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| 1 | Inpatient capsule endoscopy leads to frequent incomplete small bowel examinations显示文摘AIM:To examine the predictive factors of capsule endoscopy(CE) completion rate(CECR) including the effect of inpatient and outpatient status.METHODS:We identified 355 consecutive patients who completed CE at Rush University Medical Center between March 2003 and October 2005.Subjects for CE had either nothing by mouth or clear liquids for the afternoon and evening of the day before the procedure.CE exams were reviewed by two physicians who were unaware of the study hypotheses.After retrospective analysis,21 cases were excluded due to capsule malfunction,prior gastric surgery,endoscopic capsule placement or insufficient data.Of the remaining 334 exams [264 out-patient(OP),70 in-patient(IP)],CE indications,findings,location of the patients [IP vs OP and intensive care unit(ICU) vs general medical floor(GMF)] and gastrointestinal transit times were analyzed.Statistical analysis was completed using SPSS version 17(Chicago,IL).Chi-square,t test or fisher exact-tests were used as appropriate.Multivariate logistic regression analysis was used to identify variables associated with incomplete CE exams.RESULTS:The mean age for the entire study population was 54.7 years.Sixty-one percent of the study population was female,and gender was not different between IPs vs OPs(P = 0.07).The overall incomplete CECR was 14% in our study.Overt obscure gastrointestinal bleeding(OGB) was a significantly more common indication for the IP CE(P = 0.0001),while abdominal pain and assessment of IBD were more frequent indications for the OP CE exams(P = 0.002 and P = 0.01,respectively).Occult OGB was the most common indication and arteriovenous malformations were the most common finding both in the IPs and OPs.The capsule did not enter the small bowel(SB) in 6/70 IPs and 8/264 OPs(P = 0.04).The capsule never reached the cecum in 31.4%(22/70) of IP vs 9.5%(25/264) of OP examinations(P < 0.001).The mean gastric transit time(GTT) was delayed in IPs compared to OPs,98.5 ± 139.5 min vs 60.4 ± 92.6 min(P = 0.008).Minimal SB transit time was significantly prolonged in the IP compared to the OP setting [IP = 275.1 ±111.6 min vs OP = 244.0 ± 104.3 min(P = 0.037)].CECR was also significantly higher in the subgroup of patients with OGB who had OP vs IP exams(95% vs 80% respectively,P = 0.001).The proportion of patients with incomplete exams was higher in the ICU(n = 7/13,54%) as compared to the GMF(n = 15/57,26%)(P = 0.05).There was only a single permanent SB retention case which was secondary to a previously unknown SB stricture,and the remaining incomplete SB exams were due to slow transit.Medications which affect gastrointestinal system motility were tested both individually and also in aggregate in univariate analysis in hospitalized patients(ICU and GMF) and were not predictive of incomplete capsule passage(P > 0.05).Patient location(IP vs OP) and GTT were independent predictors of incomplete CE exams(P < 0.001 and P = 0.008,respectively).CONCLUSION:Incomplete CE is a multifactorial problem.Patient location and related factors such as severity of illness and sedentary status may contribute to incomplete exams. | Cemal Yazici John Losurdo Michael D Brown Scott Oosterveen Robert Rahimi Ali Keshavarzian Leila Bozorgnia Ece Mutlu | 2012 | World Journal of Gastroenterology2012，18，36： | 6 |
| 2 | CALUX生物学检测二噁方法在环境流行病学调查中的应用显示文摘目的探讨Chemically-ActivatedLuciferaseeXpression(CALUX)生物学方法作为检测二的一种方法在环境流行病学调查中的实用性。方法分别采用高分辨率气相色谱和质谱仪联机(HRGC-MS)法和CALUX方法测定同一来源的人体脂肪、血液和母乳中二毒性当量,观察两种不同方法测定结果间的相关性。结果两种方法测定脂肪组织和母乳中二毒性当量结果之间的相关系数分别为0.8675和0.9581,具有显著的正相关关系(P<0.05)。二毒性当量>20pg/gfat的血液样品,两种方法测定结果之间也具有密切的相关关系(P<0.05或<0.01)。结论CALUX生物学方法可适用于一般人群的脂肪组织和乳汁样品以及二类暴露人群的血液中二类污染物的筛查。 | 金一和 陈慧池 唐慧君 金秀花 刘惠芳 李珍 香山不二雄 滨松昌彦 匂坂馨 Brown D Clark G 中村昌文 | 2003 | 环境与健康杂志2003，20，3： | 6 |
| 3 | 高热致胚胎发育毒性机理的研究——热休克蛋白合成显示文摘按Kimmel实验条件热暴露孕10天大鼠。暴露后2小时取胚胎用^(35)S—蛋氨酸标记,SDS—PAGE蛋白分析,可见70和90KilodaltonKD热休克蛋白合成增加。70KD HSP合成用Westernblot分析又进一步得到证实。离体培养胚胎热暴露后,用同样方法分析蛋白,证实70和90KD HSPs合成增加。结果与Kimmel骨骼畸形和胚胎体节融合发生率相符合。本结果为German提出的环境致畸机理假说提供了依据。 | 芦春林 C A Kimmel G L Kimmel D J Heredia B R Fisher N T Brown | 1993 | 北京医科大学学报1993，25，6： | 4 |
| 4 | 评估超高温灭菌奶安全和质量的2个重要参数显示文摘使用了一套电子程序表格,用于评估在连续热交换器中经过不同升温和降温处理后牛奶的安全和质量参数。安全参数包括致死率F0值、微生物灭活B*值;质量参数包括化学变化C*值、硫胺素损失量、乳果糖生成量、美拉德褐变及羟甲基糠醛值等。在牛奶中试加工车间中,利用升温和降温的温度变化数值可对牛奶的上述参数进行预测,温度范围为120~150℃,时间包括4、27和58 s。在同一中试车间按上述条件对牛奶进行加工,并选择一系列牛奶样品对该电子程序进行校正。结果表明,所有C*〈3的牛奶样品阿沙芬堡浊度都呈阳性。在乳果糖活化能等于122 k J/mol时,预测值和试验观测值一致性最好。最佳质量终产品对应的牛奶加工条件为135℃/10 s,此时B*=1.24,C*=0.55。在此条件下加工的牛奶与其它2个牛奶相比,感官特性与C*=1.5对应条件下加工的牛奶类似,但与C*=6对应条件下加工的牛奶不同。牛奶刚加工完成时,仅热处理非常强烈的样品有可见的褐变,若在≥30℃条件下存储,褐变会变得比较明显。该电子程序可以用来比较不同热处理模式下生产产品的特性;或作为一种手段,用于在升温和降温速率固定的情况下UHT设备运行条件的优化。 | 陈美霞 Browning E Lewis M Macdougall D | 2016 | 中国乳业2016，，5： | 3 |
| 5 | The rationale behind complete mesocolic excision (CME) and a central vascular ligation for colon cancer in open and laparoscopic surgery显示文摘 | K. S?ndenaa P. Quirke W. Hohenberger K. Sugihara H. Kobayashi H. Kessler G. Brown V. Tudyka A. D’Hoore R. H. Kennedy N. P. West S. H. Kim R. Heald K. E. Storli A. Nesbakken B. Moran | 2014 | International Journal of Colorectal Disease2014，，4： | 3 |
| 6 | Computing the Lyapunov spectrum of a dynamical system from an observed time series显示文摘 | Brown R Bryant P Abarbanel D I | 1991 | Physical Review A1991，43，3： | 3 |
| 7 | Quality Improvement Guidelines for the Treatment of Lower Extremity Deep Vein Thrombosis with Use of Endovascular Thrombus Removal显示文摘 | Suresh Vedantham Patricia E. Thorpe John F. Cardella Clement J. Grassi Nilesh H. Patel Hector Ferral Lawrence V. Hofmann Bertrand M. Janne d’Othée Vittorio P. Antonaci Elias N. Brountzos Daniel B. Brown Louis G. Martin Alan H. Matsumoto Steven G. Meranze | 2006 | Journal of Vascular and Interventional Radiology2006，，3： | 3 |
| 8 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 9 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 10 | Variation in fibre diameter profile characteristics between wool staple in Merino sheep 显示文摘 | Brown D J Crook B J Purvis I W | 2000 | Wool Technology and Sheep Breeding2000，，48： | 2 |
| 11 | Myosin binding protein C:Structural abnormalities in familial hypertrophic cardiomyopathy显示文摘The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insight into the intricate workings of this protein in the heart. While some regions of the MyBPC molecule have been assigned a function in the regulation of muscle contraction, the interaction of other regions with various parts of the myosin molecule and the sarcomeric proteins, actin and titin, remain obscure. In additic n, several intra-domain interactions between adjacent MyBPC molecules have been identified. Although the basic structure of the molecule (a series of immunoglobulin and fibronectin domains) has been elucidated, the assembly of MyBPC in the sarcomere is a topic for debate. By analysing the MyBPC sequence with respect to FHC-causing mutations it is possible to identify individual residues or regions of each domain that may be important either for binding or regulation. This review looks at the current literature, in concert with alignments and the structural models of MyBPC, in an attempt to understand how FHC mutations may lead to the disease state. | Cecily E OAKLEY Brett D HAMBLY Paul MG CURMI Louise J BROWN | 2004 | Cell Research2004，14，2： | 2 |
| 12 | Immobilisation of TiO2 powder for the treatment of polluted water显示文摘 | BYME J A EGGINS B R BROWN N M D | 1998 | Appl Catal B1998，17，： | 2 |
| 13 | Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence显示文摘 | Juan C. Acosta Ana O’Loghlen Ana Banito Maria V. Guijarro Arnaud Augert Selina Raguz Marzia Fumagalli Marco Da Costa Celia Brown Nikolay Popov Yoshihiro Takatsu Jonathan Melamed Fabrizio d’Adda di Fagagna David Bernard Eva Hernando Jesús Gil | 2008 | Cell2008，，6： | 2 |
| 14 | Glucose requirement for morula to blastocyst transition during culture of 1-cell F2 hybrid mouse embryos 显示文摘 | Brown J J G Whitingham D G | 1990 | J Reprod Fertile1990，521，： | 2 |
| 15 | A comparative chemical and serological study of the full and particles of foot-and-mouth disease virus 显示文摘 | Rowlands D J Sangar D V Brown F | 1975 | J Gen Virol1975，26，： | 2 |
| 16 | The importance of dietary polyamines in cell regeneration and growth显示文摘 | Bardocz S Grant G Brown D S | 1995 | British Journal of Nutrition1995，73，： | 2 |
| 17 | 多聚酶链式反应测定慢性乙型肝炎患者经α—干扰...显示文摘 | Brown,D 徐建业 | 1992 | 中华内科杂志1992，31，5： | 2 |
| 18 | Steady State plasma- noradrenaline kinetics in quadriplegic chronic spinal cordinjury patients 显示文摘 | Krum H Brown D J Rowe P R | 1990 | J Auton Pharmacol1990，10，4： | 1 |
| 19 | Conflict and Power-Dependence Relations in Retailer-Supplier Channels 显示文摘 | James R Brown Robert F Lusch and Darrel D Muehling | 1983 | Journal of Retailing1983，59，4： | 1 |
| 20 | Effective interventions for lifestyle change after myocardial infarction or coronary artery revascularization显示文摘 | COBB S L BROWN D J DAVIS L L | 2006 | J Am Acad Nurs Pract2006，18，1： | 1 |
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