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| 1 | 国际糖尿病足工作组:糖尿病足溃疡分类指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘国际糖尿病足工作组(IWGDF)自1999年以来一直以循证为基础发布糖尿病足病的预防和管理指南。本文中针对日常临床工作中糖尿病足溃疡的分类提出了新指南,并对既有的分类进行了综述。新指南只对现患糖尿病足溃疡进行分类,不包括用于定义未来溃疡风险的分类系统。本指南的制定是基于对现有文献的综述以及专家对最大程度影响临床结局的8个关键因素的鉴定。分类级别是根据关键因素的数量、内部和外部有效性验证以及使用意向而制定的。判定分类评分的关键因素有3种:患者相关的因素(终末期肾衰竭)、肢体相关的因素(周围动脉病变和保护性感觉丧失)和溃疡相关的因素(面积、深度、部位、单发或多发以及感染)。特殊分类系统要考虑以下5种临床情况:①卫生专业人员之间交流;②预测单个溃疡预后;③对个案临床决策的辅助;④伤口评估,有感染或无感染及周围动脉病变(评估灌注及血管重建的潜在益处);⑤用于地方、区域或国家人群结局的稽查。指南推荐:①医务人员之间交流使用SINBAD系统。②无适用于预测个体溃疡预后的分类。③感染的评估采用美国传染病学会/国际糖尿病足工作组(IDSA/IWGDF)分类系统。④评估灌注及血管重建的潜在获益使用创面、缺血、足感染(WIfI)系统。⑤人群结局的稽查使用SINBAD系统。 | Matilde Monteiro-Soares David Russell Edward J Boyko William Jeffcoate Joseph L Mills Stephan Morbach Fran Game 无 王爱红(译) 冉兴无(审校) | 2019 | 感染.炎症.修复2019，20，4： | 10 |
| 2 | Expression of tissue factor in pancreatic adenocarcinoma is associated with activation of coagulation显示文摘瞄准:在 thromboembolism 的开发在胰腺的癌症和它的角色学习织物因素(TF ) 的表示。方法:TF 表示被北污点和间接免疫荧光在八根人的胰腺的癌房间线学习。或者拼接的 TF (asTF ) 的表示被 RT-PCR 估计。另外, TF 表示被免疫荧光与胰腺的腺癌(PCa ) 在 19 个病人的胰腺的纸巾决定,有慢性胰炎(CP ) 的 9 个病人和 20 正常控制。血浆样品(30 PCa 病人, 13 CP 病人和 20 控制) 为可溶的 TF 层次和凝结激活标记被调查[thrombin-antithrombin III 建筑群(梭织) ,凝血素碎片 1 + 2 (F1 + 2 )] 。结果:所有胰腺的癌房间线表示了 TF (8/8 ) ,他们中的大多数表示了 asTF (6/8 ) 。在蛋白质水平的 TF 表示没与癌房间线的区别相关。几乎,二件胰腺的癌症组织样品染色了为 TF (17/19 ) 积极。在 CP 的所有样品,弱染色被限制为胰腺的管房间,而一些仅仅内皮下房间在正常控制的 9/20 是积极的。TF 并且在 PCa 病人梭织层次而 2 铺平的提高的 F1 + 没与控制相比到达统计意义,显著地与控制相比被提高。在病人们梭织的 CP 和 F1 + , 2 个层次证明了显著地与控制相比被提高,尽管梭织举起少些比在 PCa 病人被读。结论:我们结束那除了起来房间膜上的 TF 的调整表示,可溶的 TF 可能在胰腺的癌症贡献凝结系统的激活。 | Stephan L Haas Ralf Jesnowski Michael Steiner Frank Hummel Jrg Ringel Christine Burstein Horst Nizze Stefan Liebe J Matthias Lhr | 2006 | World Journal of Gastroenterology2006，12，30： | 9 |
| 3 | Mucosal healing and deep remission: What does it mean?显示文摘The use of specific terms under different meanings and varying definitions has always been a source of confusion in science.When we point our efforts towards an evidence based medicine for inflammatory bowel diseases(IBD)the same is true:Terms such as'mucosal healing'or'deep remission'as endpoints in clinical trials or treatment goals in daily patient care may contribute to misconceptions if meanings change over time or definitions are altered.It appears to be useful to first have a look at the development of terms and their definitions,to assess their intrinsic and context-independent problems and then to analyze the different relevance in present-day clinical studies and trials.The purpose of such an attempt would be to gain clearer insights into the true impact of the clinical findings behind the terms.It may also lead to a better defined use of those terms for future studies.The terms'mucosal healing'and'deep remission'have been introduced in recent years as new therapeutic targets in the treatment of IBD patients.Several clinical trials,cohort studies or inception cohorts provided data that the long term disease course is better,when mucosal healing is achieved.However,it is still unclear whether continued or increased therapeutic measures will aid or improve mucosal healing for patients in clinical remission.Clinical trials are under way to answer this question.Attention should be paid to clearly address what levels of IBD activity are looked at.In the present review article authors aim to summarize the current evidence available on mucosal healing and deep remission and try to highlight their value and position in the everyday decision making for gastroenterologists. | Gerhard Rogler Stephan Vavricka Alain Schoepfer Peter L Lakatos | 2013 | World Journal of Gastroenterology2013，19，43： | 4 |
| 4 | Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis显示文摘AIM: To investigate interleukin-18 (IL-18) in patients with chronic panreatitis (CP). METHODS: We studied 29 patients with CP and 30 healthy controls. Peripheral blood mononuclear cells (PBMC) were isolated and incubated with 50 mmol/L ethanol, lipopolysaccharide (LPS) (doses 25 g/L, 250 g/L, 2500 g/L) and both agents for 24 h. Levels of IL-18 in the supernatants, and levels of IL-18, IL-12, interferon (IFN)-γ and soluble CD14 in the serum were analysed by ELISA technique. Expression of IL-18 in PBMC was investigated by reverse-transcription (RT)-PCR. IL-18 protein levels in CP tissue and in normal pancreas were studied by ELISA technique. IL-18 levels in PBMC and pancreatic tissue were determined by Westernblot. Im-munohistochemistry for pancreatic IL-18 expression was performed. RESULTS: In patients, IL-18 serum levels were signifi-cantly enhanced by 76% (mean: 289.9 ± 167.7 ng/L) compared with controls (mean: 165.2 ± 43.6 ng/L; P < 0.0005). IL-12 levels were enhanced by 25% in patients (18.3 ± 7.3 ng/L) compared with controls (14.7 ± 6.8ng/L, P = 0.0576) although not reaching the statistical significance. IFN-γ and soluble CD14 levels were not in-creased. In vitro, LPS stimulated significantly and dose-dependently IL-18 secretion from PBMC. Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%. The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls. In PBMC, no significant differences in IL-18 protein levels were detected between patients and controls. IL-18 protein levels were increased in CP tissues compared to normal pancreatic tissues. IL-18 was expressed by pancreatic acinar cells and by infiltrating inflammatory cells within the pancreas. CONCLUSION: IL-18 originates from the chronically inflammed pancreas and appears to be involved in the fibrotic destruction of the organ. | Alexander Schneider Stephan L Haas Ralf Hildenbrand Sren Siegmund Iris Reinhard Helmut Nakovics Manfred V Singer Peter Feick | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 5 | Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis显示文摘AIM:To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy.METHODS: An open label multicenter study was carried out in 39 patients with active ulcerative colitis (CAI6-8) despite continuous use of steroids (a minimum total dose of 400 mg prednisone within the last 4 wk).Patients received a total of five aphereses using a granulocyte adsorptive technique (Adacolumn(R), Otsuka Pharmaceutical Europe, UK). Assessments at wk 6 and during follow-up until 4 mo comprised clinical (CAI) and endoscopic (EI) activity index, histology, quality of life(IBDQ), and laboratory tests.RESULTS: Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 (37.1%) patients achieved clinical remission and 10/35 (28.6%) patients had endoscopic remission (CAI<4, EI<4). Quality of life (IBDQ) increased significantly (24 points, P<0.01)at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia.CONCLUSION: In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent. | Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert L(o|¨)fberg | 2005 | World Journal of Gastroenterology2005，11，44： | 4 |
| 6 | Can a polymorphism in the thalassemia gene and a heterozygote CFTR mutation cause acute pancreatitis?显示文摘The case of a 32-year-old black woman of African descent who suffered from repeated episodes of acute pancreatitis, initially triggered when flying on airplanes, is reported. She did not drink alcohol or smoke. Genetic analysis was negative for cationic trypsinogen, serine protease inhibitor Kazal type 1 and chymotrypsin C. However, hemoglobin F was elevated. Sequencing of the thalassemia gene revealed a novel alteration in the 5' region indicative of a functional abnormality of the molecule. Sequencing the cystic fibrosis transmembrane conductance regulator(CFTR) gene revealed a heterozygote sequence variant. The combination of a hemoglobin gene mutation known for thalassemia in conjunction with the hitherto undescribed CFTR mutation is suggested to pave the road for initial and repetitive pancreatitis attacks. This will be discussed. | J-Matthias L?hr Stephan Haas | 2014 | World Journal of Clinical Cases2014，2，3： | 2 |
| 7 | Hemisynthesis of all the O-monomethylated analogues of quercetin including the major metabolites, through selective pro-tection of phenolic functions 显示文摘 | Mohamed B Stephane L Aziz A | 2002 | Tetrahedron2002，58，10： | 1 |
| 8 | Effect of supplementing head-down displays with 3-Daudio during visual target acquisition显示文摘 | PARKER S P A SIMITH S E STEPHAN K L | 2004 | InternationalJournal of aviation psychology2004，14，3： | 1 |
| 9 | Crustal strain in the Southern Alps,France, 1948-1998显示文摘 | Calais E Gallsson L Stephan J F | 2000 | Tectonophysics2000，319，： | 1 |
| 10 | The Oxidation State of Phospholipids Controls the Oxidative Burst in Neutrophil Granulocytes显示文摘 | STEPHAN B BERIT R AKOS L | 2008 | J Immunology2008，181，： | 1 |
| 11 | Hemisynthesis of all the O-monomethylated analogues of quercetin including the major metabolites, through selective protection of phenolic functions 显示文摘 | Mohamed B Stephane L Aziz A | 2002 | Tetrahedron2002，58，10： | 1 |
| 12 | 显示文摘 | Stephane C Thomas R Martine L B | 2007 | IEEE Trans Comp and Pack Tech2007，30，： | 1 |
| 13 | Design and Optimization of Three-dimesional Extrusion Dies Using Constraint Optimization Algorithm显示文摘 | Nadhir L Fahriee S Stephan P | 2009 | Analysis and Design2009，45，： | 1 |
| 14 | Distribution and function of the adhesion molecule BEN during rat development显示文摘 | Stephan JP Bald L Roberts PE | 1999 | Dev Biol1999，212，2： | 1 |
| 15 | Functional imaging of memory retrieval in deficit vs nodeficit schizophrenia显示文摘 | Stephan Heckers Donald Goff Daniel L Schacter | 1999 | Arch Gen Psychiatry1999，56，： | 1 |
| 16 | Selenium and Tellurium Systematics of the Earth's Mantle from High Precision Analyses of Ultra-Depleted Orogenic Peridotites显示文摘 | Stephan K Ambre L Jean P L | 2012 | Geochimical et Cosmochimica Acta2012，86，： | 1 |
| 17 | Imaging insights into basal ganglia function,Parkinson's disease,and dystonia显示文摘 | Jon SA Stephane L Stofella AP | 2014 | Lancet2014，384，： | 1 |
| 18 | Singularity detection and processing with wavelets显示文摘 | STEPHANE M WEN L H | 1992 | IEEE Transactions on Information Theory1992，38，2： | 1 |
| 19 | A Usability Survey at theUniversity of Mississippi Libraries for the Improvement ofthe Library Home Page 显示文摘 | Stephan E Cheng D T Young L M | 2006 | The Journal of AcademicLibrarianship2006，32，1： | 1 |
| 20 | The epidemiology of nephrotoxicity associated with conventional amphotericin B therapy显示文摘 | Stephan Harbarth Stanley L Pestotnik James F Lloyd John P Burke Matthew H Samore | 2001 | The American Journal of Medicine2001，，： | 1 |
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