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| 1 | Colorectal cancer in inflammatory bowel disease:What is the real magnitude of the risk?显示文摘The association between inflammatory bowel disease(IBD) and colorectal cancer(CRC) has been recognised since 1925 and still accounts for 10%-15% of deaths in IBD.IBD-associated CRC(IBD-CRC) affects patients at a younger age than sporadic CRC.The prognosis for sporadic CRC and IBD-CRC is similar,with a 5-year survival of approximately 50%.Identifying at risk patients and implementing appropriate surveillance for these patients is central to managing the CRC risk in IBD.The increased risk of colorectal cancer in association with IBD is thought to be due to genetic and acquired factors.The link between inflammation and cancer is well recognised but the molecular biology,immune pathobiology and genetics of IBD-CRC are areas of much ongoing research.This review examines the literature relating to IBD-CRC,focusing on the incidence of IBD-CRC and examining potential risk factors including age at diagnosis,gender,duration and extent of colitis,severity of inflammation,family history of sporadic CRC and co-existent primary sclerosing cholangitis(PSC).Confirmed risk factors for IBD-CRC are duration,severity and extent of colitis,the presence of co-existent PSC and a family history of CRC.There is insufficient evidence currently to support an increased frequency of surveillance for patients diagnosed with IBD at a younger age.Evidence-based guidelines advise surveillance colonoscopy for patients with colitis 8 to 10 years after diagnosis,with the interval for further surveillance guided by risk factors(extent of disease,family history of CRC,post-inflammatory polyps,concomitant PSC,personal history of colonic dysplasia,colonic strictures).There is a move away from using random colonic biopsies towards targeted biopsies aimed at abnormal areas identified by newer colonoscopic techniques(narrow band imaging,chromoendoscopy,confocal microendoscopy). | Jessica K Dyson Matthew D Rutter | 2012 | World Journal of Gastroenterology2012，18，29： | 22 |
| 2 | European evidence based consensus for endoscopy in inflammatory bowel disease显示文摘 | Vito Annese Marco Daperno Matthew D. Rutter Aurelien Amiot Peter Bossuyt James East Marc Ferrante Martin G?tz Konstantinos H. Katsanos Ralf Kie?lich Ingrid Ordás Alessandro Repici Bruno Rosa Shaji Sebastian Torsten Kucharzik Rami Eliakim | 2013 | Journal of Crohn’s and Colitis2013，，12： | 7 |
| 3 | Surveillance of colonic polyps:are we getting it right?显示文摘Colorectal cancer(CRC) is the third most commonly diagnosed cancer worldwide. The identification of colonic polyps can reduce CRC mortality through earlier diagnosis of cancers and the removal of polyps: the precursor lesion of CRC. Following the finding and removal of colonic polyps at an initial colonoscopy, some patients are at an increased risk of developing CRC in the future. This is the rationale for postpolypectomy surveillance colonoscopy. However, not all individuals found to have colonic adenomas have a risk of CRC higher than that of the general population. This review examines the literature on post-polypectomy surveillance including current international clinical guidelines. The potential benefits of surveillance procedures must be weighed against the burden of colonoscopy: resource use, the potential for patient discomfort, and the risk of complications. Therefore surveillance colonoscopy is best utilised in a selected group of individuals at a high risk of developing cancer. Further study is needed into the specific factors conferring higher risk as well as the efficacy of surveillance in mitigating this risk. Such evidence will better inform clinicians and patients of the relative benefits of colonoscopic surveillance for the individual. In addition, the decision to continue with surveillance must be informed by the changing profile of risks and benefits of further procedures with the patient's advancing age. | Stewart N Bonnington Matthew D Rutter | 2016 | World Journal of Gastroenterology2016，22，6： | 6 |
| 4 | Quality in screening colonoscopy: position statement of the European Society of Gastrointestinal Endoscopy (ESGE)显示文摘 | B. Rembacken C. Hassan J. Riemann A. Chilton M. Rutter J.-M. Dumonceau M. Omar T. Ponchon | 2012 | Endoscopy2012，，10： | 3 |
| 5 | Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests显示文摘 | Richard F A Logan Julietta Patnick Claire Nickerson Lynn Coleman Matt D Rutter Christian von Wagner | 2012 | Gut2012，，10： | 2 |
| 6 | Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis显示文摘 | Matthew Rutter Brian Saunders Kay Wilkinson Steve Rumbles Gillian Schofield Michael Kamm Christopher Williams Ashley Price Ian Talbot Alastair Forbes | 2004 | Gastroenterology2004，，： | 2 |
| 7 | Thirty-Year Analysis of a Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis显示文摘 | Matthew D. Rutter Brian P. Saunders Kay H. Wilkinson Steve Rumbles Gillian Schofield Michael A. Kamm Christopher B. Williams Ashley B. Price Ian C. Talbot Alastair Forbes | 2006 | Gastroenterology2006，，： | 2 |
| 8 | ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic β-cells显示文摘 | Xavier G S Rutter G A Diraison F | 2006 | J Lip Res2006，11，47： | 1 |
| 9 | Theassociation of comorbid depression with mortality in patients withtype 2 diabetes显示文摘 | Katon Wayne J Rutter Carolyn PHD Simon Greg MD | 2005 | Diabetes Care2005，28，11： | 1 |
| 10 | In situ phytoextraction of polychlorinated biphenyl (PCB) contaminated soil显示文摘 | ASLUND M L W ZEEB B A RUTTER A | 2007 | Sci Total Environ2007，374，1： | 1 |
| 11 | Scattering and interference in epitaxial grapheme显示文摘 | Rutter G M Crain J N Stroscio J A | 2007 | Science2007，317，： | 1 |
| 12 | Regulation of CLOCK and NPAS2DNA binding by the redox state of NAD cofactors显示文摘 | Rutter J Reick M Wu L C W | 2001 | Science2001，293，： | 1 |
| 13 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 14 | Insulin- stimulated fatty acid synthase gene expression does not require increased sterol response element binding protein 1 transcription in primary adipoeytes显示文摘 | PALMER D G RUTTER G A TAVARE J M | 2002 | Biochem Bio- ph Res Commun2002，291，3： | 1 |
| 15 | Psychosocial resilience and protective mechanisms显示文摘 | Rutter M | | 0，，03： | 1 |
| 16 | Assessment of hunger in growing broiler breeders in relation to a commercial restricted feeding programme 显示文摘 | Savory C J Maros K Rutter S M | 1993 | Anim Welf1993，2，： | 1 |
| 17 | Emotion and adherence to treatment in people with asthma: An application of theemotional Stroop paradigm显示文摘 | Donna C Jessop DR Rutter | 2004 | Br J Psychology2004，95，2： | 1 |
| 18 | Interstitial collagenases as markers of tumor progression显示文摘 | Brinckerhoff CE Rutter JL Benbow U | 2000 | Clin Cancer Res2000，6，12： | 1 |
| 19 | Influence of rare earth metals on the nucleation and solidification behavior of iron and 1045 steel显示文摘 | Li H McLean A Rutter J W and Sommerville I D | 1988 | Metallurgical Transactions B1988，19，3： | 1 |
| 20 | Fasting glucose,obesity,and coronary artery calcification in community-based people without diabetes显示文摘 | Rutter MK Massaro JM Hoffmann U | 2012 | Diabetes Care2012，5，9： | 1 |
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