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| 1 | Eastern Asian endemic seed plant genera and their paleogeographic history throughout the Northern Hemisphere显示文摘We review the fossil history of seed plant genera that are now endemic to eastern Asia. Although the majority of eastern Asian endemic genera have no known fossil record at all, 54 genera, or about 9%, are reliably known from the fossil record. Most of these are woody (with two exceptions), and most are today either broadly East Asian, or more specifically confined to Sino-Japanese subcategory rather than being endemic to the Sino-Himalayan area. Of the 'eastern Asian endemic' genera so far known from the fossil record, the majority formerly occurred in Europe and/or North America, indicating that eastern Asia served as a late Tertiary or Quaternary refugium for taxa. Hence, many of these genera may have originated in other parts of the Northern Hemisphere and expanded their ranges across continents and former sea barriers when tectonic and climatic conditions al- lowed, leading to their arrival in eastern Asia. Although clear evidence for paleoendemism is provided by the gymnosperms Amentotaxus, Cathaya, Cephalotaxus, Cunninghamia, Cryptomeria, Glyptostrobus, Ginkgo, Ketel-eeria, Metasequoia, Nothotsuga, Pseudolarix, Sciadopitys, and Taiwania, and the angiosperms Cercidiphyllum, Choerospondias, Corylopsis, Craigia, Cyclocarya, Davidia, Dipelta, Decaisnea, Diplopanax, Dipteronia, Em-menopterys, Eucommia, Euscaphis, Hemiptelea, Hovenia, Koelreuteria, Paulownia, Phellodendron, Platycarya, Pteroceltis, Rehderodendron, Sargentodoxa, Schizophragma, Sinomenium, Tapiscia, Tetracentron, Toricellia, Trapella, and Trochodendron, we cannot rule out the possibility that neoendemism plays an important role especially for herbaceous taxa in the present-day flora of Asia, particularly in the Sino-Himalayan region. In addition to reviewing paleobotanical occurrences from the literature, we document newly recognized fossil occurrences that expand the geographic and stratigraphic ranges previously known for Dipelta, Pteroceltis, and Toricellia. | Steven R. MANCHESTER Zhi-Duan CHEN An-Ming LU Kazuhiko UEMURA | 2009 | Journal of Systematics and Evolution2009，47，1： | 40 |
| 2 | Pharmacokinetics of radioimmunotherapeutic agent of direct labeling mAb ^(188)Re-HAb18显示文摘AIM: To labed Anti-hepatoma monoclonal antibody (mAb)fragment HAb18 F (ab')2 was labeled with 188 Re for thepharmacokinetic model of 188 Re-HAb18 F (ab')2 and toevaluate its pharmacokinetic parameters in hepatoma-bearing nude mice.METHODS: HAb18 F(ab')2 was directly labeled with 188Reusing 2-mercaptoethanol (2-ME) as reducing agents.Labeling efficiency and immunoreactivity of 188 Re-HAb18 F( ab')2 were evaluated by Whatman 3MM paperchromatography and live cell assay, respectively.Biodiatribution analysis was also conducted in nude micebearing human hepatoma in which animals were sacrificed atdifferent time points(1, 4, 18, 24 and 24h) after 188Re-HAb18F(ab' )2 was injected through tail-vein into hepatoma-bearingnude mice. The blood and radioactivity of organs and masswere measured. The concentrations of 188 Re-HAb18 F(ab')2were evaluated with a pharmacokinetic 3P97 software.RESULTS: The optimum labeling efficiency andimmunoreactive fraction were 91.7% and 0.78%,respectively. The parameters of 188Re-HAb18 F(ab')2 were:T1/2, 2.29h; Vd, 1.49 × 10-9L@ Bq- 1; AUC, 20.49 × 109Bq@ h@L-1 ;CL, 0.45 × 10-3L@ h- 1. 188Re- HAb18 F(ab')2 could locatespecially in hepatoma with high selective reactivity of HAb18F(ab')2. 188 Re-HAb18 F(ab')2 was mainly eliminated bykidney. The maximal tumor to blood ratio was at 48h, andmaximal tumor to liver ratio was at 18h.CONCLUTION: The pharmacokinetics of 188Re-HAb18 F(ab')2fit a I-compartment model. 188 Re-HAb18 F(ab')2 can beuptaken selectively at the hepatoma site. | Chao Lou Zhi-Nan Chen Hui-Jie Bian Department of Cell Engineering Research Centre,Jie Li,Department of Oral Cell Biology,Qingdu Hospital,Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China Shou-Bo Zhou School of Biological Sciences,University of Manchester,Oxford Road,United Kingdom | 2002 | World Journal of Gastroenterology2002，8，1： | 14 |
| 3 | A new phylogenetic tribal classification of the grape family (Vitaceae)显示文摘Vitaceae (葡萄家庭) 由 16 个类和 ca 组成。首先在热带区域散布的 950 种类。家庭为葡萄的经济重要性是著名的,并且作为热带、适度的森林里的主导的登山者与许多种类也是生态地重要的。最近种系发生并且从所有三个染色体的顺序数据的 phylogenomic 分析在 Vitaceae 以内支持了五主要 clades:(i) 白蔹属, Nekemias, Rhoicissus,和 Clematicissus 的 clade;(ii ) Cissus clade;(iii ) Cayratia, Causonis, Cyphostemma, Pseudocayratia, Tetrastigma,和 undescribed 类 Afrocayratia 的 clade;(iv ) Parthenocissus 和 Yua 的 clade;并且(v) 葡萄类 Vitis 和它的近热带的亲戚 Ampelocissus, Pterisanthes 和 Nothocissus,与在 Ampelocissus 以内嵌套的 Nothocissus 和 Pterisanthes。基于种系发生、词法(主要开花期,花并且种子人物) 证据,新分类把 950 种类和 16 个类放进五个部落:(i) 部落 Ampelopsideae J.Wen 与 Z.L.Nie, trib。nov。(在四个类的 47 种类;白蔹属, Nekemias, Rhoicissus 和 Clematicissus ) ;(ii ) 部落 Cisseae Rchb。(在一个类的 300 种类;Cissus ) ;(iii ) 部落 Cayratieae J.Wen 与 L.M.Lu, trib。nov。(在七个类的 370 种类;Cayratia, Causonis, Afrocayratia, Pseudocayratia, Acareosperma, Cyphostemma 和 Tetrastigma ) ;(iv ) 部落 Parthenocisseae J.Wen 与 Z.D.Chen, trib。nov。( ca。16 spp。在二个类;Parthenocissus 和 Yua ) ;并且(v) 部落 Viteae Dumort。( ca。在二个类的 190 种类;Ampelocissus 和 Vitis ) 。 | JunWen Li-Min Lu Ze-Long Nie Xiu-Qun Liu Ning Zhang Stefanie Ickert-Bond Jean Gerrath Steven R. Manchester John Boggan Zhi-Duan Chen | 2018 | Journal of Systematics and Evolution2018，56，4： | 6 |
| 4 | Searching for the Nano-Hertz Stochastic Gravitational Wave Background with the Chinese Pulsar Timing Array Data ReleaseⅠ显示文摘Observing and timing a group of millisecond pulsars with high rotational stability enables the direct detection of gravitational waves(GWs).The GW signals can be identified from the spatial correlations encoded in the times-of-arrival of widely spaced pulsar-pairs.The Chinese Pulsar Timing Array(CPTA)is a collaboration aiming at the direct GW detection with observations carried out using Chinese radio telescopes.This short article serves as a“table of contents”for a forthcoming series of papers related to the CPTA Data Release 1(CPTA DR1)which uses observations from the Five-hundred-meter Aperture Spherical radio Telescope.Here,after summarizing the time span and accuracy of CPTA DR1,we report the key results of our statistical inference finding a correlated signal with amplitude logA_(c)=-14.4_(-2.8)^(+1.0)for spectral index in the range ofα∈[-1.8,1.5]assuming a GW background(GWB)induced quadrupolar correlation.The search for the Hellings–Downs(HD)correlation curve is also presented,where some evidence for the HD correlation has been found that a 4.6σstatistical significance is achieved using the discrete frequency method around the frequency of 14 n Hz.We expect that the future International Pulsar Timing Array data analysis and the next CPTA data release will be more sensitive to the n Hz GWB,which could verify the current results. | Heng Xu Siyuan Chen Yanjun Guo Jinchen Jiang Bojun Wang Jiangwei Xu Zihan Xue RNicolas Caballero Jianping Yuan Yonghua Xu Jingbo Wang Longfei Hao Jingtao Luo Kejia Lee Jinlin Han Peng Jiang Zhiqiang Shen Min Wang Na Wang Renxin Xu Xiangping Wu Richard Manchester Lei Qian Xin Guan Menglin Huang Chun Sun Yan Zhu | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 3 |
| 5 | Paleogene fossil fruits of Stephania (Menispermaceae) from North America and East Asia显示文摘 | Meng Han Steven R. Manchester Qiong-Yao Fu Jian-Hua Jin Cheng Quan | 2018 | Journal of Systematics and Evolution2018，56，2： | 3 |
| 6 | Robust fault diagnosis for non-Gaussian stochastic systems based on the rational square-root approximation model显示文摘The task of robust fault detection and diagnosis of stochastic distribution control(SDC) systems with uncertainties is to use the measured input and the system output PDFs to still obtain possible faults information of the system. Using the rational square-root B-spline model to represent the dynamics between the output PDF and the input,in this paper,a robust nonlinear adaptive observer-based fault diagnosis algorithm is presented to diagnose the fault in the dynamic part of such systems with model uncertainties. When certain conditions are satisfied,the weight vector of the rational square-root B-spline model proves to be bounded. Convergency analysis is performed for the error dynamic system raised from robust fault detection and fault diagnosis phase. Computer simulations are given to demonstrate the effectiveness of the proposed algorithm. | YAO LiNa1 & WANG Hong2,3 1 School of Electrical Engineering,Zhengzhou University,Zhengzhou 450001,China 2 Control Systems Centre,University of Manchester,Manchester M60 1QD,UK 3 Institute of Automation,Chinese Academy of Sciences,Beijing 100080,China | 2008 | Science in China(Series F)2008，51，9： | 3 |
| 7 | Anastomotic Leaks After Intestinal Anastomosis: It?s Later Than You Think显示文摘 | Neil Hyman Thomas L. Manchester Turner Osler Betsy Burns Peter A. Cataldo | 2007 | Annals of Surgery2007，，2： | 2 |
| 8 | Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin显示文摘 | Russel J. Reiter Sergio D. Paredes Lucien C. Manchester Dan-Xian Tan | 2009 | Critical Reviews in Biochemistry and Molecular Biology2009，，4： | 2 |
| 9 | The shape of pulsar radio beams显示文摘 | Lyne A G Manchester R N | 1988 | Month Notic Roy Astronom Soci1988，234，： | 1 |
| 10 | Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation 显示文摘 | Tan D X Manchester L C Reiter R J | 2000 | Free Radic Biol Med2000，29，11： | 1 |
| 11 | Chiari's syndrome 显示文摘 | Hirsh HL Manchester B | 1946 | N Engl J Med1946，3，235： | 1 |
| 12 | High capacity mercury adsorption on freshly ozone-treated carbon surfaces显示文摘 | Manchester S Wang X Kulaots I | | 0，，03： | 1 |
| 13 | Purslane : a plant source of omega - 3 fatty acids and melatonin 显示文摘 | Simopoulos AP Tan DX Manchester LC | 2005 | J Pineal Res2005，39，3： | 1 |
| 14 | Functional roles of melatonin in plants, and perspectives in nutritional and agricultural science 显示文摘 | Tan DX Hardeland R Manchester LC | 2012 | Journal of Experimental Bota- ny2012，63，2： | 1 |
| 15 | Clinical and neurnpathological cri- teria for frontotemporal dementia显示文摘 | The Lund and Manchester Groups | 1994 | J Neurol Neurosurg Psychiatry1994，57，4： | 1 |
| 16 | Sequence requirements of the HIV-1 protease flap region determined by saturation mutagenesis and kinetic analysis of flap mutants显示文摘 | Shao W Everitt L Manchester M | 1997 | Proc Natl Acad Sci USA1997，94，6： | 1 |
| 17 | Fruits and seeds of Craigia bronnii ( Malvaceae - Tili- oideae) and associated flower buds from the late Mio- cene Inden Formation, Lower Rhine Basin, Germany 显示文摘 | KVA~EK Z MANCHESTER S R ZETYER R | 2002 | Rev of Palaeobot and Palyn2002，119，： | 1 |
| 18 | Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger 显示文摘 | Tan D X Reiter R J Manchester L C | 2002 | Curr Topic Med Chem2002，2，： | 1 |
| 19 | Mechanisms underlying the resistance to diet-induced obesity in germ-free mice显示文摘 | Backhed F Manchester JK Semenkovich CF | 2007 | PNAS2007，104，3： | 1 |
| 20 | High physiological levels of melatonin in the bile of mammals显示文摘 | Dun-xian Tan Lucien C. Manchester Russel J. Reiter Wenbo Qi Martha A. Hanes Norma J. Farley | 1999 | Life Sciences1999，，23： | 1 |
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