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| 1 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 2 | Indications and surgical options for small bowel, large bowel and perianal Crohn's disease显示文摘Despite advancements in medical therapy of Crohn's disease(CD), majority of patients with CD will eventually require surgical intervention, with at least a third of patients requiring multiple surgeries. It is important to understand the role and timing of surgery, with the goals of therapy to reduce the need for surgery without increasing the odds of emergency surgery and its associated morbidity, as well as to limit surgical recurrence and avoid intestinal failure. The profile of CD patients requiring surgical intervention has changed over the decades with improvements in medical therapy with immunomodulators and biological agents. The most common indication for surgery is obstruction from stricturing disease, followed by abscesses and fistulae. The risk of gastrointestinal bleeding in CD is high but the likelihood of needing surgery for bleeding is low. Most major gastrointestinal bleeding episodes resolve spontaneously, albeit the risk of re-bleeding is high. The risk of colorectal cancer associated with CD is low. While current surgical guidelines recommend a total proctocolectomy for colorectal cancer associated with CD, subtotal colectomy or segmental colectomy with endoscopic surveillance may be a reasonable option. Approximately 20%-40% of CD patients will need perianal surgery during their lifetime. This review assesses the practice parameters and guidelines in the surgical management of CD, with a focus on the indications for surgery in CD(and when not to operate), and a critical evaluation of the timing and surgical options available to improve outcomes and reduce recurrence rates. | James WT Toh Peter Stewart Matthew JFX Rickard Rupert Leong Nelson Wang Christopher J Young | 2016 | World Journal of Gastroenterology2016，22，40： | 2 |
| 3 | Is Preoperative Chemotherapy Followed by Surgery the Appropriate Treatment for Signet Ring Cell Containing Adenocarcinomas of the Esophagogastric Junction and Stomach?显示文摘 | Ulrike Heger Susanne Blank Christiane Wiecha Rupert Langer Wilko Weichert Florian Lordick Thomas Bruckner Martin Dobritz Maria Burian Christoph Springfeld Lars Grenacher J?rg-Rüdiger Siewert Markus Büchler Katja Ott | 2014 | Annals of Surgical Oncology2014，，5： | 2 |
| 4 | High Proportion of Leukemic Stem Cells at Diagnosis Is Correlated with Unfavorable Prognosis in Childhood Acute Myeloid Leukemia显示文摘 | Kai-Erik Witte J?rg Ahlers Iris Sch?fer Maya André Gunter Kerst Hans-Gerhard Scheel-Walter Carl Philipp Schwarze Matthias Pfeiffer Peter Lang Rupert Handgretinger Martin Ebinger | 2011 | Pediatric Hematology-Oncology2011，，2： | 1 |
| 5 | Evidence for a genetic basis for altitude illness: 2010 update 显示文摘 | Macinnis M J Koehle MS Rupert JL | 2010 | High Ah Med B iol2010，11，4： | 1 |
| 6 | Genetic polymorphisms in the renin-angiotensin system in high-altitude and low-altitude native american populations 显示文摘 | RUPERT J L KIDD K K NORMAN L E | 2003 | Annals of Human Genetics2003，67，1： | 1 |
| 7 | CT-MIBI image fusion: A new preoperative localization technique for primary, recurrent, and persistent hyperparathyroidism显示文摘 | Christoph Profanter Gerold J Wetscher Michael Gabriel Tonja Sauper Michael Rieger Peter Kovacs Reto Bale Rupert Prommegger | 2004 | Surgery2004，，： | 1 |
| 8 | Evidence for a ge- netic basis for altitude illness: 2010 update显示文摘 | MacInnis M J Koehle M S Rupert J L | 2010 | High Alt Med Biol2010，11，4： | 1 |
| 9 | The photo-fenton reaction an effective photochemical waste water treatment process显示文摘 | RUPERT G BAUER R HEISL ER G J | 1993 | J Photochem Photobiol A:Chem1993，73，： | 1 |
| 10 | High pressure phase equilibria in the carbon dioxide-n-hexadecane and carbon dioxide-water systems 显示文摘 | D'Souza Rupert Patrick J R Teja A S | 1988 | Can J Chem Eng1988，66，： | 1 |
| 11 | A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome 显示文摘 | Carolyn J Brown Andrea Ballabio James L Rupert | 1991 | Nature1991，349，6304： | 1 |
| 12 | The block move sum normal moveout correction显示文摘 | Rupert G B Chun J H | 1975 | Geophysics1975，40，1： | 1 |
| 13 | 6-A- mino-2- ( 4-fluomphenyl ) -4-methoxy-3-( 4-pyridyl ) -1H-pyrrolo pyridine ( RWJ 68354) : a potent and selective p38 kinase inhibitor显示文摘 | HENRY J R RUPERT K C DODD J H | | J Med Chem0，41，22： | 1 |
| 14 | Beta2-adrenergic receptor allele frequencies in the quechua, a high altitude native population 显示文摘 | RUPERT J L MONSALVE M V DEVINE D V | 2000 | Annals of Human Genetics2000，64，2： | 1 |
| 15 | A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome 显示文摘 | Brown C J Ballabio A Rupert J L | 1991 | Nature1991，349，6304： | 1 |
| 16 | Common haplotypes in the Beta-2 adrenergic receptor gene are not associated with acute mountain sickness susceptibility in nepalese 显示文摘 | WANG P KOEHLE M S RUPERT J L | 2007 | High Altitude Medicine & Biology2007，8，3： | 1 |
| 17 | No association between alleles of the bradykinin receptor-B2 gene and acute mountain sickness 显示文摘 | P Wang M S Koehle J L Rupert | 2010 | Experimental Biology and Medicine2010，235，6： | 1 |
| 18 | Navigated versus conventional transfixation of AC joint injuries: Feasibility and accuracy显示文摘 | Timo Stü big Torsten J? hnisch Maximilian Petri Nael Hawi Christian Zeckey Christian Krettek Musa Citak Rupert Meller | 2013 | Computer Aided Surgery . 2013 (3-4)2013，，： | 1 |
| 19 | High pressure phase equilibria in the carbon dioxide-n-hexadecane and carbon dioxide-water systems 显示文摘 | RUPERT D PATRICK J R TEJA A S | 1988 | Can J Chem Eng1988，66，2： | 1 |
| 20 | Genetic approaches to understanding human adaptation to altitude in the Andes 显示文摘 | Rupert J Hochachka P | 2001 | J Exp Biol2001，204，18： | 1 |
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