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| 1 | 塞来昔布治疗骨关节炎的随机对照试验显示文摘目的 :比较塞来昔布、萘普生以及安慰剂在治疗膝关节骨关节炎时的疗效、安全性。方法 :10 0 3名有症状的膝关节骨关节炎患者随机接受塞来昔布 5 0 ,10 0 ,2 0 0mg ,bid ;萘普生 5 0 0mg ,bid或安慰剂 12周。患者在停用既往NSAID药或止痛治疗后 2~ 7d以及服用受试药物治疗后 2 ,6 ,12周 ,根据标准疗效判定方法进行评估。结果 :塞来昔布在改善骨关节炎的症状和体征上有显著效果。在治疗后的 2d内疼痛明显缓解 ,最大抗炎和镇痛作用出现在 2周内并持续至 12周。各剂量的塞来昔布与安慰剂比较均有效 ,但 5 0mg ,bid的剂量效果较差 ;较大剂量的塞来昔布 (10 0和 2 0 0mg ,bid)疗效相似 ,所观察到的改善程度与萘普生 5 0 0mg ,bid相当。各剂量的塞来昔布和萘普生均有良好的耐受性。结论 :COX 2抑制剂塞来昔布是治疗骨关节炎的有效药物 ,对骨关节炎临床症状和体征的改善与萘普生相当。 | Bensen WG Fiechtner JJ Mcmillen JI Zhao WW Yu SS Woods EM Hubbard RC Isakson PC Verburg KM Geis GS | 2000 | 中国新药杂志2000，9，8： | 17 |
| 2 | Incomplete Polyp Resection During Colonoscopy—Results of the Complete Adenoma Resection (CARE) Study显示文摘 | Heiko Pohl Amitabh Srivastava Steve P. Bensen Peter Anderson Richard I. Rothstein Stuart R. Gordon L. Campbell Levy Arifa Toor Todd A. Mackenzie Thomas Rosch Douglas J. Robertson | 2013 | Gastroenterology2013，，： | 2 |
| 3 | The colonoscopic miss rate and true one- year recurrence of eolorectal eoplasfic polyps显示文摘 | Bensen S Mort LA Dain B | 1999 | Polyp Pre- vention Study Group1999，，： | 1 |
| 4 | Fractures about theshoulder:conservative management显示文摘 | Mckoy B E Bensen C V Hartsock L A | 2000 | Orthop Clin North Am2000，31，2： | 1 |
| 5 | Cloning and characterization of the maize Anl gene显示文摘 | Bensen R J Johal G S Crane V C | 1995 | The Plant Ce111995，7，： | 1 |
| 6 | Fractures about the shoulder:conservative management显示文摘 | McKoy BE Bensen CV Hartsock LA | 2000 | Orthop Clin North Am2000，31，： | 1 |
| 7 | Bacteri- al RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condi- tions显示文摘 | CASTIGLIONI P WARNER D BENSEN R J | 2008 | Plant Physiology2008，147，2： | 1 |
| 8 | Management of patients with atrial fibrillation: a statement for healthcare professionals from the subcommittee on electrocardiography and electrophysiology, American Heart Association显示文摘 | Prystowsky EN Bensen DW Jr Fuster V | 1996 | Circulation1996，93，6： | 1 |
| 9 | Treatment of osteoarthritis with eeleeoxib, a cyclooxygenase-2 inhibitor: a randomized controlled trial 显示文摘 | Bensen WG Fieehtner JJ McMillen JI | 1999 | Mayo Clin Proe1999，74，11： | 1 |
| 10 | Fractures about the shoulder: conservative management显示文摘 | Mekoy BE Bensen CV Hartsock LA | 2000 | Orthop Clin North Am2000，31，： | 1 |
| 11 | Fractures about the shoulder, concervative, management显示文摘 | Mckoy BE Bensen CV Hartsock LA | 2000 | Orthopelin North (Am)2000，31，2： | 1 |
| 12 | Fracture about the shoulder con- cervative management 显示文摘 | Mckoy BE Bensen CV Hartseek LA | 2000 | Orthop Clin Noah Am2000，31，2： | 1 |
| 13 | Fractures about the shoulder:conservative management显示文摘 | McKoy BE Bensen CV Hartsock LA | 2000 | Orthop Clin North Am2000，31，2： | 1 |
| 14 | Fractures about the shoulder conservative management 显示文摘 | Mckoy BE Bensen CV Hartsock LA | 2000 | Orthop Clin North Am2000，31，： | 1 |
| 15 | Lansoprazole associated microscopic colitis: a case series显示文摘 | Thomson RD Lestina LS Bensen SP | 2002 | Am J Gastroenterol2002，97，11： | 1 |
| 16 | Fractures about the shoulder: conervtive management 显示文摘 | McKoy BE Bensen CV Hartsock LA | 2000 | Orthop Clin North Am2000，31，2： | 1 |
| 17 | Water deficit-induced changes in abscisic acid, growth, polysomes and translatable RNA in soybean hypocotyls显示文摘 | Bensen R J Boyer J S Mullet J E | 1988 | Plant Physiology1988，88，： | 1 |
| 18 | Fractures about the shoul- der:conservative management显示文摘 | McKoy BE Bensen CV hartsock LA | 2000 | Orthop Clin North Am2000，，31： | 1 |
| 19 | Salmon calcitonin nasal spray in the prevention of corticosteroid-induced osteoporosis显示文摘 | Adachi D Bensen G Bell J | 1997 | Rheumetol1997，36，： | 1 |
| 20 | Fractures about the shoulder:eoncervative management显示文摘 | Mckoy B E Bensen C V Hartsoek L A | 2000 | Ortbopclin North Am2000，31，2： | 1 |
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