|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evaluation of acoustic radiation force impulse imaging for determination of liver stiffness using transient elastography as a reference显示文摘AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan■ (FS)] as a reference. METHODS: Six hundred and six patients were enrolled in this study.All patients underwent liver stiffness measurement with FS (FS-LS) and ARFI (with shear wave velocity quantification; ARFI-SWV) and the performance of ARFI in comparison to FS was determined. Sixtyeight patients underwent liver biopsy. RESULTS: Significantly higher success rates for the determination of liver stiffness were found using ARFI as compared to FS [604/606 (99.7%) vs 482/606 (79.5%); P < 0.001]. ARFI-SWV correlated significantly with FS-LS (r = 0.920, P < 0.001). ARFI-SWV increased significantly with the stage of fibrosis (1.09 ± 0.13 m/s for patients with no significant fibrosis (FS-LS < 7.6 kPa); 1.46 ± 0.27 m/s for patients with significant liver fibrosis (7.6 < FS-LS ≤ 13.0 kPa); and 2.55 ± 0.77 m/s for patients with liver cirrhosis (FS-LS > 13.0 kPa)). ARFI-SWV cut-off values were identified for no significant fibrosis (1.29 m/s; sensitivity 91.4% and specificity 92.6%) and for liver cirrhosis (1.60 m/s; sensitivity 92.3% and specificity 96.5%). The optimal cut-off value for predicting liver fibrosis (F ≥ 2) was 1.32 m/s (sensitivity 87.0% and specificity 80.0%) and for liver cirrhosis (F4) 1.62 m/s (sensitivity 100% and specificity 85.7%), for patients who underwent liver biopsy. An excellent inter-and intraobserver reproducibility was observed for ARFI-SWV determinations. CONCLUSION: An ARFI-SWV cut-off value of 1.29 m/s seems to be optimal for patients with no significant liver fibrosis and 1.60 m/s for patients with liver cirrhosis. | Gerald Kircheis Abdurrahman Sagir Christoph Vogt Stephan vom Dahl Ralf Kubitz Dieter Hussinger | 2012 | World Journal of Gastroenterology2012，18，10： | 30 |
| 2 | Endocrine and paracrine role of bile acids显示文摘Bile acids are not only important for the absorption of dietary lipids and fat soluble vitamins but are signalling molecules with diverse endocrine and paracrine functions. Bile acids regulate bile acid, lipid and glucose metabolism and modulate temperature and energy homeostasis. Furthermore, bile acids can not only promote cell proliferation and liver regeneration but can also induce programmed cell death. Bile acid functions are mediated through different pathways which comprise the activation of nuclear hormone receptors, of intracellular kinases and of the plasma membrane-bound, G-protein coupled bile acid receptor TGR5/Gp-bar-1. | Verena Keitel Ralf Kubitz Dieter Hussinger | 2008 | World Journal of Gastroenterology2008，14，37： | 7 |
| 3 | The Nesting Problem in the Leather Manufacturing Industry显示文摘 | Ralf H Thomas L | 1995 | Annals of Operational Research1995，57，： | 3 |
| 4 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 5 | Seasonal dynamic of gross nitrification and N2O emission at two tropical rainforest sites in Queensland 显示文摘 | Ralf K Bob H Klaus B | 2008 | Australia Plant Soil2008，309，： | 1 |
| 6 | Osmoregulation of Bile Formation显示文摘 | Ralf Kubitz Dieter H?ussinger | 2007 | Methods in Enzymology2007，，： | 1 |
| 7 | Endoscopic therapy for esophageal perforation or anastomotic leak with a self-expandable metallic stent显示文摘 | Jessica M. Leers Carlo Vivaldi Hartmut Sch?fer Marc Bludau Jan Brabender Georg Lurje Till Herbold Arnulf H. H?lscher Ralf Metzger | 2009 | Surgical Endoscopy2009，，10： | 1 |
| 8 | Synthesis,crystal structure and magnetic properties of a ferromagnetically coupled difluoro-bridged dinuclear chromium(Ⅲ) complex with a substituted tetrahydros-alen derivative as ligand显示文摘 | Ralf S Arnd B Horst E Martina H Wolfgang H | 1996 | Inorg Chem1996，35，26： | 1 |
| 9 | Application of ultrasonic irradiation for the degradation of chemical contaminants in water显示文摘 | Hoffmann Michael R Hua Inez H?chemer Ralf | 1996 | Ultrasonics Sonochemistry1996，3，3： | 1 |
| 10 | Secretory meningiomas:clinical and immunohisto chemical observations显示文摘 | Ralf B Heinz-Hermann H Hubertus MM | | 0，，02： | 1 |
| 11 | Human cytomegalovirus prevents replication licensing by inhibiting MCM loading onto chromatin 显示文摘 | Luder W Ralf U Christian H | 2003 | EMBO reports2003，4，1： | 1 |
| 12 | Brain oedema in secretory meningiomas显示文摘 | Ralf B Heinz-Hermarm H Hubertus MM | | 0，，01： | 1 |
| 13 | Linking Transgene Expression of Engineered Mesenchymal Stem Cells and Angiopoietin-1–induced Differentiation to Target Cancer Angiogenesis显示文摘 | Claudius Conrad Yves Hüsemann Hanno Niess Irene von Luettichau Ralf Huss Christian Bauer Karl-Walter Jauch Christoph A. Klein Christiane Bruns Peter J. Nelson | 2011 | Annals of Surgery2011，，3： | 1 |
| 14 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 15 | Sixteen-slice spiral CT versus MR imaging for the assessment of left ventricular function in acute myocardial infarcion显示文摘 | Andreas H M Ralf K Marcus K | 2005 | Eur Radiol2005，15，1： | 1 |
| 16 | An introduction to spatial database systems显示文摘 | Ralf H-G Praktische I-IV FernUniversit t H | 1994 | SPECIAL ISSUE:Special issue on spatial database systems1994，3，4： | 1 |
| 17 | Hyperbranched polymers prepared via the core-dilution/low addition technique computer simulation of molecular weight distribution and degree of branching 显示文摘 | Ralf H Dirk H Holger F | 1998 | Macromolecules1998，，31： | 1 |
| 18 | Human cytomegalovirus prevents replication licensing by inhibiting MCM loading onto chromation显示文摘 | Lüder W Ralf U Christian H | 2003 | EMBO Reports2003，4，1： | 1 |
| 19 | BerlinMOD: a benchmark for moving object databases 显示文摘 | CHRISTIAN D THOMAS B RALF H G | 2009 | The VLDB Journal2009，，18： | 1 |
| 20 | A random linear network coding approach to multicast显示文摘 | Tracey H Muriel M'E Ralf K | 2006 | IEEE Transactions on Information Theory2006，52，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员