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| 1 | Impact of mechanical bowel preparation in elective colorectal surgery:A meta-analysis显示文摘AIM To analyse the effect of mechanical bowel preparation vs no mechanical bowel preparation on outcome in patients undergoing elective colorectal surgery.METHODS Meta-analysis of randomised controlled trials and observational studies comparing adult patients receiving mechanical bowel preparation with those receiving no mechanical bowel preparation, subdivided into those receiving a single rectal enema and those who received no preparation at all prior to elective colorectal surgery. RESULTS A total of 36 studies(23 randomised controlled trials and 13 observational studies) including 21568 patients undergoing elective colorectal surgery were included. When all studies were considered, mechanical bowel preparation was not associated with any significant difference in anastomotic leak rates(OR = 0.90, 95%CI: 0.74 to 1.10, P = 0.32), surgical site infection(OR = 0.99, 95%CI: 0.80 to 1.24, P = 0.96), intraabdominal collection(OR = 0.86, 95%CI: 0.63 to 1.17, P = 0.34), mortality(OR = 0.85, 95%CI: 0.57 to 1.27, P = 0.43), reoperation(OR = 0.91, 95%CI: 0.75 to 1.12, P = 0.38) or hospital length of stay(overall mean difference 0.11 d, 95%CI:-0.51 to 0.73, P = 0.72), when compared with no mechanical bowel preparation, nor when evidence from just randomized controlledtrials was analysed. A sub-analysis of mechanical bowel preparation vs absolutely no preparation or a single rectal enema similarly revealed no differences in clinical outcome measures. CONCLUSION In the most comprehensive meta-analysis of mechanical bowel preparation in elective colorectal surgery to date, this study has suggested that the use of mechanical bowel preparation does not affect the incidence of postoperative complications when compared with no preparation. Hence, mechanical bowel preparation should not be administered routinely prior to elective colorectal surgery. | Katie E Rollins Hannah Javanmard-Emamghissi Dileep N Lobo | 2018 | World Journal of Gastroenterology2018，24，4： | 33 |
| 2 | Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients显示文摘BACKGROUND Asymptomatic children with Crohn's disease(CD) require ongoing monitoring to ensure early recognition of a disease exacerbation.AIM In a cohort of pediatric CD patients, we aimed to assess the utility of serial fecal calprotectin measurements to detect intestinal inflammatory activity and predict disease relapse.METHODS In this prospective longitudinal cohort study, children with CD on infliximab therapy in clinical remission were included. Fecal calprotectin levels were assessed at baseline and at subsequent 2-5 visits. Clinical and biochemical disease activity were assessed using the Pediatric Crohn's Disease Activity Index, Creactive protein and erythrocyte sedimentation rate at baseline and at visits over the following 18 mo.RESULTS 53 children were included and eighteen patients(34%) had a clinical disease relapse during the study. Baseline fecal calprotectin levels were higher in patients that developed symptomatic relapse [median(interquartile range), relapse 723μg/g(283-1758) vs 244 μg/g(61-627), P = 0.02]. Fecal calprotectin levels > 250μg/g demonstrated good predictive accuracy of a clinical flare within 3 mo(area under the receiver operator curve was 0.86, 95% confidence limits 0.781 to 0.937).CONCLUSION Routine fecal calprotectin testing in children with CD in clinical remission is useful to predict relapse. Levels > 250 μg/g are a good predictor of relapse in the following 3 mo. This information is important to guide monitoring standards used in this population. | Alice Jane Foster Matthew Smyth Alam Lakhani Benjamin Jung Rollin F Brant Kevan Jacobson | 2019 | World Journal of Gastroenterology2019，25，10： | 3 |
| 3 | Chemokines 显示文摘 | Rollins BJ | 1997 | Blood1997，90，3： | 2 |
| 4 | Pemetrexed: A multitargeted antifolate显示文摘 | Kristan D. Rollins Celeste Lindley | 2005 | Clinical Therapeutics2005，，9： | 2 |
| 5 | Is there evidence of selection in the dopamine receptor D4 gene in Australian invasive starling populations?显示文摘 | Lee Ann ROLLINS Michael R. WHITEHEAD Andrew R WOOLNOUGH Ron SINCLAIR William B. SHERWIN | 2015 | Current Zoology2015，61，3： | 2 |
| 6 | Increased RhoA translocation in aorta of diabetic rats显示文摘瞄准:在糖尿病的老鼠的主动脉分析 RhoA 表示和激活。方法:男 SD 老鼠(n=70 ) 被划分成 2 个组:糖尿病的组和控制组。糖尿病被 streptozotocin (55 mg/kg ) 的静脉注射导致。老鼠 3 个星期在糖尿病的正式就职以后被学习。西方的弄污被用来测量 Rho 的表示和激活。结果:心搏率被测量 24 h/d;它在糖尿病的老鼠由 58+/-13 beats/min 减少了。当由 KCl 和血清素刺激了时,等轴的紧张证明糖尿病的主动脉的收缩显著地与控制主动脉的相比被减少。当由醋胆素刺激了时,糖尿病的主动脉的松驰被减少。在糖尿病的老鼠的大动脉的纸巾的提高的 RhoA 易位被膜界限 RhoA 的 90% 增加决定,显示 RhoA 的激活显著地在糖尿病的主动脉被增加。结论:我们的数据在调整 RhoA 上面建议那能涉及糖尿病的老鼠的脉管的机能障碍。 | Jiping TANG Ikuyo KUSAKA Amber R MASSEY Shadon ROLLINS John H ZHANG | 2006 | Acta Pharmacologica Sinica2006，27，5： | 2 |
| 7 | Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease显示文摘 | Rollins SA Madri JA | 1995 | Proc Natl Aca Sci USA1995，92，： | 1 |
| 8 | Identification of in vivo induced bacterial protein antigens during human infection with Salmonella enterica serovar typhi显示文摘 | HARRISJ B BARESCH-BERNAL A ROLLINS S M | 2006 | Infect Immun2006，74，9： | 1 |
| 9 | Effect of hyperoxia on vascular endothelial growth factor levels in a wound model显示文摘 | Sheikh A Y Gibson J J Rollins M D | 2000 | Arch Surg2000，135，11： | 1 |
| 10 | Mechanism of endothelin-1-induced contraction in rabbit basilar artery显示文摘 | Zubkov AY Rollins KS Parent AD | 2000 | Stroke2000，31，： | 1 |
| 11 | Employee research is a powerful tool in leading the time-based organization显示文摘 | Roberts D R and Rollins T | 1995 | Employee Relations Today1995，22，4： | 1 |
| 12 | Chemokines and disease 显示文摘 | Gerard C Rollins BJ | 2001 | Nat Immunol2001，2，11： | 1 |
| 13 | The effect of hair color on the incorporation of codeine into human hair显示文摘 | Rollins DE Wilkins DG Krueger GG | 2003 | J Anal Toxicol2003，27，8： | 1 |
| 14 | Treponema- specific tests for serodiagnosis of syphilis: comparative evaluation of seven assays 显示文摘 | B1NNICKER M J JESPERSEN D J ROLLINS L O | 2011 | J Clin Microbiol2011，49，4： | 1 |
| 15 | ELISA for the detection of antibodies to Ebola virus显示文摘 | Ksiazek TG West CP Rollin PE | 1999 | J Infect Dis1999，179，： | 1 |
| 16 | Discovery and development of the complement inhibitor ecuJizumab for the treatment of paroxysmal nocturnal hemoglobinuria 显示文摘 | Rother RP Rollins SA Mojcik CF | 2007 | Nature Biotechnology2007，25，11： | 1 |
| 17 | Treponema-specific tests for serodiagnosis of syphilis: comparative evaluation of seven assays 显示文摘 | BINNICKER MJ JESPERSEN DJ ROLLINS LO | 2011 | J Clin Microbiol2011，49，4： | 1 |
| 18 | Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria 显示文摘 | Rother RP Rollins SA Mojcik CF | 2007 | Nat Biotechnol2007，25，11： | 1 |
| 19 | Application of in vivo induced antigen technology(IVIAT) to Bacillus anthracis显示文摘 | ROLLINS S M PEPPERCORN A YOUNG J S | 2008 | PLoS 0ne2008，3，3： | 1 |
| 20 | Pemetrexed: a multitargeted antifolate 显示文摘 | Rollins KD Lindly C | 2005 | Clin Ther2005，27，9： | 1 |
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