|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The dynamics of the piglet gut microbiome during the weaning transition in association with health and nutrition显示文摘Background: Understanding the composition of the microbial community and its functional capacity during weaning is important for pig production as bacteria play important roles in the pig's health and growth performance. However,limited information is available regarding the composition and function of the gut microbiome of piglets in early-life.Therefore, we performed 16 S rRNA gene and whole metagenome shotgun sequencing of DNA from fecal samples from healthy piglets during weaning to measure microbiome shifts, and to identify the potential contribution of the early-life microbiota in shaping piglet health with a focus on microbial stress responses, carbohydrate and amino acid metabolism.Results: The analysis of 16 S rR NA genes and whole metagenome shotgun sequencing revealed significant compositional and functional differences between the fecal microbiome in nursing and weaned piglets. The fecal microbiome of the nursing piglets showed higher relative abundance of bacteria in the genus Bacteroides with abundant gene families related to the utilization of lactose and galactose. Prevotel a and Lactobacil us were enriched in weaned piglets with an enrichment for the gene families associated with carbohydrate and amino acid metabolism. In addition, an analysis of the functional capacity of the fecal microbiome showed higher abundances of genes associated with heat shock and oxidative stress in the metagenome of weaned piglets compared to nursing piglets.Conclusions: Overal, our data show that microbial shifts and changes in functional capacities of the piglet fecal microbiome resulted in potential reductions in the effects of stress, including dietary changes that occur during weaning.These results provide us with new insights into the piglet gut microbiome that contributes to the growth of the animal. | Robin B.Guevarra Sang Hyun Hong Jin Ho Cho Bo-Ra Kim Jiwon Shin Jun Hyung Lee Bit Na Kang Young Hwa Kim Suphot Wattanaphansak Richard E.Isaacson Minho Song Hyeun Bum Kim | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 16 |
| 2 | Commitment and matching contributions to public goods 显示文摘 | Robin Boadway Zhen Song Jean-Francois Tremblay | 2007 | Journal of Public Economics2007，，91： | 1 |
| 3 | Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo 显示文摘 | Jesse J Smith Renee Deehan Kenney David J Gagne Brian P Frushour William Ladd Heidi L Galonek Kristine Israelian Jeffrey Song Giedre Razvadauskaite Amy V Lynch David P Carney Robin J Johnson Siva Lavu Andre Iffland Peter J Elliott Philip D Lambert Keith O Elliston Michael R Jirousek Jill C Milne and Olivier Boss | 2009 | BMC Systems Biology2009，284，27： | 1 |
| 4 | Potent antitumor activity of cabozantinib, a c‐ MET and VEGFR 2 inhibitor, in a colorectal cancer patient‐derived tumor explant model显示文摘 | Eun‐Kee Song WM Tai Wells A. Messersmith Stacey Bagby Alicia Purkey Kevin S. Quackenbush Todd M. Pitts Guoliang Wang Patrick Blatchford Rachel Yahn Jeffrey Kaplan Aik Choon Tan Chloe E. Atreya Gail Eckhardt Robin K. Kelley Alan Venook Eunice L. Kwak David | 2015 | Int. J. Cancer2015，，8： | 1 |
| 5 | Interplays of liver fibrosis-associated microRNAs:Molecular mechanisms and implications in diagnosis and therapy显示文摘microRNAs(miRNAs)are a class of non-coding functional small RNA composed of 21e23 nucleotides,having multiple associations with liver fibrosis.Fibrosis-associated miRNAs are roughly classified into pro-fibrosis or anti-fibrosis types.The former is capable of activating hepatic stellate cells(HSCs)by modulating pro-fibrotic signaling pathways,mainly including TGF-b/SMAD,WNT/b-catenin,and Hedgehog;the latter is responsible for maintenance of the quiescent phenotype of normal HSCs,phenotypic reversion of activated HSCs(aHSCs),inhibition of HSCs proliferation and suppression of the extracellular matrix-associated gene expression.Moreover,several miRNAs are involved in regulation of liver fibrosis via alternative mechanisms,such as interacting between hepatocytes and other liver cells via exosomes and increasing autophagy of aHSCs.Thus,understanding the role of these miRNAs may provide new avenues for the development of novel interventions against hepatic fibrosis. | Hong Li Tingli Liu Yongchun Yang William C.Cho Robin J.Flynn Majid Fasihi Harandi Houhui Song Xuenong Luo Yadong Zheng | 2023 | Genes & Diseases2023，10，4： | 1 |
| 6 | Commitment and matching contributions to public goods显示文摘 | Robin Boadway Zhen Song Jean-Francois Tremblay | | 0，，02： | 1 |
| 7 | An ultra-low concentration electrolyte with fluorine-free bulky anions for stable potassium metal batteries显示文摘Potassium metal battery is a promising alternative to Li-ion battery for large-scale energy storage due to the abundant potassium resources and high energy density.However,it suffers from rapid capacity fading and safety issues due to the uncontrolled dendrite growth.Herein,we design a fluorine-free ultra-low concentration electrolyte(ULCE)with the super bulky[BPh_(4)]^(−) anions for stable potassium metal battery.In this special electrolyte,the migration rate of K+in the electrolyte is about six times faster than that of the[BPh_(4)]^(−) anions because of the super bulky structure of the[BPh_(4)]^(−) anions,thus resulting in a high K^(+)transference number of 0.76.This high transference number can effectively make up for the deficiency of K^(+)in ULCE for ensuring the normal operation of the potassium metal battery.In addition,the improved transference number can also promote the uniform distribution of K^(+)flux on the surface of the K metal anode,resulting in uniform K deposition.As a result,this electrolyte achieves a high K plating/stripping Coulombic efficiency of 92.6%over 200 cycles and a stable discharging/charging for 100 cycles under the full battery configuration(K used as the anode and perylene-3,4,9,10-tetracarboxylic dianhydride used as the cathode). | Qinguang Liu Mei Geng Ting Yu Li Zhang Changdong Wu Jie Liu Shulin Zhao Qingxin Yang Robin Song Jingjuan Ye Fenfen Wang Yuping Wu Dengji Xiao Yuhui Chen | 2023 | Nano Research2023，16，6： | 0 |
| 8 | Chalcogenide Ovonic Threshold Switching Selector显示文摘Today’s explosion of data urgently requires memory technologies capable of storing large volumes of data in shorter time frames,a feat unattain-able with Flash or DRAM.Intel Optane,commonly referred to as three-dimensional phase change memory,stands out as one of the most promising candidates.The Optane with cross-point architecture is constructed through layering a storage element and a selector known as the ovonic threshold switch(OTS).The OTS device,which employs chalcogenide film,has thereby gathered increased attention in recent years.In this paper,we begin by providing a brief introduction to the discovery process of the OTS phenomenon.Subsequently,we summarize the key elec-trical parameters of OTS devices and delve into recent explorations of OTS materials,which are categorized as Se-based,Te-based,and S-based material systems.Furthermore,we discuss various models for the OTS switching mechanism,including field-induced nucleation model,as well as several carrier injection models.Additionally,we review the progress and innovations in OTS mechanism research.Finally,we highlight the successful application of OTS devices in three-dimensional high-density memory and offer insights into their promising performance and extensive prospects in emerging applications,such as self-selecting memory and neuromorphic computing. | Zihao Zhao Sergiu Clima Daniele Garbin Robin Degraeve Geoffrey Pourtois Zhitang Song Min Zhu | 2024 | Nano-Micro Letters2024，16，5： | 0 |
| 9 | Transition edge sensor-based detector:from X-ray to γ-ray显示文摘A transition edge sensor(TES)is extremely sensitive to changes in temperature,and combined with a high-Z metal of a certain thickness,it can realize high-energy resolution measurements of particles such as X-rays.X-rays with energies below 10 keV have a weak penetrating ability,hence,only gold or bismuth of a few micrometers in thickness can guarantee a quantum efficiency higher than 70%.Therefore,the entire structure of the TES X-ray detector in this energy range can be realized using a microfabrication process.However,for X-rays or γ-rays from 10 keV to 200 keV,submillimeter absorber layers are required,which cannot be realized using the microfabrication process.This paper first briefly introduces a set of TES X-ray detectors and their auxiliary systems,and then focuses on the introduction of the TES γ-ray detector with an absorber based on a submillimeter lead-tin alloy sphere.The detector achieved a quantum efficiency above 70% near 100 keV and an energy resolution of approximately 161.5 eV at 59.5 keV. | Shuo Zhang Jing-Kai Xia Tao Sun Wen-Tao Wu Bing-Jun Wu Yong-Liang Wang Robin Cantor Ke Han Xiao-Peng Zhou Hao-Ran Liu Fu-You Fan Si-Ming Guo Jun-Cheng Liang De-Hong Li Yan-Ru Song Xu-Dong Ju Qiang Fu Zhi Liu | 2022 | Nuclear Science and Techniques2022，33，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员