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45篇 您的检索式：作者名="Lecube"

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	题名	作者	年代	出处	被引量
1	通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients.	Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe	2012	World Journal of Hepatology2012，4，12：	6
2	Effect of glycemic control on nocturnal arterial oxygen saturation: A case‐control study in type 2 diabetic patients 血糖控制对夜间动脉血氧饱和度的影响:一项2型糖尿病患者的病例对照研究显示文摘	Albert Lecube Andreea Ciudin Gabriel Sampol Silvia Valladares Cristina Hernández Rafael Simó	2015	Journal of Diabetes2015，，：	2
3	High prevalence of jlucose abnortnelities in patients with hepatitis C virus infection:a multivariate analysis cons idering the liver ingury显示文摘	Lecube A Hemandez C Jenesca J	2004	Diabetes2004，27，5：	1
4	Diabetes is the main factor accounting for the high ferritin levels detected in chronic hepatitis C virus infection 显示文摘	Lecube A Jardi R Hernandez C	2004	Diatebes Care2004，27，：	1
5	Free insulin growth factor-Ⅰ and vascular endothelial growth factor in the vitreous fluid of patients with proliferative diabetic retinopathy显示文摘	Simo R Lecube A Segura RM	2002	Am J Ophthalmol2002，134，：	1
6	Soluble transferrin receptors and ferritin in Type 2 diabetic patients显示文摘	Hem a ndez C Lecube A Carrera A	2005	Diabetes Med2005，22，：	1
7	High prevalence of glucose abnormalities in patients with hepatitis C virus infection: a multivariate analysis considering the liver injury 显示文摘	Lecube A Hemandez C Genesca J	2004	Diabetes Care2004，27，5：	1
8	Lymphocytic hypophysitis successfully treated with azathioprine: first case report显示文摘	Lecube A Francisco G Rodriguez D	2003	J Neurol Neurosurg Psychiatry2003，74，11：	1
9	Sustained virological response correlates with reduction in the incidence of glucose abnormalities in patients with chronic hepatitis C virus infection显示文摘	SIMO R LECUBE A GENESCA J	2006	Diabetes Care2006，29，11：	1
10	Glucose abnormalities in patients with hepatitis C virus infection: epidemiology and pathogenesis显示文摘	LECUBE A HERNANDEZ C GENESCA J	2006	Diabetes Care2006，29，7：	1
11	Deficit of somatostatin-like immunoreactivity in the vitreous fluid of diabetic patients:possible role in the development of proliferative diabetic retinopathy显示文摘	Simo R Lecube A Sararols L	2002	Diabetes Care2002，25，12：	1
12	V804M RET mutation and familial medullary thyroid carcinoma:report of a large family with expression of the disease only in the homozygous gene carriers显示文摘	Lecube A Hernandez C Oriola J	2002	Surgery2002，131，：	1
13	Lower zinc-alpba2-gly- coprotein production by adipose tissue and liver in obese patients un-related to insulin resistance显示文摘	Selva DM Lecube A Hernandez C	2009	Journal of Clinical Endocrinology & Metabolism2009，94，11：	1
14	Iron Deficiency in obese postmenopausal women显示文摘	LECUBE A CARRERA A LOSADA E	2006	Obesity (Silver Spring)2006，14，10：	1
15	Lower zinc-a2- glycoprotein production by adipose tissue and liver in obese patients unrelated to insulin resistance显示文摘	Selva DM Lecube A Hernardez C	2009	J Cli Endocrinol Meta2009，94，11：	1
16	Factors accounting for high ferritin levels in obesity 显示文摘	LECUBE A HEMANDEZ C PELEGN D	2008	Int J Obes2008，32，11：	1
17	Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity:relationship with glucose abnormalities显示文摘	Miranda M Ceperuelo-Mallafre V Lecube A	2009	Metabolism2009，58，12：	1
18	Lymphocytic hypophysitis successfully treated with azathioprine: first case report显示文摘	Lecube A Francisco G Rodriguez D	2003	J Neurol Neurosurg Psychiatry2003，74，11：	1
19	Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity: relationship with glucose abnomlalities显示文摘	Miranda M Ceperuelo-Mallafre V Lecube A	2009	Metabolism2009，58，12：	1
20	High prevalence of glucose abnormalities in patients with hepatitis C virus infection: a multivariate analysis considering the liver injury 显示文摘	LECUBE A HERNANDEZ C GENESCA J	2004	Diabetes Care2004，27，5：	1

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