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| 1 | Systematic review and meta-analysis on the prophylactic role of non-steroidal anti-inflammatory drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘AIM: To critically appraise the published randomized, controlled trials on the prophylactic effectiveness of the non-steroidal anti-inflammatory drugs(NSAIDs), in reducing the risk of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis. METHODS: A systematic literature search(MEDLINE, Embase and the Cochrane Library, from inception of the databases until May 2015) was conducted to identify randomized, clinical trials investigating the role of NSAIDs in reducing the risk of post-ERCP pancreatitis. Random effects model of the meta-analysis was carried out, and results were presented as odds ratios(OR) with corresponding 95%CI.RESULTS: Thirteen randomized controlled trials on 3378 patients were included in the final meta-analysis. There were 1718 patients in the NSAIDs group and 1660 patients in non-NSAIDs group undergoing ERCP. The use of NSAIDs(through rectal route or intramuscular route) was associated with the reduced risk of post-ERCP pancreatitis [OR, 0.52(0.38-0.72), P = 0.0001]. The use of pre-procedure NSAIDs was effective in reducing approximately 48% incidence of post-ERCP pancreatitis, number needed to treat were 16 with absolute risk reduction of 0.05. But the risk of post-ERCP pancreattis was reduced by 55% if NSAIDs were administered after procedure. Similarly, diclofenac was more effective(55%) prophylactic agent compared to indomethacin(41%).CONCLUSION: NSAIDs seem to have clinically proven advantage of reducing the risk of post-ERCP pancreatitis. | Muhammad S Sajid Amir H Khawaja Mazin Sayegh Krishna K Singh Zinu Philipose | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 14 |
| 2 | Environmental risk factors for inflammatory bowel diseases: Evidence based literature review显示文摘AIM: To advances in genetics and immunology have contributed to the current understanding of the pathogenesis of inflammatory bowel diseases(IBD). METHODS: The current opinion on the pathogenesis of IBD suggests that genetically susceptible individuals develop intolerance to dysregulated gut microflora(dysbiosis) and chronic inflammation develops as a result of environmental insults. Environmental exposures are innumerable with varying effects during the life course of individuals with IBD. Studying the relationship between environmental factors and IBD may provide the missing link to increasing our understanding of the etiology and increased incidence of IBD in recent years with implications for prevention, diagnosis, and treatment. Environmental factors are heterogeneous and genetic predisposition, immune dysregulation, or dysbiosis do not lead to the development of IBD in isolation. RESULTS: Current challenges in the study of environmental factors and IBD are how to effectively translate promising results from experimental studies to humans in order to develop models that incorporate the complex interactions between the environment, genetics, immunology, and gut microbiota, and limited high quality interventional studies assessing the effect of modifying environmental factors on the natural history and patient outcomes in IBD.CONCLUSION: This article critically reviews the current evidence on environmental risk factors for IBD and proposes directions for future research. | Ayokunle T Abegunde Bashir H Muhammad Owais Bhatti Tauseef Ali | 2016 | World Journal of Gastroenterology2016，22，27： | 11 |
| 3 | Ever-increasing diversity of drug-induced pancreatitis显示文摘With over 100000 hospital admissions per annum,acute pancreatitis remains the leading gastrointestinal cause of hospitalization in the United States and has farreaching impact well beyond.It has become increasingly recognized that druginduced pancreatitis(DIP),despite accounting for less than 3%of all cases,represents an important and growing though often inconspicuous cause of acute pancreatitis.Nevertheless,knowledge of DIP is often curtailed by the limited availability of evidence needed to implicate given agents,especially for nonprescription medications.Indeed,the majority of available data is derived from case reports,case series,or case control studies.Furthermore,the mechanism of injury and causality for many of these drugs remain elusive as a definitive correlation is generally not established(<10%of cases).Several classification systems have been proposed,but no single system has been widely adopted,and periodic updates are required in light of ongoing pharmacologic expansion.Moreover,infrequently prescribed medications or those available over-thecounter(including herbal and other alternative remedies)are often overlooked as a potential culprit of acute pancreatitis.Herein,we review the ever-increasing diversity of DIP and the potential mechanisms of injury with the goal of raising awareness regarding the nature and magnitude of this entity.We believe this manuscript will aid in increasing both primary and secondary prevention of DIP,thus ultimately facilitating more expedient diagnosis and a decrease in DIPrelated morbidity. | Simcha Weissman Muhammad Aziz Ryan B Perumpail Tej I Mehta Rutwik Patel James H Tabibian | 2020 | World Journal of Gastroenterology2020，26，22： | 8 |
| 4 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 5 | Surface plasmon polariton at the interface of dielectric and graphene medium using Kerr effect显示文摘We theoretically investigate the control of surface plasmon polariton(SPP) generated at the interface of dielectric and graphene medium under Kerr nonlinearity. The controlled Kerr nonlinear signal of probe light beam in a dielectric medium is used to generate SPPs at the interface of dielectric and graphene medium. The positive, negative absorption, and dispersion properties of SPPs are modified and controlled by the control and Kerr fields. A large amplification(negative absorption) is noted for SPPs under the Kerr nonlinearity. The normal/anomalous slope of dispersion and propagation length of SPPs is modified and controlled with Kerr nonlinearity. This leads to significant variation in slow and fast SPP propagation. The controlled slow and fast SPP propagation may predict significant applications in nano-photonics, optical tweezers, photovoltaic devices, plasmonster, and sensing technology. | Bakhtawar Muhammad Haneef B A Bacha H Khan M Atif | 2018 | Chinese Physics B2018，27，11： | 3 |
| 6 | Pam3CSK4 enhances adaptive immune responses to recombinant Mycobacterium bovis bacille Calmette-Guérin expressing Plasmodium falciparum C-terminus merozoite surface protein-1显示文摘Objective: To determine the effects of toll-like receptor 2(TLR-2) agonist, Pam3 CSK4, on cellular and humoral immune response against recombinant Mycobacterium bovis bacille Calmette-Guérin(rBCG) expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum.Methods: Six groups of mice(n=6 per group) received intraperitoneal phosphate buffered saline T80(PBS-T80), BCG or rBCG in the presence or absence of Pam3 CSK4. Enzymelinked immunosorbent assay was carried out to measure serum total IgG, IgG1, IgG2 a, and Ig G2 b production. Spleens were also harvested and splenocytes were co-cultured with rBCG antigen for in vitro determination of IL-4 and IFN-γ via enzyme-linked immunosorbent assay.Results: The production of total IgG and the isotype IgG1, IgG2 a and IgG2 b was significantly higher in rBCG-immunised mice than in the BCG and PBS-T80-immunised mice, and Pam3 CSK4 further enhanced their productions. A similar pattern was also observed in IFN-γ production. Moreover, there was no significant difference in IL-4 production in all groups either in the presence or absence of Pam3 CSK4.Conclusions: We present evidence of the adjuvant effects of TLR-2 agonist in enhancing the production of total IgG, IgG1, IgG2 a, IgG2 b, as well as IFN-γ in response to rBCG. However, the presence or absence of Pam3 CSK4 had no effect on IL-4 production. | Mohamed H Abdikarim Muhammad A Abbas Munirah N Zakaria Robaiza Zakaria Rapeah Suppian | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，7： | 3 |
| 7 | Preventive health measures in inflammatory bowel disease显示文摘We aim to review the literature and provide guidance on preventive health measures in inflammatory bowel disease(IBD). Structured searches were performed in Pub Med,MEDLINE,EMBASE,Web of Science and Cochrane Library from January 1976 to June 2016 using the following keywords:(inflammatory bowel disease OR Crohn's disease OR ulcerative colitis) AND(health maintenance OR preventive health OR health promotion). Abstracts of the articles selected from each of these multiple searches were reviewed,and those meeting the inclusion criteria(that is,providing data regarding preventive health or health maintenance in IBD patients) were recorded. Reference lists from the selected articles were manually reviewed to identify further relevant studies. Patients with IBD are at increased risk of developing adverse events related to the disease course,therapeutic interventions,or non-adherence to medication. Recent studies have suggested that IBD patients do not receive preventive services with the same thoroughness as patients with other chronic diseases. Preventive health measures can avert morbidity and improve the quality of life of patients with IBD. Gastroenterologists and primary care physicians(PCPs) should have an up to date working knowledge of preventive health measures for IBD patients. A holistic approach and better communication between gastroenterologists and PCPs with explicit clarification of roles will prevent duplication of services and streamline care. | Ayokunle T Abegunde Bashir H Muhammad Tauseef Ali | 2016 | World Journal of Gastroenterology2016，22，34： | 2 |
| 8 | Physiological and biochemical appraisal for mulching and partial rhizosphere drying of cotton显示文摘Water is the main factor for the healthy life of plant.One of the main negative effects of climate change is the increasing scarcity of water that is lethal for plant.Globally,for water deficit regions(arid and semi-arid),drought is the main factor responsible for low production of agriculture,especially for cotton.Great efforts have been and are being made to find alternatives to water saving practices.This study aimed to examine the effects of partial rhizosphere drying(PRD,half of the root system irrigated at one event,and the other half irrigated in the next event,and so on)with and/or without various mulching treatments on physiological and biochemical traits of cotton.To explore this objective,we laid out experiments in completely randomized design with factorial arrangement in the Islamia University of Bahawalpur,Pakistan in 2016.Two factors included were four mulching treatments(M0,no mulching;M1,black plastic mulching;M2,wheat straw mulching;and M3,cotton sticks mulching)and two irrigation levels(I0,control(full irrigation);and I1,PRD).Fisher's analysis of variance among means of treatments was compared using least significant difference test at 5% probability level.Results revealed that the maximum plant height,leaf area,leaf gas exchange(photosynthetic rate and stomata conductance),chlorophyll,proline and total sugar contents,and enzyme activities were higher under M2 than under other three mulching treatments.As for irrigation levels,higher values of plant height,photosynthesis and water related parameters(leaf water potential,leaf osmotic potential,leaf turgor potential,etc.)were recorded.Contents of total sugar and proline and activities of antioxidant enzymes were significantly higher in PRD-treated plants than in control plants.It was concluded that combined application of PRD and mulching was more effective than the rest of the treatments used in the experiment.Similar study can be conducted in the field by applying irrigation water in alternate rows in semi-arid regions. | Rashid IQBAL Muhammad A S RAZA Muhammad F SALEEM Imran H KHAN Salman AHMAD Muhammad S ZAHEER Muhammad U ASLAM Imran HAIDER | 2019 | Journal of Arid Land2019，11，5： | 2 |
| 9 | Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis. | Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic | 2019 | Cellular & Molecular Immunology2019，16，2： | 2 |
| 10 | Mycorrhiza and Phosphate Solubilizing Bacteria:Potential Bioagents for Sustainable Phosphorus Management in Agriculture显示文摘Phosphorus(P)is a critical nutrient that plays an essential role in improving soil fertility for optimum plant growth and productivity.It is one of the most deficient macro-nutrients in agricultural soils after nitrogen and is considered inadequate for plant growth and production.To P availability in soils,the farmers are applying huge amounts of synthetic P fertilizers that adversely affect the wider environment,groundwater,soil fertility and microbial population.Many beneficial microbes are known to release and supply soluble P for improving growth and yield of a variety of plants in a sustainable manner in P deficient soils.Thus,inoculation of these microbes,including arbuscular mycorrhizal fungi(AMF)and phosphate solubilizing bacteria(PSB)to soil to enhance crop production without harming the environment,is an alternative approach to chemical fertilizers.The combined role of AMF and PSB in P solubilization is not well understood and the application and mode of action of these microbial groups are often naive due to variation in the environment.Therefore,the current review article would develop a better understanding of the interactive role and mechanisms of AMF and PSB in improving P availability from both organic and inorganic sources in a sustainable crop production system.Finally,the current review would loop out further avenues for researchers interested to commercially produce effective AMF and PSB-based biofertilizers for sustainable management of phosphorus over a wide range of agricultural crops worldwide. | Fazli Wahid Muhammad Sharif Shah Fahad Amjad Ali Muhammad Adnan Rafiullah Shah Saud Subhan Danish Muhammad Arif Ali Niaz Ahmed Hüseyin Arslan Doğan Arslan Murat Erman Ayman EL Sabagh Fatemeh Gholizadeh Rahul Datta | 2022 | Phyton-International Journal of Experimental Botany2022，91，2： | 2 |
| 11 | One-time password system with infinite nested hash chains显示文摘 | MOHAMED H E MUHAMMAD K K KHALED A | 2010 | Communications in Computer and Information Science2010，122，： | 1 |
| 12 | Structure-activityrelationships of quassinoids for eukaryotic protein synthesis显示文摘 | Fukamiya N Lee K H Muhammad I | 2005 | Cancer Lett2005，220，1： | 1 |
| 13 | A novel FP- GA implementation of AES-128 using reduced res- idue of prime numbe based S-Box 显示文摘 | Muhammad H Rais Syed M Qasim | 2009 | IJCSNS International Journal of Computer Science and Net- work Security2009，9，9： | 1 |
| 14 | Common cause failure analysis of PWR containment spray system by GO-FLOW methodology显示文摘 | Muhammad H Hidekazu Y Takeshi M | 2013 | Nuclear Engineering and Design2013，262，9： | 1 |
| 15 | Synthesis, chemical characterization, DNA binding, antioxidant, antibacterial, and antifungal activities of ferrocence incorporated selenoureas 显示文摘 | RAJA A H AMIN B MUHAMMAD N T | 2014 | J Biochem Mol Toxico12014，28，2： | 1 |
| 16 | Infection with Influenza Virus Induces IL-33 in Murine Lungs显示文摘 | Le Goffic Ronan Arshad Muhammad Imran Rauch Michel L’Helgoualc’h Annie Delmas Bernard Piquet-Pellorce Claire Samson Michel | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，6： | 1 |
| 17 | Inhibition of α-glucosidase by oleanolic acid and its synthetic derivatives显示文摘 | Muhammad J Syed S H | 2002 | Phytochemistry2002，60，： | 1 |
| 18 | Hyperspectral Remote Sensing:Dimensional Reduction and End Member Extraction显示文摘 | Muhammad A Sungyoung L Ihsan U H | | 0，，02： | 1 |
| 19 | Antiseptics,iodine,povidone iodine and traumatic wound cleansing显示文摘 | Muhammad N Khan Abul H Naqvi | 2006 | Tiss Viab Soc2006，16，4： | 1 |
| 20 | Comparative study on vegetative,reproductive and qualitative traits of seven diploid and tetraploid watermelon lines显示文摘 | Muhammad J J Sung W K Dae H K | 2005 | Euphytica2005，145，3： | 1 |
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