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| 1 | Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system显示文摘允许的技术内长的基因的特定的规定为基因功能的学习是珍贵的并且在治疗学有大潜力。我们创造了在 CRISPR 上系统,由核酸酶死者 Cas9 (dCas9 ) 蛋白质组成的二部件的 transcriptional 使活跃之物与互补顺序与 transcriptional 激活域和单个指南 RNA (sgRNAs ) 熔化了到基因倡导者。我们证明在 CRISPR 上能高效地以一种悦耳的方式在人和老鼠房间激活外长的记者基因。另外,我们证明在 vivo 的柔韧的记者基因激活能被把系统部件注入老鼠接合子完成。而且,我们证明在 CRISPR 上能激活内长的 IL1RN, SOX2,和 OCT4 基因。最有效的基因激活被对近似倡导者有约束力的 3-4 sgRNAs 的簇完成,建议他们在基因正式就职的 synergistic 行动。显著地,当指向多重基因的 sgRNAs 同时被介绍进房间时,柔韧的多路的内长的基因激活被完成。染色体宽的表示介绍表明了系统的高特性。 | Albert W Cheng Haoyi Wang Hui Yang Linyu Shi Yarden Katz Thorold W Theunissen Sudharshan Rangarajan Chikdu S Shivalila Daniel B Dadon Rudolf Jaenisch | 2013 | Cell Research2013，23，10： | 65 |
| 2 | Landscape diagnosis on different space and time scales-a challenge for landscape planning 显示文摘 | OLAF B RUDOLF K ZDENEK L | 2006 | Landscape Ecol2006，21，： | 1 |
| 3 | Cultured gill epithelial cells from tilapia(Oreochromis niloticus): a new in vitro assay for toxicants显示文摘 | Zhou B S Liu W H Rudolf S S | 2005 | Aquatic Toxicology2005，71，1： | 1 |
| 4 | A Multiplicity Result for a Periodic Boundary Value Problem显示文摘 | Rudolf B | 1997 | Nonlinear Analysis1997，28，1： | 1 |
| 5 | Flow-through ultrasonic emulsification combined with static micromixing for aseptic 显示文摘 | Freitas S Rudolf B Merkle H P | 2008 | Eur J Pharm Biopharm2008，61，3： | 1 |
| 6 | Relationship Learning and Performance Enhancement via Advanced Information Technology:The Case of Taiwanese Dragon Electronics firms显示文摘 | JEAN R J B RUDOLF R S | 2010 | International Marketing Review2010，27，2： | 1 |
| 7 | Vertical distribution and composition of phytoplankton under the influence of an upper mixed layer显示文摘 | RYABOV A B RUDOLF L BLASIUS B | 2010 | J Theor Biol2010，263，1： | 1 |
| 8 | Fruit and vegetable consumption and risk of aggressive and non-aggressive urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition显示文摘 | Martine M. Ros H. Bas Bueno-de-Mesquita Ellen Kampman Frederike L. Büchner Katja K.H. Aben Lars Egevad Kim Overvad Anne Tj?nneland Nina Roswall Francoise Clavel-Chapelon Marie Christine Boutron-Ruault Sophie Morois Rudolf Kaaks Birgit Teucher Steffen Weik | 2012 | European Journal of Cancer2012，，17： | 1 |
| 9 | Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition12345显示文摘 | Martine M Ros H Bas Bueno-de-Mesquita Ellen Kampman Katja KH Aben Frederike L Büchner Eugene HJM Jansen Carla H van Gils Lars Egevad Kim Overvad Anne Tj?nneland Nina Roswall Marie Christine Boutron-Ruault Marina Kvaskoff Florence Perquier Rudolf Kaaks Jen | 2012 | American Journal of Clinical Nutrition2012，，4： | 1 |
| 10 | Slope stability of geosynthetic clay line test plots 显示文摘 | David D Robert K Rudolf B | 1998 | J Geotech Geoenviron Eng1998，124，7： | 1 |
| 11 | 2q37 as a Susceptibility Locus for Idiopathic Basal Ganglia Calcification (IBGC) in a Large South Tyrolean Family显示文摘 | Claudia Béu Volpato Alessandro De Grandi Ebba Buffone Maurizio Facheris Uwe Gebert Günther Schifferle Rudolf Sch?nhuber Andrew Hicks Peter P. Pramstaller | 2009 | Journal of Molecular Neuroscience2009，，3： | 1 |
| 12 | Modelling and monitoring urban built environment via multi-source integrated and fused remote sensing data显示文摘 | Anna B Eyal B D Rudolf R | 2013 | International Journal of Image and Data Fusion2013，4，1： | 1 |
| 13 | Combined oral benzo pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa mice显示文摘 | ESTHER M H ANNEMIEKE D V RUDOLF B B | 2003 | Carcinogenesis2003，24，3： | 1 |
| 14 | Coflex inter spinous implant:motion preservation treatment inlumbar degenerative stenosis patients minimum 1 year results显示文摘 | Rudolf B | 2006 | Spine2006，6，5： | 1 |
| 15 | Development and validation of a liquid chromatography/tandem mass spectro-metric method for the determination of 39 mycotoxins in wheat and maize 显示文摘 | Michael S Franz B Rudolf K | 2006 | Rapid Commun Mass Spectrom2006，20，： | 1 |
| 16 | Haze trendsover the United States,1980-1995显示文摘 | Schichtel B A Rudolf B H Stefan R Fe t al | 2001 | Atmospheric Envi-ronment2001，35，30： | 1 |
| 17 | Global precipitation estimates based on a technique for combining satellite-based estimates,rain gauge analysis,and NWP model precipitation information显示文摘 | Huffman G J Adler R F Rudolf B | 1995 | Journal of Climate1995，，8： | 1 |
| 18 | Preclinical evalucation of HBY097, a new non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 republication 显示文摘 | Jorg PK Rudolf B Gunther R | 1995 | Antimicrob Agents Chemother1995，39，10： | 1 |
| 19 | The effects of supplier involvement and knowledge protection on product innovation in customer-supplier relationships : a study of global automotive suppliers in China 显示文摘 | RUEY jer B J RUDOLF R S THOMAS P H | 2014 | Journal of product innovation management2014，31，1： | 1 |
| 20 | The effects of supplier involvement and knowledge protection on product innovation in customer-supplier relationships: a study of global automotive suppliers in China显示文摘 | Ruey-Jer B J Rudolf R Sinkovics Thomas P Hiebaum | 2014 | (1): 462014，，1： | 1 |
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