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| 1 | Cardioprotection and pharmacological therapies in acute myocardial infarction: Challenges in the current era显示文摘In patients with an acute ST-segment elevation myocardial infarction, timely myocardial reperfusion using primary percutaneous coronary intervention is the most effective therapy for limiting myocardial infarct size, preserving left-ventricular systolic function and reducing the onset of heart failure. Within minutes after the restoration of blood flow, however, reperfusion itself results in additional damage, also known as myocardial ischemia-reperfusion injury. An improved understanding of the pathophysiological mechanisms underlying reperfusion injury has resulted in the identification ofseveral promising pharmacological(cyclosporin-A, exenatide, glucose-insulin-potassium, atrial natriuretic peptide, adenosine, abciximab, erythropoietin, metoprolol and melatonin) therapeutic strategies for reducing the severity of myocardial reperfusion injury. Many of these agents have shown promise in initial proofof-principle clinical studies. In this article, we review the pathophysiology underlying myocardial reperfusion injury and highlight the potential pharmacological interventions which could be used in the future to prevent reperfusion injury and improve clinical outcomes in patients with coronary heart disease. | Alberto Dominguez-Rodriguez Pedro Abreu-Gonzalez Russel J Reiter | 2014 | World Journal of Cardiology2014，6，3： | 18 |
| 2 | Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats显示文摘瞄准:决定 melatonin 预告的处理的效果并且在 L 精氨酸(L-Arg ) 的严厉上处理以后在老鼠的导致的试验性的胰腺炎。方法:男 Wistar 老鼠(25 ) 被划分成五个组。那些在 1h 的间隔在组 A 收到了 3.2g/kg 体重 L-Arg i.p 的二注射。在组麻省,老鼠与 50 mg/kg 体重 melatonin i.p 被对待在 L-Arg 管理以前的 30 min。在组 AM,在 L-Arg 被给以后,老鼠收到了 melatonin 1h 的一样的剂量。在组 M, melatonin 的单次量是以前描述了被管理。在组 C,对照动物收到了生理盐水注射 i.p 所有老鼠被给在第二 L-Arg 注射以后的 24 h。结果:引起严重引起坏死胰腺炎的 L-Arg 管理在浆液淀粉酶水平,胰腺的重量 / 身体重量比率(pw/bw ) ,胰腺的 IL-6 内容和 myeloperoxidase 由重要举起证实了活动,相对控制值。浆液淀粉酶水平的举起显著地在与仅仅与 L-Arg 注射的老鼠相比给 melatonin 追随者 L-Arg 的老鼠被减少。胰腺的抗氧化剂酶(Cu/Zn-superoxide 歧化酶(Cu/Zn-SOD ) 和过氧化氢酶(猫)) 的活动显著地被增加在胰腺炎以后的 24 h 感应。显著地在 L-Arg 之前给的 Melatonin 在独自与 L-Arg 对待的老鼠相对那减少了胰腺的猫活动。在肝, L-Arg 显著地每氧化水平,和谷胱甘肽过氧化物酶和 Cu/Zn-SOD 活动增加了类脂化合物,而 Mn 草皮活动作为与控制老鼠相比被减少。Melatonin 预告的处理阻止了这些变化。结论:Melatonin 是能在尖锐胰腺炎期间抵抗一些 L-Arg-induced 变化的一种抗氧化剂,并且可能因此在有尖锐引起坏死胰腺炎的病人的支持的治疗有用。 | Annamaria Szabolcs Russel J Reiter Tamas Letoha Peter Hegyi Gabor Papai Ilona Varga Katalin Jarmay Jozsef Kaszaki Reka Sari Zoltan Rakonczay Jr Janos Lonovics Tamas Takacs | 2006 | World Journal of Gastroenterology2006，12，2： | 13 |
| 3 | Ti64合金的电子束冷床熔炼研究(英文)显示文摘电子束冷床熔炼工艺作为一种新熔炼技术,可应用于生产航空发动机转动件用优质钛合金和回收残钛。利用500kW电子束冷床熔炼设备,研究了熔炼速度与Ti64合金铸锭化学成分和TiN夹杂溶解速度的关系。熔炼速度分别为70,100,140kg/h时,Al挥发损失分别为22%、16%、12%。经超声探伤,在熔炼电极中加入的TiN夹杂能够全部消除。所熔炼的铸锭外部是均匀的柱状晶粒,心部是细小的晶粒。 | 张英明 周廉 孙军 韩明臣 Georg Reiter Jochen Flinspach 杨建朝 赵永庆 | 2008 | 稀有金属材料与工程2008，37，11： | 12 |
| 4 | 电子束冷床熔炼参数对熔池表面温度的影响显示文摘使用M9100图像高温仪精确测定了TC4合金电子束冷床熔炼时坩埚和冷床熔池表面的温度。结果表明,结果表明,熔炼工艺参数如熔化速度、熔炼功率、电子束扫描方式和扫描频率都会对熔池表面温度产生剧烈影响。 | 韩明臣 周义刚 赵铁夫 张英明 周廉 Reiter G. Flinspach J. | 2006 | 稀有金属2006，30，z1： | 10 |
| 5 | Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia显示文摘AIM:To evaluate blood concentration of melatonin and urinary excretion of its metabolite,6-sulfatoxymelatonin(6-OHMS),in functional dyspepsia(FD).METHODS:Ninety individuals were enrolled in the study:30 in each study group:patients with postprandial distress syndrome(PDS),epigastric pain syndrome(EPS),and controls.Blood samples were drawn at 02:00 and 09:00 h and 24-h urine collection was performed.Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay.RESULTS:Serum melatonin concentration at night and in the morning was significantly(P < 0.001) higher in PDS patients [at 02:00 h-93.3 pg/mL,quartile range(QR):79.8-116.2;at 09.00 h-14.3 pg/mL,QR:7.06-19.0] than in EPS(57.2 pg/mL,QR:42.6-73.1;8.1 pg/mL,QR:4.1-9.3) and control patients(57.7 pg/mL,QR:51.2-62.5;8.1 pg/mL,QR:5.4-10.3).A similar relationship was observed for urinary 6-OHMS excretion.Patients with severe PDS symptoms had a higher melatonin concentration than these with moderate syndromes,whereas patients with severe EPS had a lower urinary 6-OHMS excretion than patients with moderate symptoms.CONCLUSION:Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD. | Cezary Chojnacki Tomasz Poplawski Grazyna Klupinska Janusz Blasiak Jan Chojnacki Russel J Reiter | 2011 | World Journal of Gastroenterology2011，17，21： | 8 |
| 6 | Evaluation of enterochromaffin cells and melatonin secretion exponents in ulcerative colitis显示文摘AIM: To study an assessment of the number of enterochromaffin cells and expression of hydroxyindole-Omethyltransferase in colonic mucosa and urine excretion of 6-sulfatoxymelatonin in patients with ulcerative colitis. METHODS: The study included 30 healthy subjects (groupⅠ-C), 30 patients with ulcerative proctitis [group Ⅱ-ulcerative proctitis (UP)] and 30 patients with ulcerative colitis [group Ⅲ-ulcerative colitis (UC)] in acute phases of these diseases. The number of enterochromaffin cells (EC) was estimated in rectal and colonic mucosa. Bioptates were assembled from many different parts of the large intestine. Immunorective cells collected from various parts of the colon were counted according to the Eurovision DAKO (Dako A/S, Copenhagen, Denmark) System in the range of 10 fields in each bioptate at × 200 magnification. The level of mRNA expression of hydroxyindole-O-methyltransferase (HIOMT) in colonic mucosa was estimated with RT-PCR. Urine 6-sulfatoxymelatonin (6-HMS) excretion was determined immunoenzymatically using an IBL (IBL International GmbH, Hamburg, Germany) kit (RE 54031). RESULTS: The number of EC cells in healthy subjects (C) was 132.40 ± 31.26. In patients of group Ⅱ (UP) and group Ⅲ (UC) the number of these cells was higher 225.40 ± 37.35 (P < 0.001) and 225.24 ± 40.50 (P < 0.001) respectively. Similar differences were related to HIOMT expression, which was 1.04 ± 0.36 in group C, 1.56 ± 0.56 (P < 0.01) in group UP and 2.00 ± 0.35 (P < 0.001) in group UC. Twenty-four hour 6-HMS urinary excretion was as follows: C 16.32 ± 4.95 μg/24 h, UP 26.30 ± 7.29 μg/24 h (P < 0.01), UC 42.30 ± 12.56 μg/24h (P < 0.001). A correlation between number of EC cells and 6-HMS excretion was noted in all groups: r = 0.766 in patients with UP, r = 0.703 with UC and r = 0.8551 in the control group; the correlation between the results is statistically significant. CONCLUSION: In the acute phases of both UP and UC, proliferation of EC cells and high expression of HIOMT and urine excretion of 6-HMS is noted. These changes may represent a beneficial response in the anti-inflammatory and defense mechanism. | Cezary Chojnacki Maria Wisniewska-Jarosińska Grazyna Kulig Ireneusz Majsterek Russel J Reiter Jan Chojnacki | 2013 | World Journal of Gastroenterology2013，19，23： | 5 |
| 7 | Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4^(-/-) mouse model显示文摘AIM: To study the interleukin-1(IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4^(-/-)(Abcb4^(-/-)) mouse model.METHODS: Female and male Abcb4^(-/-) mice from 6 to 13 mo of age were analysed for the degree of cholestasis(liver serum tests), extent of liver fibrosis(hydroxyproline content and Sirius red staining) and tissue-specific activation of signalling pathways such as the IL-1 pathway [quantitative polymerase chain reaction(q PCR)]. For in vivo experiments, murine hepatic stellate cells(HSCs) were isolated via pronasecollagenase perfusion followed by density gradient centrifugation using female mice. Murine HSCs were stimulated with up to 1 ng/m L IL-1β with or without 2.5 μg/m L Anakinra, an IL-1 receptor antagonist, respectively. The proliferation of murine HSCs was assessed via the Brd U assay. The toxicity of Anakinra was evaluated via the fluorescein diacetate hydrolysis(FDH) assay. In vivo 8-wk-old Abcb4^(-/-) mice with an already fully established hepatic phenotype were treated with Anakinra(1 mg/kg body-weight daily intraperitoneally) or vehicle and liver injury and liver fibrosis were evaluated via serum tests, q PCR, hydroxyproline content and Sirius red staining. RESULTS: Liver fibrosis was less pronounced in males than in female Abcb4^(-/-) animals as defined by a lower hydroxyproline content(274 ± 64 μg/g vs 436 ± 80 μg/g liver, respectively; n = 13-15; P < 0.001; MannWhitney U-test) and lower m RNA expression of the profibrogenic tissue inhibitor of metalloproteinase-1(TIMP)(1 ± 0.41 vs 0.66 ± 0.33 fold, respectively; n = 13-15; P < 0.05; Mann-Whitney U-test). Reduced liver fibrosis was associated with significantly lower levels of F4/80 m RNA expression(1 ± 0.28 vs 0.71 ± 0.41 fold, respectively; n = 12-15; P < 0.05; Mann-Whitney U-test) and significantly lower IL-1β m RNA expression levels(1 ± 0.38 vs 0.44 ± 0.26 fold, respectively; n = 13-15; P < 0.001; Mann-Whitney U-test). No gender differences in the serum liver parameters [bilirubin; alanine aminotransferase(ALT); aspartate aminotransferase and alkaline phosphatase(AP)] were found. In vitro, the administration of IL-1β resulted in a significant increase in HSC proliferation [0.94 ± 0.72 arbitrary units(A.U.) in untreated controls, 1.12 ± 0.80 A.U. at an IL-1β concentration of 0.1 ng/m L and 1.18 ± 0.73 A.U. at an IL-1β concentration of 1 ng/m L in samples from n = 6 donor animals; P < 0.001; analyses of variance(ANOVA)]. Proliferation was reduced significantly by the addition of 2.5 μg/m L Anakinra(0.81 ± 0.60 A.U. in untreated controls, 0.92 ± 0.68 A.U. at an IL-1β concentration of 0.1 ng/m L, and 0.91 ± 0.69 A.U. at an IL-1β concentration of 1 ng/m L; in samples from n = 6 donor animals; P < 0.001; ANOVA) suggesting an anti-proliferative effect of this clinically approved IL-1 receptor antagonist. The FDH assay showed this dose to be non-toxic in HSCs. In vivo, Anakinra had no effect on the hepatic hydroxyprolinecontent, liver serum tests(ALT and AP) and profibrotic(collagen 1α1, collagen 1α2, transforming growth factor-β, and TIMP-1) and anti-fibrotic [matrix metalloproteinase 2(MMP2), MMP9 and MMP13 ] gene expression after 4 wk of treatment. Furthermore, the hepatic IL-1β and F4/80 m RNA expression levels were unaffected by Anakinra treatment.CONCLUSION: IL-1β expression is associated with the degree of liver fibrosis in Abcb4^(-/-) mice and promotes HSC proliferation. IL-1 antagonism shows antifibrotic effects in vitro but not in Abcb4^(-/-) mice. | Florian P Reiter Ralf Wimmer Lena Wottke Renate Artmann Jutta M Nagel Manuel O Carranza Doris Mayr Christian Rust Peter Fickert Michael Trauner Alexander L Gerbes Simon Hohenester Gerald U Denk | 2016 | World Journal of Hepatology2016，8，8： | 3 |
| 8 | Simulation of Mould Level Velocities During Continuous Casting of Round Bloom Strands With Mould-Electromagnetic Stirring显示文摘In modern continuous casting of round steel blooms rotating electromagnetic fields are commonly employed to improve the product quality.Mould-electromagnetic stirrers(M-EMS)are used to excite a rotary motion along the solidification front in the liquid core.These velocities lead to a better strand surface quality as well as enhancing the transition from columnar to equiaxed solidification.Although the usage of electromagnetic stirrers is widespread,not all effects are fully known or understood.Due to harsh conditions at the plant,measurements are scarce and limited.Water model experiments-an established alternative for investigating continuous casting of steel-cannot be used due to the low electrical conductivity of water.Experiments with liquid metals like mercury,Galinstan or Wood's metal are either expensive or difficult to perform.Thus numeric simulations are essential to gain a better understanding of the processes involved in continuous casting with electromagnetic stirring.However numeric simulations should always be validated with experiments and/or measurements.While the velocity field inside the liquid core of the bloom cannot be measured at the caster,the velocity at the mould level can be measured by dipping a nail into it.The skull forming at the tip of the nail is directly linked to the occurring surface velocity.These measurements can then be compared with numeric simulations of the nail dipping process.The numeric model is restricted to the upper part of the strand.The lower part of the strand is also taken into account through adjusted boundary conditions(velocity field etc.taken from a simulation of the whole strand).In this work the influence of the stirring field strength on the simulation results will be investigated.In the future these nail dipping simulations will be validated with plant measurements.This can then to a certain extentvalidate the simulation of the strand with M-EMS too,as it serves as the basis for the nail dipping model. | BARNAMartin JAVUREK Mirko REITER Jurgen WATZINGER Josef KAUFMANN Bernhard HACKL Gemot | 2012 | Journal of Iron and Steel Research(International)2012，19，S2： | 3 |
| 9 | Risk stratification in patients with unstable angina using absolute serial changes of three high sensitive Troponin Assays显示文摘 | Tobias Reichlin Raphael Twerenbold Claudia Maushart Miriam Reiter Berit Moehring Nora Schaub Cathrin Balmelli Maria Rubini Gimenez Rebeca Hoeller Konstantin Sakarikos Beatrice Drexler Philip Haaf Stefan Osswald Christian Mueller | 2012 | American Heart Journal2012，，： | 2 |
| 10 | Pharmacological actions of melatonin in acute and chronic inflammation显示文摘 | Cuzzocrea S Reiter RJ | 2002 | Curr Top Med Chem2002，2，2： | 2 |
| 11 | 血清中43种滥用药物的固相萃取法研究显示文摘使用CLEANSCREEN○R 固相萃取柱分别对血清中43种滥用药物进行提取方法的研究,其提取物分别采用GC-MS和UV方法测定.结果表明:在43种滥用药物中,回收率超过90%的药物有26种,居80%~90%的药物有8种,居60%~80%的药物有另外8种,小于60%的药物仅有1种.因此CLEANSCREEN○R 固相萃取柱可用于血清中该43种滥用药物的提取或筛选分析,且是一种快速、简便及具有较高回收率的提取方法. | 杨丽君 REITER A | 2003 | 云南大学学报(自然科学版)2003，25，5： | 2 |
| 12 | Pharmacological action of melatonin in shock,inflammation and ischemia/reperfusion injury显示文摘 | Cuzzocrea S Reiter RJ | 2001 | EurJPharmacol2001，426，12： | 2 |
| 13 | Crowds:anonymity for web transactions显示文摘 | Reiter M K Rubin A D | 1998 | ACM Transactions on Information and System Security1998，1，1： | 2 |
| 14 | 小剂量肾上腺素推注治疗PICU内急性低血压显示文摘目的了解低剂量肾上腺素推注在危重患儿急性低血压发作或心脏骤停前期的使用情况。设计机构审查委员会批准,单中心回顾性医学病历分析。场所一家独立三级儿童医院内的大型内外科综合性PICU。对象2015年6月1日至2016年6月1日间入住PICU且静脉推注低剂量肾上腺素(≤5mcg/kg)患儿。 | Reiter PD Roth J Wathen B 方伯粱 钱素云 | 2018 | 中国小儿急救医学2018，25，3： | 2 |
| 15 | Recombinant Fv immunotoxins and Fv fragments as novel agents for cancer therapy and diagnosis 显示文摘 | Reiter Y Pastan I | 1998 | Trends Biotech1998，16，12： | 2 |
| 16 | Melatonin membrane receptors in peripheral tissues: Distribution and functions显示文摘 | Radomir M. Slominski Russel J. Reiter Natalia Schlabritz-Loutsevitch Rennolds S. Ostrom Andrzej T. Slominski | 2012 | Molecular and Cellular Endocrinology2012，，2： | 2 |
| 17 | Crowds显示文摘 | Michael K. Reiter Aviel D. Rubin | 1998 | ACM Transactions on Information and System Security (TISSEC)1998，，1： | 2 |
| 18 | Utility of Absolute and Relative Changes in Cardiac Troponin Concentrations in the Early Diagnosis of Acute Myocardial Infarction显示文摘 | Tobias Reichlin Affan Irfan Raphael Twerenbold Miriam Reiter Willibald Hochholzer Hanna Burkhalter Stefano Bassetti Stephan Steuer Katrin Winkler Federico Peter Julia Meissner Philip Haaf Mihael Potocki Beatrice Drexler Stefan Osswald Christian Mueller | 2011 | Circulation2011，，2： | 2 |
| 19 | Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin显示文摘 | Russel J. Reiter Sergio D. Paredes Lucien C. Manchester Dan-Xian Tan | 2009 | Critical Reviews in Biochemistry and Molecular Biology2009，，4： | 2 |
| 20 | Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with thet(12:13)(p13:q12)显示文摘 | Chase A Reiter A Burci L | 1999 | Blood1999，93，3： | 1 |
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