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| 1 | 人体1型糖尿病中的关键免疫细胞显示文摘1型糖尿病患者胰岛β细胞被破坏与胰岛自身反应性T细胞之间的直接联系从未被证明,对诊断后的疾病进程也所知无几。最近美国科学家的研究第一次对此有了直接的证据。冷冻胰腺样本来自病程在1周到超过50年的45例死亡患者的遗体捐赠,14例非糖尿病患者对照样本,5例有自身抗体的非糖尿病患者样本,2例孕期糖尿病患者样本,以及6例2型糖尿病患者样本。系统检查样本的组织切片是否存在有足够胰岛素的β细胞、CD8阳性的胰岛病变和1型HLA过度表达。最后,对表达HLA-A2的样本的连续切片用四聚体染色法针对6种已知确定的与1型糖尿病有关的胰岛自身抗原进行CD8 T细胞反应性检查。在临床确诊后最长达8年的分组患者胰岛样本中单一和多种CD8 T细胞反应性都检测到了。1型糖尿病特有的1型HLA过度表达和胰岛炎等病理特征存在于一小部分病程很长的患者中。在受影响的器官中,胰岛病变持续存在,表现为不同程度的浸润和β细胞丢失。该研究为人体胰岛自身反应性提供了第一个直接证据并强调了发病历程的异质性和长期性。 | Coppieters KT Dotta F Amirian N | 2012 | 中国烧伤创疡杂志2012，24，3： | 9 |
| 2 | Mesenchymal stem cells secretome:The cornerstone of cell-free regenerative medicine显示文摘Mesenchymal stem cells(MSCs)are the most frequently used stem cells in clinical trials due to their easy isolation from various adult tissues,their ability of homing to injury sites and their potential to differentiate into multiple cell types.However,the realization that the beneficial effect of MSCs relies mainly on their paracrine action,rather than on their engraftment in the recipient tissue and subsequent differentiation,has opened the way to cell-free therapeutic strategies in regenerative medicine.All the soluble factors and vesicles secreted by MSCs are commonly known as secretome.MSCs secretome has a key role in cell-to-cell communication and has been proven to be an active mediator of immunemodulation and regeneration both in vitro and in vivo.Moreover,the use of secretome has key advantages over cell-based therapies,such as a lower immunogenicity and easy production,handling and storage.Importantly,MSCs can be modulated to alter their secretome composition to better suit specific therapeutic goals,thus,opening a large number of possibilities.Altogether these advantages now place MSCs secretome at the center of an important number of investigations in different clinical contexts,enabling rapid scientific progress in this field. | Alberto González-González Daniel García-Sánchez Monica Dotta JoséC Rodríguez-Rey Flor M Pérez-Campo | 2020 | World Journal of Stem Cells2020，12，12： | 2 |
| 3 | Diagnosis and approach to posttransplant diabetes 显示文摘 | Bonato V Cataldo D Dotta F | 2009 | Curr Diab Rep2009，9，4： | 1 |
| 4 | Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets:evidence that beta-cell death is caspase mediated,partially dependent on ceramide pathway,and Bcl-2 regulated显示文摘 | Lupi R Dotta F Marselli L | 2002 | Diabetes2002，51，5： | 1 |
| 5 | Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin显示文摘 | Bolli G Dotta F Colin L | | 0，，： | 1 |
| 6 | Severity of Unilateral Spatial Neglect Is an Independent Predictor of Functional Out come After Acute Inpatient Rehabilitation in Individuals With Right Hemispheric Stroke显示文摘 | Monaco M Schintu S Dotta M | 2011 | Archives of Physical Medicine and Rehabilitation2011，92，8： | 1 |
| 7 | Prolonged exposure to free fatty acids has cytostatic and proapoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and BcL-2 regulated 显示文摘 | Lupi R Dotta F Marselli L | 2002 | Diabetes2002，51，5： | 1 |
| 8 | Guidelines for the treatment and management of new-onset diabetes after transplantation 显示文摘 | Wilkinson A Davidson J Dotta F | 2005 | Clin Transplant2005，19，： | 1 |
| 9 | Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets:evidence that 13-cell death is caspase mediated,partially dependent on ceramide pathway,and bcl-2 regulated显示文摘 | Lupi R Dotta F Marselli L | 2002 | Diabetes2002，51，5： | 1 |
| 10 | Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets:evidence that beta-cell death is caspase mediated,partially dependent on ceramide pathway,and Bcl-2 regulated显示文摘 | Lupi R Dotta F Marselli L | 2002 | Diabetes2002，51，5： | 1 |
| 11 | Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreaticislets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated 显示文摘 | Lupi R Dotta F Marselli L | 2002 | Diabe- tes2002，51，5： | 1 |
| 12 | Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets:evidence that beta-cell death is caspase mediated,partially dependent on ceramide pathway,and Bcl -2 regulated显示文摘 | Lupi R Dotta F Marselli L | 2002 | Diabetes2002，51，5： | 1 |
| 13 | Exenatidc twice daily versus glimepiride for prevention of glyeaemic deterioration in patients with type 2 diabetes with metformin failure (EU- REXA ) : an open-label, randomised controlled trial显示文摘 | GALLWITZ B GUZMAN J DOTTA F | 2012 | Lancet2012，379，9833： | 1 |
| 14 | Latent autoim mune diabetes in adults(LADA)should be less latent显示文摘 | Fourlanos S Dotta F Greenbaum CJ | 2005 | Diabetologia2005，48，11： | 1 |
| 15 | Prolonged exposure to free fatty acids has cytosatatic and pro-apototic effects on human pancreastic islets:evidence that beta-cell death is caspase mediated,partially dependent on ceramide pathway and Bcl-2 redulated显示文摘 | Lupi R Dotta F Marscella L | 2002 | Diabetes2002，51，5： | 1 |
| 16 | Th2 cytokines have a partial direct protective effect on the function and survival of isolated human islet exposed to combined proinflammatory and Th1 cytokines 显示文摘 | Marselli L Dotta F Piro S | 2001 | J Clin Endocrinol Metab2001，86，10： | 1 |
| 17 | Prolonged exposure to free fatty acids has eytostatic and pro-apoptotic effects on human pancreatic islets:evidence that beta-cell death is caspase mediated,partially de- pendent on ceramide pathway,and Bcl-2 regulated显示文摘 | Lupi R Dotta F Marselli L | 2002 | Diabetes2002，51，5： | 1 |
| 18 | Prolonged exposure to free fatty acids has cytostatic and pro-apoptotie effects on human pancreatic islets: evidance that beta-cell death is caspase mediated ,partially dependent on cemmide'pathway , and Bcl-2 regulated 显示文摘 | Lupi R Dotta F Marselli L | 2002 | Diabetes2002，，51： | 1 |
| 19 | Prolonged exposure to free fatty acids has cytostatic and pro - apoptotic effect on human pancreatic islets显示文摘 | Lupi R Dotta F Marselli L | 2002 | Diabetes2002，51，5： | 1 |
| 20 | Latent autoimmune diabetes in adults (LADA) should be less latent 显示文摘 | Fourlanos S Dotta F Greenbaum C J et 31 | 2005 | Diabetologia2005，48，11： | 1 |
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