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| 1 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 2 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 3 | 老年人尿失禁的流行病学和病因学显示文摘尿失禁是老年人的一个普遍问题。22%~34%的妇女声称患过尿失禁。其患病率随尿失禁程度和询问方式不同而变化很大。65岁以上妇女按尿失禁保守定义即常见的尿失禁或按限制定义即压迫性尿失禁,其患病率为10%~30%。这一患病率在长期疗养院内还要高且随被检人群的年龄上升而增高。男性发病率为25%或低于妇女。 | Edward J.McGuire Martin Resnick S.V.Yalla Ruth Kirschner-Hermanns Enrique Broseta Cath McGrother Christa Müller Annette Welz-Barth G.Ch.Fischer Johann Mattelaer 李小刚 | 1999 | 德国医学1999，16，6： | 4 |
| 4 | Increasing applicability of liver transplantation for patients with hepatitis B–related liver disease显示文摘 | Thomas Steinmüller Daniel Seehofer Nada Rayes Andrea R. Müller Utz Settmacher Sven Jonas Ruth Neuhaus Thomas Berg Uwe Hopf Peter Neuhaus | 2002 | Hepatology2002，，6： | 2 |
| 5 | Increasing applicability of liver transplantation for patients with hepatitis B–related liver disease显示文摘 | Thomas Steinmüller Daniel Seehofer Nada Rayes Andrea R. Müller Utz Settmacher Sven Jonas Ruth Neuhaus Thomas Berg Uwe Hopf Peter Neuhaus | 2002 | Hepatology2002，，6： | 2 |
| 6 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 7 | Characterization and expression pattern of zebrafish anti-Mullerian hormone (AMH) relative to sox9a, sox9b, and cyp191a, during gonad development 显示文摘 | Adriana R M Yan Y L Ruth A B | 2005 | Gene Expression Patterns2005，5，： | 1 |
| 8 | Pesticide application practices, pest knowledge, and cost-benefits of plantain production in the Bribri-Caber car Indigenous Territories, Costa Rica显示文摘 | Beth A Polidoro Ruth M Dahlquist | 2008 | Environmental Research2008，108，： | 1 |
| 9 | Influence of 13-1acto- globulin, pH and presence of other aroma compounds on the air/liquid partition coefficients of 20 aroma compounds varying in functional group and chain length 显示文摘 | VAN RUTH S M VILLENEUVE E | 2002 | Food Chemistry2002，79，2： | 1 |
| 10 | Studies of the uptake of nitrate barley显示文摘 | SIDDIGI M Y GLASS A D M RUTH T J | 1990 | Plant Physiology1990，93，： | 1 |
| 11 | Tandem DNA recognition by PhoB, a two - component signal transduction transcriptional activator显示文摘 | BLANCO A G SOLA M GOMIS - RUTH F X | 2002 | Structure (Camb)2002，10，5： | 1 |
| 12 | Gas chromatography/snitIing port analysis and sensory evaluation of commercially dried bell peppers(Capsicum annuum) after rehydration显示文摘 | Van Ruth S M Roozen J P | 1994 | Food Chemistry1994，51，： | 1 |
| 13 | Studies of theuptake of nitrate in barley显示文摘 | Siddiqi M Y Glass A D Ruth T J | 1990 | Plant Physiology1990，，93： | 1 |
| 14 | Regional energy demand responses to climate change methodology and application to the commonwealth of Massachusetts 显示文摘 | Amato A D Ruth M Kirshen P | 2005 | Climate Change2005，71，1： | 1 |
| 15 | FSW takes off at Boeing显示文摘 | Ruth J M | 1999 | Welding Journal1999，，2： | 1 |
| 16 | The effect of mosapride, a novel prokinetic, on acid reflux variables in patients with gastroesophageal reflux disease 显示文摘 | RUTH M HAMELIN B ROHSS K | 1998 | Aliment Pharmacol Ther1998，12，35： | 1 |
| 17 | O'Conner's GOOD COUNTRY PEOPLE 显示文摘 | Holsen Ruth M | 1984 | Explicator1984，，3： | 1 |
| 18 | An Overview of Analytical Methods for Determining the Geographical Origin of Food Products 显示文摘 | LUYKX D M RUTH S M | 2008 | Food Chemistry2008，107，2： | 1 |
| 19 | Responses of dairy cows and calves to each other’s vocalizations after early separation显示文摘 | Jeremy N M Ruth M M Weary D M | 2002 | Applied Animal Behaviour Science2002，78，1： | 1 |
| 20 | Intercomparison of measurements of NO<sub>2</sub> concentrations in the atmosphere simulation chamber SAPHIR during the NO3Comp campaign显示文摘 | Fuchs H. Ball S. M. Bohn B. Brauers T. Cohen R. C. Dorn H.-P. Dubé W. P. Fry J. L. H?seler R. Heitmann U. Jones R. L. Kleffmann J. Mentel T. F. Müsgen P. Rohrer F. Rollins A. W. Ruth A. A. Kiendler-Scharr A. Schlosser E. Shillings A. J. L. Tillmann R. Var | 2010 | Atmospheric Measurement Techniques2010，，5： | 1 |
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