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| 1 | Systematic review and meta-analysis on the prophylactic role of non-steroidal anti-inflammatory drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘AIM: To critically appraise the published randomized, controlled trials on the prophylactic effectiveness of the non-steroidal anti-inflammatory drugs(NSAIDs), in reducing the risk of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis. METHODS: A systematic literature search(MEDLINE, Embase and the Cochrane Library, from inception of the databases until May 2015) was conducted to identify randomized, clinical trials investigating the role of NSAIDs in reducing the risk of post-ERCP pancreatitis. Random effects model of the meta-analysis was carried out, and results were presented as odds ratios(OR) with corresponding 95%CI.RESULTS: Thirteen randomized controlled trials on 3378 patients were included in the final meta-analysis. There were 1718 patients in the NSAIDs group and 1660 patients in non-NSAIDs group undergoing ERCP. The use of NSAIDs(through rectal route or intramuscular route) was associated with the reduced risk of post-ERCP pancreatitis [OR, 0.52(0.38-0.72), P = 0.0001]. The use of pre-procedure NSAIDs was effective in reducing approximately 48% incidence of post-ERCP pancreatitis, number needed to treat were 16 with absolute risk reduction of 0.05. But the risk of post-ERCP pancreattis was reduced by 55% if NSAIDs were administered after procedure. Similarly, diclofenac was more effective(55%) prophylactic agent compared to indomethacin(41%).CONCLUSION: NSAIDs seem to have clinically proven advantage of reducing the risk of post-ERCP pancreatitis. | Muhammad S Sajid Amir H Khawaja Mazin Sayegh Krishna K Singh Zinu Philipose | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 14 |
| 2 | Robotic total meso-rectal excision for rectal cancer: A systematic review following the publication of the ROLARR trial显示文摘AIM To compare outcomes in patients undergoing rectal resection by robotic total meso-rectal excision(RTME) vs laparoscopic total meso-rectal excision(LTME).METHODS Standard medical electronic databases such as Pub-Med, MEDLINE, EMBASE and Scopus were searched to find relevant articles. The data retrieved from all types of included published comparative trials in pati-ents undergoing RTME vs LTME was analysed using the principles of meta-analysis. The operative, post-operative and oncological outcomes were evaluated to assess the effectiveness of both techniques of TME. The summated outcome of continuous variables was expressed as standardized mean difference(SMD) and dichotomous data was presented in odds ratio(OR).RESULTS One RCT(ROLARR trial) and 27 other comparative studies reporting the non-oncological and oncological outcomes following RTME vs LTME were included in this review. In the random effects model analysis using the statistical software Review Manager 5.3, the RTME was associated with longer operation time(SMD, 0.46; 95%CI: 0.25, 0.67; z = 4.33; P = 0.0001), early passage of first flatus(P = 0.002), lower risk of conversion(P = 0.00001) and shorter hospitalization(P = 0.01). The statistical equivalence was seen between RTME and LTME for non-oncological variables like blo-od loss, morbidity, mortality and re-operation risk. The oncological variables such as recurrence(P = 0.96), number of harvested nodes(P = 0.49) and positive circumferential resection margin risk(P = 0.53) were also comparable in both groups. The length of distal resection margins was similar in both groups. CONCLUSION RTME is feasible and oncologically safe but failed to demonstrate any superiority over LTME for many sur-gical outcomes except early passage of flatus, lower risk of conversion and shorter hospitalization. | Katie Jones Mohamed G Qassem Parv Sains Mirza K Baig Muhammad S Sajid | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 4 |
| 3 | Black phosphorus-based field effect transistor devices for Ag ions detection显示文摘Black phosphorus(BP), an attractive two-dimensional(2 D) semiconductor, is widely used in the fields of optoelectronic devices, biomedicine, and chemical sensing. Silver ion(Ag^+), a commonly used additive in food industry, can sterilize and keep food fresh. But excessive intake of Ag^+will harm human health. Therefore, high sensitive, fast and simple Ag+detection method is significant. Here, a high-performance BP field effect transistor(FET) sensor is fabricated for Ag^+detection with high sensitivity, rapid detection speed, and wide detection concentration range. The detection limit for Ag^+is 10^(-10) mol/L. Testing time for each sample by this method is 60 s. Besides, the mechanism of BP-FET sensor for Ag^+detection is investigated systematically. The simple BP-FET sensor may inspire some relevant research and potential applications, such as providing an effective method for the actual detection of Ag^+, especially in witnessed inspections field of food. | 王慧德 David K Sang 郭志男 曹睿 赵劲来 Muhammad Najeeb Ullah Shah 范涛健 范滇元 张晗 | 2018 | Chinese Physics B2018，27，8： | 4 |
| 4 | Endoglin in liver fibrogenesis: Bridging basic science and clinical practice显示文摘Endoglin, also known as cluster of differentiation CD105, was originally identified 25 years ago as a novel marker of endothelial cells. Later it was shown that endoglin is also expressed in pro-fibrogenic cells including mesangial cells, cardiac and scleroderma fibroblasts, and hepatic stellate cells. It is an integral membranebound disulfide-linked 180 kDa homodimeric receptor that acts as a transforming growth factor-β(TGF-β) auxiliary co-receptor. In humans, several hundreds of mutations of the endoglin gene are known that give rise to an autosomal dominant bleeding disorder that is characterized by localized angiodysplasia and arteriovenous malformation. This disease is termed hereditary hemorrhagic telangiectasia type Ⅰ and induces various vascular lesions, mainly on the face, lips, hands and gastrointestinal mucosa. Two variants of endoglin(i.e., S- and L-endoglin) are formed by alternative splicing that distinguishes from each other in the length of their cytoplasmic tails. Moreover, a soluble form of endoglin, i.e.,sol-Eng, is shedded by the matrix metalloprotease-14 that cleaves within the extracellular juxtamembrane region. Endoglin interacts with the TGF-β signaling receptors and influences Smad-dependent and-independent effects. Recent work has demonstrated that endoglin is a crucial mediator during liver fibrogenesis that critically controls the activity of the different Smad branches. In the present review, we summarize the present knowledge of endoglin expression and function, its involvement in fibrogenic Smad signaling, current models to investigate endoglin function, and the diagnostic value of endoglin in liver disease. | Steffen K Meurer Muhammad Alsamman David Scholten Ralf Weiskirchen | 2014 | World Journal of Biological Chemistry2014，5，2： | 3 |
| 5 | Intensive care unit complications and outcomes of adult patients with hemophagocytic lymphohistiocytosis: A retrospective study of 16 cases显示文摘AIM To study the management, complications and outcomes of adult patients admitted with hemophagocytic lymphohistiocytosis(HLH) in the intensive care unit(ICU).METHODS We performed a retrospective observational study of adult patients with the diagnosis of 'HLH' admitted to the two academic medical ICUs of Baylor College of Medicine between 01/01/2013 to 06/30/2017. HLH was diagnosed using the HLH-2004 criteria proposed by the Histiocyte Society.RESULTS Sixteen adult cases of HLH were admitted to the medical ICUs over 4 years.Median age of presentation was 49 years and 10(63%) were males. Median Sequential Organ Failure Assessment(SOFA) score at the time of ICU admission was 10. Median ICU length of stay(LOS) was 11.5 d and median hospital LOS was 29 d. Septic shock and acute respiratory failure accounted for majority of diagnoses necessitating ICU admission. Septic shock was the most common ICU complication seen in(88%) patients, followed by acute kidney injury(81%) and acute respiratory failure requiring mechanical ventilation(75%). Nine patients(56%) developed disseminated intravascular coagulation and eight(50%) had acute liver failure. 10 episodes of clinically significant bleeding were observed.Multi system organ failure was the most common cause of death seen in 12(75%)patients. The 30 d mortality was 37%(6 cases) and 90 d mortality was 81%(13 cases). There was no difference in mortality based on age(above or less than 50 years), SOFA score on ICU admission(more than or less than 10),immunosuppression, time to diagnose HLH or direct ICU admission versus floor transfer.CONCLUSION HLH is a devastating disease associated with poor outcomes in ICU. Intensivists need to have a high degree of clinical suspicion for HLH in patients with septic shock/multi system organ failure and progressive bi/pancytopenia who are not responding to standard management in ICU. | Sumit Kapoor Christopher K Morgan Muhammad Asim Siddique Kalpalatha K Guntupalli | 2018 | World Journal of Critical Care Medicine2018，7，6： | 3 |
| 6 | Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model 显示文摘 | KING G D MUHAMMAD A K CURTIN J F | 2008 | Neuro Oncol2008，10，1： | 1 |
| 7 | One-time password system with infinite nested hash chains显示文摘 | MOHAMED H E MUHAMMAD K K KHALED A | 2010 | Communications in Computer and Information Science2010，122，： | 1 |
| 8 | Structure-activityrelationships of quassinoids for eukaryotic protein synthesis显示文摘 | Fukamiya N Lee K H Muhammad I | 2005 | Cancer Lett2005，220，1： | 1 |
| 9 | Information Regarding Agronomic Practices and Plant Protection Measures Obtained by the Farmers through Electronic Media显示文摘 | Khan G A Muhammad S Ch K M | 2013 | Journal of Animal and Plant Sciences2013，23，2： | 1 |
| 10 | All-digital synthesizer and discrete-time receiver for in 130 nm CMOS显示文摘 | Staszewki R B TX frequency Bluetooth radio Circuits 2004 Muhammad K Leipold D | 2004 | IEEE J Solid State2004，39，12： | 1 |
| 11 | Prevalence and distribution of peste des petits ruminants virus infection in small ruminants 显示文摘 | Haider A K Muhammad S Muhammad A | 2008 | Small Ruminant Res2008，79，： | 1 |
| 12 | 显示文摘 | Muhammad I Bo-Kyung K | 2010 | Polymer Degradation and Sta bilit y2010，95，9： | 1 |
| 13 | Probing the role of surface treated montmorillonite on the properties of semi-aromatic polyamide/clay nanocomposites显示文摘 | Zulfiqar S Ayesha K Muhammad R | 2008 | Applied Surface Science2008，255，5： | 1 |
| 14 | In Vivo Effects of the Anti-Interleukin-6 Receptor Inhibitor Tocilizumab on the B Cell Compartment显示文摘 | Roll P Muhammad K Schumann M | 2011 | Arthritis Rheum2011，63，： | 1 |
| 15 | Estimation the parameters of Chirp Signals: An Iterative Approach显示文摘 | Muhammad Z Ikram K Abed-Mwraim Yingbo Hua | 1998 | IEEE Transcation on Signal Processing1998，36，12： | 1 |
| 16 | Verification of digital RF processors: RF, analog, baseband and software 显示文摘 | MUHAMMAD K MURPHY T STASZEWSKI R B | 2007 | IEEE J Sol Sta Circ2007，42，5： | 1 |
| 17 | A New Iterative Method for Solving Absolute Value Equations显示文摘 | MUHAMMAD A N JAVED I SANJAY K | 2011 | International Journal of the Physical Sciences2011，6，7： | 1 |
| 18 | Evaluation of growth and flowering potential of rosa hybrida cuhivars under faisalabad climatic conditions 显示文摘 | Muhammad N Muhammad A K Atif Riaz | 2011 | Pak J Agri Sci2011，，4： | 1 |
| 19 | Anti-inflammatoryactivities of Sieboldogenin from Smilax china Linn:Experimentaland computational studies显示文摘 | Inamullah K Muhammad N Farooq E | 2009 | J Ethnopharmacol2009，121，1： | 1 |
| 20 | Application of native and phosphorylated tapioca starches in potato starch noodle显示文摘 | Muhammad K Kusnandar F Rahman R A | 1999 | International Journal of FOod Science and Technology1999，34，： | 1 |
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