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| 1 | Mesenchymal stem cells-based therapy as a potential treatment in neurodegenerative disorders: is the escape from senescence an answer?显示文摘Aging is the most prominent risk factor contributing to the development of neurodegenerative disorders. In the United States, over 35 million of elderly people suffer from age-related diseases. Aging impairs the self-repair ability of neuronal cells, which undergo progressive deterioration.Once initiated, this process hampers the already limited regenerative power of the central nervous system, making the search for new therapeutic strategies particularly difficult in elderly affected patients. So far, mesenchymal stem cells have proven to be a viable option to ameliorate certain aspects of neurodegeneration, as they possess high proliferative rate and differentiate in vitro into multiple lineages. However, accumulating data have demonstrated that during longterm culture, mesenchymal stem cells undergo spontaneous transformation. Transformed mesenchymal stem cells show typical features of senescence, including the progressive shortening of telomers, which results in cell loss and, as a consequence, hampered regenerative potential. These evidences, in line with those observed in mesenchymal stem cells isolated from old donors, suggest that senescence may represent a limit to mesenchymal stem cells exploitation in therapy, prompting scholars to either find alternative sources of pluripotent cells or to arrest the age-related transformation. In the present review, we summarize findings from recent literature, and critically discuss some of the major hurdles encountered in the search of appropriate sources of mesenchymal stem cells, as well as benefits arising from their use in neurodegenerative diseases. Finally, we provide some insights that may aid in the development of strategies to arrest or, at least, delay the aging of mesenchymal stem cells to improve their therapeutic potential. | Alessandro Castorina Marta Anna Szychlinska Rubina Marzagalli Giuseppe Musumeci | 2015 | Neural Regeneration Research2015，10，6： | 8 |
| 2 | Chromosome-scale scaffolding of the black raspberry (Rubus occidentalis L.) genome based on chromatin interaction data显示文摘Black raspberry(Rubus occidentalis L.)is a niche fruit crop valued for its flavor and potential health benefits.The improvement of fruit and cane characteristics via molecular breeding technologies has been hindered by the lack of a high-quality reference genome.The recently released draft genome for black raspberry(ORUS 4115-3)lacks assembly of scaffolds to chromosome scale.We used high-throughput chromatin conformation capture(Hi-C)and Proximity-Guided Assembly(PGA)to cluster and order 9650 out of 11,936 contigs of this draft genome assembly into seven pseudo-chromosomes.The seven pseudo-chromosomes cover~97.2%of the total contig length(~223.8 Mb).Locating existing genetic markers on the physical map resolved multiple discrepancies in marker order on the genetic map.Centromeric regions were inferred from recombination frequencies of genetic markers,alignment of 303 bp centromeric sequence with the PGA,and heat map showing the physical contact matrix over the entire genome.We demonstrate a high degree of synteny between each of the seven chromosomes of black raspberry and a high-quality reference genome for strawberry(Fragaria vesca L.)assembled using only PacBio long-read sequences.We conclude that PGA is a cost-effective and rapid method of generating chromosome-scale assemblies from Illumina short-read sequencing data. | Rubina Jibran Helge Dzierzon Nahla Bassil Jill M.Bushakra Patrick P.Edger Shawn Sullivan Chad E.Finn Michael Dossett Kelly J.Vining Robert VanBuren Todd C.Mockler Ivan Liachko Kevin M.Davies Toshi M.Foster David Chagné | 2018 | Horticulture Research2018，5，1： | 4 |
| 3 | Acute kidney injury from different poisonous substances显示文摘AIM To report our experience of acute kidney injury(AKI) developed after exposure to poisonous substance.METHODS Retrospective study where data was collected from case records of patients coming to this institute during January 1990 to May 2016.This institution is a tertiary care center for renal care in the metropolitan city of Karachi,Pakistan.History of ingested substance,symptoms on presentation,basic laboratory tests on arrival,mode of treatment and outcome were recorded from all patients and are presented here.Patients developing AKI after snake envenomation or scorpion stings are not included in this study.RESULTS During studied period 184 cases of AKI developing after poisoning were seen at our institution.The largest group was from paraphenyline diamine poisoning comprising 135 patients,followed by methanol in 8,organophosphorus compounds in 5,paraquat in 5,copper sulphate in 5,tartaric acid in 4,phenobarbitone in 3 and benzodiazipines,datura,rat killer,fish gall bladder,arsenic,boiler water,ammonium dichromate,acetic acid and herbs with lesser frequency.In 8 patients multiple substances were ingested in combination.Renal replacement therapy was required in 96% of patients.Complete recovery was seen in 72.28% patients,20% died during acute phase of illness.CONCLUSION It is important to report poisonous substances causing vital organ failure to increase awareness among general population as well as health care providers. | Rubina Naqvi | 2017 | World Journal of Nephrology2017，6，3： | 4 |
| 4 | Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury显示文摘 | Yumiko Imai Keiji Kuba G. Greg Neely Rubina Yaghubian-Malhami Thomas Perkmann Geert van Loo Maria Ermolaeva Ruud Veldhuizen Y.H. Connie Leung Hongliang Wang Haolin Liu Yang Sun Manolis Pasparakis Manfred Kopf Christin Mech Sina Bavari J.S. Malik Peiris Ar | 2008 | Cell2008，，2： | 4 |
| 5 | Evaluation of a Non-invasive Method to Detect Cytomegalovirus (CMV)-DNA in Stool Samples of Patients with Inflammatory Bowel Disease (IBD): A Pilot Study显示文摘 | Hans H. Herfarth Millie D. Long Tara C. Rubinas Mikki Sandridge Melissa B. Miller | 2010 | Digestive Diseases and Sciences2010，，4： | 2 |
| 6 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 7 | Crosslinked electrospun PVA nanofibrous membranes: Elu- cidation of their physicochemical, physicomechanieal and molecular disposition显示文摘 | Rubina P Shaikh Pradeep Kumar Yahya E Choonara | 2012 | Biofabrication2012，4，02： | 1 |
| 8 | Fact ors affecting hazardous wast e solidif ieation/stabilization 显示文摘 | Raehana M Rubina C | 2006 | Journal of Hazardous Materials2006，137，1： | 1 |
| 9 | Factors of afeeting hazardous waste solidification/stabilization 显示文摘 | Raehana M Rubina C | 2006 | J Hazard Mater2006，137，1： | 1 |
| 10 | 子宫颈抹片检查常规筛查宫颈组织、癌前病变或癌变在发展中国家门诊中的运用(英文)显示文摘Objective: Papanicolou (Pap) smear screening has dramatically reduced the incidence of invasive cervical cancer worldwide. Pap smear screening is still not widely available in developing countries and therefore cannot be used as mass screening tool. This study was designed to establish the role of Pap smear as a routine investigation for females presented to gynecological department. Methods: It was a hospital based study. Patients attending with complaints including irregular vaginal bleeding, vagina discharge, dyspareunia, low backache or lower abdominal pain and primary or secondary infertility were included in the study. All these patients underwent pap smear. Results: Age of females was 25 to 60 years. Ninety females had dysplasia. Mild to moderate dysplasia was positive in 84 females. Six patients had severe dysplasia suspicious for squamous cell carcinoma (SCC) which was confirmed as invasive SCC on biopsy. All patients with mild to moderate dysplasia were regularly followed at 4 to 6 months. Thirty patients were lost during follow up. Forty had negative smear at 6 months, while fourteen having persistent dysplasia on repeated pap smears were referred for biopsies. Histopathology confirmed invasive SCC in five patients while chronic cervicitis was reported in nine patients. Only two of screened patients with high suspicion for cancer showed false negative results. Directed biopsies done in these confirmed invasive SCC. Conclusion: Pap smear is a useful, simple, non-invasive and reliable screening tool for cervical cancer. It may be practiced as a routine investigation in outpatients in developing countries, where mass screening is not available. | Rubina Mukhtar Maham Munir Allah Rakha Abdul Mateen Rab Nawaz Maken Muhammad Arif | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，10： | 1 |
| 11 | Performance evaluation of a mechanical vapour compression desalination system显示文摘 | RUBINA B HAWLADER M N A LIANG S W | 2004 | Desalination2004，166，123： | 1 |
| 12 | Tackling dipeptidyl peptidase Ⅳ in neurological disorders显示文摘Dipeptidyl peptidase Ⅳ(DPP-IV) is a serine protease best known for its role in inactivating glucagon-like peptide-1(GLP-1), pituitary adenylate cyclase-activating polypeptide(PACAP) and glucose-dependent insulinotropic peptide(GIP), three stimulators of pancreatic insulin secretion with beneficial effects on glucose disposal. Owing to the relationship between DPP-IV and these peptides, inhibition of DPP-IV enzyme activity is considered as an attractive treatment option for diabetic patients. Nonetheless, increasing studies support the idea that DPP-IV might also be involved in the development of neurological disorders with a neuroinflammatory component, potentially through its non-incretin activities on immune cells. In this review article, we aim at highlighting recent literature describing the therapeutic value of DPP-IV inhibitors for the treatment of such neurological conditions. Finally, we will illustrate some of the promising results obtained using berberine, a plant extract with potent inhibitory activity on DPP-IV. | Ghaith Al-Badri Gian Marco Leggio Giuseppe Musumeci Rubina Marzagalli Filippo Drago Alessandro Castorina | 2018 | Neural Regeneration Research2018，13，1： | 1 |
| 13 | Performance evaluation of a mechanical vapor compression desalination system 显示文摘 | Rubina Bahar M N A Hawlader Liang song Woei | 2004 | Desalination2004，166，13： | 1 |
| 14 | Treatment of haz-ardous organic and inorganic compounds through aqueous-phase photocatalysis : A review 显示文摘 | Kavita K Rubina C Rameshwar L | 2004 | Ind Eng Chem Res2004，43，24： | 1 |
| 15 | Mesenchymal stem cells in tissue growth and repair显示文摘 | Kalinina NI Sysoeva VY Rubina KA | 2011 | Acta Naturae2011，3，4： | 1 |
| 16 | Factors affecting hazardous waste solidification/ stabilization显示文摘 | Rachana M Rubina C | 2006 | Journal of Hazardous Materials2006，137，1： | 1 |
| 17 | Leaching behavior and immobilization of heavy metals in solidified/stabilized products显示文摘 | Rachana Malviya Rubina Chaudhary | 2006 | Journal of Hazardous Materials2006，，1： | 1 |
| 18 | Hydrogel drop microchips with immobilized DNA: properties and methods for large-scale production显示文摘 | RUBINA A Y PAN'KOV S V DEMENTIEVA E I | 2004 | Anal Biochem2004，325，1： | 1 |
| 19 | Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesisin vivo显示文摘 | Ingo H Riichiro A Rubina W | 2001 | FASEB2001，15，5： | 1 |
| 20 | Adipose slromal cel]s stimulate angiogenesis via promoting progenitor cell differentia- tion, secretion of angiogenic factors, and enhancing vessel matu- ration显示文摘 | Rubina K Kalinina N Efimenko A | 2009 | Tissue Eng Part A2009，15，8： | 1 |
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