead to mucinous intraperitoneal ascites, a syndrome known as pseudomyxoma peritonei. Optimal management of mucoceles is achieved through accurate preoperative identification and subsequent careful resection. We report two cases and subsequently discuss the clinical presentation of mucocoeles, their association with pseudomyxoma peritonei and an optimal management of both conditions. | Anupam Dixit John HP Robertson Satvinder S Mudan Charles Akle | 2007 | World Journal of Gastroenterology2007，13，16： | 14 |
| 3 | Na^+,K^+和ABA对盐胁迫大麦根液泡膜ATPase活性的影响显示文摘许多植物液泡膜ATPaso活性与植物抗盐性有关(Bremberger等1988,Matsumoto和Chung 1988,Gabarino和Dupont 1988)。当植物生长在高浓度NaCl环境中时。 | 王宝山 Haschke HP | 1991 | 植物生理学报(0257-4829)1991，17，4： | 12 |
| 4 | 三结构域蛋白27通过降解转化生长因β活化激酶1结合蛋白2/3减轻肝缺血再灌注损伤显示文摘【据Hepatology 2021年2月报道】题:三结构域蛋白27通过降解转化生长因β活化激酶1结合蛋白2/3减轻肝缺血再灌注损伤(作者Chen SY等)肝缺血再灌注(IR)损伤是肝移植术后器官功能障碍的主要原因,其主要涉及炎症反应和细胞凋亡等过程。作为调控多种细胞炎症和凋亡的关键介质,三结构域蛋白27(TRIM27)在肝IR损伤中的作用值得研究。 | CHEN SY ZHANG HP LI J 陈三洋 | 2021 | 临床肝胆病杂志2021，37，6： | 11 |
| 5 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 6 | Metastatic pattern in esophageal and gastric cancer:Influenced by site and histology显示文摘BACKGROUND Detailed information on metastatic patterns in of patients with esophageal and gastric cancer is limited.Early recognition of metastases is important to avoid futile locoregional treatments.Furthermore,knowledge on metastatic patterns is necessary for further development of personalized treatment modalities.AIM To gain insight into the metastatic pattern of gastroesophageal cancer.METHODS A nationwide retrospective autopsy study of 3876 patients with adenocarcinoma(AC)or squamous cell carcinoma(SCC)of the esophagus or stomach between 1990 and 2017 was performed.Only patient with metastases were included for analysis.The metastatic pattern was analyzed according to the primary tumor location and histological subtype.RESULTS Metastatic disease was found in 268 esophageal and 331 gastric cancer patients.In esophageal cancer,the most common metastatic locations were liver(56%),distant lymph nodes(53%)and lung(50%).Esophageal AC showed more frequently metastases to the peritoneum and bone compared with esophageal SCC.In gastric cancer,the most common metastatic locations were distant lymph nodes(56%),liver(53%)and peritoneum(51%).Intestinal-type AC of the stomach showed metastases to the liver more frequently,whereas metastases to the bone,female reproductive organs and colorectum were observed more frequently in diffuse-type gastric AC.CONCLUSION This study showed differences in metastatic patterns of patients with esophageal and gastric cancer according to the primary tumor location and histological subtype. | Moniek HP Verstegen Mitchell Harker Carlijn van de Water Jolanda van Dieren Niek Hugen Iris D Nagtegaal Camiel Rosman Rachel S van der Post | 2020 | World Journal of Gastroenterology2020，26，39： | 9 |
| 7 | Preliminary study on light hydrocarbons in ore-forming fluids of gold and antimony deposits in southwestern Guizhou, China显示文摘METAL minerals precipitate generally from ore-forming fluid. It is suggested that organic mat-ter in ore-forming fluid is one of the best media which show the role of organic matter in oregenesis. Because mineralizing temperatures of many ore deposits exceeded the stable rangesof liquid hydrocarbons, only light hydrocarbons were preserved well in inclusions. Thus, | Zhuang, HP Lu, JL Fu, JM Liu, JZ Shi, JX | 1997 | Chinese Science Bulletin1997，42，20： | 8 |
| 8 | 南极半岛海洋气候区的土壤——Ⅲ.冻-融作用与水分状况显示文摘自由水活动在南极海洋性气候区土壤形成与演化过程中发挥极为重要的作用。本文对土壤自由水的来源、冻-融作用、永冻层和活动层动态以及自由水参与下的物质迁移过程等几个方面进行了论述,讨论了上述不同过程的影响因素以及土壤发生学意义,指出以土壤水形态转化和自由水活动为基础的土壤过程具有显著的微域性特点,是决定本区土壤发生类型与分布模式的重要因素之一。 | 陈杰 龚子同 阮心玲 Blume HP | 2004 | 土壤2004，36，1： | 8 |
| 9 | Renin and angiotensinogen expression and functions in growth and apoptosis of human glioblastoma显示文摘The expression and function in growth and apoptosis of the renin-angiotensin system(RAS)was evaluated inhuman glioblastoma.Renin and angiotensinogen(AGT)mRNAs and proteins were found by in situ hybridisationand immunohistochemistry in glioblastoma cells.Angiotensinogen was present in glioblastoma cystic fluids.Thus,human glioblastoma cells produce renin and AGT and secrete AGT.Human glioblastoma and glioblastoma cellsexpressed renin,AGT,renin receptor,AT(2)and/or AT(1)mRNAs and proteins determined by RT-PCR and/ | Juillerat-Jeanneret L Celerier J Chapuis Bernasconi C Nguyen G Wostl W Maerki HP Janzer RC Corvol P Gasc JM | 2004 | 中国神经肿瘤杂志2004，2，1： | 8 |
| 10 | 成人缺血性卒中早期治疗指南(节译Ⅲ)显示文摘该指南是美国在2003年卒中指南基础上的更新版本,汇集了近年来缺血性卒中的最新临床研究数据,从循证医学的角度提出了科学的治疗建议。全文包括卒中救治的组织、早期评价、急性期整体治疗、溶栓治疗、抗栓治疗、扩容及升压治疗、血管外科与血管内干预、再灌注治疗、并发症处理等内容,涉及急性缺血性卒中从发病、转送、诊断、治疗、预后等多个方面。尽管该指南主要是基于欧美人种的临床研究结果,但对于中国急性缺血性卒中患者的处理亦具借鉴意义。鉴于篇幅,本刊分3期连载(节译Ⅰ见2007年第4卷第7期第332~334页,节译Ⅱ见2007年第4卷第8期第381~384页)。 | Adams HP del Zoppo JG Alberts MJ 焦力群 马妍 李萌 凌锋 | 2007 | 中国脑血管病杂志2007，4，9： | 7 |
| 11 | 姜黄的药理学(待续)显示文摘 | Ammo.,HP 叶祖光 | 1992 | 国外医学(中医中药分册)1992，14，2： | 4 |
| 12 | Dyslipidemia: evidence of efficacy of the pharmacological and non-pharmacological treatment in the elderly显示文摘为心血管的疾病(CVD ) 控制风险因素在的临床的决定老考虑下列:(1 ) 老预期寿命;(2 ) 老生物年龄和功能的能力;(3 ) 在老组的心血管的疾病的角色;(4 ) 风险因素在的流行老;并且(5 ) 风险因素在的治疗的有效性老。很多研究显示出 dyslipidemia 的第二等、主要的预防的功效在老。然而,在 80 年包括了病人的唯一的审判是心保护学习(HPS ) 。Statins 为阴沉的低密度的脂蛋白胆固醇(LDL-C ) 被认为第一线治疗。因为生活方式变化是很困难的完成,医生们一般来说趋于开许多药控制心血管的风险因素。然而,健康食物消费在主要、第二等的心血管的预防仍然是一块奠基石并且应该被每个人实现。 | Claudia F Gravina Marcelo Bertolami Giselle HP Rodrigues | 2012 | Journal of Geriatric Cardiology2012，9，2： | 3 |
| 13 | Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia显示文摘Actinorhizal plants contain numerous antioxidants that may play a crucial role in preventing the formation of tumors.H-Ras p21,a member of the Ras-GTPase family,is a promising target to treat various kinds of cancers.An in silico docking study was carried out to identify the inhibitory potential of compounds of these plants against H-Ras by using Discovery Studio 3.5 and by using Autodock 4.2.Docking studies revealed that four compounds,isorhamnetin-7-rhamnoside,quercetin-3-glucoside-7-rhamnoside(present in H.rhamnoides),zeaxanthin,and translutein(present in H.salicifolia) significantly bind with binding energies-17.1534,-14.7936,-10.2105 and-17.2217 Kcal/mol,respectively,even though they slightly deviate from Lipinski's rule.Absorption,distribution,metabolism,excretion and toxicity(ADME/tox) analyses of these compounds and their stereoisomers showed that they were less toxic and non-mutagenic.Amongst them,isorhamntein-7-rhamnoside showed hepatotoxicity.Hence,these compounds can be further investigated in vivo to optimize their formulation and concentration and to develop potential chemical entities for the prevention and treatment of cancers. | Talambedu Usha Sushil Kumar Middha Arvind Kumar Goyal Mahesh Karthik DA Manoj Syed Faizan Peyush Goyal HP Prashanth Veena Pande | 2014 | The Journal of Biomedical Research2014，28，5： | 3 |
| 14 | 南极半岛海洋气候区的土壤 Ⅱ.有机质积累过程显示文摘南极海洋性气候土壤形成过程中具有明显的有机质积累作用,有机质对成土过程和土壤性状产生重要影响,如土壤酸化、有机-金属螯合物的形成和生物成矿现象。受地表生物活动强弱影响,不同土壤有机C、N含量差异明显。冻扰作用、灰化作用以及物理性裂隙渗漏是有机质在剖面的迁移和重新分配的主要途径。 | 陈杰 龚子同 Blume HP | 2003 | 土壤2003，35，5： | 3 |
| 15 | Removal of endogenous leptin from the circulation by the kidney显示文摘 | Cumin F Baum HP Gasparo M | | 0，，： | 2 |
| 16 | 中国幽门螺杆菌耐药状况及耐药对治疗的影响[J]显示文摘 | 中华医学会消化病学分会HP学组 | | 胃肠病学0，，： | 2 |
| 17 | Cloning and identification of an angiostatic molecule IP-10/crg-2显示文摘AIM To obtain human and murine cDNAsencoding IFN--y inducible protein 10 (lP--10) andcytokine responsive gene--2 (Crg-2).METHODS The encoding genes of lP-10 and Crg2 were amplified by RT--PCR from Cultured humanfibroblast cells and Balb/ c mouse liver treatedby IFN-y and TNF-a, respectively, and clonedinto plasmids of PUC19 and PGEM3Zf(+ ).RESULTS The nucleotide sequences ot theamplified DNA were confirmed by endonucleasesdigestion and sequencing.CONCLUSION Recombinant lP-10/ crg--2 geneclones with 306 hp and 314 hp inserts wereestablished for further research on biologicalactivities and ligands of hiP-10/mCrg--2. | Liu ZG Yang JH An HZ Wang HY He FT Han ZY Han Y Wu HP Xiao B Fan DM | 1999 | World Journal of Gastroenterology1999，5，3： | 2 |
| 18 | 健康促进和疾病预防干预活动可作为评价社区卫生的补充指标显示文摘1 研究背景与资料
1997年欧洲理事会设立了"健康监测规划",旨在建立一套社区卫生的监测指标体系,以便衡量整个社区的健康水平、健康影响因素和健康趋势,促进社区卫生规划及其监测评价,并为欧盟成员国提供适当的卫生信息用于相互比较和支持国家的卫生政策。 | 姚岚 刘运国 Dauben HP Fφrde OH Loud ML | 2010 | 中国循证医学杂志2010，10，11： | 2 |
| 19 | Densification of the Tungsten Heavy Alloys at 1473 K and Fabrication of W-Mo System FGM with Density Gradient显示文摘The tungsten heavy alloys with Ni-Al and Fe-Al additives were sintered by hot-press method at 1473 K for 1 h. It was found that the relativedensity of the W-Fe alloy could be increased evidently by addition of Al. However, the relative density of W- Ni-Al alloy with low content of Al was conversely decreased considerably compared with that of W-Ni alloy. The causes have been studied. The sinter ing experiments of Mo aloy and W-Mo alloys with 3 wt pct Fe-1.5 wt pct Al additives were also carried out under the same sintering condition of low temperature.Finally, W-Mo system FGM with density gradient was successfully fabricated.Its density changed gradually from 17.0x103 kg/m3 to 9.5x103 kg/m3 within the middfe 1.1 mm thickness | Xiong, HP Zhang, LM Li, JG Yuan, RZ | 1999 | Journal of Materials Science & Technology1999，15，3： | 2 |
| 20 | Identification and speed control of ultrasonic motors based on neural networks显示文摘 | Xu X Liang YC Lee HP | 2003 | Journal of Micromechanics and Microengineering2003，13，1： | 2 |
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