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| 1 | Integrating insulin-like growth factor 1 and sex hormones into neuroprotection:Implications for diabetes显示文摘Brain integrity and cognitive aptitude are often impaired in patients with diabetes mellitus, presumably a result of the metabolic complications inherent to the disease. However, an increasing body of evidence has demonstrated the central role of insulin-like growth factor 1(IGF1) and its relation to sex hormones in many neuroprotective processes. Both male and female patients with diabetes display abnormal IGF1 and sexhormone levels but the comparison of these fluctuations is seldom a topic of interest. It is interesting to note that both IGF1 and sex hormones have the ability to regulate phosphoinositide 3-kinase-Akt and mitogen-activated protein kinases-extracellular signal-related kinasesignaling cascades in animal and cell culture models of neuroprotection. Additionally, there is considerable evidence demonstrating the neuroprotective coupling of IGF1 and estrogen. Androgens have also been implicated in many neuroprotective processes that operate on similar signaling cascades as the estrogen-IGF1 relation. Yet, androgens have not been directly linked to the brain IGF1 system and neuroprotection. Despite the sex-specific variations in brain integrity and hormone levels observed in diabetic patients, the IGF1-sex hormone relation in neuroprotection has yet to be fully substantiated in experimental models of diabetes. Taken together, there is a clear need for the comprehensive analysis of sex differences on brain integrity of diabetic patients and the relationship between IGF1 and sex hormones that may influence brain-health outcomes. As such, this review will briefly outline the basic relation of diabetes and IGF1 and its role in neuroprotection. We will also consider the findings on sex hormones and diabetes as a basis for separately analyzing males and females to identify possible hormone-induced brain abnormalities. Finally, we will introduce the neuroprotective interplay of IGF1 and estrogen and how androgen-derived neuroprotection operates through similar signaling cascades. Future research on both neuroprotection and diabetes should include androgens into the interplay of IGF1 and sex hormones. | Jacob Huffman Christina Hoffmann George T Taylor | 2017 | World Journal of Diabetes2017，8，2： | 4 |
| 2 | 共享经济遇上反垄断法:Uber是公司,还是卡特尔,或是介于两者之间?显示文摘共享经济是一种新兴的产业结构,通过互联网即时通信以及个人企业家和消费者生活、工作和购买习惯的改变得以实现。反垄断法是美国的一种经济监管体制,可追溯到1890年,旨在解决被集中控制的经济力量以及这种集中对消费者利益和经济效率造成的威胁。在现代企业结构中,成千上万的独立合同方联合起来通过彼此之间的协议来提供服务,为了适应这一结构,反垄断法需要重新构想并谨慎适用。Uber、Airbnb和其他共享经济公司的成功以及这些公司承诺的消费者利益,体现了重新构想的难度与重要性。I.引言共享经济是一种挑战了大量法律结构和制度结构的干扰势力。像Uber和Airbnb这样的共享经济平台公司每天都将数千家供应商与数百万消费者连接起来。平台公司运用即时通信和大量的信息分类技术来协调供应商之间的行为,并与消费者匹配。在这个过程中,平台公司已经改变了构成商业公司的基本概念。伴随着明显的反垄断法关切与大规模消费者利益证据之间的冲突,由此对反垄断法和反垄断政策造成的影响模糊不清。 | Mark Anderson Max Huffman 时建中 王佳倡 | 2018 | 竞争政策研究2018，，3： | 4 |
| 3 | 正确识别并治疗急性心肌梗死患者所发生的抑郁与焦虑显示文摘The objective of this study was to determine the ability of providers(medical residents and nurse practitioners) on inpatient cardiac units to recognize and appropriately treat patients with clinically significant depression and anxiety among a cohort admitted with acute myocardial infarction. Patients within 72 hours of acute myocardial infarction underwent screening with the Standardized Clinical Instrument for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition module for major depressive disorder(MDD), the Beck Depression Inventory(BDI-Ⅱ), and the Beck Anxiety Inventory(BAI). In addition, the study psychiatrist and a treatment team clinician independently assessed whether they believed that patients had clinically significant depression or anxiety. Prescription of antidepressants and benzodiazepines during hospitalization was recorded by chart review. Assessments were completed for 74 patients. Providers identified< 15%of patients with current MDD or with a BDI score ≥10; 11%of patients with current MDD had appropriate treatment with antidepressants. There was no significant correlation of providers’assessment of depression with current MDD, BDI scores, or psychiatrists’clinical assessment of depression. In contrast, providers identified 31%of patients with a BAI score ≥10 and 50%of patients who were assessed by psychiatrists as anxious; >80%of patients with high anxiety received benzodiazepines. Providers’assessments of anxiety were significantly correlated with BAI scores and with psychiatrists’clinical assessments. In conclusion, medical residents and nurse practitioners routinely under-recognize and undertreat depression among patients with acute myocardial infarction on inpatient cardiac units. Recognition and treatment of anxiety is substantially better, up to 50%of patients who are found to be anxious by psychiatrists after acute myocardial infarction remain unrecognized. | Huffman J.C. Smith F.A. Blais M.A. 杜媛 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 2 |
| 4 | Farm technology and technical efficiency: Evidence from four regions in China显示文摘 | Zhuo Chen Wallace E. Huffman Scott Rozelle | 2009 | China Economic Review2009，，2： | 2 |
| 5 | Quantitative analysis of all major forms of sulfur in coal by x-ray absorption fine structure spectroscopy 显示文摘 | Huffman G P Mitra S Huggins F E | 1991 | Energy and Fuels1991，5，4： | 1 |
| 6 | Evaluation of the immunoglobu/in G avidity test for diagnosis of toxoplasmie lymphadenopathy显示文摘 | MontoyaJG Huffman HB Remington JS | 2004 | J Clin Microbiol2004，42，10： | 1 |
| 7 | Band gap fluorescence from individual single-walled carbon nanotubes显示文摘 | O'Connell M J Bachilo S M Huffman C B | 2002 | Science2002，297，： | 1 |
| 8 | Laparoscopic cholecystectomy for treatment of biliary dyskinesia is safe and effective in the pediatric population 显示文摘 | Hofeldt M Richmond B Huffman K | 2008 | Am Surg2008，74，11： | 1 |
| 9 | Ureteroscopic retrieval of proximally located ureteral stents显示文摘 | Bagley DH Huffman JL | 1991 | Urology1991，37，5： | 1 |
| 10 | Metabolic syndrome and high-sensitivity C-reactive protein in Cubans显示文摘 | Huffman FG Gomez GP Zarini GG | 2009 | Ethn Dis2009，19，2： | 1 |
| 11 | The supercooled warm rain process and the specifi cation of freezing precipitation显示文摘 | Huffman G J | 1988 | Monthly Weather Review1988，116，11： | 1 |
| 12 | The development of aimproved coal ash viscosity temperature relationship for assessment of slagging propensity in coal fired boiler 显示文摘 | Huffman G P Huggins F E Sliah N | 1990 | Prog Energy Combust Sci1990，16，： | 1 |
| 13 | The Infrared and Ultraviolet Absorption Spectra of Laboratory-Produced Carbon Dust: Evidence for the Presence of the C60 Molecule 显示文摘 | Kratschmer W Fostiropoulos K Huffman D | 1990 | Chem Phys Lett1990，170，： | 1 |
| 14 | Pre-existing major depression predicts in-hospital cardiac complications after acute myocardial infarction 显示文摘 | Huffman JC Smith FA Blais MA | 2008 | Psyehosomaties2008，49，4： | 1 |
| 15 | the impact of mental illness on cardiac outcomes:a review for the cardiologist显示文摘 | Sowden GL Huffman JC | 2009 | Int J Cardiol2009，132，1： | 1 |
| 16 | Changes in stiffness of resin-infiltrated demineralized dentin after remineralization by a bottom-up biomimetic approach显示文摘 | Gu LS Huffman BP Arola DD | 2010 | Acta Biomater2010，6，4： | 1 |
| 17 | SIRTI is signifi- cantly elevated in mouse and human prostate cancer显示文摘 | Huffman DM Grizzle WE Bamman MM | 2007 | Cancer Res2007，67，14： | 1 |
| 18 | Effect of gas atmospheres On microbial growth, color and pH of beef 显示文摘 | HUFFMAN D L DAVIS K A MARPLE D N | 1975 | Journal of Food Science1975，40，6： | 1 |
| 19 | Tax Analysis in a Real- business- cycle Model:On Measuring Harberg- er Triangles and Okun Gaps 显示文摘 | Greenwood Huffman | 1991 | Journal of Mo- netary Economics Elsevier1991，27，2： | 1 |
| 20 | Value pricing: How low can you go?显示文摘 | David K. Hayes Lynn M. Huffman | 1995 | Cornell Hotel and Restaurant Administration Quarterly1995，，1： | 1 |
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