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| 1 | Comprehensive evaluation of the metabolic effects of insect meal from Tenebrio molitor L.in growing pigs by transcriptomics, metabolomics and lipidomics显示文摘Background:The hypothesis was tested that insect meal(IM)as protein source influences intermediary metabolism of growing pigs.To test this,30 male,5-week-old crossbred pigs were randomly assigned to 3 groups of 10 pigs each with similar body weights(BW)and fed isonitrogenous diets either without(CON)or with 5%IM(IM5)or 10%IM(IM10)from Tenebrio molitor L.for 4 weeks and key metabolic tissues(liver,muscle,plasma)were analyzed using omics-techniques.Results:Most performance parameters did not differ across the groups,whereas ileal digestibilities of most amino acids were 6.7 to 15.6%-units lower in IM10 than in CON(P<0.05).Transcriptomics of liver and skeletal muscle revealed a total of 166 and 198,respectively,transcripts differentially expressed between IM10 and CON(P<0.05).Plasma metabolomics revealed higher concentrations of alanine,citrulline,glutamate,proline,serine,tyrosine and valine and a lower concentration of asparagine in IM10 than in CON(P<0.05).Only one out of fourteen quantifiable amino acid metabolites,namely methionine sulfoxide(MetS),in plasma was elevated by 45%and 71%in IM5 and IM10,respectively,compared to CON(P<0.05).Plasma concentrations of both,major carnitine/acylcarnitine species and bile acids were not different across groups.Lipidomics of liver and plasma demonstrated no differences in the concentrations of triacylglycerols,cholesterol and the main phospholipids,lysophospholipids and sphingolipids between groups.The percentages of all individual phosphatidylcholine(PC)and phosphatidylethanolamine(PE)species in the liver showed no differences between groups,except those with 6 double bonds(PC 38:6,PC 40:6,PE 38:6,PE 40:6),which were markedly lower in IM10 than in CON(P<0.05).In line with this,the percentage of C22:6n-3 in hepatic total lipids was lower in IM10 than in the other groups(P<0.05).Conclusions:Comprehensive analyzes of the transcriptome,lipidome and metabolome of key metabolic tissues indicate that partial or complete replacement of a conventional protein source by IM in the diet has only a weak impact on the intermediary metabolism of growing pigs.Thus,it is concluded that IM from Tenebrio molitor L.can be used as a dietary source of protein in pigs without causing adverse effects on metabolism. | Sandra Meyer Denise K.Gessner Maria S.Braune Theresa Friedhoff Erika Most Marcus Höring Gerhard Liebisch Holger Zorn Klaus Eder Robert Ringseis | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 4 |
| 2 | High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet显示文摘 | Günther Silbernagel Marketa Kovarova Alexander Cegan Jürgen Machann Fritz Schick Rainer Lehmann Hans-Ulrich H?ring Norbert Stefan Erwin Schleicher Andreas Fritsche Andreas Peter | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，12： | 3 |
| 3 | Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study显示文摘 | Nauck Michael Frid Anders Hermansen Kjeld Shah Nalini S Tankova Tsvetalina Mitha Ismail H Zdravkovic Milan Düring Maria Matthews David R | 2009 | Diabetes Care2009，，： | 2 |
| 4 | Interaction between atmospheric CO2 and glucosinolates in Broccoli显示文摘 | SCHONHOF I KLRING H P KRUMBEIN A | 2007 | Journal of Chemical Ecology2007，33，： | 1 |
| 5 | Intermittent intravenous ibandronate injections reduce vertebral fracture risk in corticosteroid-induced osteoporosis:results from a long-term comparative study显示文摘 | Ringe D Dorst A Faber H | 2003 | Osteoporos Int2003，14，： | 1 |
| 6 | Structuring cooperative relationships between organizations显示文摘 | Ring P S A H Van De Ven | 1992 | Strategic Management Journal1992，7，13： | 1 |
| 7 | The relationship between mean flow velocity and functional and neurologic parameters of ischemic stroke patients undergoing rehabilitation显示文摘 | Treger I Streifler JY Ring H | 2005 | Arch Phys Med Rehabil2005，86，3： | 1 |
| 8 | Hepatoeyte-nuclear-factor-lalpha(HNF-lalpha), GATA-4 and caudal-related homeodomain protein Cdx2 functionally interact to modulate intestinal gene transcription:Implication for the developmental regulation of the sucrase-isomaltase gene 显示文摘 | Boudreau F Rings E H Wering H M V | 2002 | Journal of Biological Chemistry2002，，31： | 1 |
| 9 | Developmental processes of cooperative inter organizational relationships 显示文摘 | Ring P S Van de Ven A H | 1994 | Academy of Management Review1994，19，1： | 1 |
| 10 | Intermittent intravenous ibandronate injections reduce vertebral fracture risk in corticosteroid-induced osteoporosis:results from a long-term comparative study显示文摘 | Ringe JD Dorst A Faber H | 2003 | Osteoporos Int2003，14，10： | 1 |
| 11 | Extended right liver grafts obtained by an ex situ split can be used safely for primary and secondary transplantation with acceptable biliary morbidity显示文摘 | Takebe A Schrem H Ringe B | | 0，，07： | 1 |
| 12 | Simple modeling of Donnan separation processes 显示文摘 | RING S HASSON D SHEMER H | 2015 | Journal of Membrane Science2015，476，： | 1 |
| 13 | Processing monosized TiO2 powders generated with HPC dispersant显示文摘 | JEAN J H RING T A | 1986 | Am Ceram Soc Bull1986，65，12： | 1 |
| 14 | Processing Monosized TiO2 Powders Generated with HPC Dispersant显示文摘 | Jean J H Ring T A | 1986 | Am Ceram Soc Bull1986，65，12： | 1 |
| 15 | Innovative approa ches for the development of ntidepressant dugs:eurrent and fu ture strategies 显示文摘 | Schechter L E Ring R H Beyer C E | 2002 | NeuroRx2002，2，4： | 1 |
| 16 | Postural stability in stroke patients: vectorial expression of asymmetry, sway activity and relative sequence of reactive forees显示文摘 | Mizrahi J Solzi P Ring H | 1989 | Med Biol Eng Comput1989，27，： | 1 |
| 17 | Effect of a sterically stabilizing surfactant on the nucleation, growth and agglomeration of monosized ceramic powders 显示文摘 | JEAN J H RING T A | 1988 | Colloids Surf1988，29，3： | 1 |
| 18 | Specfic immunomodulation and therapy by means of high pressure treated allergens显示文摘 | MEYER-PITTROFF R BEHRENDT H RING J | 2007 | High Pressure Research2007，27，1： | 1 |
| 19 | Assessment of spatial neglect using computerised feature and conjunction visual search tasks显示文摘 | EREZ A B KATZ N RING H | 2009 | Neumpsychol Rehabil2009，19，5： | 1 |
| 20 | Structuring cooperative relationship between organization 显示文摘 | Ring P S Van DE Van A H | 1992 | Strategic Management Journal1992，，13： | 1 |
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