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| 1 | 青海都兰过去2000年来的气候重建及其变迁显示文摘根据青海都兰地区树木年轮样本建立了目前我国最长的年轮年表序列。通过年表与气候要素间相关函数、响应函数及响应面分析 ,选择了可被重建的气候因子 ,建立了重建方程 ,恢复了青海都兰地区历史时期的平均温度 ;并分析讨论了近 2 0 0 0年来该地区的气候变化。阐述了这个地区的冷暖交替及周期循环。对一些重大气候事件 ,如中世纪暖期、小冰期和近一个世纪以来的升温等 ,逐个事件进行了剖析。并与全球温度变化进行了对照。都兰温度曲线为青藏高原东部地区提供了一个较好的气候变化信息表。 | 康兴成 张其花 Lisa J.Graum lich Paul Sheppard | 2000 | 地球科学进展2000，15，2： | 50 |
| 2 | A 1 835 a tree-ring chronology and its preliminary analyses in Dulan region, Qinghai显示文摘TREE-ring analysis is one of the important ways for paleoclimatic reconstruction because tree-ring series of several hundred or even thousands of years are available, and can be matched orextended and accurately dated, and the tree rings can record changes in climate. In China,several thousand paleoclimatic series of data are obtained from the historical documents, | Kang, XC Graumlich, LJ Sheppard, P | 1997 | Chinese Science Bulletin1997，42，13： | 6 |
| 3 | Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21显示文摘Chromosome copy number aberrations, anueploidies, are common in the human population but generally lethal. However, trisomy of human chromosome 21 is compatible with life and people born with this form of aneuploidy manifest the features of Down syndrome, named after Langdon Down who was a 19th century British physician who first described a group of people with this disorder. Down syndrome includes learning and memory deficits in all cases, as well as many other features which vary in penetrance and expressivity in different people. While Down syndrome clearly has a genetic cause - the extra dose of genes on chromosome 21-we do not know which genes are important for which aspects of the syndrome, which biochemical pathways are disrupted, or, generally how design therapies to ameliorate the effects of these disruptions. Recently, with new insights gained from studying mouse models of Down syndrome, specific genes and pathways are being shown to be involved in the pathogenesis of the disorder. This is opening the way for exciting new studies of potential therapeutics for aspects of Down syndrome, particularly the learning and memory deficits. | Aarti Ruparelia Frances Wiseman Olivia Sheppard Victor L.J.Tybulewicz Elizabeth M.C.Fisher | 2010 | The Journal of Biomedical Research2010，24，2： | 4 |
| 4 | Retrofit Slagging Coal Combustor Ready for Commercialisation in 1986 显示文摘 | Stansel J C Sheppard D B Petrill F M | 1984 | Modern Power Systems1984，4，3： | 2 |
| 5 | C-Reactive protein predicts short-term mortality in patients with cirrhosis显示文摘 | Jean-Paul Cervoni Thierry Thévenot Delphine Weil Emilie Muel Olivier Barbot Frances Sheppard Elisabeth Monnet Vincent Di Martino | 2012 | Journal of Hepatology2012，，6： | 2 |
| 6 | Prevalence and risk factors of Campylobacter infection in broiler flocks from southern Spain显示文摘 | Alicia Torralbo Carmen Borge Alberto Allepuz Ignacio García-Bocanegra Samuel K. Sheppard Anselmo Perea Alfonso Carbonero | 2014 | Preventive Veterinary Medicine2014，，： | 2 |
| 7 | Diagnosis and management of blunt pancreatic ductal injury in the era of high-resolution computed axial tomography显示文摘 | Swee H. Teh Brett C. Sheppard Richard J. Mullins Martin A. Schreiber John C. Mayberry | 2007 | The American Journal of Surgery2007，，5： | 2 |
| 8 | Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis显示文摘变化 F508del 是基因疾病的最普通的原因膀胱的纤维变性(CF ) 。CF 在身体破坏许多机关的函数,最尤其是肺,由使不安,盐和水搬运到对面上皮的表面。F508del 以二个主要方法引起伤害。首先,变化阻止膀胱的纤维变性 transmembrane 传导力管理者(CFTR ) 的交货到它的正确细胞的地点,顶端(面对腔) 上皮的房间的膜。第二, F508del 使不安由破坏隧道 gating 的 CFTR 的 Cl − 隧道功能。这里,我们为 CF 讨论合理新治疗的发展那目标 F508del-CFTR。我们加亮结构的研究怎么由 ATP 绑定和水解作用的周期在隧道 gating 的规定提供新卓见进 F508 的角色。我们强调为治疗开发识别铅混合物的高产量的屏蔽的使用。这些混合物包括在救 F508del-CFTR gating 缺点的上皮的房间和 CFTR potentiators 的顶端的膜恢复 F508del-CFTR 的表示的 CFTR 修正者。从 CFTR 修正者和 potentiators 的临床的试用的起始的结果预示指向 CF 的根原因的小分子治疗的发展顺利:在 CFTR 的变化。 | Zhi-wei CAI Jia LIU Hong-yu LI David N SHEPPARD | 2011 | Acta Pharmacologica Sinica2011，32，6： | 2 |
| 9 | QUANTITATIVE EVALUATIONS OF MECHANISMS OF RADIOFREQUENCY INTERACTIONS WITH BIOLOGICAL MOLECULES AND PROCESSES显示文摘 | Asher R. Sheppard Mays L. Swicord Quirino Balzano | 2008 | Health Physics2008，，4： | 2 |
| 10 | Cardiovascular Magnetic Resonance, Fibrosis, and Prognosis in Dilated Cardiomyopathy显示文摘 | Ravi G. Assomull Sanjay K. Prasad Jonathan Lyne Gillian Smith Elizabeth D. Burman Mohammed Khan Mary N. Sheppard Philip A. Poole-Wilson Dudley J. Pennell | 2006 | Journal of the American College of Cardiology2006，，： | 2 |
| 11 | Effects of ambient air pollution on symptom severity and medication use in children with asthma显示文摘 | James C. Slaughter Thomas Lumley Lianne Sheppard Jane Q. Koenig Gail G. Shapiro | 2003 | Annals of Allergy Asthma & Immunology2003，，4： | 2 |
| 12 | The use of lenses with annular aperture in scanning optical microscopy显示文摘 | Sheppard C J R | 1997 | Optik1997，48，： | 2 |
| 13 | Advances in processing of ferroelectrie thin films 显示文摘 | Laure M Sheppard | 1992 | Ceramic Bulletin1992，71，1： | 1 |
| 14 | Detecting second-layer fatigue cracks under installed skins and fasteners with low-frequency eddy current array显示文摘 | Hill B Sheppard W | 1992 | Material Evaluation1992，50，12： | 1 |
| 15 | Fowl adenovirus recombinant expressing VP2 of infectious bursal disease virus induces protective immunity against bursal disease显示文摘 | Sheppard M Werner W Johnson M | 1998 | Arch Virol1998，143，： | 1 |
| 16 | 11β-Hydroxysteroid dehydrogenase 1 transforms 11-dehydrocorticosterone intotranscriptionally active glucocorticoid in neonatal rat heart显示文摘 | Sheppard K E Autelitano D J | 2002 | Endocrinology2002，143，2： | 1 |
| 17 | The MTS assay as an indicator of chemosensitivity/resistance in malignant gynae- cological turnouts显示文摘 | O'Toole SA Sheppard BL Mcguinness EP | 2003 | Cancer Detect Prev2003，27，1： | 1 |
| 18 | New synthetic approach and iron chelating studies of 1-alkyl- 2-methyl- 3-hydroxypyrid-4-ones 显示文摘 | Kontoghiorghes G J Sheppard L Chambers S | 1987 | ArzneimForsch1987，37，10： | 1 |
| 19 | 13C NMR studies of some naturally occurring amentoflavone and hinokiflavone biflavonoids显示文摘 | Kenneth R Markham Carolyn Sheppard Hans Geiger 1987 | 1987 | Phytochemistry1987，26，12： | 1 |
| 20 | The dialectics of geographic and virtual space 显示文摘 | Aoyama Y Sheppard E | 2003 | Environment and Planning A2003，35，7： | 1 |
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