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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 3 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 4 | Advances in the Treatment and Outcome of Brainstem Cavernous Malformation Surgery: A Single-Center Case Series of 300 Surgically Treated Patients显示文摘 | Adib A Abla Gregory P Lekovic Jay D Turner Jean G de Oliveira Randall Porter Robert F Spetzler | 2011 | Neurosurgery2011，，2： | 2 |
| 5 | A rapid pulsed-field gel electrophoresis method for analysis of Bifidobacterio 显示文摘 | BRICZINSKI E P ROBERTS R F | 2006 | J Dairy Sci2006，89，： | 1 |
| 6 | Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains显示文摘 | George P Robert F Gerry S | 1987 | PNAS1987，84，： | 1 |
| 7 | Application of Burkholderia cepacia and Trichoderma virens,alone and in combinations,a-gainst Meloidogyne incognita on bell pepper显示文摘 | MEYER S L F ROBERTS D P CHITWOOD D J | 2001 | Nematropica2001，，： | 1 |
| 8 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 9 | Geniculate neuralgiaand audiovestibular disturbances due to compression of the intermediate and eighth nerves by the postero-inferior cerebellar artery显示文摘 | Ouaknine GE Robert F Molina-Negro P | 1980 | Surg Neuroi1980，13，2： | 1 |
| 10 | Henoch-Schonlein purpura: a review article 显示文摘 | ROBERTS P F WALLER T A BRINKER T M | 2007 | South Med J2007，100，8： | 1 |
| 11 | Low-level expression of HER2 and CK19 in normal peripheral blood mononuclear cells: relevance for detection of circulating tumor cells显示文摘 | You F Roberts L A Kang S P | 2008 | J Hematol Oncol2008，28，1： | 1 |
| 12 | Zinc and carbon co-limitation of marine phytoplankton显示文摘 | Morel F M M Reinfelder J R Roberts S B Chamberlain C P Lee J G Yee D | 1994 | Nature1994，369，6483： | 1 |
| 13 | Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity显示文摘 | Stephane L Judit P Robert P F | 1998 | Genes and development1998，12，： | 1 |
| 14 | CTLA-4 and PD-1/PD-L1 blockade : new immunotherapentic modalities with durable clini- cal benefit in melanoma patients 显示文摘 | Ott P A Hodi F S Robert C | 2013 | Clinical Cancer Re- search2013，19，19： | 1 |
| 15 | Analytical procedures for the measurement of boron isotope compositions by ion microprobe in meteorites and mantle rocks显示文摘 | Chaussidon M Robert F Mangin D Hanon P Rose E F | 1997 | Geostand Newslett1997，21，1： | 1 |
| 16 | Class-Based n-gram Models of Natural Language显示文摘 | PETER F B VINCENT J D P PETER V D JENIFER C L ROBERT L M | 1992 | Computational Linguistics1992，，： | 1 |
| 17 | ZapA,a virulence factor in a rat model of Proteus mirabilis induced acute and chronic prostatitis显示文摘 | Van P Robert B Brendan F G | 2008 | Infect Immun2008，11，： | 1 |
| 18 | Is the normalisation of blood pres- sure inbleeding trauma patients harrnful?显示文摘 | Roberts I Evans P Bunn F | 2001 | Laneet2001，357，9272： | 1 |
| 19 | The role of elevation and soil chemistry in the distribution and ion accumulation of floral morphs of Streptanthus polygaloides Gray (Brassicaceae), a Californian nickel?hyperaccumulator 显示文摘 | Nathaniel P Michael F Robert S B | 2014 | Plant ecology & diversity2014，7，42： | 1 |
| 20 | Synthesis of functionally substituted asymmetric biaryls via a novel double metal catalyzed coupling reaction 显示文摘 | JOSEPH A M ROBERT P F | 1998 | Tetrahedron Lett1998，39，40： | 1 |
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