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您的检索式：作者名="Subramanian Raghunandhakumar"
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| 1 | Thymoquinone inhibits the migration of mouse neuroblastoma(Neuro-2a) cells by down-regulating MMP-2 and MMP-9显示文摘Thymoquinone(TQ), an active component derived from the medial plant Nigella sativa, has been used for medical purposes for more than 2 000 years. Recent studies have reported that TQ blocked angiogenesis in animal model and reduced migration, adhesion, and invasion of glioblastoma cells. We have recently shown that TQ could exhibit a potent cytotoxic effect and induce apoptosis in mouse neuroblastoma(Neuro-2a) cells. In the present study, TQ treatment markedly decreased the adhesion and migration of Neuro-2a cells. TQ down-regulated MMP-2 and MMP-9 protein expression and m RNA levels and their activities. Furthermore, TQ significantly down-regulated the protein expression of transcription factor NF-κB(p65) but not significantly altered the expression of N-Myc. Taken together, our data indicated that TQ's inhibitory effect on the migration of Neuro-2a cells was mediated through the suppression of MMP-2 and MMP-9 expression, suggesting that TQ treatment can be a promising therapeutic strategy for human malignant neuroblastoma. | Arumugam Paramasivam Subramanian Raghunandhakumar Jayaseelan Vijayashree Priyadharsini Gopalswamy Jayaraman | 2016 | Chinese Journal of Natural Medicines2016，14，12： | 6 |
| 2 | Implications of m6A modification in autoimmune disorders显示文摘N6-Methyladenosine(m6A)is the most common and abundant modification of RNA molecules,including mRNAs,microRNAs(miRNAs),and long noncoding RNAs(lncRNAs).1 The m6A modification is catalyzed and dynamically regulated by recently discovered enzymes termed“writers”(methyltransferases including METTL3,METTL14,and WTAP),“erasers”(demethylases including FTO and ALKBH5)and“readers”(m6A-binding proteins including YTHDC1,YTHDC2,YTHDF1,YTHDF2,and YTHDF3).These modifications were recently shown to be involved in the regulation of different biological processes. | Arumugam Paramasivam Jayaseelan Vijayashree Priyadharsini Subramanian Raghunandhakumar | 2020 | Cellular & Molecular Immunology2020，17，5： | 2 |
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