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| 1 | Changing face of hepatic encephalopathy:Role of inflammation and oxidative stress显示文摘The face of hepatic encephalopathy(HE) is changing.This review explores how this neurocognitive disorder,which is associated with both acute and chronic liver injury,has grown to become a dynamic syndrome that spans a spectrum of neuropsychological impairment,from normal performance to coma.The central role of ammonia in the pathogenesis of HE remains incontrovertible.However,over the past 10 years,the HE community has begun to characterise the key roles of inflammation,infection,and oxidative/nitrosative stress in modulating the pathophysiological effects of ammonia on the astrocyte.This review explores the current thoughts and evidence base in this area and discusses the potential role of existing and novel therapies that might abrogate the oxidative and nitrosative stresses inflicted on the brain in patients with,or at risk of developing,HE. | Amit S Seyan Robin D Hughes Debbie L Shawcross | 2010 | World Journal of Gastroenterology2010，16，27： | 23 |
| 2 | Definition and classification of cancer cachexia: an international consensus显示文摘 | Kenneth Fearon Florian Strasser Stefan D Anker Ingvar Bosaeus Eduardo Bruera Robin L Fainsinger Aminah Jatoi Charles Loprinzi Neil MacDonald Giovanni Mantovani Mellar Davis Maurizio Muscaritoli Faith Ottery Lukas Radbruch Paula Ravasco Declan Walsh Andrew | 2011 | Lancet Oncology2011，，5： | 8 |
| 3 | Pathophysiology of cerebral oedema in acute liver failure显示文摘Cerebral oedema is a devastating consequence of acute liver failure(ALF)and may be associated with the development of intracranial hypertension and death.In ALF,some patients may develop cerebral oedema and increased intracranial pressure but progression to lifethreatening intracranial hypertension is less frequent than previously described,complicating less than one third of cases who have proceeded to coma since the advent of improved clinical care.The rapid onset of encephalopathy may be dramatic with the development of asterixis,delirium,seizures and coma.Cytotoxic and vasogenic oedema mechanisms have been implicated with a preponderance of experimental data favouring a cytotoxic mechanism.Astrocyte swelling is the most consistent neuropathological finding in humans with ALF and ammonia plays a definitive role in the development of cytotoxic brain oedema.The mechanism(s)by which ammonia induces astrocyte swelling remains unclear but glutamine accumulation within astrocytes has led to the osmolyte hypothesis.Current evidence also supports an alternate‘Trojan horse’hypothesis,with glutamine as a carrier of ammonia into mitochondria,where its accumulation results in oxidative stress,energy failure and ultimately astrocyte swelling.Although a complete breakdown of the blood-brain barrier is not evident in human ALF,increased permeation to water and other small molecules such as ammonia has been demonstrated resulting from subtle alterations in the protein composition of paracellular tight junctions.At present,there is no fully efficacious therapy for cerebral oedema other than liver transplantation and this reflects our incomplete knowledge of the precise mechanisms underlying this process which remain largely unknown. | Teresa R Scott Victoria T Kronsten Robin D Hughes Debbie L Shawcross | 2013 | World Journal of Gastroenterology2013，19，48： | 8 |
| 4 | Muscle force and movement variability before and after total knee arthroplasty: A review显示文摘Variability in muscle force output and movement variability are important aspects of identifying individuals with mobility deficits, central nervous system impairments, and future risk of falling. This has been investigated in elderly healthy and impaired adults, as well as in adults with osteoarthritis(OA), but the question of whether the same correlations also apply to those who have undergone a surgical intervention such as total knee arthroplasty(TKA) is still being investigated. While there is a growing body of literature identifying potential rehabilitation targets for individuals who have undergone TKA, it is important to first understand the underlying post-operative impairments to more efficiently target functional deficits that may lead to improvedlong-term outcomes. The purpose of this article is to review the potential role of muscle force output and movement variability in TKA recipients. The narrative review relies on existing literature in elderly healthy and impaired individuals, as well as in those with OA before and following TKA. The variables that may predict longterm functional abilities and deficits are discussed in the context of existing literature in healthy older adults and older adults with OA and following TKA, as well as the role future research in this field may play in providing evidence-based data for improved rehabilitation targets. | Jessica W Smith Jesse C Christensen Robin L Marcus Paul C LaStayo | 2014 | World Journal of Orthopedics2014，5，2： | 3 |
| 5 | Safety of Green Tea Extracts: A Systematic Review by the US Pharmacopeia显示文摘 | Sarma Dandapantula N Barrett Marilyn L Chavez Mary L Gardiner Paula Ko Richard Mahady Gail B Marles Robin J Pellicore Linda S Giancaspro Gabriel I Dog Tieraona Low | 2008 | Drug Safety2008，，6： | 2 |
| 6 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 7 | Semiparametric efficient estimation of dynamic panel data models显示文摘 | Byeong U. Park Robin C. Sickles Léopold Simar | 2006 | Journal of Econometrics2006，，1： | 2 |
| 8 | Semiparametric-efficient estimation of AR(1) panel data models显示文摘 | Byeong U. Park Robin C. Sickles Léopold Simar | 2003 | Journal of Econometrics2003，，2： | 2 |
| 9 | The efects of starvation and subsequent feeding on survival growth of Fulton channel sockeye salmon ( Oncorhynchus nerka) 显示文摘 | Bihon H T Robins G L | 1973 | J Fish Res Board1973，30，： | 1 |
| 10 | 2-Methoxyestradiol-a unique blend of activities generating a new class of anti-tumour/ anti-inflammatory agents 显示文摘 | TARA E S ROBIN L A RICHARD A H | 2007 | J Biol Chem2007，12，1314： | 1 |
| 11 | Synthesis and characterization poly (styrene-b-n-butyl acrylate-b-styrene) triblock copolymers using a dialkoxyamine as initiator显示文摘 | Robin S Guerret O Couturier J L | 2002 | Maromolecules2002，35，10： | 1 |
| 12 | Evidence for a K/ T impact event in the Pacific Ocean显示文摘 | Robin E Froget L Jehanno C | 1993 | Nature1993，363，6430： | 1 |
| 13 | Estimation of tropical forest structural characteristics using large-footprint lidar显示文摘 | Jason B Drake Ralph O Dubayah David B Clark Robert G Knox J.Bryan Blair Michelle A Hofton Robin L Chazdon John F Weishampel Steve Prince | 2001 | Remote Sensing of Environment2001，，2： | 1 |
| 14 | Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity 显示文摘 | Robin L J | 2008 | Expert Rev Cardiovasc Ther2008，6，10： | 1 |
| 15 | Long term outcome after bone marrow transplantation for severe aplastic anemia显示文摘 | Ades L mary JY robin M | 2004 | Blood2004，103，7： | 1 |
| 16 | Formation of spinels in cosmic objects during atmospheric entry: A clue to the Cretaceous-Tertiary boundary event显示文摘 | Robin E Bonte P Froget L | 1992 | Earth and Planetary Science Letters1992，108，4： | 1 |
| 17 | Precision manufacturing of inertial confinement fusion double shell laser targets for omega显示文摘 | HIBBARD Robin L BONO Matthew J AMENDT Peter A | 2004 | Fusion Sciences&stechnology2004，45，2： | 1 |
| 18 | Stromal cell-derived factor 1 alpha mediates neural progenitor cell motility after focal cerebral ischemia显示文摘 | Robin AM Zhang ZG Wang L | 2006 | J Cereb Blood Flow Metab2006，26，1： | 1 |
| 19 | Prevalence of verocytotoxigenieEshehefiehia coil serotype 01, I:H7 in children with diarrhoea attendingaSydney hospital显示文摘 | Ony J Zhe L Robins Browne R | 1993 | Jpaediatr Child Health1993，29，3： | 1 |
| 20 | Quantifica- tion of volatile PAHs present at trace levels in air flow by aqueous trapping - SPE and HPLC analysis with fluorimetric detection显示文摘 | Portet - Kohalo F Oukebdane K Robin L | 2007 | Talanta2007，71，： | 1 |
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