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| 1 | Mortalin imaging in normal and cancer cells with quantum dot immuno conjugates显示文摘Quantum dots are the nanoparticles that are recently emerging as an alternative to organic fluorescence probes in cell biology and biomedicine,and have several predictive advantages.These include their i)broad absorption spectra allowing visualization with single light source,ii)exceptional photo-stability allowing long term studies and iii)narrow and symmetrical emission spectrum that is controlled by their size and material composition.These unique properties allow simultaneous excitation of different size of quantum dots with a single excitation light source,their simultaneous resolution and visualization as different colors.At present there are only a few studies that have tested quantum dots in cellular imaging.We describe here the use of quantum dots in mortalin imaging of normal and cancer cells.Mortalin staining pattern with quantum dots in both normal and cancer cells mimicked those obtained with organic florescence probes and were considerably stable. | ZEENIA KAUL TOMOKO YAGUCHI SUNIL C KAUL TAKASHI HIRANO RENU WADHWA KAZUNARI TAIRA | 2003 | Cell Research2003，13，6： | 14 |
| 2 | Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses显示文摘Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune responses.However,when human peripheral blood mononuclear cells(PBMCs)are transferred into NOG(NOD/Shi-scid,IL-2rg null)mice,severe graft versus host disease(GVHD)hinders long term detailed analysis.Administration of human PBMCs into newly developed murine MHC class I-and class II-deficient NOG(NOG-dKO;NOG-Iab,B2m-double-knockout)mice showed sufficient engraftment of human immune cells with little sign of GVHD.Immunization with influenza vaccine resulted in an increase in influenza-specific human IgG Ab,indicating induction of antigen-specific B cells in the NOG-dKO mice.Immunization with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells,indicating the induction of antigen-specific T cells in the NOG-dKO mice.Adoptive cell therapies(ACTs)using melanoma antigen recognized by T cells(MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T cells.ACTs using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice,in which changes in human cancer phenotypes by immune intervention,such as increased CD271 expression,could be evaluated.Therefore,NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice. | Tomonori Yaguchi Asuka Kobayashi Takashi Inozume Kenji Morii Haruna Nagumo Hiroshi Nishio Takashi Iwata Yuyo Ka Ikumi Katano Ryoji Ito Mamoru Ito Yutaka Kawakami | 2018 | Cellular & Molecular Immunology2018，15，11： | 6 |
| 3 | 多育赛多孢菌性鼻窦炎1例——致病菌的鉴定和体外抗真菌药物敏感性研究显示文摘目的报告国内首例多育赛多孢菌致鼻窦炎,并探讨致病菌的鉴定及其对抗真菌药物体外敏感性。方法取患者左侧上颌窦分泌物进行真菌培养和形态学鉴定,分离菌株β-球蛋白、rDNAITS序列分析确切鉴定,对分离菌进行7种抗真菌药体外药敏试验。结果根据菌株的形态学特点和基因序列结果鉴定为多育赛多孢菌。体外药敏试验显示该菌对7种抗真菌药物耐药。结论多育赛多孢菌所致的真菌病较少见,其确切鉴定靠形态学特征和基因分析。该菌株对多种抗真菌药物耐药。 | 帕丽达.阿布利孜 Takashi Yaguchi 罗德梅 惠艳 Katsuhiro Kamei Kazuko Nishimura | 2010 | 中国真菌学杂志2010，5，1： | 3 |
| 4 | 通过生存素反义基因加强顺铂在头颈部鳞状细胞癌治疗中的敏感度显示文摘 | Kojima H Iida M Yaguchi Y 菅鑫妍 | 2006 | 中国处方药2006，，8： | 3 |
| 5 | Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acid显示文摘 | Yaguchi M Miyazawa K Katagiri T | 1997 | Leukemia1997，11，6： | 2 |
| 6 | Minimally invasive surgery for resection of duodenal carcinoid tumors: endoscopic full-thickness resection under laparoscopic observation显示文摘 | Hironori Tsujimoto Takashi Ichikura Shigeaki Nagao Tomoki Sato Satoshi Ono Satoshi Aiko Shuichi Hiraki Yoshihisa Yaguchi Naoko Sakamoto Takemaru Tanimizu Junji Yamamoto Kazuo Hase | 2010 | Surgical Endoscopy2010，，2： | 2 |
| 7 | Apoptosis/diffefentiation-inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukeamia cells显示文摘 | Miyazawa K Yaguchi M Funato K | 2001 | Leukemia2001，15，7： | 2 |
| 8 | Combination of 22-oxa-1,25-dihydroxyvitamin D3, a vitamin D3 derivative, with vitamin K2(VK2) synergistically enhances cell differentiation but suppresses VK2-inducing apoptosis in HL-60 cells显示文摘 | Funato K Miyazawa K Yaguchi M | 2002 | Leukemia2002，16，8： | 2 |
| 9 | Surface coating influence on scandate cathode performance显示文摘 | SASAKI S YAGUCHI T NONAKA Y | 2002 | Appl Surf Sci2002，195，： | 1 |
| 10 | Early recanalization and plasma brain natriuretic peptide as an indicator of left ventricular function after acute myocardial infarction 显示文摘 | INOUE T SSKUMA M YAGUCHI I | 2002 | Am Heart J2002，143，5： | 1 |
| 11 | In vitro cytotoxicity of imidazolyl-1,3,5-triazine derivatives显示文摘 | Yaguchi S Izumisawa Y Sato M | 1997 | Biol Pharm Bull1997，20，： | 1 |
| 12 | Combination of 22-oxa1,25-dihydroxy vitaminD3,a vitam in D3 derivative,with vitamin K2 (VK2) synergistically enhances cell differentiation but suppresses VK2-inducing apoptosis in H L-60 cells显示文摘 | Funato K Miyazawa K Yaguchi M | 2002 | Leukemia2002，16，8： | 1 |
| 13 | Effect of MnS inclusion size on machinabilty of low-carbon, leaded, resulfurized free-machining steel显示文摘 | Hiroshi Yaguchi | 1986 | Journal of Applied Metalworking1986，，3： | 1 |
| 14 | Platelet function in sepsis显示文摘 | Yaguchi A Lobo FL Vincent JL | 2004 | J Thromb Haemost2004，2，： | 1 |
| 15 | Inhibitory mechanism of caffeine on insulin-stimulatedglucose uptake in adipose cells显示文摘 | Akiba T Yaguchi K Tsutsumi K | 2004 | Biochem Pharmacol2004，68，10： | 1 |
| 16 | A case of cardiac myxoma presenting with multiple cerebellar hemorrhages and elevation of interleukin-6 in the cerebrospinal fluid显示文摘 | Yaguchi H Murakami Y Sengoku R | 2004 | Rinsho Shinkeigaku2004，44，10： | 1 |
| 17 | Early recanalization and plasma brain natriuretic peptide as an indicate of left ventricular function after acute myocardial infarction显示文摘 | Sakuma M Yaguchi I | 2002 | Am Heart J2002，143，5： | 1 |
| 18 | Correlation between visual and colorimetric scales ranging from threshold to large color difference显示文摘 | Xu H S Yaguchi H Shioiri S | 2002 | Col Res Appl2002，27，5： | 1 |
| 19 | Distribution of two types of lymphocytes (intraepithelial and lamina propria associated) in the murine small intestine显示文摘 | Tamura A Soga H Yaguchi K | 2003 | Cell Tissue Res2003，313，1： | 1 |
| 20 | Successful gastric submucosal tumor resection using laparoscopic and endoscopic cooperative surgery显示文摘 | Tsujimoto H Yaguchi Y Kumano I | 2012 | World J Surg2012，36，2： | 1 |
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