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| 1 | Do pathological variables have prognostic significance in rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and surgery?显示文摘AIM To clarify which factors may influence pathological tumor response and affect clinical outcomes in patients with locally advanced rectal carcinoma treated with neo-adjuvant chemoradiotherapy and surgery.METHODS Tumor regression grade(TRG) according to the Dworak system and yT NM stage were assessed and correlated with pre-treatment clinico-pathological variables in 215 clinically locally advanced(c TNM stage Ⅱ and Ⅲ) rectal carcinomas. Prognostic value of all pathological and clinical factors on disease free survival(DFS) and cancer specific survival(CSS) was analyzed by Kaplan Meier and Cox-regression analyses.RESULTS cN + status, mucinous histotype or poor differentiation in the pre-treatment biopsy were significantly associated with lower pathological response(low Dworak grade and TNM remaining unchanged/upstaging). Cases showing acellular mucin pools in surgical specimens all had unremarkable clinical courses with no deaths or recurrences during follow-up. Dworak grade had prognostic significance for DFS and CSS. However, compared to the 5-tiered system, a simplified twotiered grading system, in which grades 0, 1 and 2 were grouped as absent/partial regression and grades 3 and 4 were grouped as total/subtotal regression, was more reproducible and prognostically informative. The twotiered Dworak system, yN stage, craniocaudal extension of the tumor and radial margin status were significant independent prognostic variables. CONCLUSION Our data suggest that caution should be applied in using a conservative approach in rectal carcinomas with c N+ status, extensive/lower involvement of the rectum and mucinous histotype or poor differentiation. Although Dworak TRG is prognostically significant, a simplified two-tiered system could be preferable. Finally, cases with acellular mucin pools should be carefully evaluated to definitely exclude residual mucinous carcinoma. | Luca Reggiani Bonetti Simona Lionti Federica Domati Valeria Barresi | 2017 | World Journal of Gastroenterology2017，23，8： | 7 |
| 2 | PEComas: the past, the present and the future显示文摘 | Guido Martignoni Maurizio Pea Daniela Reghellin Giuseppe Zamboni Franco Bonetti | 2008 | Virchows Archiv2008，，2： | 4 |
| 3 | Heavily calcified gastrointestinal stromal tumors:Pathophysiology and implications of a rare clinicopathologic entity显示文摘Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, and are characterized by a broad spectrum of clinical, histological and molecular features at presentation. Although focal and scattered calcifications are not uncommon within the primary tumor mass, heavy calcification within a GIST is rarely described in the literature and the clinical-biological meaning of this feature remains unclear. Cases with such an atypical presentation are challenging and may be associated with diagnostic pitfalls. Herein, we report a gastric GIST with the unusual presentation of prominent calcifications that was identified incidentally on imaging during a post-trauma diagnostic work-up. The patient underwent laparoscopic surgery with a radical resection of the mass, which was subsequently characterized by histological analysis as spindle-shaped tumor cells, positive for CD117/c-KIT, CD34 and DOG1, and with calcified areas. Given the intermediate risk of recurrence, no adjuvant therapy was recommended andthe patient underwent regular follow-up for 22 mo, with no evidence of relapse. Our case can be considered of interest because of the rarity of clinical presentation and the uniquely large size of the GIST at diagnosis(longest diameter exceeding 9 cm). In closing, we discuss the pathophysiology and clinical implications of calcifications in GISTs by reviewing the most up-to-date relevant literature. | Massimiliano Salati Giulia Orsi Luca Reggiani Bonetti Fabrizio Di Benedetto Giuseppe Longo Stefano Cascinu | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 2 |
| 4 | Morbidity and mortality in compensated cirrhosis type C: A retrospective follow-up study of 384 patients显示文摘 | G Fattovich G Giustina F Degos F Tremolada G Diodati P Almasio F Nevens A Solinas D Mura JT Brouwer H Thomas C Njapoum C Casarin P Bonetti P Fuschi J Basho A Tocco A Bhalla R Galassini F Noventa SW Schalm G Realdi | 1997 | Gastroenterology1997，，2： | 2 |
| 5 | Cost-effectiveness of Osimertinib in activating epidermal growth factor receptor gene(EGFR)-mutations in first-line for advanced non-small cell lung cancer显示文摘The introduction of first-or second-generation epidermal growth factor receptor gene(EGFR)tyrosine kinase inhibitors(TKIs)in chemonaive patients with advanced non-small cell lung cancer(NSCLC)has radically changed the treatment in this molecular subgroup,with an improvement in progression-free survival(PFS)compared to standard chemotherapy[1]. | Jacopo Giuliani Andrea Bonetti | 2021 | Cancer Drug Resistance2021，4，3： | 2 |
| 6 | Clinical outcome of low- and high-risk malignant colorectal polyps: results of a population-based study and meta-analysis of the available literature显示文摘 | Carmela Di Gregorio Luca Reggiani Bonetti Carmela Gaetani Monica Pedroni Shaniko Kaleci Maurizio Ponz de Leon | 2014 | Internal and Emergency Medicine2014，，2： | 2 |
| 7 | Anti-interferon antibodies during interferon therapy for chronic hepatitis C显示文摘 | Bonetti P Chemello L ALberti A | 1994 | Hepatol1994，20，： | 1 |
| 8 | Left atrial size after cardioversion for atrial fibrillation:effect of external direct current shock显示文摘 | Mattioli AV Bonatti S Bonetti L | 2003 | J Am Soc Echocardiogr2003，16，： | 1 |
| 9 | Orthodontic extraction: riskless extraction of impacted lower third molars close to the mandibular canal显示文摘 | ALESSANDRI BONETTI G BENDANDI M LAINO L | 2007 | J Oral Maxillofac Surg2007，65，12： | 1 |
| 10 | Mag - netic ce with gadolinium administration in sessing the efficacy of 02 -03 therapy in lumbardisc hemiation显示文摘 | Bonetti M Cottcelli B Valdanassi L | 2001 | Rivista Neumradiolo- gia2001，14，： | 1 |
| 11 | Nucleophosmin and its AML- asso- ciated mutant regulate c-Myc turnover through Fbw7 gamma 显示文摘 | Bonetti P Davoli T Sironi C | 2008 | Cell Bio12008，182，1： | 1 |
| 12 | Intraforaminal O (2)-O (3) versus periradicular steroidal infiltrations in lower back pain: randomized controlled study显示文摘 | Bonetti M Fontana A Cotticelli B | 2005 | AJNR Am J Neuroradiol2005，26，5： | 1 |
| 13 | Passive Archwires for Intermaxillary Fixation 显示文摘 | Giulio Alessri Bonetti Serena Incerti Parenti Antonio Gracco | 2012 | Journal of the Canadian Dental Association = Journal de l''Association demaire canadierme2012，78，1： | 1 |
| 14 | Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering显示文摘 | BONETTI P O WILSON S H RODRIGUEZ-POR- CEL M | 2002 | J Am Coll Cardiol2002，40，： | 1 |
| 15 | Statin effects beyond lipid lowering are they clinically relevant 显示文摘 | Bonetti PO Lerman LO Napoli C | 2003 | Eur Heart J2003，24，3： | 1 |
| 16 | High-performance liquid chromatographic determination of sulfonylureas in siol and water 显示文摘 | GALLETTI G C BONETTI A DINELLI G | 1995 | Journal of Chromatography A1995，，692： | 1 |
| 17 | Statin effects beyond lipid lowering: are they clinically relevant显示文摘 | Bonetti PO Lerman LO Napoli C | 2003 | Eur Heart J2003，24，： | 1 |
| 18 | Intra for a minalO2-O3 versus periradicular steroidal infiltrations in lower back pain:randomized controlled study 显示文摘 | Bonetti M Fontana A Cotticelli B | 2005 | AJNR2005，26，5： | 1 |
| 19 | Intraforaminal O ( 2)-O ( 3 ) versus periradicular steroidal infiltrations in lower back pain: randomized controlled study 显示文摘 | BONETTI M FONTANA A COTTICELLI B | 2005 | AJNRAmJ Neuroradiol2005，26，5： | 1 |
| 20 | Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproduction 显示文摘 | Bonetti TC Borges E Jr Braga DP | 2013 | Reprod Biomed Online2013，26，1： | 1 |
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