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| 1 | 细胞内脂肪堆积和β细胞增殖的关系显示文摘目的研究脂肪酸(FA)对β细胞增殖抑制与细胞内的脂肪堆积的关系及相关的葡萄糖(Glu)浓度的影响。方法培养胰岛β细胞株Ins1E细胞,用3H胸腺嘧啶和3H棕榈酸掺入的方法分别研究β细胞增殖及β细胞内脂肪堆积。利用RTPCR方法测定肉毒碱棕榈酰转移酶1(CPT1)基因表达。结果与3.3mmol/LGlu比较,24小时后6.6mmol/L和11mmol/LGlu使细胞增殖增加2.27和3.04倍(P<0.05);加入0.4mmol/L棕榈酸后细胞增殖降为1.1和0.86倍(与无棕榈酸相比P<0.05)。高浓度的Glu使细胞内脂肪堆积增加15%~92%。TriacsinC或Wy14643能减少13%~54%的脂肪堆积,同时缓解FA对细胞增殖的抑制作用48%~71%。FA刺激CPT1基因的表达,Glu对其有剂量依赖性的抑制,20mmol/LGlu使CPT1基因的表达减少50%(P<0.05)。结论FA对β细胞增殖的抑制与脂肪在细胞内堆积有关,Glu可能通过抑制FA刺激CPT1基因的表达,增加FA堆积从而介导FA对细胞增殖的抑制作用。 | 萧建中 杨文英 Kjeld Hermansen | 2006 | 中国糖尿病杂志2006，14，2： | 4 |
| 2 | Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo : studies in the diabetic Goto-Kakizaki (GK) rats显示文摘 | P.B. Jeppesen S. Gregersen K.K. Alstrup K. Hermansen | 2002 | Phytomedicine2002，，1： | 2 |
| 3 | Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study显示文摘 | Nauck Michael Frid Anders Hermansen Kjeld Shah Nalini S Tankova Tsvetalina Mitha Ismail H Zdravkovic Milan Düring Maria Matthews David R | 2009 | Diabetes Care2009，，： | 2 |
| 4 | Efficacy and safety comparison of liraglutide,glimepiride,and placebo,all in combination with metformin,in type 2 diabetes:the LEAD (liraglutide effect and action in diabetes)-2 study显示文摘 | Nauck M Frid A Hermansen K | | Diabetes Care0，，： | 2 |
| 5 | Experiences after 10 years of waterflooding the Ekofisk Field,Norway显示文摘 | LANDA H A SYLTE J E | 2000 | J Pet Sci Eng2000，26，： | 1 |
| 6 | Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study显示文摘 | Vessby B Uusitupa M Hermansen K | 2001 | Diabetologia2001，44，3： | 1 |
| 7 | Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in pa- tients with type 2 diabetes mellitus inadequately con- trolled glimepiride alone or on glimepiride and mefformin 显示文摘 | Hermansen K Kipnes M Luo E | 2007 | Diabetes Obes Metab2007，9，5： | 1 |
| 8 | Diet, muscle glycogen and physical performance 显示文摘 | BERGSTR M J HERMANSEN L HULTMAN E | 1967 | Acta Physiol Stand1967，71，2： | 1 |
| 9 | The sensitivity of bladder wash flow cytometry, bladder wash cytology, and voided cy- tology in the detection of bladder carcinoma 显示文摘 | Badalament RA Hermansen DK Kimmel M | 1987 | Cancer1987，60，7： | 1 |
| 10 | Impact of Organic Pig Production Systems on CO2 Emission, C Sequestra- tion and Nitrate Pollution 显示文摘 | HALBERG N HERMANSEN J E KRISTENSEN I S | 2010 | Agronomy for Sustainable Develop- ment2010，30，4： | 1 |
| 11 | Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD(liraglutide effect and action in diabetes)-2 study显示文摘 | Nauck M Frid A Hermansen K | 2009 | Diabetes Care2009，32，1： | 1 |
| 12 | A 26-week,randomized,parallel,treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucoselowering dmgs in insulin-naive people with type 2 diabetes显示文摘 | HERMANSEN K DAVIES M DEREZINSKI T | 2006 | Diabetes Care2006，29，6： | 1 |
| 13 | Preliminary estimates of contemporary soil organic carbon stocks in Denmark using multiple datasets and four scaling-up methods显示文摘 | Krogh L Noergaard A Hermansen M | 2003 | Agriculture Ecosystems and Environment2003，96，： | 1 |
| 14 | Alcohol and type 2 diabetes显示文摘 | Pietraszek A Gregersen S Hermansen K | 2010 | Nutr metab Cardiovasc Dis2010，20，： | 1 |
| 15 | Long-term efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with mefformin in type 2 diabetes: 2-year results from the LEAD-2 study显示文摘 | Nauck M Frid A Hermansen K | 2013 | Diabetes Obes Metab2013，150，： | 1 |
| 16 | Can the glycemic index(GI) be used as a tool in the prevention and management of type 2 diabetes 显示文摘 | Hermansen M F Eriksen N M Mortensen L S | 2006 | Rev Diabet Stud2006，3，2： | 1 |
| 17 | Effects of stage of lactation,milk protein genotype and body condition at calving on protein composition and renneting properties of bovine milk显示文摘 | FOLDAGER J HERMANSEN J E | 1997 | J Dairy Res1997，64，： | 1 |
| 18 | Organic livestock production systems and appropriate development in relation to public expectations 显示文摘 | Hermansen J E | 2003 | Livestock Production Science2003，80，： | 1 |
| 19 | Inconsis-tent Immunohistochemical Expression Patterns of Four Different CD133 Antibody Clones in Glioblastoma显示文摘 | Hermansen SK Christensen KG Jensen SS | 2011 | J Histochem Cy-tochem2011，59，4： | 1 |
| 20 | Six years' experience of using the BacT/ALERT system to screen all platelet concentrates,and additional testing of outdated platelet concentrates to estimate the frequency of false-negative results显示文摘 | Larsen CP Ezligini F Hermansen NO | 2005 | Vox Sang2005，88，2： | 1 |
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