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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Pulmonary Arterial Coil Embolization for the Management of Persistent Type I Hepatopulmonary Syndrome after Liver Transplantation显示文摘 | Nael E.A. Saad David E. Lee David L. Waldman Wael E.A. Saad | 2007 | Journal of Vascular and Interventional Radiology2007，，12： | 2 |
| 3 | Results of Resection in Non-Oat Cell Carcinoma of the Lung with Mediastinal Lymph Node Metastases显示文摘 | NAEL MARTINI BETTY J. FLEHINGER MUHAMMAD B. ZAMAN EDWARD J. BEATTIE | 1983 | Annals of Surgery1983，，3： | 2 |
| 4 | A Taxonomy of Wireless Micro-Sensor Network Models显示文摘 | Sameer Tilak Nael B Abu-Ghazaleh | 2002 | ACM Mobile Computing and Communications Review2002，6，4： | 2 |
| 5 | Formation of fluid heavy oil-in-water emulsions for pipeline transportationt显示文摘 | Nehal S A Amal M N Nael N Z | 1999 | Fuel1999，78，59： | 1 |
| 6 | Endovascular Management of Central Thoracic Veno-Occlusive Diseases in Hemodialysis Patients: A Single Institutional Experience in 69 Consecutive Patients显示文摘 | Kambiz Nael Stephen T. Kee Houman Solomon Steven G. Katz | 2009 | Journal of Vascular and Interventional Radiology2009，，： | 1 |
| 7 | Identification of speculative bubbles using state-space models with Markov-switching显示文摘 | Nael Al-Anaswah Bernd Wilfling | 2010 | Journal of Banking and Finance2010，，5： | 1 |
| 8 | Model-based control of particulate processes 显示文摘 | Panagiotis D Christofides Nael El-Farra | 2008 | Chemical Engineering Science2008，63，5： | 1 |
| 9 | Response of soil quality indicators and their spatial variability to land degradation in central Iran显示文摘 | Nael Khademi H Hajabbasi M A | 2004 | Applied Soil Ecology2004，27，： | 1 |
| 10 | Response of soil quality indicators and their spatial variability to land degradation in central iran显示文摘 | NAEL M KHADEMI H HAJABBASI M A | 2004 | Applied Soil Ecology2004，，27： | 1 |
| 11 | Cardiac Mr imaging: state of the technology显示文摘 | Finn JP Nael K Deshpande V | 2006 | Radiology2006，241，： | 1 |
| 12 | A data model and a query language for multimedia documents databases 显示文摘 | Nael Hirzalla Ahmed Karmouch | 1999 | Multimedia Systems1999，，7： | 1 |
| 13 | Dynamic pulmonary perfusion and flow quantification with MR imaging,3.0T vs,1.5T:initial results显示文摘 | Nael K Michaely H J Lee M | | 0，，： | 1 |
| 14 | Cryotrapping of CO2- rich atmospheres for the analysis of volatile metal compounds using capillary GC ICP-MS显示文摘 | J Feldmann L Naels K Haas | 2001 | J Anal At Spectrom2001，16，10： | 1 |
| 15 | Cardiac MR imaging state of the technology显示文摘 | Finn JP Nael K Deshpande V | 2006 | J radiology2006，241，： | 1 |
| 16 | Response of soil quality indicators and their spatial variability to land degradation in central Iran显示文摘 | Nael M Khademi H Hajabbasi M A | 2004 | Applied Soil Ecology2004，27，： | 1 |
| 17 | Contrast-enhanced MR angiography at 3T in the evaluation of intracranial aneurysms:a comparison with time of flight MR angiography显示文摘 | Nael K Villablanca JP Saleh R | 2006 | Am J Neuroradiol2006，27，： | 1 |
| 18 | Identification of Speculative Bubbles Using State-space Models withMarkov-switching显示文摘 | Nael A1-Anaswah Bernd Wilfling | 2011 | Joumal of Banking & Finance2011，，35： | 1 |
| 19 | Cardiac MR imaging: state of the technology显示文摘 | Finn JP Nael K Deshpande V | 2006 | Radiology2006，241，2： | 1 |
| 20 | Bayesian estimation of cerebral perfusion using reduced-contrast-dose dynamic susceptibility contrast perfusion at 3T显示文摘 | Nael K Mossadeghi B Boutelier T | 2015 | AJNR Am J Neuroradiol2015，36，4： | 1 |
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