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| 1 | Evolving management of colorectal cancer显示文摘This article reviews recent advances in surgical techniques and adjuvant therapies for colorectal cancer, including total mesorectal excision, the resection of liver and lung metastasis and advances in chemoradiation and foreshadows some interventions that may lie just beyond the frontier. In particular, little is known about the intracellular and extracellular cascades that may influence colorectal cancer cell adhesion and metastasis. Although the phosphorylation of focal adhesion kinases and focal adhesion associated proteins in response to integrin-mediated cell matrix binding ('outside in integrin signaling') is well described, the stimulation of cell adhesion by intracellular signals activated by pressure prior to adhesion represents a different signal paradigm. However, several studies have suggested that increased pressure and shear stress activate cancer cell adhesion. Further studies of the pathways that regulate integrin-driven cancer cell adhesion may identify ways to disrupt these signals or block integrin-mediated adhesion so that adhesion and eventual metastasis can be prevented in the future. | Jochem van der Voort van Zijp Harald J Hoekstra Marc D Basson | 2008 | World Journal of Gastroenterology2008，14，25： | 16 |
| 2 | Intestinal mucosal atrophy and adaptation显示文摘Mucosal adaptation is an essential process in gut homeostasis.The intestinal mucosa adapts to a range of pathological conditions including starvation,short-gut syndrome,obesity,and bariatric surgery.Broadly,these adaptive functions can be grouped into proliferation and differentiation.These are influenced by diverse interactions with hormonal,immune,dietary,nervous,and mechanical stimuli.It seems likely that clinical outcomes can be improved by manipulating the physiology of adaptation.This review will summarize current understanding of the basic science surrounding adaptation,delineate the wide range of potential targets for therapeutic intervention,and discuss how these might be incorporated into an overall treatment plan.Deeper insight into the physiologic basis of adaptation wil identify further targets for intervention to improve clinical outcomes. | Darcy Shaw Kartik Gohil Marc D Basson | 2012 | World Journal of Gastroenterology2012，18，44： | 3 |
| 3 | Pancreaticβ-cell dysfunction in type 2 diabetes:Implications of inflammation and oxidative stress显示文摘Insulin resistance and pancreaticβ-cell dysfunction are major pathological mechanisms implicated in the development and progression of type 2 diabetes(T2D).Beyond the detrimental effects of insulin resistance,inflammation and oxidative stress have emerged as critical features of T2D that defineβ-cell dysfunction.Predominant markers of inflammation such as C-reactive protein,tumor necrosis factor alpha,and interleukin-1βare consistently associated withβ-cell failure in preclinical models and in people with T2D.Similarly,important markers of oxidative stress,such as increased reactive oxygen species and depleted intracellular antioxidants,are consistent with pancreaticβ-cell damage in conditions of T2D.Such effects illustrate a pathological relationship between an abnormal inflammatory response and generation of oxidative stress during the progression of T2D.The current review explores preclinical and clinical research on the pathological implications of inflammation and oxidative stress during the development ofβ-cell dysfunction in T2D.Moreover,important molecular mechanisms and relevant biomarkers involved in this process are discussed to divulge a pathological link between inflammation and oxidative stress duringβ-cell failure in T2D.Underpinning the clinical relevance of the review,a systematic analysis of evidence from randomized controlled trials is covered,on the potential therapeutic effects of some commonly used antidiabetic agents in modulating inflammatory makers to improveβ-cell function. | Phiwayinkosi V Dludla Sihle E Mabhida Khanyisani Ziqubu Bongani B Nkambule Sithandiwe E Mazibuko-Mbeje Sidney Hanser Albert Kotze Basson Carmen Pheiffer Andre Pascal Kengne | 2023 | World Journal of Diabetes2023，14，3： | 2 |
| 4 | Gut homeostasis, injury, and healing: New therapeutic targets显示文摘The integrity of the gastrointestinal mucosa plays a crucial role in gut homeostasis,which depends upon the balance between mucosal injury by destructive factors and healing via protective factors.The persistence of noxious agents such as acid,pepsin,nonsteroidal anti-inflammatory drugs,or Helicobacter pylori breaks down the mucosal barrier and injury occurs.Depending upon the size and site of the wound,it is healed by complex and overlapping processes involving membrane resealing,cell spreading,purse-string contraction,restitution,differentiation,angiogenesis,and vasculogenesis,each modulated by extracellular regulators.Unfortunately,the gut does not always heal,leading to such pathology as peptic ulcers or inflammatory bowel disease.Currently available therapeutics such as proton pump inhibitors,histamine-2 receptor antagonists,sucralfate,5-aminosalicylate,antibiotics,corticosteroids,and immunosuppressants all attempt to minimize or reduce injury to the gastrointestinal tract.More recent studies have focused on improving mucosal defense or directly promoting mucosal repair.Many investigations have sought to enhance mucosal defense by stimulating mucus secretion,mucosal blood flow,or tight junction function.Conversely,new attempts to directly promote mucosal repair target proteins that modulate cytoskeleton dynamics such as tubulin,talin,Ehm^(2),filamin-a,gelsolin,and flightless I or that proteins regulate focal adhesions dynamics such as focal adhesion kinase.This article summarizes the pathobiology of gastrointestinal mucosal healing and reviews potential new therapeutic targets. | Sema Oncel Marc D Basson | 2022 | World Journal of Gastroenterology2022，28，17： | 2 |
| 5 | The 21-nueleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans显示文摘 | Reinhart BJ Slack FJ Basson M | 2000 | Nature2000，403，： | 1 |
| 6 | Collagen Ⅳ-dependent ERK activation in human Caco-2 intestinal epithelial cells requires focal adhesion kinase显示文摘 | Sanders MA Basson MD | 2000 | J Biol Chem2000，275，38： | 1 |
| 7 | Mutations in human TBX5 cause limb and cardiac malformation in HoltOram syndrome显示文摘 | Basson CT Bachinsky DR Lin RC | 1997 | Nat Genet1997，15，1： | 1 |
| 8 | Practical application of probabilistic approaches to the management of water resource systems 显示文摘 | Basson M S Van Rooyen J A | 2001 | Journal of Hydrology2001，241，1： | 1 |
| 9 | Deep myocardial bridging is a risk factor for sudden death in hypertrophic cardiomyopathy显示文摘 | Basson C Maron B Corrado B | 2006 | Circulation2006，114，8： | 1 |
| 10 | The effect of a lacticacid bacterial inoculant with enzymes on the fermentation dynamics, intake and digestibility of Digitaria eriantha silage 显示文摘 | Meeske R Basson H M Gruywagen C W | 1999 | Animal Feed Science and Technology1999，81，34： | 1 |
| 11 | Universal changes in biomarkers of and inflammation occur in patients with severe regardless of causative micro-organism显示文摘 | Kinasewitz GT Yan SB Basson B | 2004 | Crit Care Med2004，8，2： | 1 |
| 12 | Universal changes in biomarkers of coagulation an d inflammation occur in patients withsevere sepsis, regardless of causative micro - organism 显示文摘 | Kinasewits GT Yah SB Basson B | 2004 | Crit Care Med2004，8，2： | 1 |
| 13 | Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutations显示文摘 | Basson CT Huang T Lin RC | 1999 | Proc Nail Acad Sci USA1999，96，6： | 1 |
| 14 | The modelling of anchors using the material point method显示文摘 | COETZEE C J VERMEER P A BASSON A H | 2005 | International Journal for Numerical and Analytical Methods in Geomechanics2005，29，： | 1 |
| 15 | Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis,regardless of causative micro-organism显示文摘 | Kinasewitz GT Yan SB Basson B | | 0，，： | 1 |
| 16 | Universal changes in biomakers of coagulation and inflamation occur in patients with severe sepsis,regardless of causative microrganism显示文摘 | Kinasewitz G T Yan S B Basson B | 2004 | Crit Care2004，8，2： | 1 |
| 17 | The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans 显示文摘 | Reinhart BJ Slack FJ Basson M | 2000 | Nature2000，403，6772： | 1 |
| 18 | The pathology of ephemeral fever: A study of the experimental disease in cattle 显示文摘 | Basson P A Pienaar J G Van Der Westhuizzen B | 1970 | J S Afr Vet Med Assoc1970，40，： | 1 |
| 19 | The 21-nucleotidelet-7 RNA regulates developmental timing in Caenorhabditis elegans显示文摘 | Reinhart BJ Slack FJ Basson M | 2000 | Nature2000，403，： | 1 |
| 20 | FAK association with multiple signal proteins mediates pressure-induce colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway显示文摘 | Thamilselvan V Craig DH Basson MD | 2007 | The FASEB Journal2007，21，1： | 1 |
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