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| 1 | Braking Performance of a Biomimetic Squid-Like Underwater Robot显示文摘 | Md. Mahbubar Rahman Sinpei Sugimori Hiroshi Miki Risa Yamamoto Yugo Sanada Yasuyuki Toda | 2013 | Journal of Bionic Engineering2013，10，3： | 13 |
| 2 | 为用离合器切割器的食道的小粒的房间肿瘤的内视镜的 submucosal 解剖显示文摘 Endoscopic submucosal dissection (ESD) with a knife is a technically demanding procedure associated with a high complication rate.The shortcomings of this method are the deficiencies of fixing the knife to the target lesion,and of compressing it.These shortcomings can lead to major complications such as perforation and bleeding.To reduce the risk of complications related to ESD,we developed a new grasping type scissors forceps (Clutch Cutter,Fujifilm,Japan) which can grasp and incise the targeted tissue using an electrosurgical current.Esophagogastroduodenoscopy on a 59-year-old Japanese man revealed a 16mm esophageal submucosal nodule with central depression.Endoscopic ultrasonography demonstrated a hypoechoic solid tumor limited to the submucosa without lymph node involvement.The histologic diagnosis of the specimen obtained by biopsy was granular cell tumor.It was safely and accurately resected without unexpected incision by ESD using the CC.No delayed hemorrhage or perforation occurred.Histological examination confirmed that the granular cell tumor was completely excised with negative resection margin.We report herein a case of esophageal granular cell tumor successfully treated by an ESD technique using the CC. | Keishi Komori Kazuya Akahoshi Yoshimasa Tanaka Yasuaki Motomura Masaru Kubokawa Soichi Itaba Terumasa Hisano Takashi Osoegawa Naotaka Nakama Risa Iwao Masafumi Oya Kazuhiko Nakamura | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，1： | 8 |
| 3 | Familial pancreatic cancer: Concept, management and issues显示文摘Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (<20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, 'anticipation' is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society. | Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 4 | Endoscopic submucosal dissection of a rectal carcinoid tumor using grasping type scissors forceps显示文摘Endoscopic submucosal dissection (ESD) with a knife is a technically demanding procedure associated with a high complication rate. The shortcomings of this method are the inability to fix the knife to the target lesion, and compression of the lesion. These can lead to major complications such as perforation and bleeding. To reduce the risk of complications related to ESD, we developed a new grasping type scissors forceps (GSF), which can grasp and incise the targeted tissue using electrosurgical current. Colonoscopy on a 55-year-old woman revealed a 10-mm rectal submucosal nodule. The histological diagnosis of the specimen obtained by biopsy was carcinoid tumor. Endoscopic ultrasonography demonstrated a hypoechoic solid tumor limited to the submucosa without lymph node involvement. It was safely and accurately resected without unexpected incision by ESD using a GSF. No delayed hemorrhage or perforation occurred. Histological examination confirmed the carcinoid tumor was completely excised with negative resection margin. | Kazuya Akahoshi Yasuaki Motomura Masaru Kubokawa Noriaki Matsui Manami Oda Risa Okamoto Shingo Endo Naomi Higuchi Yumi Kashiwabara Masafumi Oya Hidefumi Akahane Haruo Akiba | 2009 | World Journal of Gastroenterology2009，15，17： | 4 |
| 5 | 基于眼前节相干光断层扫描成像的核性白内障分类算法显示文摘白内障是导致视觉损害和致盲的主要眼病,眼前节光学相干断层成像技术(Anterior Segment Optical Coherence Tomography,AS-OCT)具有非接触、高分辨率、检查快速、客观定量化测量等特点,在临床上已经被广泛应用于眼病的诊断。目前缺乏基于眼前节OCT图像的核性白内障分类研究工作,为此提出了一种基于眼前节OCT图像的核性白内障分类算法。首先,利用自适应阈值方法、边缘检测Canny算法和手工校正相结合的方式从眼前节OCT图像中提取晶状体的核性区域;然后,基于图像强度和直方图的特征统计方法提取18个像素特征,并应用皮尔逊相关系数方法分析提取像素特征与核性白内障严重程度之间的相关性;最后,利用随机森林算法构建分类模型,从而得到核性白内障分类结果。在一个眼前节OCT图像数据集上的实验结果表明,所提算法对核性白内障严重程度的分类准确率和召回率分别达到了75.53%和74.04%,具有作为核性白内障临床诊断的定量分析参考工具的潜力。 | 章晓庆 方建生 肖尊杰 陈浜 Risa HIGASHITA 陈婉 袁进 刘江 | 2022 | 计算机科学2022，49，3： | 3 |
| 6 | Hemorrhagic shock due to submucosal esophageal hematoma along with mallory-weiss syndrome:A case report显示文摘BACKGROUND Esophageal submucosal hematoma is a rare condition.Although the exact etiology remains uncertain,vessel fragility with external factors is believed to have led to submucosal bleeding and hematoma formation;the vessel was ruptured by a sudden increase in pressure due to nausea,and the hematoma was enlarged by antiplatelet or anticoagulant therapy.Serious conditions are rare,with a better prognosis.We present the first known case of submucosal esophageal hematoma-subsequent hemorrhagic shock due to Mallory-Weiss syndrome.CASE SUMMARY A 73-year-old female underwent endovascular treatment for an unruptured cerebral aneurysm.The patient received aspirin and clopidogrel before surgery and heparin during surgery,and was well during the surgery.Several hours after returning to the ICU,she complained of chest discomfort,vomited 500 m L of fresh blood,and entered hemorrhagic shock.Esophageal submucosal hematoma with Mallory-Weiss syndrome was diagnosed through an endoscopic examination and computed tomography.In addition to a massive fluid and erythrocyte transfusion,we performed a temporary compression for hemostasis with a Sengstaken-Blakemore(S-B)tube.Afterwards,she became hemodynamically stable.On postoperative day 1,we performed an upper gastrointestinal endoscopy and confirmed no expansion of the hematoma nor any recurring bleeding;therefore,we removed the S-B tube and clipped the gastric mucosal laceration at the esophagogastric junction.We started oral intake on postoperative day 10.The patient made steady progress,and was discharged on postoperative day 33.CONCLUSION We present the first known case of submucosal esophageal hematoma subsequent hemorrhagic shock due to Mallory-Weiss syndrome. | Jiro Oba Daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Kenki Usami Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita | 2022 | World Journal of Clinical Cases2022，10，27： | 3 |
| 7 | The role of TGF-β superfamily signaling in neurological disorders显示文摘发信号的 TGF- 总科在 embryogenesis 期间并且在成年织物动态平衡涉及许多生物过程。TGF- 总科因此表明的 transduces 导致的发信号的小径的有缺点的规定很多疾病,例如癌症和心血管、新陈代谢、尿、肠、骨胳、有免疫力的疾病。在最近的年里,很多研究阐明了 TGF-s 和 BMP 的必要角色在在适当神经分布和 neuronal 活动的维护的 neuronal 开发期间。新前进含有在神经病学的混乱的致病发信号的异常 TGF- 总科的重要角色。在这评论,我们编含有的很多份报告在致病表明小径的 TGF-/BMP 的解除管制认知并且在动物模型和病人的 neurodegenerative 混乱。我们预先道歉评论达不到提供 TGF-/BMP 发信号或位于神经病学的混乱的致病下面的机制的角色的细节。这篇文章的目标是关于在表明小径和 neuronal 织物动态平衡和开发的 TGF-/BMP 之间的协会在我们的知识揭示差距并且与一个潜力便于研究由 modulating 为神经病学的疾病开发新治疗小径。 | Risa Kashima Akiko Hata | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 3 |
| 8 | Efficacy of direct-acting antiviral treatment for chronic hepatitis C: A single hospital experience显示文摘AIM To evaluate the efficacy of direct-acting antivirals(DAAs) in Kanto Rosai Hospital. METHODS All patients with hepatitis C virus(HCV) who underwent DAA prescription were enrolled in this study. The present study was a single center retrospective analysis using patients infected with HCV genotype 1 or 2. Resistance analysis was performed by using direct sequencing and cycleave PCR in genotype 1 patients treated with interferon(IFN)-free DAA. The primary endpoint was sustained virologic response at 12 wk after therapy(SVR12).RESULTS A total of 117 patients participated in the study, including 135 with genotype 1 and 42 with genotype 2. Of the 135 patients with genotype 1, 16 received protease inhibitor + IFN + ribavirin and all achieved SVR. Of the 119 patients who received IFN-free DAA(in different combinations), 102 achieved SVR and 9 failed(7/9 were on daclatasvir/asunaprevir and 2/9 on ledipasvir/sofosbuvir). Efficacy analysis was done only for 43 patients who received daclatasvir/asunaprevir. From this analysis, Y93 resistance-associated substitutions were significantly correlated with SVR.CONCLUSION The SVR rate was 98% for genotype 1 and 100% for genotype 2. However, caution is needed for HCV NS5 A resistance-associated substitutions that are selected by HCV NS5 A inhibitors because cerebrovascular adverse events are induced by some DAA drugs. | Rena Kaneko Natsuko Nakazaki Risa Omori Yuichiro Yano Masazumi Ogawa Yuzuru Sato | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 9 | Scheduled infliximab monotherapy to prevent recurrence of Crohn’s disease following ileocolic or ileal resection: A 3‐year prospective randomized open trial显示文摘 | Koji Yoshida Ken Fukunaga Hiroki Ikeuchi Koji Kamikozuru Nobuyuki Hida Yoshio Ohda Yoko Yokoyama Masaki Iimuro Naohisa Takeda Kyoichi Kato Risa Kikuyama Kazuko Nagase Kazutoshi Hori Shiro Nakamura Hiroto Miwa Takayuki Matsumoto | 2011 | Inflamm Bowel Dis2011，，9： | 2 |
| 10 | Angiotensin receptor blocker neprilysin inhibitors显示文摘Heart failure(HF)is a clinical syndrome that results from a structural or functional cardiac disorder that reduces the ability of the ventricle of the heart to fill with,or eject,blood.It is a multifaceted clinical condition that affects up to 2%of the population in the developed world,and is linked to significant morbidity and mortality;it is therefore considered a major concern for public health.Regarding the mechanism of HF,three neurohumoral factors-the reninangiotensin-aldosterone system,the sympathetic nervous system,and natriuretic peptides—are related to the pathology of chronic HF(CHF),and the targets of treatment.Angiotensin receptor blocker and neprilysin inhibitor(angiotensinreceptor neprilysin inhibitor),namely sacubitril/valsartan(SAC/VAL),has been introduced as a treatment for CHF.SAC/VAL is an efficacious,safe,and costeffective therapy that improves quality of life and longevity in patients with HF with reduced ejection fraction(HFrEF),and reduces hospital admissions.An inhospital initiation strategy offers a potential new avenue to improve the clinical uptake of SAC/VAL.In the last five years,SAC/VAL has been established as a cornerstone component of comprehensive disease-modifying medical therapy in the management of chronic HFrEF.On the other hand,further work,with carefully designed and controlled preclinical studies,is necessary for understanding the molecular mechanisms,effects,and confirmation of issues such as long-term safety in both human and animal models. | Daisuke Usuda Toshihiro Higashikawa Yuta Hotchi Kenki Usami Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Toshihiko Yoshizawa Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita | 2021 | World Journal of Cardiology2021，13，8： | 2 |
| 11 | Video-assisted thoracoscopic surgery for esophageal cancer attenuates postoperative systemic responses and pulmonary complications显示文摘 | Hironori Tsujimoto Risa Takahata Shinsuke Nomura Yoshihisa Yaguchi Isao Kumano Yusuke Matsumoto Kazumichi Yoshida Hiroyuki Horiguchi Shuichi Hiraki Satoshi Ono Junji Yamamoto Kazuo Hase | 2012 | Surgery2012，，5： | 1 |
| 12 | Forecasting the demand for an employee park and ride service using commuters' stated choices 显示文摘 | Arne Risa Hole | 2004 | Transport Policy2004，11，4： | 1 |
| 13 | Climatic conditions and hydrological change recorded in a high-resolution stableisotope profile of a re- cent laminated tufa on a subtropical island,southern Japan显示文摘 | Akihiro Kano Risa Hagiwara | 2007 | Journal of Sedimentary Research2007，77，： | 1 |
| 14 | GLP-1-related proteins attenuate the effects of mitochondrial membrane damage in pancreatic β cells显示文摘 | Makiko Ogata Naoko Iwasaki Risa Ide Miho Takizawa Yasuko Uchigata | 2014 | Biochemical and Biophysical Research Communications2014，，1： | 1 |
| 15 | Detection of Four Plasmodium Species by Genus-and Species-Specific Loop-Mediated Isothermal Amplification for Clinical Diagnosis显示文摘 | Eun-Taek H Risa W Jetsumon S | | 0，，08： | 1 |
| 16 | The cholesterol fats: a Summary of the evidence dence relation dietary fats,Serum cholesterol and Coronary heart disease显示文摘 | Gott A M La Risa J C Hmuminghake D the Task Force on cholesterol issue | 1990 | Circulation1990，81，： | 1 |
| 17 | In vitro sequence-dependent interaction between nedaplatin and paclitaxel in human cancer cell lines显示文摘 | Risa Tanaka Yasushi Takii Yoshihiro Shibata Hiroshi Ariyama Baoli Qin Eishi Baba Hitoshi Kusaba Kenji Mitsugi Mine Harada Shuji Nakano | 2005 | Cancer Chemotherapy and Pharmacology2005，，3： | 1 |
| 18 | Correlation between the number of segmental chromosome aberrations and the age at diagnosis of diploid neuroblastomas without MYCN amplification显示文摘 | Ryota Souzaki Tatsuro Tajiri Risa Teshiba Yoshiaki Kinoshita Ryota Yosue Kenichi Kohashi Yoshinao Oda Tomoaki Taguchi | 2011 | Journal of Pediatric Surgery2011，，12： | 1 |
| 19 | Clinical features of Hirschsprung's disease associated with Down syndrome:a 30-year retrospective nationwide survey in Japan显示文摘 | Satoshi I Mayumi H Risa T | | 0，，12： | 1 |
| 20 | Application of a yeastestrogen reporter system for screening zearalenone degrading microbes显示文摘 | KRIFATON C KRISZT B RISA A | 2013 | Journal of hazardous materials2013，244，： | 1 |
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