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| 1 | Bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke: a randomized controlled trial显示文摘Using robotic devices might improve recovery post-stroke, but the optimal way to apply robotic assistance has yet to be determined. The current study aimed to investigate whether training under the robotic active-assisted mode improves bimanual motor skill learning(biMSkL) more than training under the active mode in stroke patients. Twenty-six healthy individuals(HI) and 23 chronic hemiparetic stroke patients with a detectable lesion on MRI or CT scan, who demonstrated motor deficits in the upper limb, were randomly allocated to two parallel groups. The protocol included a two-day training on a new bimanual cooperative task, LIFT-THE-TRAY, under either the active or activeassisted modes(where assistance decreased in a pre-determined stepwise fashion) with the bimanual version of the REAplan? robotic device. The hypothesis was that the active-assisted mode would result in greater biMSkL than the active mode. The biMSkL was quantified by a speed-accuracy trade-off(SAT) before(T1) and immediately after(T2) training on days 1 and 2(T3 and T4). The change in SAT after 2 days of training(T4/T1) indicated that both HI and stroke patients learned and retained the bimanual cooperative task. After 2 days of training, the active-assisted mode did not improve biMSkL more than the active mode(T4/T1) in HI nor stroke patients. Whereas HI generalized the learned bimanual skill to different execution speeds in both the active and active-assisted subgroups, the stroke patients generalized the learned skill only in the active subgroup. Taken together, the active-assisted mode, applied in a pre-determined stepwise decreasing fashion, did not improve biMSkL more than the active mode in HI and stroke subjects. Stroke subjects might benefit more from robotic assistance when applied 'as-needed.' This study was approved by the local ethical committee(Comité d'éthique médicale, CHU UCL Namur, MontGodinne, Yvoir, Belgium;Internal number: 54/2010, Eudra CT number: NUB B039201317382) on July 14, 2016 and was registered with ClinicalTrials.gov(Identifier: NCT03974750) on June 5, 2019. | Maral Yeganeh Doost Benoît Herman Adrien Denis Julien Sapin Daniel Galinski Audrey Riga Patrice Laloux Benoît Bihin Yves Vandermeeren | 2021 | Neural Regeneration Research2021，16，8： | 3 |
| 2 | Indirect comparison of clobazam and other therapies for Lennox-Gastaut syndrome显示文摘 | Cramer JA Sapin C Francois C | 2013 | Acta Neurol Scand2013，128，2： | 1 |
| 3 | Frequency, risk factors, and outcome of hyperlactatemia in HIV-positive persons: implications for the management of treated patients显示文摘 | Vincent Sapin | 2003 | Clinical Chemistry2003，49，： | 1 |
| 4 | Insulin measurements in haemolysed serum: influence of insulinase inhibitors 显示文摘 | Sapin R Ongagna JC Gasser F | 1998 | Clin Chim Acta1998，274，1： | 1 |
| 5 | comparison of two- and three-dimensional echocardiography with cineventriculography for measurement of left ventricular volume in patients 显示文摘 | SAPIN P M SCHRODER K M GOPAL A S | 1994 | J Am Coll Cardiol1994，24，5： | 1 |
| 6 | Low molecular weight heparin gels, based on nanoparticles, for topical delivery 显示文摘 | LOIRA P C SAPIN M A DIAB R | 2012 | Int J Pharm2012，426，12： | 1 |
| 7 | Implication of inferior ST-segment elevation accompanying anterior wall acute myocardial infarction for the angiographic morphology of the left anterior descending coronary artery morphology and site of occlution显示文摘 | Sapin PM Musselman DR Dehmer GL | 1992 | Am J Cardiol1992，69，9： | 1 |
| 8 | Importance of bile acids for infra-hepatic cholestasis of pregnancy显示文摘 | Favre N Bourdel N Sapin V | | Gynecologie Obstetrique and Fertilite0，，： | 1 |
| 9 | Evaluation of Elecsys free triiodothyronine assay: relevance of age-related reference ranges显示文摘 | Sapin R Schlienger JL Goichot B | 1998 | Clin Biochem1998，31，： | 1 |
| 10 | Seismic anisotropy as an indicator of mantle flow beneath the Himalayas and Tibet 显示文摘 | HIRN A JIANG M SAPIN M | 1995 | Nature1995，375，： | 1 |
| 11 | Insulin measurements in haemolysed serum:influence of insulinase inhibltors显示文摘 | Sapin R Ongagna JC Gasser F | 1998 | Clin Chim Acta1998，274，1： | 1 |
| 12 | Interference of hemolysis and hemoglobin: example of insulin assay显示文摘 | Sapin R | 2001 | Ann Biol Clin2001，59，1： | 1 |
| 13 | Apparent Young's modulus of vertebral cortico-cancellous bone specimens显示文摘 | El Masri F Sapin de Brosses E Rhissassi 1( | 2012 | Comput Methods Biomech Biomed Engin2012，15，1： | 1 |
| 14 | Insulin assays:previously known and new analytical features显示文摘 | Sapin R | 2003 | Clin Lab2003，49，34： | 1 |
| 15 | Seismic anisotropy as an indicator of mantle flow beneath the Himalayas and Tibet显示文摘 | Hirn A Jiang M Sapin M | 1995 | Nature1995，375，： | 1 |
| 16 | Trophoblastic remodeling in normal and preeclamptic pregnancies: implication of cytokines显示文摘 | Kharfi A Giguere Y Sapin V | 2003 | Clin Biochem2003，36，5： | 1 |
| 17 | MD-2 controls bacterial lipopo- lysaccharide hyporesponsiveness in human intestinal epithelial cells 显示文摘 | Lenoir C Sapin C Broquet AH | 2008 | Life Sci2008，82，910： | 1 |
| 18 | Modeling,simulation, and test of a three-level vohage-source inverter with output LC filter and direct torque control显示文摘 | SAPIN A STEIMER P K SIMOND J J | 2007 | IEEE Transactions on Industry Applications2007，43，2： | 1 |
| 19 | Insulin measurements in haemolysed serum:influence of insulinase inhibitors显示文摘 | Sapin R Ongagna JC Gasser F | 1998 | Clin Chim Acta1998，8274，1： | 1 |
| 20 | MD-2 controls bacterial lipopolysaccharide hyporesponsiveness in human intestinal epithelial cells 显示文摘 | Lenoir C Sapin C Broquet AH | 2008 | Life Sci2008，82，910： | 1 |
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