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| 1 | Orchestration between ILC2s and Th2 cells in shaping type 2 immune responses显示文摘The type 2 immune response is critical for host defense against large parasites such as helminths.On the other hand,dysregulation of the type 2 immune response may cause immunopathological conditions,including asthma,atopic dermatitis,rhinitis,and anaphylaxis.Thus,a balanced type 2 immune response must be achieved to mount effective protection against invading pathogens while avoiding immunopathology.The classical model of type 2 immunity mainly involves the differentiation of type 2 T helper(Th2)cells and the production of distinct type 2 cytokines,including interleukin-4(IL-4),IL-5,and IL-13.Group 2 innate lymphoid cells(ILC2s)were recently recognized as another important source of type 2 cytokines.Although eosinophils,mast cells,and basophils can also express type 2 cytokines and participate in type 2 immune responses to various degrees,the production of type 2 cytokines by the lymphoid lineages,Th2 cells,and ILC2s in particular is the central event during the type 2 immune response.In this review,we discuss recent advances in our understanding of how ILC2s and Th2 cells orchestrate type 2 immune responses through direct and indirect interactions. | Rama Krishna Gurram Jinfang Zhu | 2019 | Cellular & Molecular Immunology2019，16，3： | 19 |
| 2 | Identifying who best tolerates moderate sedation:Results from a national database of gastrointestinal endoscopic outcomes显示文摘BACKGROUND With increasing volume and cost of gastrointestinal endoscopic procedures,the proper selection of patients for moderate sedation becomes increasingly relevant.The current literature lacks consistent findings that allow for appropriate selection of patients for moderate sedation.AIM To analyze a nationwide registry of patients to identify patient and procedural factors associated with lower sedation requirements for endoscopy.METHODS The Clinical Outcomes Research Initiative National Endoscopic Database was queried to assess adult patients undergoing moderate sedation for esophagogastroduodenoscopy(EGD)and colonoscopy from 2008 to 2014.Patients were stratified into two groups[low dose(LD)and high dose sedation]based on sedation requirements.Anthropometric,procedural,and anesthesia data were compared,and multivariable analysis was performed to identify factors associated with LD sedation.RESULTS Of the 371102 patients included in the study,63137 where stratified into the LD sedation group and 307965 were in the high dose group.Moderate sedation was managed primarily by endoscopists(50%)and anesthesia providers(47%).Patients undergoing EGDs and procedures performed in the inpatient setting,in ambulatory surgery centers,intensive care units or hospital wards,required less sedation than colonoscopies,outpatient procedures and procedures done in endoscopy suites,respectively(P<0.0001 for all).On multivariable analysis,factors predictive of tolerance with lower sedation requirements for EGDs and colonoscopies were female gender,age≥50,non-White race,Hispanic descent,body mass index≤25 kg/m^(2),and higher American Society of Anesthesia Class(P<0.0001 for all).CONCLUSION Clinicians should consider these patient profiles in determining which patients will better tolerate moderate sedation vs those better suited for alternative sedation methods. | Monica Passi Farial Rahman Sandeep Gurram Sheila Kumar Christopher Koh | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，4： | 2 |
| 3 | Yield, composition and rheelogical characteristics of cheddar cheese made with high pressure processed milk显示文摘 | San Mart N-Gonz Lez M F Rodr Guez J J Gurram S | 2007 | LWT - Food Science and Technology2007，40，4： | 1 |
| 4 | Mechanical properties of biorenewable fiber/plastic composites 显示文摘 | JAMES J GURRAM S STOKKE D D | 2004 | J Appl Polym Sci2004，93，： | 1 |
| 5 | Spectral-domain Covariance Estimation with a Priori Knowledge显示文摘 | Gurram P R Goodman N A | 2006 | IEEE Transactions on Aerospace and Electronic Systems2006，42，3： | 1 |
| 6 | Prophylactic Dexamethasone for Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Dose Ranging and Safety Evaluation Study显示文摘 | Rashmi Madan Anuj Bhatia Sajith Chakithandy Rajeshwari Subramaniam Gurram Rammohan Shrinivas Deshpande Manorama Singh H L. Kaul | 2005 | Anesthesia & Analgesia2005，，6： | 1 |
| 7 | Mechanical properties of biorenewable fiber/plastic composites显示文摘 | James L Julson Gurram Subbarao Stokke D D | 2004 | Journal of Applied Polymer Science2004，93，： | 1 |
| 8 | HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation显示文摘Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been reported.Previous studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to depression.Here,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with depression.Interestingly,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 activation.Our data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human PBMCs.Furthermore,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in vitro.Mice with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of inflammation.In conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s. | Zhishuo Wang Chenghua Yan Qizhen Du Yuying Huang Xuezhen Li Dan Zeng Ruizhi Mao Rama Krishna Gurram Shipeng Cheng Wangpeng Gu Lin Zhu Weiguo Fan Liyan Ma Zhiyang Ling Ju Qiu Dangsheng Li Enmei Liu Yaguang Zhang Yiru Fang Jinfang Zhu Bing Sun | 2023 | Cellular & Molecular Immunology2023，20，4： | 1 |
| 9 | Spectral-domain covariance estimation with a priori knowledge显示文摘 | P R Gurram N A Goodman | 2006 | IEEE Transactions on Aerospace and Electronic Systems2006，42，3： | 1 |
| 10 | Effect of nesiritide versus milrinone in the treatment of acute decompensated heart failure 显示文摘 | Lewis DA Gurram NR Abraham WT | 2003 | Am J Health Syst Pharm2003，60，4： | 1 |
| 11 | Support-vector-based hyperspectral anomaly detection using optimized kernel parameters显示文摘 | Gurram R Kwon H | | 0，，1545： | 1 |
| 12 | Effectiveness of d - dimer as a screening test for venous thromboembolism: an update显示文摘 | Pulivarthi S Gurram MK | 2014 | N Am J Med Sci2014，6，10： | 1 |
| 13 | Subcritical open-channel junction flow显示文摘 | Gurram | 2000 | Journal of Hydraulic Engineering2000，126，11： | 1 |
| 14 | Sparse kernel based hyperspectral anomaly detection 显示文摘 | GURRAM P HEESUNG KWON HAN T | 2012 | Geoscience and Remote Sensing Letters IEEE2012，9，5： | 1 |
| 15 | The interaction of exercise ability and body mass index upon long-term outcomes among patients undergoing stress- rest perfusion single-photon emission computed tomography imaging 显示文摘 | Uretsky S Supariwala A Gurram S | 2013 | Am Heart J2013，166，1： | 1 |
| 16 | Dual PPAR-α and-γ activators derived from novel benzoxazinone containing thiazolidinediones having antidiabetic and hypolipidemie potential显示文摘 | GURRAM RM RANJAN C REDDT KA | 2006 | Bioorg Med Chem2006，14，2： | 1 |
| 17 | A Simple and Efficient Method forα-bromination of Carbonyl Compo-unds using N-bromosuccinimide in the Presence of Silicasupported Sodium Hydrogen Sulfate as a Heterogene-ous Catalyst显示文摘 | Biswanath D Katta V Gurram M | 2005 | Tetrahedron Letters2005，46，17： | 1 |
| 18 | Spectral-domain covariance estimation with a priori knowledge 显示文摘 | Gurram P R Goodman N A | 2006 | IEEE Transactions on Aerospace and Electronic Sytems2006，42，3： | 1 |
| 19 | Isolation and characteri-zation of cellulose-degrading bacteria from the deep subsurface of the Homestake gold mine,Lead,South Dakota,USA显示文摘 | Rastogi G Muppidi GL Gurram RN | 2009 | J Ind Microbiol Biotechnol2009，36，4： | 1 |
| 20 | Synthesis and antitumor ac- tivity of amine analogs of irofulven显示文摘 | Trevor C McMorris Ramesh Chimmani Mahender Gurram Michael D Staake Michael J Kelner | 2007 | Bioorganic & Medicinal Chemistry Letters2007，17，24： | 1 |
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