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| 1 | Clinical epidemiology and disease burden of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is defined as the presence of hepatic fat accumulation after the exclusion of other causes of hepatic steatosis, including other causes of liver disease, excessive alcohol consumption, and other conditions that may lead to hepatic steatosis. NAFLD encompasses a broad clinical spectrum ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis(NASH), advanced fibrosis, cirrhosis, and finally hepatocellular carcinoma(HCC). NAFLD is the most common liver disease in the world and NASH may soon become the most common indication for liver transplantation. Ongoing persistence of obesity with increasing rate of diabetes will increase the prevalence of NAFLD, and as this population ages, many will develop cirrhosis and end-stage liver disease. There has been a general increase in the prevalence of NAFLD, with Asia leading the rise, yet the United States is following closely behind with a rising prevalence from 15% in 2005 to 25% within 5 years. NAFLD is commonly associated with metabolic comorbidities, including obesity, type Ⅱ diabetes, dyslipidemia, and metabolic syndrome. Our understanding of the pathophysiology of NAFLD is constantly evolving. Based on NAFLD subtypes, it has the potential to progress into advanced fibrosis, end-stage liver disease and HCC. The increasing prevalence of NAFLD with advanced fibrosis, is concerning because patients appear toexperience higher liver-related and non-liver-related mortality than the general population. The increased morbidity and mortality, healthcare costs and declining health related quality of life associated with NAFLD makes it a formidable disease, and one that requires more in-depth analysis. | Brandon J Perumpail Muhammad Ali Khan Eric R Yoo George Cholankeril Donghee Kim Aijaz Ahmed | 2017 | World Journal of Gastroenterology2017，23，47： | 70 |
| 2 | Germline mutation analysis of MLH1 and MSH2 in Malaysian Lynch syndrome patients显示文摘AIM: To investigate the protein expression profi le of mismatch repair (MMR) genes in suspected cases of Lynch syndrome and to characterize the associated germline mutations. METHODS: Immunohistochemical analysis of tumor samples was performed to determine the protein expression profile of MMR protein. Germline mutation screening was carried out on peripheral blood samples. The entire exon regions of MLH1 and MSH2 geneswere amplifi ed by polymerase chain reaction, screened by denaturing high performance liquid chromatography (dHPLC) and analyzed by DNA sequencing to characterize the germline mutations. RESULTS: Three out of 34 tissue samples (8.8%) and four out of 34 tissue samples (11.8%) showed loss of nuclear staining by immunohistochemistry, indicating the absence of MLH1 and MSH2 protein expression in carcinoma cells, respectively. dHPLC analysis followed by DNA sequencing showed these samples to have germline mutations of MSH2 gene. However, no deleterious mutations were identifi ed in any of the 19 exons or coding regions of MLH1 gene, but we were able to identify MLH1 promoter polymorphism, -93G > A (rs1800734), in 21 out of 34 patients (61.8%). We identified one novel mutation, transversion mutation c.2005G > C, which resulted in a missense mutation (Gly669Arg), a transversion mutation in exon 1, c.142G > T, which resulted in a nonsense mutation (Glu48Stop) and splice-site mutation, c.2006-6T > C, which was adjacent to exon 13 of MSH2 gene. CONCLUSION: Germline mutations were identified in four Malaysian Lynch syndrome patients. Immunohistochemical analysis of tumor tissue proved to be a good pre-screening test before proceeding to germline mutation analysis of DNA MMR genes. | Mohd Nizam Zahary Ravindran Ankathi Human Genome Centre Gurjeet Kaur Muhammad Radzi Abu Hassan Harjinder Singh Venkatesh R Naik | 2012 | World Journal of Gastroenterology2012，18，8： | 3 |
| 3 | Autoregressive neural networks with exogenous variables for indoor temperature prediction in buildings显示文摘Thermal models of buildings are helpful to forecast their energy use and to enhance the control of their mechanical systems.However,these models are building-specific and require a tedious,error-prone and time-consuming development effort relying on skilled building energy modelers.Compared to white-box and gray-box models,data-driven(black-box)models require less development time and a minimal amount of information about the building characteristics.In this paper,autoregressive neural network models are compared to gray-box and black-box linear models to simulate indoor temperatures.These models are trained,validated and compared to actual experimental data obtained for an existing commercial building in Montreal(QC,Canada)equipped with roof top units for air conditioning.Results show that neural networks mimic more accurately the thermal behavior of the building when limited information is available,compared to gray-box and black-box linear models.The gray-box model does not perform adequately due to its under-parameterized nature,while the linear models cannot capture non-linear phenomena such as radiative heat transfer and occupancy.Therefore,the neural network models outperform the alternative models in the presented application,reaching a coefficient of determination R2 up to 0.824 and a root mean square error down to 1.11℃,including the error propagation over time for a 1-week period with a 5-minute time-step.When considering a 50-hour time horizon,the best neural networks reach a much lower root mean square error of around 0.6℃,which is suitable for applications such as model predictive control. | Benoit Delcroix Jérôme Le Ny Michel Bernier Muhammad Azam Bingrui Qu Jean-Simon Venne | 2021 | Building Simulation2021，14，1： | 3 |
| 4 | 接受他汀治疗患者新发糖尿病风险:人群为基础的研究显示文摘目的 研究接受HMG-CoA还原酶抑制剂(他汀类药物)治疗的患者的新发糖尿病风险。设计 人群为基础的队列研究,以时间事件分析的方法评估各种他汀类药物应用和新发糖尿病风险的相关性分析。计算危害比(hazard ratios,HR)来确定他汀的种类及剂量与新发糖尿病的关系。 | Aleesa A Caner Tara Gomes Ximena Camacho David N Juurlink Baiju R Shah Muhammad M Mamdani 张秀珍(译) 骆斯慧(译) 翁建平(校) | 2013 | 英国医学杂志中文版2013，16，5： | 2 |
| 5 | Core-shell particles of C-doped CdS and graphene: A noble metal-free approach for efficient photocatalytic H_(2) generation显示文摘To achieve efficient photocatalytic H_(2) generation from water using earth-abundant and cost-effective materials,a simple synthesis method for carbon-doped CdS particles wrapped with graphene(C-doped CdS@G)is reported.The doping effect and the application of graphene as cocatalyst for CdS is studied for photocatalytic H_(2) generation.The most active sample consists of CdS and graphene(CdS-0.15G)exhibits promising photocatalytic activity,producing 3.12 mmol g^-(1) h^-(1) of H_(2) under simulated solar light which is^4.6 times superior than pure CdS nanoparticles giving an apparent quantum efficiency(AQY)of 11.7%.The enhanced photocatalytic activity for H_(2) generation is associated to the narrowing of the bandgap,enhanced light absorption,fast interfacial charge transfer,and higher carrier density(N_(D))in C-doped CdS@G samples.This is achieved by C doping in CdS nanoparticles and the formation of a graphene shell over the C-doped CdS nanoparticles.After stability test,the spent catalysts sample was also characterized to investigate the nanostructure. | Muhammad Zubair Estelle Marie M.Vanhaecke Ingeborg-Helene Svenum Magnus RФnning Jia Yang | 2020 | Green Energy & Environment2020，5，4： | 2 |
| 6 | Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity显示文摘 | Muhammad A Cowley Andrew R Moloney Mark G | 2010 | Tetrahedron: Asymmetry2010，21，1314： | 1 |
| 7 | All-digital synthesizer and discrete-time receiver for in 130 nm CMOS显示文摘 | Staszewki R B TX frequency Bluetooth radio Circuits 2004 Muhammad K Leipold D | 2004 | IEEE J Solid State2004，39，12： | 1 |
| 8 | A statistical evaluation of recent full reference image quali- ty assessment algorithms显示文摘 | Sheikh Hamid R Sabir Muhammad F Bovik Alan C | 2006 | IEEE Transactions on Im- age Processing2006，15，11： | 1 |
| 9 | Probing the role of surface treated montmorillonite on the properties of semi-aromatic polyamide/clay nanocomposites显示文摘 | Zulfiqar S Ayesha K Muhammad R | 2008 | Applied Surface Science2008，255，5： | 1 |
| 10 | Verification of digital RF processors: RF, analog, baseband and software 显示文摘 | MUHAMMAD K MURPHY T STASZEWSKI R B | 2007 | IEEE J Sol Sta Circ2007，42，5： | 1 |
| 11 | Altered synaptophysin expression in the rat spinal cord after chronic constriction injury of sciatic nerve显示文摘 | Chou AK Muhammad R Huang SM | 2002 | Neurosci Lett2002，333，： | 1 |
| 12 | Application of native and phosphorylated tapioca starches in potato starch noodle显示文摘 | Muhammad K Kusnandar F Rahman R A | 1999 | International Journal of FOod Science and Technology1999，34，： | 1 |
| 13 | Characteristics of phenol biodegradation in saline solutions by monoeultures of Pseudomonas aeruginosa and Pseudornonas pseudomallei 显示文摘 | MUHAMMAD A SAMINA L SAKANDAR R etal | 2007 | Journal of Hazardous Materials2007，149，1： | 1 |
| 14 | A common variant on chromosome 4q25 is associated with prolonged PR interval in subjects with and without atrial fibrillation显示文摘 | Kolek MJ Parvez B Muhammad R | 2014 | Am J Cardiol2014，113，2： | 1 |
| 15 | Eval- uation of the genotoxicity o: Orthosiphon stamineus aqueous extract显示文摘 | Muhammad H Gomes-Carneiro M R Poca K S | 2011 | J Ethnopharmacol2011，133，2： | 1 |
| 16 | Minimal toxicity of stabilized compacted DNA nanoparticles in the murine lung 显示文摘 | Ziady A-G Gedeon C R Muhammad O | 2003 | Molecular Therapy2003，8，6： | 1 |
| 17 | Progression from graphene and graphene oxide to high performance polymer-based nanocomposite: A review显示文摘 | SHAH R KAUSAR A MUHAMMAD B | 2015 | Polymer- Plastics Technology and Engineering2015，54，2： | 1 |
| 18 | A study on the effect of tool-edge radius on critical machining characteristics in ultra-precision milling of ttmgsten carbide显示文摘 | MUHAMMAD A MUSTAFIZUR R WONG Y S | 2013 | The International Journal of Advanced Manufacturing Technology2013，67，58： | 1 |
| 19 | A Fuzzy Controller for Lower Limb Exoskeletons during Sit-to- Stand and Stand-to-Sit Movement Using Wearable Sensors 显示文摘 | Sharif Muhammad Taslim R Norhafizan A Imtiaz Ahmed C | 2014 | Sensors ( 14248220)2014，14，3： | 1 |
| 20 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
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