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| 1 | Chemotherapy for hepatocellular carcinoma:The present and the future显示文摘Hepatocellular carcinoma(HCC) is the most common primary tumor of the liver. Its relationship to chronic liver diseases, in particular cirrhosis, develops on a background of viral hepatitis, excessive alcohol intake or metabolic steatohepatitis, leads to a high incidence and prevalence of this neoplasia worldwide. Despite the spread of HCC, its treatment it's still a hard challenge, due to high rate of late diagnosis and to lack of therapeutic options for advanced disease. In fact radical surgery and liver transplantation, the most radical therapeutic approaches, are indicated only in case of early diagnosis. Even local therapies, such as transarterial chemoembolization, find limited indications, leading to an important problem regarding treatment of advanced disease. In this situation, until terminal HCC occurs, systemic therapy is the only possible approach, with sorafenib as the only standard treatment available. Anyway, the efficacy of this drug is limited and many efforts are necessary to understand who could benefit more with this treatment. Therefore, other molecules for a targeted therapy were evaluated, but only regorafenib showed promising results. Beside molecular target therapy, also cytotoxic drugs, in particular oxaliplatinand gemcitabine-based regimens, and immune-checkpoint inhibitors were tested with interesting results. The future of the treatment of this neoplasia is linked to our ability to understand its mechanisms of resistance and to find novel therapeutic targets, with the objective to purpose individualized approaches to patients affected by advanced HCC. | Marco Le Grazie Maria Rosa Biagini Mirko Tarocchi Simone Polvani Andrea Galli | 2017 | World Journal of Hepatology2017，9，21： | 11 |
| 2 | Changes in squalene and sterols associated with olive maturation显示文摘 | A. Fernández-Cuesta L. León L. Velasco R. De la Rosa | 2013 | Food Research International2013，，2： | 1 |
| 3 | Bioactive peptides in amaranth (Amaranthus hypochondriacus) seed显示文摘 | Silva-Sa'nchez C de la Rosa A P León-Galván M F | 2008 | J Agric Food Chem2008，56，4： | 1 |
| 4 | Interleukin-27R (WSX- lff-cell cytokine receptor) gene-deficient mice display enhanced resistance to Leishmania donovani infection but develop severe liv- er immunopathology显示文摘 | Rosas LE Satoskar AA Roth KM et O1 | 2006 | Am J Pathol2006，168，1： | 1 |
| 5 | Action of propolis and medications against Escherichia coli and endotoxin in root canals显示文摘 | Valera MC da Rosa JA Maekawa LE | | 0，，04： | 1 |
| 6 | Oral lichen planus: clinical and his- topathological considerations 显示文摘 | Sousa FA Rosa LE | 2008 | Braz Otorhinolaryngol2008，74，2： | 1 |
| 7 | Macrophage migration inhibitory factor plays a critical role in mediating pro- tection against the helminth parasite Taenia crassiceps 显示文摘 | Rodriguez-Sosa M Rosas LE David JR et ol | 2003 | Infect Immun2003，71，3： | 1 |
| 8 | Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani显示文摘 | Rosas LE Snider HM Barbi J | 2006 | J Immunol2006，177，4： | 1 |
| 9 | Expression pattern of claudins 1and 3-an auxiliary tool in predicting behavior of mucoepidermoidcarcinoma of salivary gland origin显示文摘 | Aro K Rosa LE Bello IO | 2011 | Virchows Arch2011，458，3： | 1 |
| 10 | Patterns of scAAV vector insertion associated with oncogenic events in a mouse model for genotoxicity显示文摘 | Rosas LE Grieves JL Zaraspe K | 2012 | Mol Ther2012，20，11： | 1 |
| 11 | Time-related increase of staphylococci,Enterobacteriaceae and yeasts in the oral cavities of comatose patients显示文摘 | Cecon F Ferre ra LE Rosa RT | 2010 | J Microbiol Immunol Infect2010，43，6： | 1 |
| 12 | Physiological ischemia/reperfusion phenomena and their relation to endogenous melatonin production显示文摘 | Dun-Xian Tan Lucien C. Manchester Rosa M. Sainz Juan C. Mayo Josefa León Russel J. Reiter | 2005 | Endocrine2005，，2： | 1 |
| 13 | Oral lichen planus:clinical and histopathological considerations显示文摘 | Sousa FA Rosa LE Braz J | 2008 | Otorhinolargngol2008，74，2： | 1 |
| 14 | Morphometric study of nucleolar organiser regions in ameloblastoma and basal cell car- cinoma显示文摘 | ROSA LE JAEGER MM JAEGER RG | 1997 | Oral Oncol1997，33，3： | 1 |
| 15 | Bioactive peptides in amaranth(Amaranthus hypochondriacus)seed显示文摘 | SILVA-SNCHEZ C ROSA A P B D L LEN-GALVN M F | 2008 | Agric Food Chem2008，56，4： | 1 |
| 16 | Optimization of human interferon gamma production in Escherichia coli by response surface methodology显示文摘 | Victor E. Balderas Hernández Luz M. T. Paz Maldonado Emilio Medina Rivero Ana P. Barba de la Rosa Leandro G. Ordo?ez Acevedo Antonio León Rodríguez | 2008 | Biotechnology and Bioprocess Engineering2008，，1： | 1 |
| 17 | A novel binary expression vector for production of human IL-10 in Escherichia coli and Bifidobacterium longum显示文摘 | M. L. Reyes Escogido A. León Rodríguez A. P. Barba de la Rosa | 2007 | Biotechnology Letters2007，，8： | 1 |
| 18 | Action of propolis and medications against Escherichia coli and endotoxin in root canals 显示文摘 | Valera MC da Rosa JA Maekawa LE | 2010 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2010，110，4： | 1 |
| 19 | Interleukin-27R (WSX-1/ T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immu-nopathology显示文摘 | Rosas LE SatoskarAA Roth KM | 2006 | Am J Pathol2006，168，1： | 1 |
| 20 | Biodiversity and ecosystem services science for a sustainable planet:the DIVERSITAS vision for 2012-20显示文摘 | Larigauderie A Prieur-Richard AH Mace GM Lonsdale M Mooney HA Brussaard L Cooper D Cramer W Daszak P Diaz S Duraiappah A Elmqvist T Faith DP Jackson LE Krug C Leadley PW Le Prestre P Matsuda H Palmer M Perrings C Pulleman M Reyers B Rosa EA Scholes RJ Spe | | 0，，： | 1 |
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