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| 1 | Treatment of acute periprosthetic infections with prosthesis retention: Review of current concepts显示文摘Periprosthetic joint infection(PJI) is a devastating complication after total joint arthroplasty, occurring in approximately 1%-2% of all cases. With growing populations and increasing age, PJI will have a growing effect on health care costs. Many risk factors have been identified that increase the risk of developing PJI, including obesity, immune system deficiencies, malignancy, previous surgery of the same joint and longer operating time. Acute PJI occurs either postoperatively(4 wk to 3 mo after initial arthroplasty, depending on the classification system), or via hematogenous spreading after a period in which the prosthesis had functioned properly. Diagnosis and the choice of treatment are the cornerstones to success. Although different definitions for PJI have been used in the past, most are more or less similar and include the presence of a sinus tract, blood infection values, synovial white blood cell count, signs of infection on histopathological analysis and one ormore positive culture results. Debridement, antibiotics and implant retention(DAIR) is the primary treatment for acute PJI, and should be performed as soon as possible after the development of symptoms. Success rates differ, but most studies report success rates of around 60%-80%. Whether single or multiple debridement procedures are more successful remains unclear. The use of local antibiotics in addition to the administration of systemic antibiotic agents is also subject to debate, and its pro's and con's should be carefully considered. Systemic treatment, based on culture results, is of importance for all PJI treatments. Additionally, rifampin should be given in Staphylococcal PJIs, unless all foreign material is removed. The most important factors contributing to treatment failure are longer duration of symptoms, a longer time after initial arthroplasty, the need for more debridement procedures, the retention of exchangeable components, and PJI caused by Staphylococcus(aureus or coagulase negative). If DAIR treatment is unsuccessful, the following treatment option should be based on the patient health status and his or her expectations. For the best functional outcome, one- or two-stage revision should be performed after DAIR failure. In conclusion, DAIR is the obvious choice for treatment of acute PJI, with good success rates in selected patients. | Jesse WP Kuiper Robin Tjeenk Willink Dirk Jan F Moojen Michel PJ van den Bekerom Sascha Colen | 2014 | World Journal of Orthopedics2014，5，5： | 12 |
| 2 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 3 | Healing of duodenal ulcer after eradication of Helicobacter heilmannii显示文摘 | Andrew F Goddard Robert PH Logan John C Atherton David Jenkins Robin C Spiller | 1997 | The Lancet1997，，9068： | 2 |
| 4 | A Resource-Based Approach to the Multibusiness Firm: Empirical Analysis of Portfolio Interrelationships and Corporate Financial Performance显示文摘 | Robins J M F Wiersema | 1995 | Strategic Management Journal1995，16，： | 1 |
| 5 | Nasal septum and facial development显示文摘 | Robin F Sharp D | 1991 | Lancet1991，338，： | 1 |
| 6 | Dietary fiber in extru- ded cereals : limitations and opportunities 显示文摘 | Robin F Schuchmann H P Palzer F | 2012 | Trends in Food Science & Technology2012，28，： | 1 |
| 7 | Estimation of tropical forest structural characteristics using large-footprint lidar显示文摘 | Jason B Drake Ralph O Dubayah David B Clark Robert G Knox J.Bryan Blair Michelle A Hofton Robin L Chazdon John F Weishampel Steve Prince | 2001 | Remote Sensing of Environment2001，，2： | 1 |
| 8 | Fabric analysis using the intercept method显示文摘 | LAUNEAU P ROBIN P Y F | 1996 | Tectonophysics1996，267，1： | 1 |
| 9 | Three-dimensional geometrical and mechanical modelling of the lumbar spine显示文摘 | Lavaste F Skalli W Robin S | | 0，，10： | 1 |
| 10 | Slowly digestible starch-its structure and health implications: a review 显示文摘 | Lehmann U Robin F | 2007 | Trends Food Sci Technol2007，18，7： | 1 |
| 11 | Genetic diversity of the Chestnut blight fungus Cryphonectria parasitica in four French populations assessed by microsatellite markers显示文摘 | Breuillin F Dutech C Robin C | 2006 | Mycological Research2006，110，3： | 1 |
| 12 | Estimating time varying risk premier in the term structure: the ARCH-M model显示文摘 | Engle R F Lilien D M Robins R P | 1987 | Econometrics1987，55，2： | 1 |
| 13 | Most mammalian mRNAs are conserved targets of microRNAs显示文摘 | Robin C F Kyle K F Christopher B B | 2009 | Genome Research2009，19，： | 1 |
| 14 | Assessment of azoospermia and hlgical evaluation of spermatogenesis 显示文摘 | Robin G Boitrelle F Lerey X | 2010 | Annales de Pathologize2010，30，3： | 1 |
| 15 | Dietary fiber in extruded cereals:Limitations and opportunities显示文摘 | Robin F Schuchmann H P Palzer S | 2012 | Trends in Food Science & Technology2012，28，1： | 1 |
| 16 | Quantifica- tion of volatile PAHs present at trace levels in air flow by aqueous trapping - SPE and HPLC analysis with fluorimetric detection显示文摘 | Portet - Kohalo F Oukebdane K Robin L | 2007 | Talanta2007，71，： | 1 |
| 17 | Slowly digestible starch-its structure and health implications:a review显示文摘 | Lehmann U Robin F | 2007 | Trends Food Sci Tech2007，18，： | 1 |
| 18 | Estimating time varying risk premia in the term structure:the ARCH-M model显示文摘 | Engle R F Lilien D M Robins R P | 1987 | Econometrica1987，55，： | 1 |
| 19 | Assessment of azoospermia and histological evaluation of spermatogenesis 显示文摘 | Robin G Boitrelle F Leroy X | 2010 | Ann Pathol2010，30，3： | 1 |
| 20 | Web reinforcement effects on deep beams 显示文摘 | Kong F K Robins P J Cole D F | 1970 | ACI Journal Proceedings1970，67，12： | 1 |
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