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| 1 | Long-term alpha interferon and lamivudine combination therapy in non-responder patients with anti-HBe-positive chronic hepatitis B:Results of an open,controlled trial显示文摘AIM: To investigate the safety and efficacy of long-term combination therapy with alpha interferon and lamivudine in non-responsive patients with anti-HBe-positive chronic hepatitis B.METHODS: 34 patients received combination treatment (1 month lamivudine, 12 month lamivudine+interferon, 6month lamivudine), 24 received lamivudine (12 months),24 received interferon (12 months). Interferon was administered at 6 MU tiw and lamivudine at 100 mg orally once daily. Patients were followed up for 6 months after treatment.RESULTS: At the end of treatment, HBV DNA negativity rates were 88 % with lamivudine+interferon, 99 % with lamivudine and 55 % with interferon, (P=0.004, combination therapy vs. interferon, and P=0.001 lamivudine vs.interferon), and serum transaminase normalization rates were 84 %, 91% and 53 % (P=0.01 combination therapy vs. interferon, and P=0.012 lamivudine vs. interferon). Six months later, HBV DNA negativity rates were 44 % with lamivudine+interferon, 33 % with lamivudine and 25 % with interferon, and serum transaminase normalization rates were 61%, 42 % and 45 %, respectively, without statistical significance. No YMDD variants were observed with lamivudine+interferon (vs. 12 % with lamivudine). The combination therapy appeared to be safe. CONCLUSION: Although viral clearance and transaminase normalization are slower with long-term lamivudine+interferon than that with lamivudine alone, the combination regimen seems to provide more lasting benefits and to protect against the appearance of YMDD variants. Studies with other regimens regarding sequence and duration are needed. | M. Francesca Jaboli Carlo Fabbri Stefania Liva Francesco Azzaroli Giovanni Nigro Silvia Giovanelli Francesco Ferrara Anna Miracolo Sabrina Marchetto Marco Montagnani Antonio Colecchia Davide Festi Letizia Bacchi Reggiani Enrico Roda Giuseppe Mazzella | 2003 | World Journal of Gastroenterology2003，9，7： | 10 |
| 2 | Commentary of the mRNA vaccines COVID-19显示文摘The World Health Organization(WHO)declared global SARS-CoV-2(COVID-19)pandemic status on March 11,2020[1].To date,data record approximately 106 million infected individuals and 2.32 million deaths due to pandemic COVID-19,worldwide.The most common symptoms of SARS-CoV-2 infection reported are:elevation of body temperature,fatigue,cough,loss of smell.In a percentage of patients,especially elderly individuals with comorbidities,COVID-19 infection can cause severe organ injury[2].Since the onset of the COVID-19 pandemic,numerous pharmacological treatments have been used off label,to treat the viral infection,with the primary aim of avoiding the most serious complications and organ injury. | Antonio Vitiello Francesco Ferrara | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，5： | 2 |
| 3 | Assessing the feasibility of full robotic interaortocaval nodal dissection for locally advanced gastric cancer显示文摘 | Franco Roviello Riccardo Piagnerelli Francesco Ferrara Edda Caputo Maximilian Scheiterle Daniele Marrelli | 2015 | Int J Med Robotics Comput Assist Surg2015，，2： | 1 |
| 4 | Molecular aspects of the cardioprotective effect of exercise in the elderly显示文摘 | Giuseppe Rengo Valentina Parisi Grazia Daniela Femminella Gennaro Pagano Claudio de Lucia Alessandro Cannavo Daniela Liccardo Francesco Giallauria Oriana Scala Carmela Zincarelli Pasquale Perrone Filardi Nicola Ferrara Dario Leosco | 2013 | Aging Clinical and Experimental Research2013，，5： | 1 |
| 5 | Higher order sliding mode controllers with optimal reaching显示文摘 | Francesco Dinuzzo Antonella Ferrara | 2009 | IEEE Trans on Automatica Control2009，54，9： | 1 |
| 6 | Takotsubo Cardiomyopathy: Overview显示文摘 | Eduardo Bossone Gianluigi Savarese Francesco Ferrara Rodolfo Citro Susanna Mosca Francesca Musella Giuseppe Limongelli Roberto Manfredini Antonio Cittadini Pasquale Perrone Filardi | 2012 | Heart Failure Clinics2012，，： | 1 |
| 7 | Higher order sli-ding mode controllers with optimal reaching显示文摘 | Dinuzzo Francesco Ferrara Antonella | 2009 | IEEETransactions on Automatic Control2009，54，9： | 1 |
| 8 | Through-the-scope large diameter self-expanding metal stent placement as a safe and effective technique for palliation of malignant colorectal obstruction: A single center experience with a long-term follow-up显示文摘 | Carmelo Luigiano Francesco Ferrara Carlo Fabbri Stefania Ghersi Marco Bassi Paola Billi Anna Maria Polifemo Patrizia Landi Vincenzo Cennamo Pierluigi Consolo Carmela Morace Angela Alibrandi Nicola D'Imperio | 2011 | Scandinavian Journal of Gastroenterology2011，，5： | 1 |
| 9 | Through-the-scope large diameter self-expanding metal stent placement as a safe and effective technique for palliation of malignant colorectal obstruction: A single center experience with a long-term follow-up显示文摘 | Carmelo Luigiano Francesco Ferrara Carlo Fabbri Stefania Ghersi Marco Bassi Paola Billi Anna Maria Polifemo Patrizia Landi Vincenzo Cennamo Pierluigi Consolo Carmela Morace Angela Alibrandi Nicola D’Imperio | 2011 | Scandinavian Journal of Gastroenterology2011，，5： | 1 |
| 10 | A Smart Procedure for the Femtosecond Laser-Based Fabrication of a Polymeric Lab-on-a-Chip for Capturing Tumor Cell显示文摘Rapid prototyping methods for the design and fabrication of polymeric labs-on-a-chip are on the rise,as they allow high degrees of precision and flexibility.For example,a microfluidic platform may require an optimization phase in which it could be necessary to continuously modify the architecture and geometry;however,this is only possible if easy,controllable fabrication methods and low-cost materials are available.In this paper,we describe the realization process of a microfluidic tool,from the computer-aided design(CAD)to the proof-of-concept application as a capture device for circulating tumor cells(CTCs).The entire platform was realized in polymethyl methacrylate(PMMA),combining femtosecond(fs)laser and micromilling fabrication technologies.The multilayer device was assembled through a facile and low-cost solvent-assisted method.A serpentine microchannel was then directly biofunctionalized by immobilizing capture probes able to distinguish cancer from non-cancer cells without labeling.The low material costs,customizable methods,and biological application of the realized platform make it a suitable model for industrial exploitation and applications at the point of care. | Annalisa Volpe Udith Krishnan Maria Serena Chiriacò Elisabetta Primiceri Antonio Ancona Francesco Ferrara | 2021 | Engineering2021，7，10： | 0 |
| 11 | The role of SARS-COV-2 infection in promoting abnormal immune response and sepsis:A comparison between SARS-COV-2-related sepsis and sepsis from other causes显示文摘Background:COVID-19 caused by SARS-CoV-2 virus is characterized by respiratory compromise and immune system involvement,even leading to serious disorders,such as cytokine storm.Methods:We then conducted a literature review on the topic of sepsis and covid-19,and in parallel conducted an experimental study on the histological finding of patients who died from SARS-Covid 19 infection and a control group.Results:Sepsis associated with covid-19 infection has some similarities and differences from that from other causes.Conclusion:In this paper the complex interplay between the 2 disorders was discussed,focusing on the similarities and on the effect that one could have on the other.A preliminary experimental section that demonstrates the multisystemic involvement in subjects who die from SARS-CoV-2 is also proposed. | Andrea Piccioni Laura Franza Federico Rosa Marcello Candelli Marcello Covino Michela Ferrara GianpietroVolonnino Giuseppe Bertozzi Maria Vittoria Zamponi Aniello Maiese Gabriele Savioli Francesco Franceschi Raffaele La Russa | 2023 | Infectious Medicine2023，2，3： | 0 |
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