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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Antibacterial approaches in tissue engineering using metal ions and nanoparticles:From mechanisms to applications显示文摘Bacterial infection of implanted scaffolds may have fatal consequences and,in combination with the emergence of multidrug bacterial resistance,the development of advanced antibacterial biomaterials and constructs is of great interest.Since decades ago,metals and their ions had been used to minimize bacterial infection risk and,more recently,metal-based nanomaterials,with improved antimicrobial properties,have been advocated as a novel and tunable alternative.A comprehensive review is provided on how metal ions and ion nanoparticles have the potential to decrease or eliminate unwanted bacteria.Antibacterial mechanisms such as oxidative stress induction,ion release and disruption of biomolecules are currently well accepted.However,the exact antimicrobial mechanisms of the discussed metal compounds remain poorly understood.The combination of different metal ions and surface decorations of nanoparticles will lead to synergistic effects and improved microbial killing,and allow to mitigate potential side effects to the host.Starting with a general overview of antibacterial mechanisms,we subsequently focus on specific metal ions such as silver,zinc,copper,iron and gold,and outline their distinct modes of action.Finally,we discuss the use of these metal ions and nanoparticles in tissue engineering to prevent implant failure. | Maria Godoy-Gallardo Ulrich Eckhard Luis M.Delgado Yolanda J.D.de Roo Puente Mireia Hoyos-Nogués F.Javier Gil Roman A.Perez | 2021 | Bioactive Materials2021，6，12： | 14 |
| 3 | Human vascular smooth muscle cells and endothelial cells cocultured on polyglycolic acid (70/30) scaffold in tissue engineered vascular graft显示文摘背景当前的修复术的、小直径显示出差的长期的明显率的脉管的接枝导致了另外的生物材料的追求。Biomaterials 成功地集成到包围织物应该匹配纸巾,而且地形学的不仅机械性质。Polyglycolic 酸(70/30 ) 被用作合成接枝决定人的脉管的光滑的肌肉房间和 endothelial 房间是否依附,幸存并且藏匿 endothelin 和 6-keto-prostaglandin F1 (6-keto-PGF1 ).Methods Endothelial 房间,光滑的肌肉房间从成年人的伟人被孤立 saphenous 静脉。他们独立在 vitro 在 polyglycolic 酸支架上被播种种脉管的补丁(分别地组织 A 和 B ) 并且在 vitro 到的 cocultured 长成脉管的补丁(组 C ) 。光滑的肌肉房间和 endothelial 房间被 immunohistochemical 分析识别, polyglycolic 酸上的房间的生长用扫描电子显微镜学被调查。在 culturing 溶液的 endothelin 和 6-keto-PGF1 的层次被 radioimmunology 检验测量光滑的肌肉房间遵守了的 endothelial function.Results 种子 polyglycolic 酸支架和超过 28 天在空隙成长了在整个支架形成一致房间分布。然后,种子 endothelial 房间在光滑的肌肉房间上形成了完全的 endothelial 层。在 culturing 答案的 endothelin 和 6-keto-prostaglandin F1 alpha 的层次是( 234 ??僚?????????????????????僚?????愠慮浥慩?湯汣獵潩獮????????????吗???吠?? | WEN Shao-jun ZHAO Li-min WANG Shen-guo LI Jing-xing CHEN Hua-ying LIU Jie-lin LIU Ya LUO Yi Roo Changizi | 2007 | Chinese Medical Journal2007，，15： | 8 |
| 4 | New classes of domains with explicit Bergman kernel显示文摘We introduce two classes of egg type domains, built on general boundedsymmetric domains, for which we obtain the Bergman kernel inexplicit formulas. As an auxiliary tool, we compute the integralof complex powers of the generic norm on a bounded symmetricdomains using the well-known integral of Selberg. Thisgeneralizes matrix integrals of Hua and leads to a specialpolynomial with integer or half-integer coefficients attached toeach irreducible bounded symmetric domain. | Roos GUY | 2004 | Science China Mathematics2004，47，3： | 8 |
| 5 | A New Kernel Function Yielding the Best Known Iteration Bounds for Primal-Dual Interior-Point Algorithms显示文摘内核函数在为解决线性优化问题为最初双的内部点的算法定义新搜索方向起一个重要作用。在这篇论文我们在场与最好已知的复杂性产出一个算法的新核功能为大更改、小更改的方法跳了。 | Yan Qin BAI Jin LiGUO Cornelis ROOS | 2009 | Acta Mathematica Sinica,English Series2009，25，12： | 7 |
| 6 | Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei(Blyth, 1847) and description of a new species显示文摘Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian colobines.Despite several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly understood.Phayre’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and controversial.Thus,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of T.phayrei,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two holotypes.Phylogenetic analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the T.pileatus group branched first,followed by the T.francoisi group,and the T.cristatus and T.obscurus groups most recently.The four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within T.phayrei,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two taxa.Following the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the T.phayrei subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three taxa.Overall,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of T.phayrei but the entire Trachypithecus genus as well. | Christian Roos Kristofer MHelgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin Aung Ko Lin Aung Lin Khin Mar Yi Paing Soe Zin Mar Hein Margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh EGrace Veatch Neil Duncan Pepijn Kamminga Marcus AHChua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael Hofreiter Dietmar Zinner Frank Momberg | 2020 | Zoological Research2020，41，6： | 5 |
| 7 | UNIFORM SUPERCONVERGENCE OF A FINITE ELEMENT METHOD WITH EDGE STABILIZATION FOR CONVECTION-DIFFUSION PROBLEMS显示文摘在现在的纸,边稳定技术在联合起来的平方上与指数的边界层被用于一个传送对流散开问题,用有在层区域的双线性的有限元素和网孔的粗糙的部分上的线性元素的一个 Shishkin 网孔。错误界限为 || u 被证明 - u [h ]||[E ] ,在 u 是答案 u 的某 interpolant 的地方并且哦分离答案。这 supercloseness 结果关于 L 暗示最佳的错误估计[2 ] 标准并且为改进分离答案打开门到 postprocessing 的申请。[从作者抽象] | Sebastian Franz Torsten Linβ Hans-Grg Roos Sebastian Schiller | 2010 | Journal of Computational Mathematics2010，28，1： | 5 |
| 8 | A Generic Workflow for the Data FAIRification Process显示文摘The FAIR guiding principles aim to enhance the Findability,Accessibility,Interoperability and Reusability of digital resources such as data,for both humans and machines.The process of making data FAIR(“FAIRification”)can be described in multiple steps.In this paper,we describe a generic step-by-step FAIRification workflow to be performed in a multidisciplinary team guided by FAIR data stewards.The FAIRification workflow should be applicable to any type of data and has been developed and used for“Bring Your Own Data”(BYOD)workshops,as well as for the FAIRification of e.g.,rare diseases resources.The steps are:1)identify the FAIRification objective,2)analyze data,3)analyze metadata,4)define semantic model for data(4a)and metadata(4b),5)make data(5a)and metadata(5b)linkable,6)host FAIR data,and 7)assess FAIR data.For each step we describe how the data are processed,what expertise is required,which procedures and tools can be used,and which FAIR principles they relate to. | Annika Jacobsen Rajaram Kaliyaperumal Luiz Olavo Bonino da Silva Santos Barend Mons Erik Schultes Marco Roos Mark Thompson | 2020 | Data Intelligence2020，2，1： | 5 |
| 9 | GRADED MESHES FOR HIGHER ORDER FEM显示文摘一个不可思议地使不安的一个维的传送对流散开问题被有限元素方法基于更高的顺序多项式数字地解决。数字解决方案在被分级的网孔上与特殊强调用 S 类型网孔被获得(基于产生函数的一个网孔) 在好网孔区域。在加权的精力标准的错误估计被证明。我们导出产生功能以便在错误估计最小化常数的一个“最佳”的网孔。一个递归的公式在好网孔区域定义的二个改编层的网孔也被考虑,为为这些网孔证明错误估计的一种新技术被介绍。纸的目的是强调为更高的顺序使用最佳的网孔的重要性有限的元素方法。数字实验支持所有理论结果。[从作者抽象] | Hans-Gorg Roos Ljiljana Teofanov Zorica Uzelac | 2015 | Journal of Computational Mathematics2015，33，1： | 4 |
| 10 | The“A”of FAIR-As Open as Possible,as Closed as Necessary显示文摘In order to provide responsible access to health data by reconciling benefits of data sharing with privacy rights and ethical and regulatory requirements,Findable,Accessible,Interoperable and Reusable(FAIR)metadata should be developed.According to the H2020 Program Guidelines on FAIR Data,data should be'as open as possible and as closed as necessary','open'in order to foster the reusability and to accelerate research,but at the same time they should be'closed'to safeguard the privacy of the subjects.Additional provisions on the protection of natural persons with regard to the processing of personal data have been endorsed by the European General Data Protection Regulation(GDPR),Reg(EU)2016/679,that came into force in May 2018.This work aims to solve accessibility problems related to the protection of personal data in the digital era and to achieve a responsible access to and responsible use of health data.We strongly suggest associating each data set with FAIR metadata describing both the type of data collected and the accessibility conditions by considering data protection obligations and ethical and regulatory requirements.Finally,an existing FAIR infrastructure component has been used as an example to explain how FAIR metadata could facilitate data sharing while ensuring protection of individuals. | Annalisa Landi Mark Thompson Viviana Giannuzzi Fedele Bonifazi Ignasi Labastida Luiz Olavo Bonino da Silva Santos Marco Roos | 2020 | Data Intelligence2020，2，1： | 4 |
| 11 | Numerical Analysis of a System of Singularly Perturbed Convection-Diffusion Equations Related to Optimal Control显示文摘We consider an optimal control problem with an 1D singularly perturbed differential state equation.For solving such problems one uses the enhanced system of the state equation and its adjoint form.Thus,we obtain a system of two convectiondiffusion equations.Using linear finite elements on adapted grids we treat the effects of two layers arising at different boundaries of the domain.We proof uniform error estimates for this method on meshes of Shishkin type.We present numerical results supporting our analysis. | Hans-Görg Roos Christian Reibiger | 2011 | Numerical Mathematics(Theory,Methods and Applications)2011，4，4： | 3 |
| 12 | 新光线下的艺术--谈博物馆与美术馆照明显示文摘博物馆和美术馆的照明是影响观众展览体验的重要因素。在使用LED等节能灯具的同时,合理有效的利用日光是当代博物馆照明的重要趋势,尽管日光的动态变化能给观众连接外部世界的体验并增加舒适度,但博物馆中日光的使用一直是充满挑战的任务,要关注照明节能,要提高观众的体验,同时保护展品免受光损伤。 | Emrah Baki Ulas Mirjam Roos | 2014 | 中国博物馆2014，，4： | 3 |
| 13 | Levels and trends of poly-and perfluoroalkyl substances in the Arctic environment-An update显示文摘Poly-and perfluoroalkyl substances(PFASs)are important environmental contaminants globally and in the early 2000s they were shown to be ubiquitous contaminants in Arctic wildlife.Previous reviews by Butt et al.and Letcher et al.have covered studies on levels and trends of PFASs in the Arctic that were available to 2009.The purpose of this review is to focus on more recent work,generally published between 2009 and 2018,with emphasis on PFASs of emerging concern such as perfluoroalkyl carboxylates(PFCAs)and short-chain perfluoroalkyl sulfonates(PFSAs)and their precursors.Atmospheric measurements over the period 2006e2014 have shown that fluorotelomer alcohols(FTOHs)as well as perfluorobutanoic acid(PFBA)and perfluoroctanoic acid(PFOA)are the most prominent PFASs in the arctic atmosphere,all with increasing concentrations at Alert although PFOA concentrations declined at the Zeppelin Station(Svalbard).Results from ice cores show generally increasing deposition of PFCAs on the Devon Ice cap in the Canadian arctic while declining fluxes were found in a glacier on Svalbard.An extensive dataset exists for long-term trends of long-chain PFCAs that have been reported in Arctic biota with some datasets including archived samples from the 1970s and 1980s.Trends in PFCAs over time vary among the same species across the North American Arctic,East and West Greenland,and Svalbard.Most long term time series show a decline from higher concentrations in the early 2000s.However there have been recent(post 2010)increasing trends of PFCAs in ringed seals in the Canadian Arctic,East Greenland polar bears and in arctic foxes in Svalbard.Annual biological sampling is helping to determine these relatively short term changes.Rising levels of some PFCAs have been explained by continued emissions of long-chain PFCAs and/or their precursors and inflows to the Arctic Ocean,especially from the North Atlantic.While the effectiveness of biological sampling for temporal trends in long-chain PFCAs and PFSAs has been demonstrated,this does not apply to the C4eC8ePFCAs,perfluorobutane sulfonamide(FBSA),or perfluorobutane sulfonate(PFBS)which are generally present at low concentrations in biota.In addition to air sampling,sampling abiotic media such as glacial cores,and annual sampling of lake waters and seawater would appear to be the best approaches for investigating trends in the less bioaccumulative PFASs. | Derek Muir Rossana Bossi Pernilla Carlsson Marlene Evans Amila De Silva Crispin Halsall Cassandra Rauert Dorte Herzke Hayley Hung Robert Letcher Frank Riget Anna Roos | 2019 | Emerging Contaminants2019，5，1： | 3 |
| 14 | 黄芪及其发酵产物对PM2.5肺损伤动态可视化微循环的影响显示文摘目的:探讨黄芪发酵产物拮抗PM2.5肺损伤的干预效果,为黄芪研究及其发酵产物的开发利用提供参考依据。方法:通过电感耦合等离子体发射光谱仪确定PM2.5重金属的主要成分。将36只Wistar大鼠随机分成空白对照组,染毒组,黄芪组,黄芪发酵产物低、中、高剂量组,根据文献采用气管滴注方法复制PM2.5肺损伤的动物模型,各组相应处理4周,最后1次滴注后,进行微循环动态可视化观察研究,并进行血气分析检测。录制直径在30~50μm的肺细静脉白细胞黏附动态视频,计算200μm长的肺细静脉内粘附白细胞数量。结果:本研究PM2.5的重金属成分以铁(Fe)、锌(Zn)、铬(Cr)为主。与空白对照组比较,染毒组肺组织白细胞聚集严重(P<0.01),PCO_(2)显著升高(P<0.05),PO_(2)和SO_(2)显著降低(P<0.05)。与染毒组比较,黄芪组及黄芪发酵产物中、高剂量组黏附于肺细静脉血管壁的白细胞数量显著减少(P<0.05),PCO_(2)显著降低(P<0.05),PO_(2)和SO_(2)显著升高(P<0.05)。结论:黄芪发酵产物能使PM2.5损伤的肺组织炎性程度降低,肺功能得到改善,对临床上呼吸系统疾病防治及其黄芪科学研究具有一定的启示作用。 | 刘必旺 赵换 马一方 张惠忠 燕小宁 栾智华 马艳苗 周文静 封雪 赵俊云 杨向竹 Baukje de Roos | 2021 | 中华中医药杂志2021，36，9： | 3 |
| 15 | Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy显示文摘 | Luuk J. Rijzewijk Rutger W. van der Meer Hildo J. Lamb Hugo W.A.M. de Jong Mark Lubberink Johannes A. Romijn Jeroen J. Bax Albert de Roos Jos W. Twisk Robert J. Heine Adriaan A. Lammertsma Johannes W.A. Smit Michaela Diamant | 2009 | Journal of the American College of Cardiology2009，，16： | 2 |
| 16 | Productivity changes in Swedish pharamacies 1980–1989: A non-parametric Malmquist approach显示文摘 | R. F?re S. Grosskopf B. Lindgren P. Roos | 1992 | Journal of Productivity Analysis (-)1992，，12： | 2 |
| 17 | Reduction of Postoperative Ileus by Early Enteral Nutrition in Patients Undergoing Major Rectal Surgery: Prospective, Randomized, Controlled Trial显示文摘 | Petra G. Boelens Fanny F. B. M. Heesakkers Misha D. P. Luyer Kevin W. Y. van Barneveld Ignace H. J. T. de Hingh Grard A. P. Nieuwenhuijzen Arnout N. Roos Harm J. T. Rutten | 2014 | Annals of Surgery2014，，4： | 2 |
| 18 | A simple raster-based model for flood inundation simulation显示文摘 | P.D Bates A.P.J De Roo | 2000 | Journal of Hydrology2000，，1： | 2 |
| 19 | On implementing a primal-dual interior-point method for conic quadratic optimization显示文摘 | E.D. Andersen C. Roos T. Terlaky | 2003 | Mathematical Programming2003，，2： | 2 |
| 20 | Phase I therapy study with186Re-labeled humanized monoclonal antibody BIWA 4(bivatuzumab)in patients with head and neck squamous cell carcinoma 显示文摘 | BORJESSON P K POSTEMA E J ROOS J C | 2003 | Clin Cancer Res2003，9，2： | 2 |
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