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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 3 | Free-ranging automatic guided-vehicle system显示文摘 | ROBINS M P | 1986 | GEC Review1986，2，2： | 1 |
| 4 | Maximum likelihood from incomplete data via the EM algorithm显示文摘 | Dempster A P Laird N M Robin D B | 1977 | Journal of the Royal Statistical Society1977，39，1： | 1 |
| 5 | Estimating time varying risk premier in the term structure: the ARCH-M model显示文摘 | Engle R F Lilien D M Robins R P | 1987 | Econometrics1987，55，2： | 1 |
| 6 | Low-dose thoracoab- dominal irradiation for the treatment of refractory chronic graft- versus-host disease显示文摘 | Robin M Guardiola P Girinsky T | 2005 | Transplantation2005，80，5： | 1 |
| 7 | Turning, compacting and the addition of water as factors affecting gaseous emissions in farm manure composting显示文摘 | E1 Kader N A Robin P Paillat J M | 2007 | Bioresource Technology2007，98，14： | 1 |
| 8 | Estimating time varying risk premia in the term structure:the ARCH-M model显示文摘 | Engle R F Lilien D M Robins R P | 1987 | Econometrica1987，55，： | 1 |
| 9 | Determinants of serum levels of surfactant protein A and B and Clara cell protein CC16 显示文摘 | Hermans C Dong P Robin M | 2003 | Biomarkers2003，8，6： | 1 |
| 10 | Earthworm effects on gaseous emissions during vermifiltration of pig fresh slurry 显示文摘 | Robin P Germain P Lecomte M | 2011 | Bioresour Technol2011，102，4： | 1 |
| 11 | Estimating Time Varying Risk Premia in the Term Structure: The ARCH-M model 显示文摘 | ENGLE R F LILIEN D M ROBINS R P | 1987 | Econometrica1987，，55： | 1 |
| 12 | Complete thrombolysis of mesenteric ein occlusion with recombinant tissue-type plasminogen actiator显示文摘 | Robin P Gruel Y Lang M | 1988 | Lancet1988，1，8599： | 1 |
| 13 | Doppler ultrasound color flow imaging in the study of breast cancer:Preliminary findings显示文摘 | Alder D D Carson P L Robin J M | 1990 | Ultrasond Med Biol1990，16，： | 1 |
| 14 | Serum levels of CC16, SP-A and SP-B reflect tobacco-smoke exposure in asymptomatic subjects显示文摘 | Robin M Dong P Hermans C | 2002 | Eur Respir J2002，20，： | 1 |
| 15 | Generation of cytotoxic T lymphocytes to autologous human leukemia cells by sensitization to pooled aUogeneic normal cells显示文摘 | Zarling J M Robins H I Raich P C | 1978 | Nature(Lond)1978，274，： | 1 |
| 16 | Turning,compacting and the addition of water as factors affecting gaseous emissions in farm manure composting显示文摘 | EL KADER N A ROBIN P PAILLAT J M | 2007 | Bioresource Technology2007，98，14： | 1 |
| 17 | Molecularpaleohydrology: Interpreting the hydrogen isotopiccomposition of lipid biomarkers from photosynthesizing organisms 显示文摘 | Sachse D Billault I Bowen G Y Chikaraishi Y Dawson T E Feakins S J Freeman K H Magill C R McInerney F A vander Meer M T J Polissar P Robins R J Sachs J P Schmidt HL Sessions A L White J W C West J B Kahmen A | 2012 | Ann Rev Earth Planet Sci2012，40，： | 1 |
| 18 | Estimating time-varying risk premia in the term structure:the arch-m model显示文摘 | Lilien D M Robins R P | 1987 | Econometrica1987，55，1： | 1 |
| 19 | Estimating Time Varying Risk Premia in the Term Structure:The ARCHM Model显示文摘 | Engle Robert David M Lilien and Russell P Robins | 1987 | Econometrica1987，，55： | 1 |
| 20 | Genetics of canine ol- faction and receptor diversity 显示文摘 | QUIGON P RIMBAULT M ROBIN S | 2012 | Mamm Genome2012，23，12： | 1 |
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