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| 1 | The proprotein convertase subtilisin/kexin type 9 geneE670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations显示文摘Background The association of E670G polymorphism in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene and serum lipid profiles is inconsistent in dif- ferent ethnic groups.Bai Ku Yao is a special subgroup of the Yao minority in China.The present study was undertaken association of PCSK9 E670G polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations.Methods A total of 649 subjects of Bai Ku Yao and 646 participants of Han Chinese were randomly selected from our previous stratified randomized cluster samples.Genotyping of the PCSK9 E670G polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis,and then confirmed by direct sequencing. Results The levels of serum total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C) and apolipoprotein(Apo) AI were lower in Bai Ku Yao than in Han(P<0.01 for all).The frequency of A and G alleles was 98.00%and 2.00%in Bai Ku Yao,and 95.20%and 4.80%in Han(P<0.01);respectively. The frequency of AA,AG and GG genotypes was 95.99%,4.01%and 0%in Bai Ku Yao,and 91.02%, 8.36%and 0.62%in Han(P<0.01);respectively.There were also significant differences in the genotypic and allelic frequencies between n and the ratio of ApoAI to ApoB in Han Chinese but not in Bai Ku Yao were different between the AA and AG/GG genotypes(P<0.05 for all).The G allele carriers had higher serum HDL-C and higher ApoAI to ApoB ratio than the G allele noncarriers.When serum lipid parameters in Han were analyzed according to sex,the G allele carriers had higher serum HDL and ApoAI levels in males (P<0.05),and lower ApoB level and higher ApoAI to ApoB ratio in females(P<0.05 for all).Multiple linear regression analysis showed that serum HDL-C levels were correlated with genotypes in both ethnic groups(P<0.05 each).Serum lipid parameters were also correlated with sex,age,body massindex,alcohol consumption,cigarette smoking,and blood pressure in both ethnic groups(P<0.05-0.001).Conclusions These results suggest that the PCSK9 E670G polymorphism is mainly associated with some serum lipid parameters in the Han population,both gender show different relations to different serum lipid parameters.The G allele carriers might have higher serum lipid profiles than the G allele noncarriers. ormal LDL-C(≤3.20 mmol/L) and high LDL-C subgroups (> 3.20 mmol/L,P<0.01;respectively) in Bai Ku Yao, and between normal ApoB(≤1.14 g/L) and high ApoB subgroups(> 1.14 g/L,P < 0.01;respectively) in Han. | Lynn Htet Aung,YIN Rui-xing,MIAO Lin,HU Xi-jiang, YAN Ting-ting,CAO Xiao-li,WU Dong-feng,LI Qing,PAN Shang-ling,WU Jin-zhen (Department of Cardiology,Institute of Cardiovascular Diseases, The First Affiliated Hospital,Guangxi Medical University, Nanning 530021,China) | 2011 | 岭南心血管病杂志2011，17，S1： | 9 |
| 2 | Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei(Blyth, 1847) and description of a new species显示文摘Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian colobines.Despite several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly understood.Phayre’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and controversial.Thus,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of T.phayrei,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two holotypes.Phylogenetic analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the T.pileatus group branched first,followed by the T.francoisi group,and the T.cristatus and T.obscurus groups most recently.The four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within T.phayrei,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two taxa.Following the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the T.phayrei subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three taxa.Overall,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of T.phayrei but the entire Trachypithecus genus as well. | Christian Roos Kristofer MHelgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin Aung Ko Lin Aung Lin Khin Mar Yi Paing Soe Zin Mar Hein Margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh EGrace Veatch Neil Duncan Pepijn Kamminga Marcus AHChua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael Hofreiter Dietmar Zinner Frank Momberg | 2020 | Zoological Research2020，41，6： | 5 |
| 3 | Fabrication and laser performance of polycrystal and single crystal Nd : YAG by advanced ceramic processing 显示文摘 | Ikesue Yan Lin Aung Yoda T | 2007 | Opt Mater2007，29，： | 1 |
| 4 | Fabrication and laser performance of polycrystal and single crystal Nd:YAG by advanced ceramic processing显示文摘 | Ikesue Akio Yan Lin Aung Yoda T | 2007 | Opt Mater2007，29，10： | 1 |
| 5 | A miRNA Involved in Phosphate-Starvation Response in Arabidopsis显示文摘 | Hiroaki Fujii Tzyy-Jen Chiou Shu-I Lin Kyaw Aung Jian-Kang Zhu | 2005 | Current Biology2005，，22： | 1 |
| 6 | Regulation of phosphate ho meostasis by microRNA in Acabidopsis thaliana 显示文摘 | Chiou T J Aung K Lin S I | 2006 | Plant Cell2006，18，2： | 1 |
| 7 | Pulmonary scar cancer: A pathologic reappraisal显示文摘 | Ignatius Tak Min Kung Irene Oi Lin Lui Shee Loong Loke M. Aung Khin Che Keung Mok Wah Kit Lam Shun Yang So | 1985 | The American Journal of Surgical Pathology1985，，6： | 1 |
| 8 | Regulation of Phosphate homeostasis by microRNA in Aiabldopsis显示文摘 | Chiou T J Aung K Lin S I | 2006 | Plant Cell2006，18，2： | 1 |
| 9 | Progress in ceramic lasers 显示文摘 | Ikesue A Yan Lin Aung Takunori Taira | 2006 | Ann Rev Mater Res2006，36，： | 1 |
| 10 | A micro RNA involved in phosphate-starvation response in arabidopsis显示文摘 | Fujii H Chiou TJ Lin SI Aung K Zhu JK | 2005 | Current Biology2005，15，： | 1 |
| 11 | Regulation of phosphate homeostasis by micro RNA in arabidopsis显示文摘 | Chiou T J Aung K Lin SI Wu CC Chiang SF Su CL | 2006 | The Plant Cell2006，18，： | 1 |
| 12 | pho2, a phosphate overaccumulator, is caused by a nonsense mutation in a microRNA399 target gene显示文摘 | Aung K Lin S I Wu C C | 2006 | Plant physiology2006，141，3： | 1 |
| 13 | Regulation of phosphate homeostasis by microRNA in Arabidopsis 显示文摘 | Chiou T J Aung K Lin S I | 2006 | The Plant Cell2006，18，2： | 1 |
| 14 | Regulation of phosphate homeostasis by microRNA in arabidopsis显示文摘 | CHIU T J AUNG K LINS I | 2006 | Plant Cell2006，18，： | 1 |
| 15 | PROGRESS IN CERAMIC LASERS显示文摘 | Akio Ikesue Yan Lin Aung Takunori Taira Tomosumi Kamimura Kunio Yoshida Gary L. Messing | 2006 | Annual Review of Materials Research2006，，： | 1 |
| 16 | Pho2,a phosphate overaccumulator,is caused by a nonsense mutation in a micrnRNA399 target gene显示文摘 | Aung K Lin S I Wu C C | 2006 | Ptant Physiology2006，141，： | 1 |
| 17 | Ceramic laser materials显示文摘 | IKESUE A AUNG Yan Lin | 2008 | Nat Photonics2008，2，： | 1 |
| 18 | Regulation of phosphate homeostasis by MicroRNA in Arabidopsis 显示文摘 | Chiou T J Aung K Lin S I | 2006 | The Plant Cell2006，18，： | 1 |
| 19 | Fabrication and laser performance of polycrystal and single crystal Nd:YAG by advanced ceramic processing显示文摘 | A. Ikesue Yan Lin Aung T. Yoda S. Nakayama T. Kamimura | 2006 | Optical Materials2006，，10： | 1 |
| 20 | Regulation of phosphate homeostasis by microRNA in Arabidopsis 显示文摘 | Chiou T J Aung K Lin S I | 2006 | Plant Cell2006，18，2： | 1 |
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