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| 1 | Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis显示文摘AIM:To investigate the association of macrophage migration inhibitory factor(MIF)promoter polymorphisms with inflammatory bowel disease(IBD)risk.METHODS:One thousand and six New Zealand Caucasian cases and 540 Caucasian controls were genotyped for the MIF SNP-173G>C(rs755622)and the repeat polymorphism CATT5-8(rs5844572)using a predesigned TaqMan SNP assay and capillary electrophoresis,respectively.Data were analysed for single site and haplotype association with IBD risk and phenotype.Meta-analysis was employed,to assess cumulative evidence of association of MIF-173G>C with IBD.All published genotype data for MIF-173G>C in IBD were identified using PubMed and subsequently searching the references of all PubMed-identified studies.Imputed genotypes for MIF-173G>C were generated from the Wellcome Trust Case Control Consortium(and National Institute of Diabetes and Digestive and Kidney Diseases).Separate meta-analyses were performed on Caucasian Crohn’s disease(CD)(3863 patients,6031controls),Caucasian ulcerative colitis(UC)(1260 patients,1987 controls),and East Asian UC(416 patients and 789 controls)datasets using the Mantel-Haenszel method.The New Zealand dataset had 93%power,and the meta-analyses had 100%power to detect an effect size of OR=1.40 atα=0.05,respectively.RESULTS:In our New Zealand dataset,single-site analysis found no evidence of association of MIF polymorphisms with overall risk of CD,UC,and IBD or disease phenotype(all P values>0.05).Haplotype analysis found the CATT5/-173C haplotype occurred at a higher frequency in New Zealand controls compared to IBD patients(0.6 vs 0.01;P=0.03,OR=0.22;95%CI:0.05-0.99),but this association did not survive bonferroni correction.Meta-analysis of our New Zealand MIF-173G>C data with data from seven additional Caucasian datasets using a random effects model found no association of MIF polymorphisms with CD,UC,or overall IBD.Similarly,meta-analysis of all published MIF-173G>C data from East Asian datasets(416UC patients,789 controls)found no association of this promoter polymorphism with UC. | James D Falvey Robert W Bentley Tony R Merriman Mark B Hampton Murray L Barclay Richard B Gearry Rebecca L Roberts | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Acoustic emission characterization of microcracking in laboratory-scale hydraulic fracturing tests显示文摘Understanding microcracking near coalesced fracture generation is critically important for hydrocarbon and geothermal reservoir characterization as well as damage evaluation in civil engineering structures.Dense and sometimes random microcracking near coalesced fracture formation alters the mechanical properties of the nearby virgin material. Individual microcrack characterization is also significant in quantifying the material changes near the fracture faces(i.e. damage). Acoustic emission(AE) monitoring and analysis provide unique information regarding the microcracking process temporally, and information concerning the source characterization of individual microcracks can be extracted. In this context,laboratory hydraulic fracture tests were carried out while monitoring the AEs from several piezoelectric transducers. In-depth post-processing of the AE event data was performed for the purpose of understanding the individual source mechanisms. Several source characterization techniques including moment tensor inversion, event parametric analysis, and volumetric deformation analysis were adopted.Post-test fracture characterization through coring, slicing and micro-computed tomographic imaging was performed to determine the coalesced fracture location and structure. Distinct differences in fracture characteristics were found spatially in relation to the openhole injection interval. Individual microcrack AE analysis showed substantial energy reduction emanating spatially from the injection interval. It was quantitatively observed that the recorded AE signals provided sufficient information to generalize the damage radiating spatially away from the injection wellbore. | Jesse Hampton Marte Gutierrez Luis Matzar Dandan Hu Luke Frash | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，5： | 6 |
| 3 | Superior growth performance in broiler chicks fed chelated compared to inorganic zinc in presence of elevated dietary copper显示文摘Background: The goal of this study was to compare the antagonism of elevated dietary Cu(250 mg/kg) from Cu SO4 on three different Zn sources(Zn SO4· H2O; [Zn bis(-2-hydroxy-4-(methylthio)butanoic acid)], Zn(HMTBa)2,a chelated Zn methionine hydroxy analogue; and Zn-Methionine), as measured using multiple indices of animal performance in ROSS 308 broilers.Methods: Three experiments were conducted in broiler chicks fed a semi-purified diet. Al birds were fed a Zn-deficient diet(8.5 mg/kg diet) for 1 wk, and then provided with the experimental diets for 2 wks.Results: Experiment 1 was a 2 × 2 factorial design with two levels of Cu(8 vs. 250 mg/kg diet from Cu SO4) and two Zn sources at 30 mg/kg [Zn SO4· H2 O vs. Zn(HMTBa)2]. Elevated Cu impaired growth performance only in birds fed Zn SO4.Compared to Zn SO4· H2 O, Zn(HMTBa)2improved feed intake(12 %; P < 0.001) and weight gain(12 %, P < 0.001) and the benefits were more pronounced in the presence of 250 mg/kg diet Cu. Experiment 2 was a dose titration of Zn SO4· H2 O and Zn(HMTBa)2at 30, 45, 60, and 75 mg/kg diet in the presence of 250 mg/kg Cu SO4. Feed:gain was decreased and tibia Zn was increased with increasing Zn levels from 30 to 75 mg/kg. Birds fed Zn(HMTBa)2consumed more food and gained more weight compared to birds fed Zn SO4, especially at lower supplementation levels(30 and45 mg/kg; interaction P < 0,05). Experiment 3 compared two organic Zn sources(Zn(HMTBa)2vs. Zn-Methionine)at 30 mg/kg with or without 250 mg/kg Cu SO4. No interactions were observed between Zn sources and Cu levels on performance or tissue mineral concentrations. High dietary Cu decreased weight gain(P < 0.01). Tibia Cu and liver Cu were significantly increased with 250 mg/kg dietary Cu supplementation(P < 0.01). No difference was observed between the two Zn sources.Conclusions: Dietary 250 mg/kg Cu significantly impaired feed intake and weight gain in birds fed Zn SO4· H2 O,but had less impact in birds fed Zn(HMTBa)2. No difference was observed between the two organic zinc sources.These results are consistent with the hypothesis that chelated organic Zn is better utilized than inorganic zinc in the presence of elevated Cu. | Junmei Zhao Robert B. Shirley Julia J. Dibner Karen J. Wedekind Frances Yan Paula Fisher Thomas R. Hampton Joseph L. Evans Mercedes Vazquez-Anon | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 6 |
| 4 | Non-steroidal anti-inflammatory drugs and statins in relation to colorectal cancer risk显示文摘AIM:To investigate the association between individual or combined use of non-steroidal anti-inflammatory drugs(NSAIDs) or statins and colorectal cancer risk.METHODS:In a population-based case-control study in women,we examined the association between NSAIDs and statin use and the risk of colorectal cancers.We further investigated whether the use of statins modifies the protective effect of NSAIDs.Female cases(n = 669) of colorectal cancer aged 50-74 years were identified from a statewide registry in Wisconsin during 1999-2001.Community control women(n = 1375) were randomly selected from lists of licensed drivers and Medicare beneficiaries.Medication use and risk factor information were gathered during a structured telephone interview.A multivariable logistic regression model was used to calculate odds ratio(OR) and 95% conf idence interval(CI) .RESULTS:Overall,NSAIDs users had a 30% reduction in risk of colorectal cancer(95% CI:0.56-0.88) .Statin use was not associated with colorectal cancer risk(OR = 1.17,95% CI:0.74-1.85) ,regardless of structural type(lipophilic or hydrophilic) ,duration of use,or recency.There was no evidence of an interaction between NSAIDs and statins and colorectal cancer risk(P-interaction = 0.28) .CONCLUSION:Although our results confirm the inverse association between NSAIDs use and colorectal cancer risk,they do not support a risk reduction in statin users,or an interaction effect of combined NSAIDs and statin use. | Mazyar Shadman Polly A Newcomb John M Hampton Karen J Wernli Amy Trentham-Dietz | 2009 | World Journal of Gastroenterology2009，15，19： | 5 |
| 5 | Non‐invasive assessment of negative pressure wound therapy using high frequency diagnostic ultrasound: oedema reduction and new tissue accumulation显示文摘 | Stephen R Young Sylvie Hampton Robin Martin | 2013 | International Wound Journal2013，，4： | 2 |
| 6 | Backpacker tourism and economic development显示文摘 | Mark P Hampton | 1997 | Annals of Tourism Research1997，，3： | 2 |
| 7 | Recurrent epiploic appendagitis and peritoneal dialysis: A case report and literature review显示文摘Epiploic appendagitis(EA)is rare cause of acute or subacute abdominal pain in patients on peritoneal dialysis(PD),where the diagnosis can be challenging as the clinical features,laboratory markers and imaging characteristics have not been described previously in this group of patients.Here,we present the management of a case of EA in a patient on PD and review published literature pertinent to the subject.The importance of establishing the diagnosis early by laparoscopy is emphasised. | Badri Shrestha James Hampton | 2014 | World Journal of Nephrology2014，3，3： | 2 |
| 8 | Delivery of a lentiviral vector in a Pluronic F127 gel to cells of the central nervous system显示文摘 | Strappe P M Hampton D W Begona C G | 2005 | Eur J Pharm Biopharm2005，61，3： | 1 |
| 9 | A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome 显示文摘 | Hampton OA Den Hollander P Miller CA | 2009 | Genome Research2009，19，2： | 1 |
| 10 | Vascular endothelial growth factor promotes cardiomyocyte differentiation of embryonic s*em cells显示文摘 | Ohen Y Amende I Hampton TG | 2006 | Am J Physiol Heart Circ Physiol2006，291，4： | 1 |
| 11 | Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo显示文摘 | Glantschnig H Hampton RA Lu P | 2010 | J Biol Chem2010，285，40： | 1 |
| 12 | Exploring welfare implications of resource equivalency analysis in natural resource damage assessments显示文摘 | Zafonte M Hampton S | 2007 | Ecological Economics2007，61，： | 1 |
| 13 | OxLDL induced cell death is inhibited by the macrophage synthesised pterin,7,8-dihydroneopterin,in U937 cells but not THP-1 cells显示文摘 | BAIRD S K REID L HAMPTON M B | 2005 | Biochem Biophys Acta2005，1745，： | 1 |
| 14 | Inhibition of bladder tumors growth by the green tea derivative epigallocateehin-3-Gallate显示文摘 | Kemberling JK Hampton JA Keck RW | 2003 | J Urol2003，170，3： | 1 |
| 15 | Partial discharge diagnostics for gas insulated substation显示文摘 | PEARSON J S FARISH O HAMPTON B F | 1995 | IEEE Transactions on Dielectrics and Electrical Insulation1995，2，5： | 1 |
| 16 | Immune response inpatients with newly diagnosed glioblastoma multiforme treated withintranodal autologous tumor lysate-dendritic cell vaccination afterradiation chemotherapy显示文摘 | Fadul CE Fisher JL Hampton TH | 2011 | J Immunother2011，34，4： | 1 |
| 17 | ER stress response: getting the UPR hand on misfolded proteins显示文摘 | HAMPTON R Y | 2000 | Curr Biol2000，10，14： | 1 |
| 18 | Utility of CEA and CA19-9 tumor markers in diagnosis and prognostic assessment of mucinous epithelial cancers of the appendix显示文摘 | Carnignani CP Hampton R Sugarbaker CE | | 0，，： | 1 |
| 19 | Maternal concern and perceptions of overweight in Australian preschoolaged children显示文摘 | Campbell MW Williams J Hampton A | | 0，，06： | 1 |
| 20 | Generation and selection of novel ful y human monoclonal antibodies that neutralize Dickkopf-1(DKK1) inhibitory function in vitro and increase bone mass in vivo显示文摘 | Glantschnig H Hampton RA Lu P | | 0，，51： | 1 |
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