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| 1 | Inducible resistance to Fas-mediated apoptosis in B cells显示文摘Apoptosis produced in B cells through Fas (APO-1, CD95) triggering is regulated by signals derived from other surface receptors: CD40 engagement produces upregulation of Fas expres. sion and marked susceptibility to Fas-induced cell death, whereas antigen receptor engagement, or IL-4R engagement, inhibits Fas killing and in so doing induces a state of Fas-resistance, even in otherwise sensitive, CD40-stimulated targets. Surfaceim. munoglobulin and IL-4R utilize at least partially distinct pathways to produce Fas-resistance that differentially depend on PKC and STAT6, respectively. Further, surface immunoglob- 'lin signaling for inducible Fas-resistance bypasses Bib, requires NF-GB, and entails new macromolecular synthesis. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic gene products, Bcl-xL and FLIP, and a novel anti-apoptotic gene that encodes FAIM (Fas Apoptosis Inhibitory Molecule). faim was identified by differential display and exists in two alternatively spliced forms; maim-S is broadly expressed, but faim-L expression is tissue-specific. The FAIM sequence is highly evolu tionarily conserved, suggesting an important role for this molecule throughout phylogeny. Inducible resistance to Fas killing is hypothesized to protect foreign antigen-specific B cells during potentially hazardous interactions with FasL-bearing T cells, whereas autoreactive B cells fail to become Fas-resistant and are deleted via Fas-dependent cytotoxicity. Inadvertent or aberrant acquisition of Fas-resistance may permit autoreactive B cells to escape Fas deletion, and malignant lymphocytes to impede anti-tumor immunity. | ROTHSTEIN THOMAS L Departments of Medicine and Microbiology, and the Evans Memorial Department of Clinical Research, Boston University Medical Center, Boston, MA, USA | 2000 | Cell Research2000，10，4： | 4 |
| 2 | Pathologic features of Hashimoto’s-associated papillary thyroid carcinomas显示文摘 | Marcello Di Pasquale Jay L Rothstein Juan P Palazzo | 2001 | Human Pathology2001，，1： | 2 |
| 3 | Predicting high explosive detonation velocities from their composition and structure显示文摘 | Rothstein L R | 1981 | Prop and Explo1981，6，： | 1 |
| 4 | Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules显示文摘 | Rock KL Gramm C Rothstein L | 1994 | Cell1994，78，5： | 1 |
| 5 | Glutanate transporter protein subtypes are expressed differentially during rat CNS development显示文摘 | Furuta A Rothstein J D Martin L J | 1997 | J Neurosci1997，17，： | 1 |
| 6 | Interannual and decadal variability of the subsurface thermal structure in the Pacific Ocean: 1961-1990 显示文摘 | ZHANG R H ROTHSTEIN L M BASALACCHI A J | 1999 | Climate Dynamic1999，15，： | 1 |
| 7 | IL-4 upregulates Iga and Igl3 protein, resulting in augmented IgM matura- tion and B cell receptor-triggered B cell activation显示文摘 | GUO B C ROTHSTEIN T L | 2013 | The Journal of Immunology2013，191，2： | 1 |
| 8 | Initial recovery of soil carbon and nitrogen pools and dynamics following disturbance in jack pine forests:A comparison of wildfire and eleareut harvesting显示文摘 | Stephen D L Rothstein D E | 2007 | Soil Biology & Biochemistry2007，39，： | 1 |
| 9 | Biological functions of asparagine synthetase in plants显示文摘 | Gauqchon L Reisdorf-Cren M Rothstein S.J | | 0，，03： | 1 |
| 10 | Localization of neuronal and glial glutamate transporters显示文摘 | Rothstein J D Martin L Levey A I | 1994 | Neuron1994，13，3： | 1 |
| 11 | Predicting high explosive detonation velocities from their composition and structure 显示文摘 | Rothstein L R Petersen R | 1979 | Propellants Explosives Pyrotechnics1979，4，： | 1 |
| 12 | Peroxidase induced wilting in transgenic tobacco plants 显示文摘 | Bradford Sandra Rothstein Steven | 1990 | The Plant Cell1990，2，： | 1 |
| 13 | Transformation of a partial nopaline synthase gene into tobaccosuppresses the expression of a resident wild-type gene显示文摘 | Goring D R Thomson L Rothstein S J | 1991 | Proc Natl Aad Sci USA1991，88，： | 1 |
| 14 | Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity 显示文摘 | Rothstein JD Jin L Dykes-Hoberg M Kuncl RW | 1993 | Proc Natl Acad Sci USA1993，90，14： | 1 |
| 15 | The double-strand-break repair model for recombination显示文摘 | SZOSTAKJ W ORR-WEAVER T L ROTHSTEIN RJ | 1983 | Cell1983，33，1： | 1 |
| 16 | Predicting High Explosive Detonation Velocities from their Composition and Structure显示文摘 | Rothstein L R Petersen R | 1979 | Propellants and Explosives1979，，4： | 1 |
| 17 | Localization of neuronal and glial glutamate transporters 显示文摘 | Rothstein JD Martin L Levey AI | 1994 | Neuron1994，13，3： | 1 |
| 18 | Kuncl RW: localization of neuronal and glial glutamate transporter 显示文摘 | Rothstein J D Martin L Levey A I | 1994 | Neurons1994，13，： | 1 |
| 19 | Location of neuronal and glial glutamate transporter显示文摘 | Rothstein JD Martin L Levey AI | 1994 | Neuron1994，13，3： | 1 |
| 20 | Human response to predicated Apollo landing impact in selected body orientations 显示文摘 | Brown W K Rothstein T D Foster L P | 1966 | Aerospace Med1966，37，1： | 1 |
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