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| 1 | Label-free SARS-CoV-2 detection and classification using phase imaging with computational specificity显示文摘Efforts to mitigate the COVID-19 crisis revealed that fast,accurate,and scalable testing is crucial for curbing the current impact and that of future pandemics.We propose an optical method for directly imaging unlabeled viral particles and using deep learning for detection and classification.An ultrasensitive interferometric method was used to image four virus types with nanoscale optical path-length sensitivity.Pairing these data with fluorescence images for ground truth,we trained semantic segmentation models based on U-Net,a particular type of convolutional neural network.The trained network was applied to classify the viruses from the interferometric images only,containing simultaneously SARS-CoV-2,H1N1(influenza-A virus),HAdV(adenovirus),and ZIKV(Zika virus).Remarkably,due to the nanoscale sensitivity in the input data,the neural network was able to identify SARS-CoV-2 vs.the other viruses with 96%accuracy.The inference time for each image is 60 ms,on a common graphic-processing unit.This approach of directly imaging unlabeled viral particles may provide an extremely fast test,of less than a minute per patient.As the imaging instrument operates on regular glass slides,we envision this method as potentially testing on patient breath condensates.The necessary high throughput can be achieved by translating concepts from digital pathology,where a microscope can scan hundreds of slides automatically. | Neha Goswami Yuchen R.He Yu-Heng Deng Chamteut Oh Nahil Sobh Enrique Valera Rashid Bashir Nahed Ismail Hyunjoon Kong Thanh H.Nguyen Catherine Best-Popescu Gabriel Popescu | 2021 | Light(Science & Applications)2021，10，9： | 3 |
| 2 | Functional outcome following endoprosthetic reconstruction of the proximal humerus显示文摘 | Christopher P. Cannon Giovanni U. Paraliticci Patrick P. Lin Valerae O. Lewis Alan W. Yasko | 2009 | Journal of Shoulder and Elbow Surgery2009，，5： | 2 |
| 3 | OSAS in children: correlation between endoscopic and polysomnographic findings 显示文摘 | Valera F C Avelino M A Pettermann M B | 2005 | Otolaryngol Head Neck Surg2005，132，2： | 1 |
| 4 | Fuzzy Approach to Environmental Performance Evaluation 显示文摘 | Valeras Kildisas Donatas Levisauskas | 2005 | Environmental re- search engineering and management2005，1，31： | 1 |
| 5 | In vitro penetration of bleaching agents into the pulp chamber 显示文摘 | Benetti AR Valera MC Mancini MN | 2004 | Int Endod J2004，37，2： | 1 |
| 6 | Clinico-genetic aspects of a pediatric non-neurofibromatosis type 1 malig- nant triton tumor with loss of chromosome X 显示文摘 | Engel EE Brassesco MS Valera ET | 2012 | Pediatr Blood Cancer2012，59，7： | 1 |
| 7 | Expression of transcription factors NF-kappaB and AP-1 in nasal polyposis 显示文摘 | Valera FC Queiroz R Scrideli C | 2008 | Clin Exp Allergy2008，38，4： | 1 |
| 8 | Functional topography of the cerebellum for motor and cognitive tasks: an fMRI study显示文摘 | Stoodley CJ Valera EM SchmahmannJO | 2012 | Neuroimage2012，59，2： | 1 |
| 9 | Cortical thming of the attention and executive function networks in adults with attention- deficit/hyperactivity disorder显示文摘 | Makris N Biederman J Valera EM | 2006 | Cereb Cortex2006，17，6： | 1 |
| 10 | Measurement and simulation of climate inside Almería-type greenhouses using computational fluid dynamics显示文摘 | Molina-Aiz F D Valera D L álvarez A J | 2004 | Agricultural and Forest Meteorology2004，125，： | 1 |
| 11 | Angiotensin-(1-7)inhibitory mechanism of norepinephrine release in hypertensive rats显示文摘 | Gironacci MM Valera MS Yujnovsky I | 2004 | Hypertension2004，44，： | 1 |
| 12 | Antibody - antigenic peptide interactions monitored by SPR and QCM-D: A model for SPR detection of IA-2 autoantibodies in human serum显示文摘 | Ayela C Roquet F Valera L | 2007 | Biosens Bioelectron2007，22，： | 1 |
| 13 | A twin study of alexithymia显示文摘 | Valera EM Berenbaum H | 2001 | Psychother Psychosom2001，70，： | 1 |
| 14 | Study of morphologies of PMMA/PP/PS ternary blends 显示文摘 | VALERA T MORITA A DEMARQUETTE N | 2006 | Macro-molecules2006，39，7： | 1 |
| 15 | The involvement of an ATP-gated ion channel,P2X1,in thymocyte apoptosis显示文摘 | Chvatchko Y Valera S Aubry J P | 1996 | Immunity1996，5，3： | 1 |
| 16 | Moyamoya syndrome associated with neurofibromatosis type l in a pediatric patient显示文摘 | Darrigo Jfinior LG Valera ET Machado Ade A | 2011 | Sao Paulo Med J2011，129，： | 1 |
| 17 | Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope显示文摘 | Piquer S Valera L Lampasona V | 2006 | J Autoimmun2006，26，3： | 1 |
| 18 | LDH-A inhibition,a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cel cancer显示文摘 | Xie H Valera VA Merino MJ Amato AM Signoretti S Linehan WM | 2009 | Mol Cancer Ther2009，8，3： | 1 |
| 19 | Endoscopic band ligation of bleedingdieulafoy lesions:the best therapeutic strategy显示文摘 | Valera JM Pino RQ Poniachik J | 2006 | Endoscopy2006，38，2： | 1 |
| 20 | Conductimetric for atrazine detection based on antibodies labelled with gold nanoparticles显示文摘 | VALERA E RAMON-AZCON J | 2008 | Sensors and Actuators B2008，134，1： | 1 |
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