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| 1 | Inflammatory pathways in the early steps of colorectal cancer development显示文摘Colorectal cancer is a major cause of cancer-related death in many countries.Colorectal carcinogenesis is a stepwise process which,from normal mucosa leads to malignancy.Many factors have been shown to influence this process,however,at present,several points remain obscure.In recent years some hypotheses have been considered on the mechanisms involved in cancer development,expecially in its early stages.Tissue injury resulting from infectious,mechanical,or chemical agents may elicit a chronic immune response resulting in cellular proliferation and regeneration.Chronic inflammation of the large bowel(as in inflammatory bowel diseases),has been associated with the subsequent development of colorectal cancer.In this review we examine the inflammatory pathways involved in the early steps of carcinogenesis,with particular emphasis on colorectal.Firstly,we describe cells and proteins recently suggested as central in the mechanism leading to tumor development.Macrophages and neutrophils are among the cells mostly involved in these processes and proteins,as cyclooxygenases and resolvins,are crucial in these inflammatory pathways.Indeed,the activation of these pathways establishes an oxidative and anaerobic microenvironment with DNA damage to epithelial cells,and shifting from an aerobic to an anaerobic metabolism.Many cellular mechanisms,such as proliferation,apoptosis,and autophagy are altered causing failure to control normal mucosa repair and renewal. | Francesco Mariani Paola Sena Luca Roncucci | 2014 | World Journal of Gastroenterology2014，20，29： | 13 |
| 2 | Attenuated adenomatous polyposis of the large bowel: Present and future显示文摘Attenuated adenomatous polyposis(AAP) is a poorly understood syndrome, that can be defined as the presence of 10-99 synchronous adenomas in the large bowel, and it is considered a phenotypic variant of familial adenomatous polyposis(FAP). This definition has the advantage of simplicity, but it may include sporadic multiple adenomas of the large bowel at an extreme, or FAP cases on the other side. AAP shows a milder phenotype than FAP, with an older age of onset of adenomas and cancer, and less frequent extracolonic manifestations. AAP may be diagnosed as a single case in a family or, less frequently, it may be present in other family members, and it shows distinct pattern of inheritance. In less than 50% of cases, it may be caused by adenomatous polyposis coli(APC) or MUTYH mutations, referred to as APC-associated polyposis, inherited as an autosomal dominant trait, or MUTYH-associated polyposis, which shows an autosomal recessive mechanism of inheritance, respectively. Surveillance should rely on colonoscopy at regular intervals, with removal of adenomas and careful histological examination. When removal of polyps is not possible or advanced lesions are observed, the surgical approach is mandatory, being subtotal colectomy with ileo-rectal anastomosis the treatment of choice. Studies on this syndrome are lacking, and controversies are still present on many issues, thus, other clinical and genetic studies are requested. | luca roncucci monica pedroni francesco mariani | 2017 | World Journal of Gastroenterology2017，23，23： | 2 |
| 3 | Myeloperoxidase-Positive Cell Infiltration in Colorectal Carcinogenesis as Indicator of Colorectal Cancer Risk显示文摘 | Roncucci L Mora E Mariani F | 2008 | Cancer Epidemiol Biomarkers Prev2008，17，9： | 1 |
| 4 | Frequency and clinical features of multiple tumors of the large bowel in the general population and in patients with hereditary colorectal carcinomas 显示文摘 | Fante R Roncucci L Di Gregorio O | 1996 | Cancer1996，77，： | 1 |
| 5 | SSJD14101300034250显示文摘 | Federica Domati Stefania Maffei Shaniko Kaleci Carmela Gregorio Monica Pedroni Luca Roncucci Piero Benatti Giulia Magnani Luigi Marcheselli Luca Reggiani Bonetti Francesco Mariani Antonio Maria Alberti Valerio Rossi Maurizio Ponz de Leon | 2014 | Internal and Emergency Medicine2014，，6： | 1 |
| 6 | K-ras and p53 mutation in human eolorectal aberrant crypt foci显示文摘 | Losi Roncucci L Gregorio CD | 1996 | J Pathol1996，17，8： | 1 |
| 7 | Frequency and clinical features of multiple tumors of the large bowel in the general poulation and in patients with hereditary colorectal carcinoma显示文摘 | Fante R Roncucci L Di-Gregorio C | 1996 | Cancer1996，77，： | 1 |
| 8 | Frequency and clinical features of multiple tumors of the large bowel in the general population and in patients with hereditary colorectal carcinoma显示文摘 | Roncucci L Di Gregorio C et at | 1996 | Cancer1996，77，10： | 1 |
| 9 | Frequency and clinical features of multiple tumors of the large bowel in the general popu- lation and in patients with hereditary colorectal carcinoma 显示文摘 | Fante R Roncucci L Tamassia MG | 1996 | Cancer1996，77，10： | 1 |
| 10 | Frequency and clin- ical features of muhiple tumors of the large bowel in gene- ral population and in patients with hereditary colorectal carcinoma显示文摘 | Fante R Roncucci L Di Gregorio C | 1996 | Cancer1996，77，10： | 1 |
| 11 | Survival for colon and rectal cancer in a population based cancer registry显示文摘 | Roncucci L Fante R Losi L etal | 1996 | Eur J Cancer1996，232，2： | 1 |
| 12 | The cause of colorectal cancer显示文摘 | Ponz de Leon M Roncucci L | 2000 | Dig Liver Dis2000，32，5： | 1 |
| 13 | Chemerin/chemR23 axis in in- flammation onset and resolution显示文摘 | Mariani F Roncucci L | 2015 | Inflamm Res2015，64，： | 1 |
| 14 | Phthalocyanine- photosensitized inactivation of a pathogenic protozoan, Acanthamoeba palestinensis显示文摘 | Kassab K Dei D Roncucci G | 2003 | Photoche Photobiol Scl2003，2，： | 1 |
| 15 | Frequency and clinical features of multiple tumors of the large bowel in the general population and in patients with hereditary colorectal carcinomad 显示文摘 | Fante R Roncucci L Gregorio C | 1996 | Cancer1996，77，： | 1 |
| 16 | Frequency and clinical features of multiple tumors of the large bowel in the general population and in patients with hereditary colorectal carcinomas 显示文摘 | Fante R Roncucci L Di Gregorio C | 1996 | Cancer1996，77，： | 1 |
| 17 | k-ras and p53 mutations in human colorectal aberrant crypt foci显示文摘 | Losi L Roncucci L Di Gregorio C | 1996 | J Pathol1996，178，： | 1 |
| 18 | Chemerin/chemR23 axis in inflammation onset and resolution 显示文摘 | Mariani F Roncucci L | 2015 | Inflamm Res2015，64，2： | 1 |
| 19 | Pattern of epithelial cell proliferation in colorectal mucosa of normal subjects and of patients with adenomatous polyps or cancer of the large bowel显示文摘 | Ponz de Leon M Roncucci L Di Donato P | 1988 | Cancer Res1988，48，14： | 1 |
| 20 | Frequency and clinical features of multiple tumors of the large bowel in the general population and in patients with hereditary cobrectal carcinom as Int显示文摘 | Fante R Roncucci L Gregorio C | 1996 | J Cancer1996，77，： | 1 |
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