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| 1 | Role of antibiotics for treatment of inflammatory boweldisease显示文摘Inflammatory bowel disease is thought to be caused by an aberrant immune response to gut bacteria in a genetically susceptible host. The gut microbiota plays an important role in the pathogenesis and complications of the two main inflammatory bowel diseases: Crohn's disease(CD) and ulcerative colitis. Alterations in gut microbiota, and specifically reduced intestinal microbial diversity, have been found to be associated with chronic gut inflammation in these disorders. Specific bacterial pathogens, such as virulent Escherichia coli strains, Bacteroides spp, and Mycobacterium avium subspecies paratuberculosis, have been linked to the pathogenesis of inflammatory bowel disease. Antibiotics may influence the course of these diseases by decreasing concentrations of bacteria in the gut lumen and altering the composition of intestinal microbiota. Different antibiotics, including ciprofloxacin, metronidazole, the combination of both, rifaximin, and anti-tuberculous regimens have been evaluated in clinical trials for the treatment of inflammatory bowel disease. For the treatment of active luminal CD, antibiotics may have a modest effect in decreasing disease activity and achieving remission, and are more effective in patients with disease involving the colon. Rifamixin, a non absorbable rifamycin has shown promising results. Treatment of suppurative complications of CD such as abscesses and fistulas, includes drainage and antibiotic therapy, most often ciprofloxacin, metronidazole, or a combination of both. Antibiotics might also play a role in maintenance of remission and prevention of post operative recurrence of CD. Data is more sparse for ulcerative colitis, and mostly consists of small trials evaluating ciprofloxacin, metronidazole and rifaximin. Most trials did not show a benefit for the treatment of active ulcerative colitis with antibiotics, though 2 meta-analyses concluded that antibiotic therapy is associated with a modest improvement in clinical symptoms. Antibiotics show a clinical benefit when used for the treatment of pouchitis. The downsides of antibiotic treatment, especially with recurrent or prolonged courses such as used in inflammatory bowel disease, are significant side effects that often cause intolerance to treatment, Clostridium dificile infection, and increasing antibiotic resistance. More studies are needed to define the exact role of antibiotics in inflammatory bowel diseases. | Orna Nitzan Mazen Elias Avi Peretz Walid Saliba | 2016 | World Journal of Gastroenterology2016，22，3： | 14 |
| 2 | Clostridium difficile and inflammatory bowel disease: Role in pathogenesis and implications in treatment显示文摘Clostridium difficile(C.difficile)is the leading cause of antibiotic associated colitis and nosocomial diarrhea.Patients with inflammatory bowel disease(IBD)are at increased risk of developing C.difficile infection(CDI),have worse outcomes of CDI-including higher rates of colectomy and death,and experience higher rates of recurrence.However,it is still not clear whether C.difficile is a cause of IBD or a consequence of the inflammatory state in the intestinal environment.The burden of CDI has increased dramatically over the past decade,with severe outbreaks described in many countries,which have been attributed to a new and more virulent strain.A parallel rise in the incidence of CDI has been noted in patients with IBD.IBD patients with CDI tend be younger,have less prior antibiotic exposure,and most cases of CDI in these patients represent outpatient acquired infections.The clinical presentation of CDI in these patients can be unique-including diversion colitis,enteritis and pouchitis,and typical findings on colonoscopy are often absent.Due to the high prevalence of CDI in patients hospitalized with an IBD exacerbation,and the prognostic implications of CDI in these patients,it is recommended to test all IBD patients hospitalized with a disease flare for C.difficile.Treatment includes general measures such as supportive care and infection control measures.Antibiotic therapy with either oral metronidazole,vancomycin,or the novel antibiotic-fidaxomicin,should be initiated as soon as possible.Fecal macrobiota transplantation constitutes another optional treatment for severe/recurrent CDI.The aim of this paper is to review recent data on CDI in IBD:role in pathogenesis,diagnostic methods,optional treatments,and outcomes of these patients. | Orna Nitzan Mazen Elias Bibiana Chazan Raul Raz Walid Saliba | 2013 | World Journal of Gastroenterology2013，19，43： | 12 |
| 3 | Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis显示文摘 | Richard Moreau Rajiv Jalan Pere Gines Marco Pavesi Paolo Angeli Juan Cordoba Francois Durand Thierry Gustot Faouzi Saliba Marco Domenicali Alexander Gerbes Julia Wendon Carlo Alessandria Wim Laleman Stefan Zeuzem Jonel Trebicka Mauro Bernardi Vicente Arro | 2013 | Gastroenterology2013，，7： | 12 |
| 4 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 5 | Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis显示文摘AIM To investigate the effect of adipose-derived mesenchymal stem cells(ADMSCs)and their conditioned media(CM) on hepatocellular carcinoma(HCC) cell tumorigenesis.METHODS The proliferation rate of HepG2 and PLC-PRF-5 HCC cancer cells was measured using the trypan blue exclusion method and confirmed using the cell-counting kit8(commonly known as CCK-8) assay. Apoptosis was detected by flow cytometry using annexin V-FITC. Protein and mRNA expression was quantified by ELISA and real time PCR, respectively. Migration and invasion rates were performed by Transwell migration and invasion assays. Wound healing was examined to confirm the data obtained from the migration assays.RESULTS Our data demonstrated that when co-culturing HCC cell lines with ADMSCs or treating them with ADMSC CM, the HCC cell proliferation rate was significantly inhibited and the apoptosis rate increased. The decreased proliferation rate was accompanied by an upregulation of P53 and Retinoblastoma mRNA and a downregulation of c-Myc and hTERT mRNA levels. More notably, ADMSCs and their CM suppressed the expression of the two important markers of HCC carcinogenicity, alpha-fetoprotein and Des-gamma-carboxyprothrombin. In addition, the migration and invasion levels of HepG2 and PLC-PRF-5 cells significantly decreased, potentially through increased expression of the tissue inhibitor metalloproteinases TIMP-1, TIMP-2 and TIMP-3.CONCLUSION These findings shed new light on a protective and therapeutic role for ADMSCs and their CM in controlling HCC invasiveness and carcinogenesis. | Rim Serhal Nagib Saliba George Hilal Mayssam Moussa Ghada S Hassan Oula El Atat Nada Alaaeddine | 2019 | World Journal of Gastroenterology2019，25，5： | 6 |
| 6 | Innovation and financial performance of companies doing business in Brazil显示文摘In this paper,we analyze the relationships among innovation efforts,the impacts of these innovations,and the financial performance of Brazilian companies.We hypothesize that innovation efforts do not directly translate into financial performance.Due to the inherent uncertainty of innovative projects,such efforts must first lead to effective innovation results or impacts before they are capable of contributing to a company's financial performance.Using the Brazilian Institute of Geography and Statistics'(IBGE)comprehensive official databases on innovation and performance,we study 5,025 firms using exploratory factor analysis and structural equation modeling.The results suggest that efforts in innovation possibly generate impacts;however,these impacts do not necessarily imply better financial performance.Therefore,although firms'efforts may lead to new products,they will not contribute to financial gains in the short term,reflecting the risky and costly nature of innovation.The study aims to contribute to the discussion on firm-level impacts of innovation from the context of a large developing country,since empirical results of the literature are mixed. | Juliana Albuquerquer Saliba de Oliveira Leonardo Fernando Cruz Basso Herbert Kimura Vinicius Amorim Sobreiro | 2018 | International Journal of Innovation Studies2018，2，4： | 2 |
| 7 | Plasma B-Type Natriuretic Peptide Levels and Recurrent Arrhythmia After Successful Ablation of Lone Atrial Fibrillation显示文摘 | Ayman A. Hussein Walid I. Saliba David O. Martin Mazyar Shadman Mohamed Kanj Mandeep Bhargava Thomas Dresing Mina Chung Thomas Callahan Bryan Baranowski Patrick Tchou Bruce D. Lindsay Andrea Natale Oussama M. Wazni | 2011 | Circulation2011，，19： | 2 |
| 8 | Pulmonary vein antrum isolation for treatment of atrial fibrillation in patients with valvular heart disease or prior open heart surgery显示文摘 | Khaykin Y Marrouche NF Saliba W | 2004 | Heart Rhythm2004，1，1： | 1 |
| 9 | Ventricular tachycardia syndromes显示文摘 | Natale A | 2001 | MedClinNorthAm2001，85，2： | 1 |
| 10 | Systemic lupus erythematosus and innammatory bowel disease 显示文摘 | NITZAN O ELIAS M SALIBA WR | 2006 | Eur J Intern Med2006，17，5： | 1 |
| 11 | Higher energy synchronized external direct current cardioversion for refractory atrial fibrillation显示文摘 | Saliba W Juratli N Chung M K | 1999 | J Am Coll Cardiol1999，34，7： | 1 |
| 12 | Circumferental ultrasonic ablation for pulmonary vein isolation:analysis of acute and chronic failures显示文摘 | Saliba W Wilber D Packer D | 2002 | J Cardiovasc Electrophysiol2002，13，6： | 1 |
| 13 | Allogeneic hematopoietic stem cell transplantation for the treatment of high-risk acute myelogenous leukemia and myelodysplastic syndrome using reduced-intensity conditioning with Fludarabine and melphalan显示文摘 | Orao B Giralt S Saliba R | 2007 | Bioi Blood Marrow Transplant2007，13，4： | 1 |
| 14 | Cytarabine,Ki-67,and SOX11 in patients with mantle cell lymphoma receiving rituximab-containing autologous stem cell transplantation during first remission显示文摘 | Chakhachiro ZL Saliba RM Okoroji GJ | 2013 | Cancer2013，119，18： | 1 |
| 15 | Atrial fibrillation ablation using a robotic catheter remote control system:initial human experience and long-term follow-up results显示文摘 | Saliba W Reddy VY Wazni O Cummings JE Burkhardt JD Haissaguerre M | | 0，，25： | 1 |
| 16 | Out- come of patients with cirrhosis requiring mechanical ventilation in ICU显示文摘 | Levesque E Saliba F Ichai P | 2014 | J Hepa- tol2014，60，3： | 1 |
| 17 | Cross-section stability of lean duplex stainless steel welded I-sections 显示文摘 | Saliba N Gardner L | 2013 | Journal of Constructional Steel Research2013，80，： | 1 |
| 18 | Acute exercise facilitates brain function and cognition in children who need it most: An ERP study of individual differences in inhibitory control capacity显示文摘 | Eric S. Drollette Mark R. Scudder Lauren B. Raine R. Davis Moore Brian J. Saliba Matthew B. Pontifex Charles H. Hillman | 2014 | Developmental Cognitive Neuroscience2014，，： | 1 |
| 19 | Seasonal, diurnal and nocturnal behaviors of lower carbonyl compounds in the urban environment of Beirut, Lebanon 显示文摘 | Moussa S G El-Fadel M Saliba N A | 2006 | Atmospheric Environment2006，40，14： | 1 |
| 20 | Characterisation of lactic acid bacteria isolated from fermented milk 'laban' 显示文摘 | Chammas Saliba R | 2006 | International Journal of Food Microbiology2006，110，1： | 1 |
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