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| 1 | Topical ocular administration of DPP-Ⅳ inhibitors:a new approach for treating diabetes-induced retinal neurodegeneration显示文摘Retinal neurodegeneration plays a significant role in the pathogenesis of diabetic retinopathy(DR),the leading cause of preventable blindness.In fact,the American Diabetes Association has defined DR as a highly specific neurovascular complication(Solomon et al.,2017).Therefore,it is no longer acceptable to consider DR as merely a microvascular complication.In this regard,the term diabetic retinal disease(DRD)has been proposed as a broader term comprising microangiopathy and neurodegeneration.However,there are currently no treatments available that directly target the neurodegenerative changes of DR.This paper will give new insights into the translational research in this field with particular emphasis on glucagon-like peptide 1/dipeptidyl peptidase IV(GLP-1/DPP-IV)inhibitors. | Rafael Simó Cristina Hernández | 2024 | Neural Regeneration Research2024，19，4： | 1 |
| 2 | Neurodegeneration:An early event of diabetic retinopathy显示文摘Diabetic retinopathy(DR) has been classically considered to be a microcirculatory disease of the retina caused by the deleterious metabolic effects of hyperglycemia per se and the metabolic pathways triggered by hyperglycemia.However,retinal neurodegeneration is already present before any microcirculatory abnormalities can be detected in ophthalmoscopic examination.In other words,retinal neurodegeneration is an early event in the pathogenesis of DR which predates and participates in the microcirculatory abnormalities that occur in DR.Therefore,the study of the mechanisms that lead to neurodegeneration will be essential to identify new therapeutic targets in the early stages of DR.Elevated levels of glutamate and the overexpression of the renin-angiotensin-system play an essential role in the neurodegenerative process that occurs in diabetic retina.Among neuroprotective factors,pigment epithelial derived factor,somatostatin and erythropoietin seem to be the most relevant and these will be considered in this review.Nevertheless,it should be noted that the balance between neurotoxic and neuroprotective factors rather than levels of neurotoxic factors alone will determine the presence or absence of retinal neurodegeneration in the diabetic eye.New strategies,based on either the delivery of neuroprotective agents or the blockade of neurotoxic factors,are currently being tested in experimental models and in clinical pilot studies.Whether these novel therapies will eventually supplement or prevent the need for laser photocoagulation or vitrectomy awaits the results of additional clinical research. | Marta Villarroel Andreea Ciudin Cristina Hernández Rafael Simó | 2010 | World Journal of Diabetes2010，1，2： | 41 |
| 3 | Effect of glycemic control on nocturnal arterial oxygen saturation: A case‐control study in type 2 diabetic patients 血糖控制对夜间动脉血氧饱和度的影响:一项2型糖尿病患者的病例对照研究显示文摘 | Albert Lecube Andreea Ciudin Gabriel Sampol Silvia Valladares Cristina Hernández Rafael Simó | 2015 | Journal of Diabetes2015，，： | 2 |
| 4 | Mechanisms of retinal neuroprotection of calcium dobesilate:therapeutic implications显示文摘Current treatments for diabetic retinopathy(DR)are based on laser photocoagulation and intravitreal injections of corticosteroids or anti-vascular endothelial growth factor(VEGF)agents.These treatments are applicable only at advanced stages of the disease.In addition,they are expensive,require a vitreoretinal specialist and are associated with significant adverse ef- | Olga Simó-Servat Cristina Solà-Adell Patricia Bogdanov Cristina Hernández Rafael Simó | 2017 | Neural Regeneration Research2017，12，10： | 2 |
| 5 | Islet cell and thyroid antibody prevalence in patients with hepatitis C virus infection: Effect of treatment with interferon显示文摘 | Sandra Piquer Cristina Hernández J. Enriquez Annemieke Ross J.Ignaci Esteban Joan Genescà Ezio Bonifacio Manuel Puig-Domingo Rafael Simó | 2001 | The Journal of Laboratory and Clinical Medicine2001，，1： | 1 |
| 6 | Islet cell and thyroid antibody prevalence in patients with hepatitis C virus infection: Effect of treatment with interferon显示文摘 | Sandra Piquer Cristina Hernández J. Enriquez Annemieke Ross J.Ignaci Esteban Joan Genescà Ezio Bonifacio Manuel Puig-Domingo Rafael Simó | 2001 | The Journal of Laboratory and Clinical Medicine2001，，1： | 1 |
| 7 | Randomized Controlled Trial of Aspiration Needle versus Automated Biopsy Device for Transjugular Liver Biopsy显示文摘 | Rafael Ba?ares Sonia Alonso María-Vega Catalina Marta Casado Diego Rincón Magdalena Salcedo Emilio Alvarez Carmen Guerrero Antonio Echenagusía Fernando Camú?ez Gonzalo Simó | 2001 | Journal of Vascular and Interventional Radiology2001，，5： | 1 |
| 8 | Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial显示文摘 | Baptist Gallwitz Juan Guzman Francesco Dotta Bruno Guerci Rafael Simó Bruce R Basson Andreas Festa Jacek Kiljański Hélène Sapin Michael Trautmann Guntram Schernthaner | 2012 | The Lancet2012，，9833： | 1 |
| 9 | Comparison of transjugular intrahepatic portosystemic shunt dysfunction in PTFE-covered stent-grafts versus bare stents显示文摘 | José Barrio Cristina Ripoll Rafael Ba?ares Antonio Echenagusia María-Vega Catalina Fernando Camú?ez Gonzalo Simó Leandro Santos | 2004 | European Journal of Radiology2004，，1： | 1 |
| 10 | Effects of intravenous albumin in patients with cirrhosis and episodic hepatic encephalopathy: A randomized double-blind study显示文摘 | Macarena Simón-Talero Rita García-Martínez Maria Torrens Salvador Augustin Susana Gómez Gustavo Pereira Mónica Guevara Pere Ginés Germán Soriano Eva Román Jordi Sánchez-Delgado Roser Ferrer Juan C. Nieto Pilar Sunyé Inma Fuentes Rafael Esteban Juan Córdob | 2013 | Journal of Hepatology2013，，6： | 1 |
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