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| 1 | SHRIMP zircon U-Pb dating for volcanic rocks of the Dasi Formation in southeast Hubei Province,middle-lower reaches of the Yangtze River and its implications显示文摘The Jinniu Basin in southeast Hubei,located at the westernmost part of middle-lower val-ley of the Yangtze River,is one of the important vol-canic basins in East China. Volcanic rocks in the Jin-niu Basin are distributed mainly in the Majiashan Formation,the Lingxiang Formation and the Dasi Formation,consisting of rhyolite,basalt and basaltic andesite,(trachy)-basalt and basaltic trachy-andesite and (trachy)-andesite and (trachy)-dacite and rhyolite respectively,in which the Dasi volcanism is volumet-rically dominant and widespread. The Dasi volcanic rocks were selected for SHRIMP zircon U-Pb dating to confirm the timing of volcanism. The results indi-cate that there exist a large amount of magmatic zir-cons characterized by high U and Th contents in the volcanic rocks. The concordia ages for 13 points are 128 ± 1Ma (MSWD = 3.0). On account of the shape of zircons and Th/U ratios,this age is considered to represent the crystallization time of the Dasi volcan-ism. The volcanic rocks in the Dasi,Majiashan and Lingxiang Formations share similar trace elementand REE partition patterns as well as Sr-Nd isotopic compositions. In combination with the regional geol-ogy,it is proposed that the southeast Hubei volcanic rocks were formed mainly during the Early Creta-ceous,just like other volcanic basins in middle-lower Yangtze valley. A lithospheric extension is also sug-gested for tectonic regime in this region in the Cre-taceous Period. | XIE Guiqing MAO Jingwen LI Ruiling ZHOU Shaodong YE Huishou YAN Quanren ZHANG Zusong | 2006 | Chinese Science Bulletin2006，51，24： | 38 |
| 2 | Effect of Intermetallic Phases on Corrosion Initiation of AZ91 Alloy With Rare Earth Y Addition显示文摘The effect of the rare earth(RE) element Y on the microstructure of AZ91 Mg alloy is investigated.A detailed description of the procedure of identifying the intermetallic phases containing Y in the AZ91 Mg alloy with 0.9 wt%Y addition is presented.The results shows that there are two different kinds of RE phases in scanning electron microscopy(SEM) images.Energy dispersive spectrum(EDS) analysis shows that one is rich in Y element and the other is rich in Mn element.According to the element mapping of electron probe microanalysis(EPMA).the element Al can be found not only in the β-Mg_(17)Al_(12) phase but also in these two RE phases.X-ray diffraction(XRD) and transmission electron microscopy(TEM) results further confirm one of the two RE phases is AI2Y;the phase of Al_(10)Mn_2Y has just been determined by transmission electron microscopy(TEM) instead of XRD probably because it is scarce.The shapes of these two RE intermetallic phases are pretty similar.The 3D digital microscopy is employed to observe in-situ the effect of the(5 phase and the above two RE intermetallic phases on the corrosion initiation of the alloys.The results show that the corrosion attack of AZ91 Mg alloy without Y addition starts around the eutectic phase β-Mg_(17)Al_(12).With the addition of 0.9 wt%Y,the two kinds of Y-rich intermetallic phases act as cathodic effect and a phase in the adjacent of them was activated and cathodic effect of the β-Mg_(17)Al_(12)phase was inhibited. | Li-na Zhang Ruiling Jia Dan Li Wei Zhang Feng Guo | 2015 | Journal of Materials Science & Technology2015，31，5： | 8 |
| 3 | Zacopride selectively activates the Kir2.1 channel via a PKA signaling pathway in rat cardiomyocytes显示文摘We recently reported that zacopride is a selective inward rectifier potassium current (IK1 ) channel agonist, suppressing ventricular arrhythmias without affecting atrial arrhythmias. The present study aimed to investigate the unique pharmacological properties of zacopride. The whole-cell patch-clamp technique was used to study IK1 currents in rat atrial myocytes and Kir2.x currents in human embryonic kidney (HEK)-293 cells transfected with inward rectifier potassium channel (Kir)2.1, Kir2.2, Kir2.3, or mutated Kir2.1 (at phosphorylation site S425L). Western immunoblots were performed to estimate the relative protein expression levels of Kir2.x in rat atria and ventricles. Results showed that zacopride did not affect the IK1 and transmembrane potential of atrial myocytes. In HEK293 cells, zacopride increased Kir2.1 homomeric channels by 40.7%±9.7% at 50 mV, but did not affect Kir2.2 and Kir2.3 homomeric channels, and Kir2.1-Kir2.2, Kir2.1-Kir2.3 and Kir2.2-Kir2.3 heteromeric channels. Western immunoblots showed that similar levels of Kir2.3 protein were expressed in rat atria and ventricles, but atrial Kir2.1 protein level was only 25% of that measured in the ventricle. In addition, 5-hydroxytryptamine (5-HT) 3 receptor was undetectable, whereas 5-HT 4 receptor was weakly expressed in HEK293 cells. The Kir2.1-activating effect of zacopride in these cells was abolished by inhibition of protein kinase A (PKA), but not PKC or PKG. Furthermore, zacopride did not activate the mutant Kir2.1 channel in HEK293 cells but selectively activated the Kir2.1 homomeric channel via a PKA-dependent pathway, independent to that of the 5-HT receptor. | ZHANG Li LIU QingHua LIU ChengFang ZHAI XuWen FENG QiLong XU RuiLing CUI XiangLi ZHAO ZhiQing CAO JiMin WU BoWei | 2013 | Science China(Life Sciences)2013，56，9： | 7 |
| 4 | Tectonic and Environmental Evolutions of the Northern Tibetan Plateau Prior to the Collision of India with Asia显示文摘Tectonic and environmental patterns and evolution of the present North Tibetan Plateau(NTP) prior to the India collision with Asia is significant to understand the formation of the Tibetan Plateau and its influence on the environment. In this study, we integrated and analyzed the tectonostratigraphy and the special sedimentary layers whose climatic implications are clear in the NTP. Additionally, we stressed the tectonic and environmental events and their evolutions from the Mesozoic to the Early Cenozoic. Our results show that four tectonic phases, which sequentially took place during the Triassic, Jurassic, Cretaceous and Paleogene, played an important role on the formation of the North Tibet. The climate was basically dry and hot from the Triassic to the Eocene and became dry and cool since the Oligocene in this region. The climatic evolution was characterized by a transition from a wet and hot phase during the Triassic- Middle Jurassic, to a dry and hot phase during the Late Jurassic- Eocene. Both phases encompassed 5 wet and hot periods followed by 5 dry and hot climate events, respectively. In addition, we found that the tectonic deformation and the climatic conditions were spatially and temporally different. In detail, in the regions north of the PaleoTian Shan and Paleo-Qilian Mts. the tectonic deformation and climatic condition were stronger and wetter than in regions south of the Paleo-Tian Shan and Paleo-Qilian Mts. during the Late Triassic – Jurassic. Whereas in the Cretaceous, the tectonic movement was intensive in the west but steady in the east, and climate was dry in the south but wet in the north of NTP. The formation of the tectonic and climatic patterns in NTP were the consequence of either global climate change or regional tectonics, including the Paleo-Asian Ocean closure and the Qiangtang block, Lhasa block and India plate collision subsequently to Asia. Furthermore, the regional tectonic events occurred before any global climate change and drove the climatic change in the NTP. | DAI Shuang ZHANG Mingzhen PENG Dongxiang WANG Huawei WU Maoxian CHEN Ruiling ZHANG Xiang | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 6 |
| 5 | Spatial-temporal Evolution Characteristics and Decoupling Analysis of Influencing Factors of China’s Aviation Carbon Emissions显示文摘The aviation industry has become one of the top ten greenhouse gas emission industries in the world. China’s aviation carbon emissions continue to increase, but the analysis of its influencing factors at the provincial level is still incomplete. This paper firstly uses Stochastic Impacts by Regression on Population, Affluence and Technology model(STIRPAT) model to analyze the time series evolution of China’s aviation carbon emissions from 2000 to 2019. Secondly, it uses the Logarithmic Mean Divisia Index(LDMI) model to analyze the influencing characteristics and degree of four factors on China’s aviation carbon emissions, which are air transportation revenue, aviation route structure, air transportation intensity and aviation energy intensity. Thirdly, it determines the various factors’ influencing direction and evolution trend of 31 provinces’ aviation carbon emissions in China(not including Hong Kong, Macao, Taiwan of China due to incomplete data). Finally, it derives the decoupling effort model and analyzes the decoupling relationship and decoupling effort degree between air carbon emissions and air transportation revenue in different provinces. The study found that from 2000 to2019, China’s total aviation carbon emissions continued to grow, while the growth rate of aviation carbon emissions showed a fluctuating downward trend. Air transportation revenue and aviation route structure promote the growth of total aviation carbon emissions, and air transportation intensity and aviation energy intensity have a restraining effect on the growth of total aviation carbon emissions. The scope of negative driving effect of air transportation revenue and air transportation intensity on total aviation carbon emissions in various provinces has increased. While the scope of positive driving influence of aviation route structure on total aviation carbon emissions of various provinces has increased, aviation energy intensity mainly has negative driving influence on total aviation carbon emissions of each province. Overall, the emission reduction trend in the areas to the west and north of the Qinling-Huaihe River Line is obvious. The decoupling mode between air carbon emissions and air transportation revenue in 31 provinces is mainly expansion negative decoupling.The air transportation intensity effect shows strong decoupling efforts in most provinces, the decoupling effort of aviation route structure effect and aviation energy intensity effect is not prominent. | HAN Ruiling LI Lingling ZHANG Xiaoyan LU Zi ZHU Shaohua | 2022 | Chinese Geographical Science2022，32，2： | 5 |
| 6 | Damage of hippocampal neurons in rats with chronic alcoholism显示文摘Chronic alcoholism can damage the cytoskeleton and aggravate neurological deficits. However, the effect of chronic alcoholism on hippocampal neurons remains unclear. In this study, a model of chronic alcoholism was established in rats that were fed with 6% alcohol for 42 days. Endogenous hydrogen sulfide content and cystathionine-beta-synthase activity in the hippocampus of rats with chronic alcoholism were significantly increased, while F-actin expression was decreased. Hippocampal neurons in rats with chronic alcoholism appeared to have a fuzzy nuclear membrane, mitochondrial edema, and ruptured mitochondrial crista. These findings suggest that chronic alcoholism can cause learning and memory decline in rats, which may be associated with the hydrogen sulfide/cystathionine-beta-synthase system, mitochondrial damage and reduced expression of F-actin. | Ailin Du Hongbo Jiang Lei Xu Na An Hui Liu Yinsheng Li Ruiling Zhang | 2014 | Neural Regeneration Research2014，9，17： | 3 |
| 7 | Histone acetylation of the htr3a gene in the prefrontal cortex of Wistar rats regulates ethanol-seeking behavior显示文摘Previous reports showed that decreased histone deacetylase activity significantly potentiated the rewarding effects of psychostimulants,and that encoding of the 5-HT3 receptor by the htr3a gene was related to ethanol-seeking behavior.However,the effects of a histone deacetylase inhibitor on ethanol-seeking behavior and epigenetic regulation of htr3a mRNA expression after chronic ethanol exposure are not fully understood.Using quantitative reverse transcription-polymerase chain reaction and chromatin immunoprecipitation analysis,we investigated the effects of chronic ethanol exposure and its interaction with a histone deacetylase inhibitor on histone-acetylation-mediated changes in htr3a mRNA expression in the htr3a promoter region.The conditioned place preference procedure was used to evaluate ethanol-seeking behavior.Chronic exposure to ethanol effectively elicited place conditioning.In the prefrontal cortex,the acetylation of H3K9 and htr3a mRNA expression in the htr3a promoter region were significantly higher in the ethanol group than in the saline group.The histone deacetylase inhibitor sodium butyrate potentiated the effects of ethanol on htr3a mRNA expression and enhanced ethanol-induced conditioned place preferences.These results suggest that ethanol upregulates htr3a levels through mechanisms involving H3K9 acetylation,and that histone acetylation may be a therapeutic target for treating ethanol abuse. | Yahui Xu Xuebing Liu Xiaojie Zhang Guanbai Zhang Ruiling Zhang Tieqiao Liu Wei Hao | 2012 | Neural Regeneration Research2012，7，13： | 3 |
| 8 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 9 | Non-coding regions of the Ebola virus genome contain indispensable phylogenetic and evolutionary information显示文摘We compared the numbers of nucleotide substitutions occurring in the non-coding regions and coding regions of Ebola virus genomes and found that non-coding regions contain indispensable phylogenetic and evolutionary information. The omission of genetic data from non-coding regions can lead to unreliable phylogenies and inaccurate estimates of evolutionary parameters. | JIANG XinQuan ZHANG ZhenJie ZHUANG DongMing CARR Michael J. ZHANG RuiLing LV Qiang SHI WeiFeng | 2015 | Science China(Life Sciences)2015，58，7： | 2 |
| 10 | Bismuth doped lead-free two-dimensional tin based halide perovskite single crystals显示文摘Heterovalent-metal doping is an efficient tool to tune the optoelectronic properties of the famous halide perovskites.Previous studies have focused on the heterovalent-doping in three-dimensional(3D) halide perovskites.However, there is a lack of such doping in two-dimensional perovskites which possess unique optoelectronic properties and improved chemical stability as compared to 3D analogues.Here, we present successful doping of Bismuth into the lattice of lead-free, two-dimensional perovskite PEA2SnBr4 single crystals.Structural characterizations demonstrate that the doped crystals possess identical crystal structure and layered morphology with the pristine one.Intriguingly, we find the PL peak and spectral shape can be tailored by tuning the concentration of Bi dopants.Femtosecond transient absorption spectroscopy is performed to understand the underlying mechanism related to tunable PL behaviors, and a clear picture of the Bismuth-doping impact is provided. | Ruiling Zhang Xin Mao Pengfei Cheng Yang Yang Songqiu Yang Tuerdi Wumaier Weiqiao Deng Keli Han | 2019 | Journal of Energy Chemistry2019，28，9： | 2 |
| 11 | Phylogeny and species differentiation of Mollitrichosiphum spp. (Aphididae, Greenideinae) based on mitochondrial CO1 and Cyt b genes显示文摘 | Ruiling ZHANG Xiaolei HUANG Liyun JIANG Gexia QIAO | 2011 | Current Zoology2011，57，6： | 2 |
| 12 | Improved cellular response on multiwalled carbon nanotube-incorporated electrospun polyvinyl alcohol/chitosan nanofibrous scaffolds显示文摘 | Huihui Liao Ruiling Qi Mingwu Shen Xueyan Cao Rui Guo Yanzhong Zhang Xiangyang Shi | 2011 | Colloids and Surfaces B: Biointerfaces2011，，2： | 1 |
| 13 | Aerobic granules formation and nutrients removal characteristics in sequencing batch airlift reactor (SBAR) at low temperature显示文摘 | Ruiling Bao Shuili Yu Wenxin Shi Xuedong Zhang Yulan Wang | 2009 | Journal of Hazardous Materials2009，，2： | 1 |
| 14 | Mechanism of rocky desertification in the karst mountain areas of Guizhou province,souwest China显示文摘 | Wang Shijie Zhang Dianfa Li Ruiling | 2002 | International Review for Environmental Strategies2002，3，1： | 1 |
| 15 | Cordyceps militaris polysaccharides can improve the immune efficacy of Newcastle disease vaccine in chicken显示文摘 | Mi Wang Xinyu Meng Ruile Yang Tao Qin Ying Li Lifang Zhang Chengzhong Fei Wenli Zhen Keyu Zhang Xiaoyang Wang Yuanliang Hu Feiqun Xue | 2013 | International Journal of Biological Macromolecules2013，，： | 1 |
| 16 | Mechanismof rocky desertification in the karst mountain areas of Guizhou province southwest China显示文摘 | Wang Shijie Zhang Dianfa Li Ruiling | 2002 | International Review for Environmental Strategies2002，3，12： | 1 |
| 17 | 粗毛牛膝菊在中国的入侵与生态位漂移有关显示文摘在外来物种入侵和扩散过程中,生态位的漂移可能起到了重要作用。粗毛牛膝菊(Galinsoga quadriradiata)在中国已造成了较为严重的入侵,占据了许多与其原产地不同的气候区。为此,本研究力图揭示粗毛牛膝菊入侵过程中的气候生态位漂移,分析其在该物种入侵中国过程中可能发挥的作用。本研究结合粗毛牛膝菊原产地和入侵地的分布点与气候数据,采用Maxent模型预测了其在中国潜在的分布,并采用主成分分析的方法评估了在入侵中国过程中粗毛牛膝菊气候生态位的漂移。模型结果显示,该物种原产地种群和入侵地种群之间只有32.7%的生态位重叠,两个种群的生态位相似性较低(Schoener's D=0.093,P<0.005),这暗示了在其入侵过程中发生了生态位漂移。相比于其原产地种群,其在中国的入侵种群气候生态位的整体范围和中心都明显地漂移向了温度更低、降水更少的区域;中国南方大部分区域属于粗毛牛膝菊的稳定适生区,而位于入侵前沿的北方地区则存在局域适应和潜在拓殖区域。这些研究结果说明,粗毛牛膝菊在中国的入侵种群仍处于准平衡阶段,未来有可能继续向新的适生区扩散入侵,其生态位的变化有力地解释了为什么该物种在中国的入侵性强、危害范围大。 | Wengang Zhang Xiaoyan Chen Ruiling Liu Xingjiang Song Gang Liu Jiabin Zou Zengqiang Qian Zhihong Zhu Langjun Cui | 2022 | Journal of Plant Ecology2022，15，3： | 1 |
| 18 | Cordyceps militaris polysaccharides can improve the immune efficacy of Newcastle disease vaccine in chicken显示文摘 | Mi Wang Xinyu Meng Ruile Yang Tao Qin Ying Li Lifang Zhang Chengzhong Fei Wenli Zhen Keyu Zhang Xiaoyang Wang Yuanliang Hu Feiqun Xue | 2013 | International Journal of Biological Macromolecules2013，，： | 1 |
| 19 | Mechanism of rocky desertification in the Karst Mountain Areas of Guizhou Province, Southwest China显示文摘 | Wang Shijie Dianfa Zhang Li Ruiling | 2002 | International Review for Environmental Strategies2002，3，1： | 1 |
| 20 | Expert consensus on the prevention and treatment of substance use and addictive behaviour-related disorders during the COVID-19 pandemic显示文摘In early 2020,the COVID-19 outbreak complicated the diagnosis,treatm ent and rehabilitation of patients with substance use disorders and increased the risks of substance abuse and addictive behaviours,such as online gaming disorders,in the general public.Substance use disorder is a chronic recurrent brain disease characterised by strong cravings,high recurrence rates,and a high proportion of comorbidity of mental and physical disorders.1 Therefore,regular long-term therapeutic interventions are critical to preventing dm g relapses while maintaining withdrawal. | Jiang Du Ni Fan Min Zhao Wei Hao Tieqiao Liu Lin Lu Jie Shi Haifeng Jiang Na Zhong Xiaochang Lan Shichao Xu Hongxian Chen Xiaojun Xiang Xuyi Wang Hongqiang Sun Bing Li Yu-Ping Ning Jing Li Wanjun Guo Yajuan Niu Lixia Sheng Yi Li Xuebin Liu Xuhui Zhou Mincai Qian Wenhua Zhou Ruiling Zhang Hongxing Hu Yan Xia Zhonghua Su Ruimin Zhang Mei Yang Fen Liu Wei Yuan | 2020 | General Psychiatry2020，33，4： | 1 |
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