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| 1 | 中国北京、西安、上海和成都地区痴呆亚型患病率的研究显示文摘 | 张振馨 Zahner GE Roman GC 刘君 洪震 屈秋民 刘协和 张晓君 周玢 武成斌 唐牟尼 洪霞 李辉 | 2005 | 中国现代神经疾病杂志2005，5，3： | 115 |
| 2 | 剖腹产疤痕子宫内膜异位症显示文摘子宫内膜异位症是一常见而又疑难的疾病,尽管一个世纪以前已有描述,但至今仍是临床医生和研究者继续争论的问题。剖腹产腹壁疤痕子宫内膜异位症不多见,文献报告更少。本文报告近5年内证实的5例,并收集1956年以来的文献19篇,共90例疤痕子宫内膜异位症,对其诊断和治疗进行讨论。所收集的疤痕子宫内膜异位症的临床特征类似。年龄范围在21~40岁,疤痕中均有周期性触痛包块。 | Wolf GC Singh KB 陈韵仙 | 1990 | 国外医学(妇产科学分册)1990，17，2： | 82 |
| 3 | 世界兽医寄生虫学促进协会(WAAVP)对驱蠕虫药抗药性的检测方法显示文摘世界兽医寄生虫学促进协会(WAAVP)对驱蠕虫药抗药性的检测方法G.C.Coles等WAAVP已制订了评价反刍动物、猪和马等驱虫药的准则,目的在于使新药评价标准化和简易代。驱虫药的使用使某些线虫对广泛使用的一种或多种主要驱蠕虫药产生了抗药性。这些药物... | Cole.,GC 何国声 | 1996 | 中国兽医寄生虫病1996，4，1： | 22 |
| 4 | WONCA研究论文摘要汇编——对乙酰氨基酚治疗脊椎疼痛和骨关节炎的疗效和安全性:对随机安慰剂对照试验的系统综述和荟萃分析显示文摘目的探讨对乙酰氨基酚(扑热息痛)治疗脊椎疼痛和骨关节炎(髋关节、膝关节)的有效性和安全性。设计系统综述和荟萃分析。数据来源Medline、荷兰医学文摘数据库(EMBase)、AMED、CINAHL、Web of Science、LILACS、国际药学文摘、Cochrane对照试验中心注册库,时间自建库至2014年12月。研究的纳入标准研究须为随机对照试验,比较扑热息痛和安慰剂治疗脊椎疼痛(颈痛或下腰痛)和骨关节炎(髋关节、膝关节)的疗效和安全性。数据的提取由2名独立的研究人员分别提取关于疼痛、失能和生活质量的数据。次要结果指标包括:不良反应、患者依从性和急救药物的使用。疼痛和失能评分转换为0(没有疼痛或失能)到100(疼痛加重和失能)的数值。采用随机效应模型计算加权均数差(WMD)或风险比(HR)以及95%可信区间(95%CI)。应用Cochrane协作工具对偏倚风险进行评估,采用GRADE方法对证据的质量进行评估,并对结论进行总结。结果共纳入12篇报道(13项随机试验)。对于下腰痛患者,扑热息痛在短期内减少疼痛强度〔WMD=-0.5,95%CI(-2.9,1.9)〕、失能〔WMD=0.4,95%CI(-1.7,2.5)〕或提高生活质量〔WMD=0.4,95%CI(-0.9,1.7)〕等方面均是无效的。对于髋关节炎或膝关节炎患者,扑热息痛在短期内减轻疼痛〔WMD=-3.7,95%CI(-5.5,1.9)〕、失能〔WMD=-2.9,95%CI(-4.9,0.9)﹞方面有显著作用,尽管在临床意义上不重要。报告任何不良反应〔HR=1.0,95%CI(0.9,1.1)〕、任何严重不良反应〔HR=1.2,95%CI(0.7,2.1)〕或因为不良事件退出研究〔HR=1.2,95%CI(0.9,1.5)〕的患者数量,在扑热息痛组和安慰剂组中类似。坚持治疗的患者数量〔HR=1.0,95%CI(0.9,1.1)〕和使用急救药物〔HR=0.7,95%CI(0.4,1.3)〕的患者数量,在两组之间也是相似的。扑热息痛组患者发生肝功能异常的概率是安慰剂组患者的4倍〔HR=3.8,95%CI(1.9,7.4)〕,但这种效应的临床意义是不确定的。结论扑热息痛在治疗腰痛方面是无效的,但可以对骨关节炎患者提供最小的短期利益。现有的临床实践指南推荐对下腰痛患者、髋关节或膝关节骨关节炎患者使用扑热息痛治疗,以上研究结果支持对这些推荐进行重新审议。 | Machado GC Maher CG Ferreira PH 本刊编辑部 | 2015 | 中国全科医学2015，18，15： | 17 |
| 5 | 非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系显示文摘尽管非维生素K拮抗口服抗凝剂(non-vitamin K antagonist oral anticoagulants, NOACs)越来越多地应用于预防血栓栓塞性疾病,但关于NOACs相关性脑出血的数据仍然有限。 | 刘青 叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF Bhatt DL Peterson ED Fonarow GC | 2018 | 中华高血压杂志2018，26，2： | 16 |
| 6 | 溶栓时间(入院到用药时间)的延迟及其对脑卒中治疗时间与预后的影响显示文摘尽管美国心脏协会/美国脑卒中协会关于脑卒中的治疗均提出了倡议,大量急性缺血性脑卒中患者仍然在到达就诊60min后才开始启动组织型纤溶酶原激活剂(阿替普酶)溶栓治疗。该研究旨在描述延迟的原因及其与患者预后之间的关系。 | 刘莉 叶鹏 Kamal N Sheng S Xian Y Matsouaka R Hill MD Bhatt DL Saver JL Reeves MJ Fonarow GC Schwamm LH Smith EE | 2017 | 中华高血压杂志2017，25，4： | 15 |
| 7 | Extraskeletal myxoid chondrosarcoma metastatic to the pancreas: A case report显示文摘Extraskeletal myxoid chondrosarcoma (EMC) is a lowgrade sarcoma characterized by developing metastases and local recurrence in high rate. It is mainly deep seated in the proximal extremities. The most common metastatic sites are the lungs, soft tissues, lymph nodes, bones and the brain. To our knowledge, no case of clearly defined EMC has been reported to date developing a metastasis in the pancreas. We describe a case of a man suffering from EMC who developed a single pancreatic metastasis 20 years after the initial diagnosis. A 49-year-old man was submitted to surgical excision of an EMC, in left thigh, 20 years ago. Fourteen years after the initial diagnosis a local recurrence in left thigh occurred. Multiple lesions of metastatic origin, in both lungs, were excised via thoracotomies until the time being. In 2003, as a part of a periodically performed imaging control, an abdominal CT scan was performed revealing a solid lesion in the pancreas. Distal pancreatectomy was performed. The histopathology of the excised specimen proved to be the one of metastatic lesion of EMC. The above-mentioned case of EMC is, as far as we know, the first one described developing a certain pancreatic metastasis. | C Fotiadis A Charalambopoulos S Chatzikokolis GC Zografos M Genetzakis R Tringidou | 2005 | World Journal of Gastroenterology2005，11，14： | 14 |
| 8 | 世界不同地区帕金森病的流行特征显示文摘帕金森病(PD)是一种较常见的老年性疾病,病因迄今未明。对本病进行流行病学调查,可以为病因学研究提供一定线索。笔者复习了近35年来有关PD患病和发病特征的有关文献,选择以人群调查为基础,提供样本量和不同性别、年龄组资料的研究,综述如下。一、地区分布:从国内资料来看,1980年上海调查PD患病粗率为18.23/10万,我国1983年6城市居民患病率为44/10万,1986年29个省市患病率为14.6/10万。用1970年美国人口构成标化后,这三个调查的年龄调整率分别为18.33/10万、57/10万、18/10万。由此可见,国内不同地区PD的患病率是不尽相同的。按行政地区划分,中南地区最高,患病粗率为21.1/10万,华北地区最低,为9.2/10万。 | 张振馨 洪霞 Roman GC | 1996 | 中华流行病学杂志1996，17，1： | 12 |
| 9 | Redistribution of carbon flux in Torulopsis glabrata by altering vitamin and calcium level显示文摘 | Liu, LM Li, Y Zhu, Y Du, GC Chert, J | 2007 | 中国生物学文摘2007，21，10： | 12 |
| 10 | 荧光原位杂交法快速鉴定金黄色葡萄球菌和凝固酶阴性葡萄球菌显示文摘目的 建立一种新的荧光原位杂交法,快速鉴定血培养中的金黄色葡萄球菌(金葡菌)和凝固酶阴性葡萄球菌。方法 将荧光同位素标记的针对金葡菌和凝固酶阴性葡萄球菌的核糖体16SrRNA序列的互补的DNA寡核苷酸探针,在同一张玻片上50℃杂交1 h,用杂交缓冲液50℃洗涤10min,干燥后置荧光显微镜下观察,全过程大约2 h。结果 探针的特异性经标准菌株和临床分离菌株证实。将259份临床标本测试与培养法比较,金葡菌的特异性和敏感性均为100%,CoNs的特异性和敏感性分别为100%和95.5%,荧光原位杂交法的最低检出限为103CFU/ml。结论 本方法适用于血培养中的金葡菌和凝固酶阴性葡萄球菌的快速鉴定。 | 王沛 Welling GW Meessen N Raangs GC | 2004 | 中华检验医学杂志2004，27，7： | 12 |
| 11 | Gardner's syndrome: A case report and review of the literature显示文摘Gardner's syndrome is an autosomal dominant disease characterized by the presence of colonic polyposis,osteomas and a multitude of soft tissue tumors. The syndrome may present at any age from 2 mo to 70 years with a variety of symptoms, either colonic or extracolonic.We present a case of a 11-year-old female patient with Gardner's syndrome who presented with a lumbar area desmoid tumor and treated with resection of the desmoid,restorative proctocolectomy and ileal pouch anal anastomosis,A review of the current literature has been performed. | C Fotiadis DK Tsekouras P Antonakis J Sfiniadakis M Genetzakis GC Zografos | 2005 | World Journal of Gastroenterology2005，11，34： | 10 |
| 12 | 射血分数保留的心力衰竭患者动脉硬化与运动的相关性显示文摘人类衰老以主动脉僵硬度增加为特征,通过降低动脉顺应性和增强收缩期波反射造成收缩期高血压。老年、高血压和肥胖是射血分数保留的心力衰竭(heart failure with preserved ejection fraction, HFpEF)发生发展最大的影响因素. | Reddy YNV Andersen MJ Obokata M Koepp KE Kane GC Melenovsky V Olson TP Borlaug BA 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，10： | 10 |
| 13 | Rural Tourism Development in China:Principles,Models and the Future显示文摘Rural tourism in China,has undergone a rapid development in the last three decades.It is an emerging and effective catalyst that promotes industrial restructuring,agricultural development and the upgrading of rural areas.However,there remains little understanding about the core issues of rural tourism in China:the exact connotation,the principles,the development models and the future directions.This review paper identifies the key issues based on literature analysis,national statistics and press reports to form a general picture of the past,the current and the future prospects of China's rural tourism.The paper firstly addresses the definition,content and principles of rural tourism,and then provides an overview and brief evaluation of the progress and the current development models in China.Finally,based on the analysis of the experiences and problems,the authors sum up with five pathways of the future development of China's rural tourism from the perspective of rural tourism resources,product,market and promotion. | WANG Ling-en CHENG Sheng-kui ZHONG Lin-sheng MU Song-lin DHRUBA Bijaya GC REN Guo-zhu | 2013 | Journal of Mountain Science2013，10，1： | 9 |
| 14 | Parkinson's disease in China: prevalence in Beijing, Xian, and Shanghai.显示文摘 | Zhang ZX Roman GC Hong Z Wu CB Qu QM Huang JB Zhou B Geng ZP Wu JX Wen HB Zhao H Zahner GE | 2006 | 中国生物学文摘2006，20，8： | 9 |
| 15 | 离子交换铒掺杂硅酸盐玻璃波导光放大特性显示文摘将集成光学放大器用于光纤通信系统中是人们越来越感兴趣的课题 ,由此导致人们寻找与此相适应的稀土掺杂玻璃材料。给出了一系列Er3 + /Yb3 + 共掺杂硅酸盐玻璃波导的制备和光谱特性的基本结果。平面和条型波导均由Ag+ Na+ 离子交换技术制备。光谱测量显示 ,所有样品在 153 2nm都观测到了荧光发射峰 ,其半高谱宽为 19nm。用波长为 514 .5nm和 980nm的激光抽运 ,测得多数样品中Er3 + 离子在亚稳态4I13 /2 能级上的荧光寿命均为 7ms左右。Er3 + /Yb3 + 共掺杂玻璃的上转换均低于单掺Er3 + 玻璃。用 2 50mW ,波长为 980nm的激光抽运 3 .5cm长的条形波导 ,在 153 6nm波段下得到的最大净增益是 5dB ,增益谱的半峰全宽是 14nm。 | 郑杰 王鹏飞 徐迈 范希武 Righini GC | 2003 | 光学学报2003，23，12： | 9 |
| 16 | 间皮素在卵巢癌肿瘤微环境中作用的研究显示文摘卵巢癌死亡率高,早期诊断困难,而提高早期诊断率至关重要。间皮素(mesothelin,MSLN)与卵巢癌的发生、发展密切相关,在卵巢癌肿瘤微环境中起到重要作用。MSLN是一种糖蛋白,在许多癌症(包括卵巢癌和间皮瘤)中过表达,在细胞存活、增殖和肿瘤进展、黏附中起作用。CA125是MSLN的配体,两者相互结合成为MSLN:CA125复合体,介导卵巢癌细胞腹膜种植。MSLN的肿瘤特异性表达可用于癌症早期诊断,评估卵巢癌的治疗效果,检测原发肿瘤和转移病灶的分布,成为新治疗靶点并进行肿瘤免疫靶向治疗。尽管已开展的MSLN靶向免疫毒素、抗MSLN嵌合抗体等药物和肿瘤疫苗的临床试验提示MSLN可作为潜在肿瘤治疗靶点,改善肿瘤治疗的临床效果,但还需要更多的研究证实MSLN在肿瘤转移中的作用及其治疗方案。 | 王路遥 蒋晶 岳欣 陆皓 霍利婷 王昊 王蓓蒂 GC GOMA 李佩玲 | 2019 | 国际妇产科学杂志2019，46，1： | 8 |
| 17 | AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma显示文摘Intrahepatic cholangiocarcinomas (ICC) are neoplasms that originate from cholangiocytes and can occur at any level of the biliary tree. Surgical resection is the current therapy of choice for this highly aggressive cancer. However, the 5-year survival still is poor, with high recurrence rates. Due to the intrahepatic growth a signifi cant proportion of patients present with advanced disease and are not candidates for curative surgery or transplantation. The existing palliative options are of limited benefit and there is a great necessity for novel therapeutic options. In this article we review the role of the phosphoinositide 3-kinase(PI3K)/ AKT and extracellular regulated kinase (ERK) signaling pathways in ICC and present new data on the prognostic value of these protein kinases. Finally, we discuss future upcoming therapeutic options based on targeting these signaling pathways. | KJ Schmitz H Lang J Wohlschlaeger GC Sotiropoulos H Reis KW Schmid HA Baba | 2007 | World Journal of Gastroenterology2007，13，48： | 8 |
| 18 | 血吸虫对吡喹酮抗药性的研究Ⅴ 吡喹酮对曼氏血吸虫吡喹酮抗性株和敏感株成虫皮层的损伤显示文摘目的 体内比较吡喹酮对曼氏血吸虫吡喹酮抗性株与敏感株成虫皮层的损伤程度。方法 用各虫株尾蚴分别感染小鼠,感染后第57天,以300mg/kg微粒化吡喹酮悬液对小鼠作灌胃治疗;在灌药后10、30min和1、12、24h后剖杀感染小鼠,门静脉灌注收集成虫,按常规方法制成扫描电镜标本,扫描电镜下观察成虫体表的变化。结果 吡喹酮诱导的皮层损伤主要为虫体表形成泡状结构的薄壁隆起;给药10min,敏感株雄虫皮层可见较多小泡状物,而抗性株则少见;1h后,敏感株虫体表可见大量的泡状物,泡状物溃破可形成皮层损伤灶,抗性株仅见少量的泡状物;24h后,敏感株雄虫体表完全受损,部分皮层剥落,暴露出肌肉层,而抗性株仅见少量泡状物和破损的泡状物。给药1h后,敏感株雌虫开始出现少量泡状物,抗性株雌虫体表未见泡状损伤;12h后,敏感株雌虫泡状物数量增加,抗性株仅在有限区域见少量泡状物。结论 抗性株和敏感株成虫体表吡喹酮诱导的皮层损伤程度存在明显差异,敏感株的损伤程度重于抗性株,雄虫重于雌虫。 | 梁幼生 戴建荣 朱荫昌 李洪军 徐明 司进 许永良 杭盘宇 GC Coles MJ Doenhoff | 2003 | 中国血吸虫病防治杂志2003，15，4： | 7 |
| 19 | Colonic duplication in adults: Report of two cases presenting with rectal bleeding显示文摘Gastrointestinal duplication is an uncommon congenital abnormality in two-thirds of cases manifesting before the age of 2 years. Ileal duplication is common while colonic duplication, either cystic or tubular, is a rather unusual clinical entity that remains asymptomatic and undiagnosed in most cases. Mostly occurring in pediatric patients,colonic duplication is encountered in adults only in a few cases. This study reports two cases of colonic duplication in adults. Both cases presented with rectal bleeding on admission. The study was focused on clinical, imaging,histological, and therapeutical aspects of the presenting cases. Gastrografin enema established the diagnosis in both cases. The cystic structure and the adjacent part of the colon were excised en-block. The study implies that colonic duplication, though uncommon, should be included in the differential diagnosis of rectal bleeding. | C Fotiadis M Genetzakis I Papandreou EP Misiakos E Agapitos GC Zografos | 2005 | World Journal of Gastroenterology2005，11，32： | 7 |
| 20 | Construction of energy transfer model of C-phycocyanin and allophycocyanin from Spirulina platensis显示文摘PHYCOBILIPROTEINS. which include phycoerythrin, phycocyanin, phycoerythroeyanin and allophycocyanin, are intensively coloured, highly fluorescent, water soluble chromoproteins. They are composed of at least two dissimilar polypeptides, α and β subunits, in a molar ratio of 1:1. The subunits possess linear tetrapyrrole prosthetic groups covalently linked to the primary structure via cysteine thioether linkages. In blue-green and red algae, phycobiliproteins occur in a supramolecular structure, the phycobilisome, located on the surface of thylakoid to | Wang, GC Zhou, BC Zeng, CK | 1997 | Chinese Science Bulletin1997，42，1： | 6 |
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