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| 1 | 高Nb X80管线钢焊接热影响区显微组织与韧性显示文摘利用Gleeble-1500模拟不同热输入的单道次焊接热循环过程,通过光学显微镜(OM)、扫描电镜(SEM)及电子背散射衍射(EBSD)对高Nb X80管线钢焊接热影响区中的粗晶区(CGHAZ)显微组织、马/奥组元(M/A)形态和分布以及原奥氏体晶粒粗化情况进行研究.结果表明:高Nb X80管线钢的焊接热输入应不高于30 kJ/cm,虽然在高Nb钢中,原奥氏体晶粒的平均尺寸不会随热输入增加过于粗大,但当热输入高于40 kJ/cm时,会使得原奥氏体晶粒内粒状贝氏体的晶体取向选择过于单一,大角晶界(≥15°)密度明显降低,有效晶粒尺寸较大,M/A组元也由于热输入过大而明显粗化.上述原因使高Nb X80管线钢在大于40 kJ/cm热输入条件下热影响区粗晶区韧性明显恶化. | 缪成亮 尚成嘉 王学敏 张龙飞 Mani Subramanian | 2010 | 金属学报2010,46,5: | 86 |
| 2 | 肠道疾病中肠上皮细胞的死亡显示文摘目前,由肠上皮细胞死亡引发的肠损伤仍然是危险且难以预测的严重疾病之一。肠上皮细胞、免疫系统和微生物组之间相互关联以维持正常肠道稳态和肠屏障的完整性。在微生物入侵时,肠上皮细胞进入死亡程序以维持肠上皮功能,并且保持其持续更新能力,维护组织稳态。但是脱离稳态的肠上皮细胞死亡会导致肠通透性增加和肠屏障功能障碍,导致多种急性和慢性肠道疾病,例如肠缺血/再灌注、败血症、炎症性肠病(inflammatory bowel diseases, IBD),坏死性小肠结肠炎(necrotizing enterocolitis, NEC)等。在病理生理状态下,过量的肠上皮细胞凋亡性死亡导致慢性炎症状态,而后转向坏死性凋亡细胞死亡机制,其诱导的病理特征比细胞凋亡的情况下更多,此外还可能诱导其它溶细胞性死亡机制,例如细胞焦亡和铁凋亡,从而增加肠道疾病的病理指征。但是,目前关于慢性肠道疾病中肠上皮细胞死亡机制的研究仍然存在空白。目前亟需对慢性肠道疾病(包括败血症,IBD,NEC和肠缺血/再灌注)中特定的细胞死亡机制进行深入了解,以开发针对此类疾病的新型的有效治疗策略。本文旨在综述肠上皮细胞不同死亡机制(例如细胞凋亡,细胞坏死,坏死性凋亡,细胞焦亡和铁凋亡)在急、慢性肠道疾病中的研究进展。 | Saravanan Subramanian 耿华 谭小弟 | 2020 | 生理学报2020,72,3: | 26 |
| 3 | Recent advances based on the synergetic effect of adsorption for removal of dyes from waste water using photocatalytic process显示文摘The problem of textile dye pollution has been addressed by various methods,mainly physical,chemical,biological,and acoustical.These methods mainly separate and/or remove the dye present in water.Recently,advanced oxidation processes(AOP)have been focused for removal of dye from waste water due to their advantages such as ecofriendly,economic and capable to degrade many dyes or organic pollutant present in water.Photocatalysis is one of the advance oxidation processes,mainly carried out under irradiation of light and suitable photocatalytic materials.The photocatalytic activity of the photocatalytic materials mainly depends on the band gap,surface area,and generation of electron–hole pair for degradation dyes present in water.It has been observed that the surface area plays a major role in photocatalytic degradation of dyes,by providing higher surface area,which leads to the higher adsorption of dye molecule on the surface of photocatalyst and enhances the photocatalytic activity.This present review discusses the synergic effect of adsorption of dyes on the photocatalytic efficiency of various nanostructured high surface area photocatalysts.In addition,it also provides the properties of the water polluting dyes,their mechanism and various photocatalytic materials;and their morphology used for the dye degradation under irradiation of light along with the future prospects of highly adsorptive photocatalytic material and their application in photocatalytic removal of dye from waste water. | Subramanian Natarajan Hari C.Bajaj Rajesh J.Tayade | 2018 | Journal of Environmental Sciences2018,30,3: | 22 |
| 4 | 抗变形X100管线钢模拟焊接热影响区的组织与韧性研究显示文摘采用Gleeble-3800热模拟机研究了多相抗变形x100高Nb含量管线钢的焊接性能,利用金相显微技术(OM)、扫描电镜(SEM)、电子背散射衍射(EBSD)对模拟焊接热影响区的组织进行了表征,结合示波冲击及微观硬度实验结果分析了影响模拟焊接热影响粗晶区(CGHAZ)的低温韧性及热影响区硬度与组织之间的关系.研究表明,高Nb抗变形X100管线钢单道次焊接热输入小于20 kJ/cm时的CGHAZ具有较高韧性,形成大角晶界密度较高的板条贝氏体或针状铁素体;焊接热输入大于等于25 kJ/cm会导致CGHAZ晶粒均匀性的恶化,使M/A组元粗化,并形成取向单一的粗大粒状贝氏体;示波冲击实验及SEM断口分析显示,粗大的M/A组元处极容易启裂,高的大角晶界密度可显著提高裂纹扩展功,使材料韧化.同时,为保证焊接热影响区不过度软化,以及高硬度产生抗氢致延迟破坏,单道次的焊接热输入以15—20 kJ/cm为宜. | 聂文金 尚成嘉 由洋 张晓兵 Sundaresa Subramanian | 2012 | 金属学报2012,48,7: | 20 |
| 5 | Transparent, stretchable, and rapid-response humidity sensor for body-attachable wearable electronics显示文摘能为连续地在人的身体或潮湿附近监视环境的湿度被纳入人的身体的可拉长、保角的湿度传感器人的皮肤铺平能在电子皮肤和个人保健应用程序起一个重要作用。然而,很可拉长的湿度传感器基于 non-stretchable 部件的几何工程,仅仅一些详细研究在在应用机械变丑下面的可拉长的湿度传感器上是可得到的。在这份报纸,我们与一个简单制造过程建议一个透明、可拉长的湿度传感器,有提供与快反应和松驰时间一起的高 stretchability,敏感,和稳定性的内在地可拉长的部件。减少的 graphene 氧化物聚氨酯 composites 和一个弹性体的传导性的电极镇静,这台设备分别地象 3.5 和 7 s 一样快展出出色的反应和松驰时间。responsivity 和反应和松驰面对在拉长直到 60% 并且在 10,000 以后的紧张下面几乎未改变的湿度遗体设备预定在 40% 紧张拉长周期。进一步,这些可拉长的湿度传感器能容易并且保角地为在人的身体,湿目标,或人的皮肤附近监视环境的湿度层次被纳入一根手指。 | Tran Quang Trung Le Thai Duy Subramanian Ramasundaram Nae-Eung Lee | 2017 | Nano Research2017,10,6: | 15 |
| 6 | Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study显示文摘 | Patrick Marcellin Edward Gane Maria Buti Nezam Afdhal William Sievert Ira M Jacobson Mary Kay Washington George Germanidis John F Flaherty Raul Aguilar Schall Jeffrey D Bornstein Kathryn M Kitrinos G Mani Subramanian John G McHutchison E Jenny Heathcote | 2012 | The Lancet2012,,: | 14 |
| 7 | Management of complex and redo cases of pelvic fracture urethral injuries显示文摘Objectives:Pelvic fracture urethral injuries(PFUI)result from traumatic disruption of the urethra.A significant proportion of cases are complex rendering their management challenging.We described management strategies for eight different complex PFUI scenarios.Methods:Our centre is a tertiary referral centre for complex PFUI cases.We maintain a prospective database(1995e2016),which we retrospectively analysed.All patients with PFUI managed at our institute were included.Results:Over two decades 1062 cases of PFUI were managed at our institute(521 primary and 541 redo cases).Most redo cases were referred to us from other centres.Redo cases had up to five prior attempts at urethroplasty.We managed complex cases,which included bulbar ischemia,young boys and girls with PFUI,PFUI with double block,concomitant PFUI and iatrogenic anterior urethral strictures.Bulbar ischemia merits substitution urethroplasty,most commonly,using pedicled preputial tube.PFUI in young girls is usually associated with urethrovaginal fistula.Young boys with PFUI commonly have a long gap necessitating trans-abdominal approach.Our success rate with individualised management is 85.60%in primary cases,79.13%in redo cases and 82.40%in cases of bulbar ischemia.Conclusion:The definition of complex PFUI is ever expanding.The best chance of success is at the first attempt.Anastomotic urethroplasty for PFUI should be performed in experienced hands at high volume centres. | Sanjay BKulkarni Sandesh Surana Devang JDesai Hazem Orabi Subramanian Iyer Jyotsna Kulkarni Ajit Dumawat Pankaj M.Joshi | 2018 | Asian Journal of Urology2018,5,2: | 13 |
| 8 | 奥氏体变形及冷却速率对低碳贝氏体组织中大角晶界分布的影响显示文摘使用电子背散射衍射技术研究了低C高Mn高Nb成分设计下,非再结晶奥氏体变形及加速冷却速率对低碳贝氏体组织取向差特征和大角晶界分布的影响.结果表明,与原奥氏体晶粒内部的相变组织相比,原奥氏体晶界附近具有更高的大角晶界密度,非再结晶区奥氏体变形及快速冷却都有利于提高共格相变的驱动力、弱化变体选择以及有效增加大角晶界密度.此外,非再结晶区的大变形除了可充分压扁奥氏体晶粒和增加单位面积的奥氏体晶界密度外,还导致奥氏体晶界上细小的非共格转变铁素体晶粒生成,且这些铁素体晶粒与相邻组织表现出大取向差. | 缪成亮 尚成嘉 Mani Subramanian | 2012 | 北京科技大学学报2012,34,3: | 12 |
| 9 | Galvanic Corrosion Behaviour of Aluminium 3004 and Copper in Tropical Marine Atmosphere显示文摘铝 3004 的流电的腐蚀行为和有不同区域比率的铜在 426 天的一个时期上在 Tuticorin 港口在热带海洋的空气被学习。A 的区域比率 < 潜水艇 class= “ a-plus-plus ” > 艾尔 :一 < 潜水艇 class= “ a-plus-plus ” > 学习的 Cu , 是 1:1, 1:2, 1:4, 1:8, 2:1, 4:1 与 8:1。金属的流电的腐蚀行为由于流电的结合以铝的腐蚀率的相对增加被学习铜,处于铜的腐蚀率的相对减少由于流电的结合到由于流电的结合的 pitting 的铝的铝,和危险性铜。系统的流电的潜在、流电的水流被监视。从温和蚀刻到穿孔的不同尺寸的坑在与铜的接触在边阶和铝的接口的表面上经验丰富。捱过的参数和在影响金属的流电的腐蚀有一个主要角色的环境污染物质也被监视。源于流电的腐蚀的腐蚀产品用 XRD 被分析,铝源于流电的腐蚀上的 pitting 以坑的坑深度,尺寸和密度被加亮,用一台高分辨率显微镜。 | G. Subramanian S. Palraj S. Palanichamy | 2014 | Journal of Marine Science and Application2014,13,2: | 11 |
| 10 | 氮对马氏体不锈钢00Cr13Ni4Mo组织和性能的影响显示文摘采用热膨胀仪、光学显微镜以及CM12型透射电子显微镜研究了添加0.04%N(质量分数)对00Cr13Ni4Mo马氏体不锈钢相变以及正火和回火后不锈钢组织变化的影响;通过拉伸、冲击实验和阳极极化曲线测定研究了N对正火和回火后马氏体不锈钢力学性能以及点蚀点位的影响。结果表明:1050℃正火后,N全部固溶于马氏体基体中,有效提高了实验钢的强度,同时降低了韧性;550℃以上回火后,在马氏体板条内部以及板条之间形成逆变奥氏体,有效提高了马氏体不锈钢的塑性和韧性;N抑制逆变奥氏体的形成,从而抑制了不锈钢在回火过程中的软化;同时,回火过程中,Cr2N在马氏体板条界面及内部大量析出,造成不锈钢韧性和点蚀点位下降。采用传统的正火+Ac1温度以上回火热处理工艺不利于含N马氏体不锈钢获得良好综合性能。 | 马小平 王立军 王园园 秦斌 刘春明 Sundaresa Subramanian | 2012 | 材料热处理学报2012,33,4: | 10 |
| 11 | miRNA-24 and miRNA-466i-5p controls inflammation in rat hepatocytes显示文摘 | Subramanian Saravanan Krishnaraj Thirugnanasambantham Hamza Hanieh Kulandaivelu Karikalan Durairaj Sekar Rukkumani Rajagopalan Villianur Ibrahim Hairul Islam | 2015 | Cellular & Molecular Immunology2015,12,1: | 7 |
| 12 | Effective and Efficient Feature Selection for Large-scale Data Using Bayes' Theorem显示文摘This paper proposes one method of feature selection by using Bayes theorem. The purpose of the proposed method is to reduce the computational complexity and increase the classification accuracy of the selected feature subsets. The dependence between two attributes (binary) is determined based on the probabilities of their joint values that contribute to positive and negative classification decisions. If opposing sets of attribute values do not lead to opposing classification decisions (zero probability), then the two attributes are considered independent of each other, otherwise dependent, and one of them can be removed and thus the number of attributes is reduced. The process must be repeated on all combinations of attributes. The paper also evaluates the approach by comparing it with existing feature selection algorithms over 8 datasets from University of California, Irvine (UCI) machine learning databases. The proposed method shows better results in terms of number of selected features, classi?cation accuracy, and running time than most existing algorithms. | Subramanian Appavu Alias Balamurugan Ramasamy Rajaram | 2009 | International Journal of Automation and computing2009,6,1: | 7 |
| 13 | Could the number of CT angiograms be reduced in emergency department patients suspected of pulmonary embolism?显示文摘BACKGROUND:This study was undertaken to identify the prevalence of pulmonary embolism(PE) in the emergency department(ED) of an urban teaching hospital and also to test a Bayesian model in estimating the number of CT pulmonary angiography(CTA) expected to be performed in an emergency department.METHODS:The data for this study was obtained through a retrospective review of electronic medical records for all ED patients suspected of PE who underwent chest CTA or ventilation perfusion scanning(V/Q) between 2009 and 2010.The data is presented as means and standard deviation for continuous variables and percentages with 95%confidence intervals(95%CI) for proportions.The prevalence of PE was used as pre-test probability in the Bayesian model.Post-test probability was obtained using a Fagan nomogram and likelihood ratios for CTA.RESULTS:A total of 778 patients(560 females) with mean age of 50 years(range 18-98 years)were enrolled(98.3%underwent chest CTA and 1.7%underwent V/Q scan).A total of 69 patients had PE,rendering an overall prevalence of 8.9%(95%CI,7.1%to 11.1%) for PE.We calculated that132 CTA's per year could be avoided in our institution,without compromising safe exclusions of PE(keeping post-test probability of PE below 2%).CONCLUSIONS:Despite differences in our patient populations and /or study designs,the prevalence of PE in our institution is about average compared to other institutions.Our proposed model for calculating redundant chest CTA is simple and can be used by institutions to identify overuse of CTA. | Zehtabchi Shahriar Rinnert Stephan Malhotra Shweta Subramanian Arun Timberger Mathew Patel Brijal Toro David Hassan Khaled Sinert Richard | 2012 | World Journal of Emergency Medicine2012,3,3: | 7 |
| 14 | 3D integration review显示文摘3-D integration delivers value by increasing the volumetric transistor density with the potential benefit of shorter electrical path lengths through use of the shorter third dimension. Several researchers have studied various aspect of 3Di such as bonding level, through silicon via processes and integration, thermomechanical reliability of the vias, and the impact of the vias on devices. In this paper, we review some of the literature with a view to understanding the key options and challenges in 3Di. We also discuss some important applications of this technology, and the constraints that have to be overcome to make it work. | FAROOQ Mukta G. IYER Subramanian S. | 2011 | Science China(Information Sciences)2011,54,5: | 7 |
| 15 | Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection显示文摘 | Nezam Afdhal Stefan Zeuzem Paul Kwo Mario Chojkier Norman Gitlin Massimo Puoti Manuel Romero-Gomez Jean-Pierre Zarski Kosh Agarwal Peter Buggisch Graham R. Foster Norbert Br?u Maria Buti Ira M. Jacobson G. Mani Subramanian Xiao Ding Hongmei Mo Jenny C. Ya | 2014 | The New England Journal of Medicine2014,,: | 6 |
| 16 | Thymoquinone inhibits the migration of mouse neuroblastoma(Neuro-2a) cells by down-regulating MMP-2 and MMP-9显示文摘Thymoquinone(TQ), an active component derived from the medial plant Nigella sativa, has been used for medical purposes for more than 2 000 years. Recent studies have reported that TQ blocked angiogenesis in animal model and reduced migration, adhesion, and invasion of glioblastoma cells. We have recently shown that TQ could exhibit a potent cytotoxic effect and induce apoptosis in mouse neuroblastoma(Neuro-2a) cells. In the present study, TQ treatment markedly decreased the adhesion and migration of Neuro-2a cells. TQ down-regulated MMP-2 and MMP-9 protein expression and m RNA levels and their activities. Furthermore, TQ significantly down-regulated the protein expression of transcription factor NF-κB(p65) but not significantly altered the expression of N-Myc. Taken together, our data indicated that TQ's inhibitory effect on the migration of Neuro-2a cells was mediated through the suppression of MMP-2 and MMP-9 expression, suggesting that TQ treatment can be a promising therapeutic strategy for human malignant neuroblastoma. | Arumugam Paramasivam Subramanian Raghunandhakumar Jayaseelan Vijayashree Priyadharsini Gopalswamy Jayaraman | 2016 | Chinese Journal of Natural Medicines2016,14,12: | 6 |
| 17 | Endoscopic Tri-Modal Imaging Is More Effective Than Standard Endoscopy in Identifying Early-Stage Neoplasia in Barrett’s Esophagus显示文摘 | Wouter L. Curvers Lorenza Alvarez Herrero Michael B. Wallace Louis–Michel Wong Kee Song Krish Ragunath Herbert C. Wolfsen Ganapathy A. Prasad Kenneth K. Wang Venkataraman Subramanian Bas L.A.M. Weusten Fiebo J. Ten Kate Jacques J.G.H.M. Bergman | 2010 | Gastroenterology2010,,4: | 6 |
| 18 | Clinical relevance of endoscopic assessment of inflammation in ulcerative colitis: Can endoscopic evaluation predict outcomes?显示文摘Ulcerative colitis(UC) is a chronic inflammatory bowel condition characterised by a relapsing and remitting course. Symptom control has been the traditional mainstay of medical treatment. It is well known that histological inflammatory activity persists despite adequate symptom control and absence of endoscopic inflammation. Current evidence suggests that presence of histological inflammation poses a greater risk of disease relapse and subsequent colorectal cancer risk. New endoscopic technologies hold promise for developing endoscopic markers of mucosal inflammation. Achieving endoscopic and histological remission appears be the future aim of medical treatments for UC. This review article aims to evaluate the use of endoscopy as a tool in assessment of mucosal inflammation UC and its correlation with disease outcomes. | Noor Mohammed Venkataraman Subramanian | 2016 | World Journal of Gastroenterology2016,22,42: | 6 |
| 19 | Does aspirin or non-aspirin non-steroidal anti-inflammatory drug use prevent colorectal cancer in inflammatory bowel disease?显示文摘AIM: To determine whether aspirin or non-aspirin nonsteroidal anti-inflammatory drugs(NA-NSAIDs) prevent colorectal cancer(CRC) in patients with inflammatory bowel disease(IBD).METHODS: We performed a systematic review and meta-analysis. We searched for articles reporting the risk of CRC in patients with IBD related to aspirin or NANSAID use. Pooled odds ratios(OR) and 95%CIs were determined using a random-effects model. Publication bias was assessed using Funnel plots and Egger's test. Heterogeneity was assessed using Cochran's Q and the I2 statistic.RESULTS: Eight studies involving 14917 patients and 3 studies involving 1282 patients provided data on the risk of CRC in patients with IBD taking NA-NSAIDs and aspirin respectively. The pooled OR of developing CRC after exposure to NA-NSAIDs in patients with IBD was 0.80(95%CI: 0.39-1.21) and after exposure to aspirin it was 0.66(95%CI: 0.06-1.39). There was significant heterogeneity(I2 > 50%) between the studies. There was no change in the effect estimates on subgroup a na ly s e s o f t he po pulat io n s t udie d o r w he t he r adjustment or matching was performed.CONCLUSION: There is a lack of high quality evidence on this important clinical topic. From the available evidence NA-NSAID or aspirin use does not appear to be chemopreventative for CRC in patients with IBD. | Nick E Burr Mark A Hull Venkataraman Subramanian | 2016 | World Journal of Gastroenterology2016,22,13: | 6 |
| 20 | 葡萄糖控制上的连续积极航线压力治疗的效果显示文摘 Obstructive sleep apnea (OSA) and diabetes mellitus are both highly prevalent disorders.There has been a recent recognition of an association between insulin resistance and sleep apnea.Continuous positive airway pressure (CPAP) has emerged as an effective therapy for treatment of OSA and has been shown to positively influence numerous pathophysiological factors that con-tribute to cardiovascular risk.There is emerging data that explores the influence of CPAP therapy,insulin sensitivity and glycemic control.In the current review,we examine this literature critically and formulate a synopsis that summarizes the current knowledge in this field. | Salim Surani Shyam Subramanian | 2012 | World Journal of Diabetes2012,3,4: | 6 |