|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 3 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 4 | Critical Evaluation of Pulmonary Contusion in the Early Post-Traumatic Period: Risk of Assisted Ventilation显示文摘 | Hamrick Miller C Duhn Ryan D Ochsner M Gage | 2009 | The American Surgeon2009，，11： | 2 |
| 5 | Is Ulnar Nerve Transposition Beneficial During Open Reduction Internal Fixation of Distal Humerus Fractures?显示文摘 | Ryan C Chen David J Harris Stephane Leduc Joseph J Borrelli Paul Tornetta William M Ricci | 2010 | Journal of Orthopaedic Trauma2010，，7： | 2 |
| 6 | Evidence that decomposition rates of organic carbon in mineral soil do not vary with temperature显示文摘 | Ryan M G | 2000 | Nature2000，404，： | 1 |
| 7 | A redeseription of Cryptosporidium galli Pavlasek, 1999 (Apicompl- exa: Cryptosporidiidae) from birds 显示文摘 | Ryan U M Xiao L Read C | 2003 | J Parasitol2003，89，： | 1 |
| 8 | Electron beam lithography-resolution limits显示文摘 | Broers A N Hoole A C F Ryan J M | 1996 | Microelectronic Engineering1996，32，： | 1 |
| 9 | Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells 显示文摘 | Ryan C J Zavodovskaya M Youngren J F | 2008 | Prostate2008，68，11： | 1 |
| 10 | Cancer- related Fatigue: the Scale of the Problem显示文摘 | Hofman M Ryan J L Figueroa-Moseley C D | 2007 | Oncologist2007，12，1： | 1 |
| 11 | Effects of Nb and Zr alloying additions on the activation behavior of Ti in hydrochloric acid显示文摘 | YU S Y BRODRICK C W RYAN M P | | 0，，12： | 1 |
| 12 | Intrinsic mo tivations and exercise adherence显示文摘 | RYAN R M FREDERICK C M LEPES D | 1997 | Int J Sport Psychol1997，28，： | 1 |
| 13 | Fractionation of hyaluronic Acid, the polydispersity of hyaluronic acid from the bovine vitreous body 显示文摘 | Laurent T C Ryan M Pietruszkiewiez A | 1960 | Biochim Biophys Acta1960，42，3： | 1 |
| 14 | An experimental study of the motion of long bubbles in inclined tubes显示文摘 | SHOSHO C E RYAN M E | 2001 | Chemical Engineering Science2001，56，6： | 1 |
| 15 | Cognitive efficiency declines over time in adults with Type 1 diabetes: effects of micro- and macrovascular complications显示文摘 | Ryan C M Geckle M O Orchard T J | 2003 | Diabetologia2003，46，7： | 1 |
| 16 | Effects of Somatic CellCount on Quality and Shelf-Life of Pasteurized Fluid Milk显示文摘 | Ma Y Ryan C Barbano D M | 2000 | J Dairy Sci2000，83，： | 1 |
| 17 | Sleep disordered breathing in group 1 pulmonary arte- rialhypertension显示文摘 | MINIC MMINIC M GRANTON J T RYAN C M | 2014 | J Clin Sleep Med2014，10，： | 1 |
| 18 | Nanometer-level comparison of three spindle error motion separation techniques显示文摘 | Eric M Jeremiall C Ryan V | 2006 | Journal of Precision Engineering2006，15，3： | 1 |
| 19 | Cultivating creativity in conservation science显示文摘 | Aslan C E Pinsky M L Ryan M E | 2014 | Conservation Biology2014，28，2： | 1 |
| 20 | Cbl and human myeloid neoplasms:the Cbl oncogeoe comes of age显示文摘 | Kales S C Ryan P E Nau M M Lipkowitz S | | 0，，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员