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| 1 | Pathophysiology of cerebral oedema in acute liver failure显示文摘Cerebral oedema is a devastating consequence of acute liver failure(ALF)and may be associated with the development of intracranial hypertension and death.In ALF,some patients may develop cerebral oedema and increased intracranial pressure but progression to lifethreatening intracranial hypertension is less frequent than previously described,complicating less than one third of cases who have proceeded to coma since the advent of improved clinical care.The rapid onset of encephalopathy may be dramatic with the development of asterixis,delirium,seizures and coma.Cytotoxic and vasogenic oedema mechanisms have been implicated with a preponderance of experimental data favouring a cytotoxic mechanism.Astrocyte swelling is the most consistent neuropathological finding in humans with ALF and ammonia plays a definitive role in the development of cytotoxic brain oedema.The mechanism(s)by which ammonia induces astrocyte swelling remains unclear but glutamine accumulation within astrocytes has led to the osmolyte hypothesis.Current evidence also supports an alternate‘Trojan horse’hypothesis,with glutamine as a carrier of ammonia into mitochondria,where its accumulation results in oxidative stress,energy failure and ultimately astrocyte swelling.Although a complete breakdown of the blood-brain barrier is not evident in human ALF,increased permeation to water and other small molecules such as ammonia has been demonstrated resulting from subtle alterations in the protein composition of paracellular tight junctions.At present,there is no fully efficacious therapy for cerebral oedema other than liver transplantation and this reflects our incomplete knowledge of the precise mechanisms underlying this process which remain largely unknown. | Teresa R Scott Victoria T Kronsten Robin D Hughes Debbie L Shawcross | 2013 | World Journal of Gastroenterology2013，19，48： | 8 |
| 2 | 支气管哮喘患者心脏性猝死与吸入性β激动剂的关系显示文摘β激动剂吸入后,可引起心功能的特异性改变,支气管哮喘患者死亡率的增加可能与β激动剂的使用有关。 | Robin E D McCauley R 朱亚玲 | 1993 | 国外医学(呼吸系统分册)1993，13，2： | 4 |
| 3 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 4 | Listeria monocytogenes following orthotopic liver transplantation:Central nervous system involvement and review of the literature显示文摘Listeria monocytogene is a well-recognized cause of bacteremia in immunocompromised individuals,including solid organ transplant recipients,but has been rarely reported following orthotopic liver transplantation. We describe a case of listeria meningitis that occurred within a week after liver transplantation. The patient developed a severe headache that mimicked tacrolimus encephalopathy,and was subsequently diagnosed with listeria meningitis by cerebrospinal fluid culture. The infection was successfully treated with three-week course of intravenous ampicillin. Recurrent hepatitis C followed and was successfully treated with interferon alfa and ribavirin. Fourteen cases of listeriosis after orthotopic liver transplantation have been reported in the English literature. Most reported cases were successfully treated with intravenous ampicillin. There were four cases of listeria meningitis,and the mortality of them was 50%. Early detection and treatment of listeria meningitis are the key to obtaining a better prognosis. | Shugo Mizuno Ivan R Zendejas Alan I Reed Robin D Kim Richard J Howard Alan W Hemming Denise C Schain Consuelo Soldevila-Pico Roberto J Firpi Shiro Fujita | 2007 | World Journal of Gastroenterology2007，13，32： | 2 |
| 5 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 6 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 7 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 8 | Non‐invasive assessment of negative pressure wound therapy using high frequency diagnostic ultrasound: oedema reduction and new tissue accumulation显示文摘 | Stephen R Young Sylvie Hampton Robin Martin | 2013 | International Wound Journal2013，，4： | 2 |
| 9 | Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R[gamma]c-deficient mice显示文摘 | Sarry Jean-Emmanuel Murphy Kathleen Perry Robin Sanchez Patricia V Secreto Anthony Keefer Cathy Swider Cezary R Strzelecki Anne-Claire Cavelier Cindy Récher Christian Mansat-De Mas Véronique Delabesse Eric Danet-Desnoyers G Carroll Martin | 2011 | Journal of Clinical Investigation2011，，1： | 2 |
| 10 | Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS显示文摘 | Simon P Dunlop David Jenkins Keith R Neal Robin C Spiller | 2003 | Gastroenterology2003，，6： | 2 |
| 11 | Postconditioning in focal cerebral ischemia: Role of the mitochondrial ATP-dependent potassium channel显示文摘 | Emmanuel Robin Malika Simerabet Sidi Mohammed Hassoun Sebastien Adamczyk Benoit Tavernier Benoit Vallet Régis Bordet Gilles Lebuffe | 2010 | Brain Research2010，，： | 2 |
| 12 | Low self-esteem is related to aggression, antisocial behavior, and delinquency 显示文摘 | o Donnellan M B Trzesniewski K H Robins R W | 2005 | Psychol Sci2005，16，4： | 1 |
| 13 | Direct enzyme21inked immu 2noassay for urinary deoxypyrinoline as a specificmarker forme- asur2ing bone resorption显示文摘 | Robins SP Woitge H Hesley R | 1994 | J Bone Miner Res1994，9，10： | 1 |
| 14 | Total parental nutrition during acute pancreatitis:clinical experience with 156 patients显示文摘 | Robin AP Campbell R Palani CK | 1990 | World J Surg1990，14，4： | 1 |
| 15 | Pyrrolizidine alkaloids from Gynura sarmentosa 显示文摘 | Matheson J R Robins D J | 1992 | Fitoterapia1992，63，6： | 1 |
| 16 | The effect of international institutional factors on properties of accounting eamings显示文摘 | Ball R Kotharis P Robin A | 2000 | Journal of Accounting and Economics2000，29，1： | 1 |
| 17 | Newall-vanadium redox cell显示文摘 | SKYLLAS-KAZACOS M RYCHCIK M ROBINS R G | 1986 | J Electrochem Soc1986，133，： | 1 |
| 18 | Incentives versus stand-ards:properties of accounting income in four east asian coun-tries and implications for acceptance of IAS显示文摘 | Ball R Robin A Wu J S | 2003 | Journal ofAccounting and Economics2003，，36： | 1 |
| 19 | Total parenteral nutrition during acute pancreatitis: clinical experience with 156 patients显示文摘 | Robin AP Campbell R Palani CK | 1990 | World J Surg1990，14，： | 1 |
| 20 | Some of the people, some of the time: susceptibil- ity to acute rheumatic fever显示文摘 | Bryant PA Robins Browne R Carapetis JR | 2009 | Circulation2009，119，5： | 1 |
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